Contribution of histamine to tyramine induced depressor response in the mean arterial blood pressure of tortoise

Purpose: Tyramine has a biphasic action consisting of depressor and presser components in the mean arterial blood pressure of the tortoise. The study was performed to investigate whether histaminergic mechanism contributes to the depressor component. Methods: Both sexes of tortoises (Testudo greaca) weighing 1200-1400 g (n = 77) were used. Each animal was anesthetized with subcutaneous injection of 5-7 ml urethan solution (%25). The mean arterial blood pressure was recorded on a smoked drum by using a Condon manometer connected to the left carotid artery. All drugs were given intravenously. Results: The depressor component of the response to tyramine was inhibited by metiamide and compound 48/80 but not by pyrilamine. The presser component was unaffected by histamine receptor antagonists and depletion of histamine stores. Conclusion: Findings suggest that endogenous histamine release may contribute to the depressor component of tyramine induced response in the tortoise

Bomonti semtinin kısa tarihi

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2014.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Öztürk, İbrahim Mert

KARIN AĞRISININ NADİR BİR NEDENİ: APENDİKS MUKOSEL OLGU SUNUMU

Apendiksin mukoseli, apendiks lümeninin anormal müsinöz sekresyonu sebebiyle dilatasyonu ile karakterize nadir görülen klinik bir durumdur. İnflamatuar bir duruma veya tümör kaynaklı olabilir. Mukosel, mukozal hiperplazi, müsinöz kistadenom veya müsinöz kistadenokarsinom sonucunda oluşabilir. Apendiks müsinöz kistadenomu en sık görülen şekli olup çok farklı klinik durumlarla kendini belli eder. Apendektomi spesimenlerinin %0.2?0.3’ünde saptanır. Preoperatif tanı konması zordur ve sıklıkla laparotomide saptanır. Rüptür riski, klinik olarak cerrahları zorlamaktadır. Cerrahi planlanmasında tam bir konsensus olmamakla birlikte genellikle apendektomi ya da sağ hemikolektomi ameliyatları uygulanır. Bu yazımızda plastron apendisit tanısıyla takip edilip sağ alt kadran ağrısı ve kitle saptanan apendiks mukosel olgusunu literatür eşliğinde tartıştık.Appendiceal mucocele is a rare clinical condition characterized by dilatation of the appendix lumen due to abnormal mucin secretion. It may be due to inflammatory conditions or neoplastic lesions. Mucocele may occur as a result of mucosal hyperplasia, mucinous cystadenoma or mucinous cystadenocarcinoma histopathologically. Mucinous cystadenoma is the most common form and it manifests itself as many different clinical pictures. It is detected in 0.2?0.3%of appendectomy specimens. As preoperative diagnosis is often difficult, it is generally detected during laparotomy. Appendiceal mucocele is a clinical challenge for surgeons due to its risks of perforation and dissemination. Although there is no consensus for type of surgical treatment, appendectomy or right hemicolectomy are usually prefered. Herein, we present an appendiceal mucocele cystadenoma case with right lower quadrant pain and palpable mass who was followed up with the pre-diagnosis of plastron appendicitis in the context of the literature

Effects of Haloperidol, Asenapine and Paliperidone on MK-801-Induced Memory Deterioration in Morris Water Maze and Radial Arm Maze Tests in Mice

Objective: One of the most important problems of schizophrenic patients is the impairment of cognitive functions. Methods: The aim of this study was to investigate the effects of haloperidol, asenapine and paliperidone on spatial learning and memory using the Morris water maze (MWM) and radial arm maze (RAM) tests; moreover the effects of haloperidol, asenapine, and paliperidone on MK-801 induced cognitive dysfunction were also evaluated in mice. Results: Both asenapine (0.05 mg/kg) and paliperidone reversed MK-801 induced increment in escape latency in 2nd, 3rd, and 4th acquisition sessions while haloperidol failed to reverse MK-801 induced this effect. Time spent in escape platform's quadrant significantly decreased while the mean distance to platform significantly increased in MK-801 group in the probe trial of MWM test and administration of asenapine and paliperidone significantly reversed MK-801 induced these effects while haloperidol had no effect. MK-801 significantly increased the speed of the animals in probe trial of the MWM test while both asenapine and paliperidone reversed this effect. In the RAM test, MK-801 significantly increased the number of errors in the retention trial and haloperidol failed to reverse this effect. Both asenapine (0.075 mg/kg) and paliperidone reversed MK-801-induced increment in a number of errors and improved MK-801 induced prolongation in latency. Conclusions: The results of this study revealed that MK-801 exerted spatial memory impairment in MWM and RAM tests; haloperidol failed to improve MK-801 induced memory deterioration in mice. Moreover both asenapine and paliperidone improved MK-801 induced spatial learning and memory impairment in the MWM and RAM tests

Effects of homeopathic Anax imperator on behavioural and pain models in mice

Backgound: Homeopathy is a medical theory and practice that asserts that disease can be cured by remedies that produce symptoms in a healthy person similar to those suffered by a patient with a malady

A Rare Cause of Abdominal Pain: A Case of Appendiceal Mucocele

Apendiksin mukoseli, apendiks lümeninin anormal müsinöz sekresyonu sebebiyle dilatasyonu ile karakterize nadir görülen klinik bir durumdur. İnflamatuar bir duruma veya tümör kaynaklı olabilir. Mukosel, mukozal hiperplazi, müsinöz kistadenom veya müsinöz kistadenokarsinom sonucunda oluşabilir. Apendiks müsinöz kistadenomu en sık görülen şekli olup çok farklı klinik durumlarla kendini belli eder. Apendektomi spesimenlerinin %0.2?0.3’ünde saptanır. Preoperatif tanı konması zordur ve sıklıkla laparotomide saptanır. Rüptür riski, klinik olarak cerrahları zorlamaktadır. Cerrahi planlanmasında tam bir konsensus olmamakla birlikte genellikle apendektomi ya da sağ hemikolektomi ameliyatları uygulanır. Bu yazımızda plastron apendisit tanısıyla takip edilip sağ alt kadran ağrısı ve kitle saptanan apendiks mukosel olgusunu literatür eşliğinde tartıştık.Appendiceal mucocele is a rare clinical condition characterized by dilatation of the appendix lumen due to abnormal mucin secretion. It may be due to inflammatory conditions or neoplastic lesions. Mucocele may occur as a result of mucosal hyperplasia, mucinous cystadenoma or mucinous cystadenocarcinoma histopathologically. Mucinous cystadenoma is the most common form and it manifests itself as many different clinical pictures. It is detected in 0.2?0.3%of appendectomy specimens. As preoperative diagnosis is often difficult, it is generally detected during laparotomy. Appendiceal mucocele is a clinical challenge for surgeons due to its risks of perforation and dissemination. Although there is no consensus for type of surgical treatment, appendectomy or right hemicolectomy are usually prefered. Herein, we present an appendiceal mucocele cystadenoma case with right lower quadrant pain and palpable mass who was followed up with the pre-diagnosis of plastron appendicitis in the context of the literature