A PSYCHOLOGICAL PERSPECTIVE ON CULTURAL DIFFERENCE: EPISTEMOLOGICAL HETEROGENEITY AND INDIVIDUAL HETEROGENEITY ACROSS CULTURES

Most cross-cultural studies of management have been sociological type. Conventional view of cultures and sociological perspective has resulted in the assumption that within each culture members are homogeneous in their psychological make-up, logic, and perspective. Although researchers have reminded us that people vary on pivotal psychological dimensions, both on a between-country and within-country basis, these reminders were not heeded. Maruyama’s theories and research on epistemological heterogeneity, and individual heterogeneity across cultures, or as it is called, mindscape, were the exception. This paper elaborates on epistemological heterogeneity and individual heterogeneity across cultures. It suggests that researchers in international management could use this line of inquiry to expand upon our understanding of effective managerial practices dealing with cultural differences among people

Effects of International Study Tours on Attitude toward Doing Business Globally: Assurance of Learning in Executive MBA Programs

The past two decades have experienced and realized the wave of globalization as pervasive and impactful imperative in the world of academia, and not just in the corporate world. This realization is reflected in the 2011-13 Report by AACSB Task Force on Globalization of Management Education (The Association to Advance Collegiate Schools of Business - International, June 2011-13). The AACSB report highlights broad globalization trends in management education that have drawn the attention of institutions, corporations and business schools alike, that are striving to prepare their key stakeholders (managers and students) to face today’s complex global challenges. Today’s increasingly integrated and complex global business environment has led many Executive MBA programs to address and incorporate global awareness, perspectives, and practices into curriculum instructions. This challenge led to many U.S.- and non-U.S. based Executive MBA (EMBA) programs to follow the mandate proclaimed by AACSB: “…AACSB recognizes institutions that uphold its mission and core values, work to advance the interests of global management education, and participate in AACSB’s community of leading business schools. In this context, AACSB focuses on continuous quality improvement in management education through innovation, engagement, and impact” (http://www.aacsb.edu/). Specifically, many EMBA programs have infused a global tour as an important component of the curriculum, albeit some of these programs have made such global tours as an optional part, whereas many EMBA programs have made it a required component. Of the curriculum; about 65 percent of EMBA programs require a global trip (http://www.emba.org/research_prog_results.htm)

Molecular imaging using by diffusion-weighted imaging of brain tumor through signal intensity: Progress in molecular cancer imaging

Introduction: Characterizing the variations of the brain tumors has the significant effect in the treatment process of affected patients. Brain metastatic tumors are usually diagnosed following by the neurological symptoms in patients. The purpose of this thesis is the role of diffusion-weighted-magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) values in the evaluation of different benign and malignant brain mass lesions before surgery with histopathological correlation. Materials and Methods: In this study MR examination of 54 patients who with brain metastatic tumor referring to 7th-Tir Hospital were randomly selected and imaged with T2W Multi-echo sequences and GRE-EPI (DWI) in addition to taking the routine sequence of the brain. Results: In analyzing the data for ADCmin values were measured within the tumors and mean values were evaluated regarding statistical differences between groups.9 The ADCmin values of low-grade gliomas(1.09 ± 0.20 × 10−3 mm2/s) were signi=icantly higher (p < .001) than those of other tumors. Generally, ADC value of 0.5613 ± 0.02580 indicates brain metastatic tumors with lung origin, ADC value of 1.009 ± 0.03820 tumors with liver and breast origin, and ADC value of 1.556 ± 0.03500 tumors with colon and prostate origin. Conclusion: According to our results, Diffusion parameters during treatment were evaluated for early noninvasive biomarkers. The ADC changes from mid- to post-treatment suggest such a possible early non-invasive biomarker

Response of an Arch Dam to Non-Uniform Excitation Generated by a Seismic Wave Scattering Model

Non-uniform ground motions are generated based on a single record available at a site and seismic wave scattering analysis. The Chino Hills 2008 earthquake records at the Pacoima Dam site are used to indicate the accuracy of the method. Dynamic analysis of the Pacoima dam-reservoir-foundation under uniform and non-uniform ground motions is carried out using the EACD-3D2008 software, and the results are compared to recorded responses at different locations on the dam. There is good agreement between computed and recorded displacements of the dam for non-uniform excitation. For uniform excitation, the displacements are underestimated in comparison with those obtained from recorded excitation. Significant intensification of stresses, especially near the foundation, and different patterns of stress distribution are observed for non-uniform excitation in comparison with uniform excitation. For uniform excitation maximum stresses occur in the crown cantilever near the crest, but for non-uniform excitation the maximum stresses occur along the sides and near the foundation

Communication: Adjusting charge transfer state energies for configuration interaction singles: Without any parameterization and with minimal cost

In a recent article, we showed that configuration interaction singles (CIS) has a systematic bias against charge-transfer (CT) states: CT vertical excitation energies are consistently too high (by 1-2 eV) as compared with non-CT energies [J. E. Subotnik, J. Chem. Phys. 137, 071104 (2011)]. We now show that this CIS error can be corrected approximately by performing a single Newton- Raphson step to reoptimize orbitals, thus establishing a new set of orbitals which better balances ground and excited state energies. The computational cost of this correction is exactly that of one coupled-perturbed Hartree-Fock calculation, which is effectively the cost of the CIS calculation itself. In other words, for twice the computational cost of a standard CIS calculation, or roughly the same cost as a linear-response time-dependent Hartree-Fock calculation, one can achieve a balanced, size-consistent description of CT versus non-CT energies, ideally with the accuracy of a much more expensive doubles CIS(D) calculation

Acellular Extracellular Matrix Bioscaffolds for Cardiac Repair and Regeneration

Heart failure is a progressive deterioration of cardiac pump function over time and is often a manifestation of ischemic injury caused by myocardial infarction (MI). Post-MI, structural remodeling of the infarcted myocardium ensues. Dysregulation of extracellular matrix (ECM) homeostasis is a hallmark of structural cardiac remodeling and is largely driven by cardiac fibroblast activation. While initially adaptive, structural cardiac remodeling leads to irreversible heart failure due to the progressive loss of cardiac function. Loss of pump function is associated with myocardial fibrosis, wall thinning, and left ventricular (LV) dilatation. Surgical revascularization of the damaged myocardium via coronary artery bypass graft (CABG) surgery and/or percutaneous coronary intervention (PCI) can enhance myocardial perfusion and is beneficial. However, these interventions alone are unable to prevent progressive fibrotic remodeling and loss of heart function that leads to clinical end-stage heart failure. Acellular biologic ECM scaffolds can be surgically implanted onto injured myocardial regions during open-heart surgery as an adjunct therapy to surgical revascularization. This presents a novel therapeutic approach to alter maladaptive remodeling and promote functional recovery. Acellular ECM bioscaffolds have been shown to provide passive structural support to the damaged myocardium and also to act as a dynamic bioactive reservoir capable of promoting endogenous mechanisms of tissue repair, such as vasculogenesis. The composition and structure of xenogenic acellular ECM bioscaffolds are determined by the physiological requirements of the tissue from which they are derived. The capacity of different tissue-derived acellular bioscaffolds to attenuate cardiac remodeling and restore ECM homeostasis after injury may depend on such properties. Accordingly, the search and discovery of an optimal ECM bioscaffold for use in cardiac repair is warranted and may be facilitated by comparing bioscaffolds. This review will provide a summary of the acellular ECM bioscaffolds currently available for use in cardiac surgery with a focus on how they attenuate cardiac remodeling by providing the necessary environmental cues to promote endogenous mechanisms of tissue repair

Effects of potassium availability on growth and development of barley cultivars

Potassium deficiency is one of the major issues affecting crop production around the globe. Giving the high cost of potassium fertilizers and environmental concerns related to inappropriate fertilization practices, developing more potassium use efficient (KUE) varieties is critical for sustainable food production in agricultural systems. In this study, we analysed the impact of potassium availability on agronomical attributes of thirty barley genotypes grown at four different levels of potassium (0.002 mM, 0.02 mM, 2 mM, 20 mM) under glasshouse conditions. The results showed that the availability of potassium in the soil had a major effect on yield components i.e., spike number, grain number and grain weight. Furthermore, grain weight showed a strong correlation with grain number and spike number at all levels of potassium supply. Although an increase in potassium supply led to an increase in plant height in all genotypes, the correlation with grain weight was very weak at all levels. Potassium supplementation caused an increase in shoot dry weight, which also showed a weak correlation with grain weight at the 0.002 mM potassium supply level. The genotypes Gebeina, Skiff, YF374, Flagship and YF374 were highly efficient in performing at suboptimal K supply levels and, thus, can be recommended to be grown in K-impoverished soils. We also suggest that grain and spike numbers could be used as proxies for KUE studies, to construct DH lines and identify QTL to improve low potassium tolerance and KUE in barley

A comparison of alternative assays to measure DNA damage in stallion spermatozoa: TUNEL test versus ‘Nicoletti assay’

The aberrations of sperm DNA may cause various problems and have negative consequences on fertility. These influence embryonic development or might lead to early embryo loss. Sperm Chromatin Structure Assay (SCSA) is the flow cytometric method most often used for the detection of DNA lesions; however, some studies using that method reached confusing conclusions. The aim of this pilot study was to adjust and compare two alternative tests, namely the TUNEL test and the Nicoletti assay. The above-mentioned two flow cytometric methods capable of detecting the fragmented DNA of sperm were tested on 12 frozen-thawed stallion semen samples. The TUNEL test demonstrated much higher DNA fragmentation ratio than the Nicoletti assay (mean ± SD: 30.77 ± 13.03% vs. 1.93 ± 0.89%, respectively). A fluorescent microscopic check of the samples showed that TUNEL labelled the plasma membrane and the mitochondria in a nonspecific way, rather than detecting only the fragmented DNA, thus eventually resulting in a false positive sign. The Nicoletti assay is simpler, quicker and does not detect nonspecific binding; however, further analyses are required to determine its diagnostic value

Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation

Multiple ssRNA viruses which infect bacteria, plants or humans use RNA Packaging Signal (PS)-mediated regulation during assembly to package their genomes faithfully and efficiently [1], [2], [3], [4], [5]. PSs typically comprise short nucleotide recognition motifs, most often presented in the unpaired region of RNA stem-loops, and often bind their cognate coat proteins (CPs) with nanomolar affinity. PSs identified to date are resilient in the face of the typical error prone replication of their virus-coded polymerases, making them potential drug targets [1], [2], [3]. An immobilised array of small molecular weight, drug-like compounds was panned [6] against a fluorescently-labelled oligonucleotide encompassing the most conserved Hepatitis B Virus (HBV) PS, PS1 [3], known to be a major determinant in nucleocapsid formation [7]. This identified > 70 compounds that bind PS1 uniquely in the array. The commercially available 66 of these were tested for their potential effect(s) on HBV nucleocapsid-like particle (NCP) assembly in vitro [8], which identified potent assembly inhibitors. Here, we describe a high-throughput screen for such effects using employing fluorescence anisotropy in a 96-well microplate format. HBV genomic RNAs (gRNA) and short oligonucleotides encompassing PS1 were 5ʹ labelled with an Alexa Fluor 488 dye. Excess (with respect to stoichiometric T=4 NCP formation [9]) HBV core protein (Cp) dimers were titrated robotically into solutions containing each of these RNAs stepwise, using a Biomek 4000 liquid handling robot. The anisotropy values of these mixtures were monitored using a POLARstar microplate reader. NCP-like structures were challenged with RNase A to identify reactions that did not result in complete NCP formation [10]. The results imply that ∼50 % of the compounds prevent complete NCP formation, highlighting both PS-meditated assembly and the PS-binding compounds as potential directly-acting anti-virals with a novel molecular target. Importantly, this method allows high-throughput in vitro screening for assembly inhibitors in this major human pathogen