Post-operative Status of Facial Nerve in Cerebello-Pontine Angle Lesion via Retro-Sigmoid Approach; Complications and Outcome

  Objective:  To assess the post-operative status of Facial Nerve in cerebellopontine angle (CPA) lesion via retro-sigmoid approach and also its complications and outcome. Materials & Methods:  This prospective study was conducted at the Department of Neurosurgery, JPMC Karachi from a period of 10-12-2021 to 10-06-2022.The sample size of our study was 37 patients. All the patients were operated for CPA lesions and followed for three months to assess the outcome efficacy. Results:  Our study showed that the mean age was 37 years, with a range of 27 to 65 years, in which the males were 18 (48.6%) and the females were 19 (51.4%). Out of 37 patients, 28 (75.7%) were diagnosed with vestibular schwannoma, while 6 (16.2%) were meningiomas, and 3 (8.1%) were epidermoid cysts. Gross total resection was performed in 14 (37.8%) patients, while subtotal resection (STR) in 23 (62.2%). Facial nerve function in terms of House-Brackmann at 3 months was found to be grade I in 26 (70.3%), grade II in 9 (24.3%), grade III in 1 (2.7%), and grade IV in 1 (2.7%). Conclusion:  The CPA is a small corridor through which important neurovascular structures pass. Identification of CN VII is important in large CPA tumours to preserve facial motor nerve function.  For all kinds of CPA lesions, gross total excision should be the aim of surgery

Development and assessment of a thermochemical cycle and SOFC-based hydrogen energy systems as a potential energy solution for the peak demand in a sustainable community

In this study, an integrated energy system is presented in which hydrogen is produced via the thermochemical cycle. The presented system would provide a potential solution for storing excess electric power in terms of hydrogen generation for a sustainable community. Principles of exergy and energy are utilized to analyze the presented system in terms of exergy and energy efficiencies. The simulation result shows that with the help of the developed system, 0.36 kg/h of hydrogen can be generated, which is utilized via SOFCs to produce and electrify the houses. Additionally, the developed system can supply 1000 kW of electric power with 3.6 kW of heating. With the use of the thermochemical cycle considered in the present study, one can produce hydrogen with an energy efficiency of 79.6% and an exergy efficiency of 62.9%. Furthermore, to see the impact of different factors on the operation of the developed system, a parametric study is also conducted by changing factors like solar irradiation, the inlet temperature of the molten salt, and the outlet temperature of the solar collector

CD133 expression in glioblastoma multiforme: A literature review

Glioblastoma, also known as glioblastoma multiforme (GBM), is the most common primary brain tumor. Extensive research has been carried out to discover the factors associated with the course and progression of GBM. CD133 is a glycoprotein antigen found in normal and malignant tissues. CD133 has been recognized as a marker for the growth of cancer cells. The association between this tissue marker and GBM is being investigated. The aim of this review was to evaluate the role of CD133 as a tumor marker for the prognosis of GBM

Point prevalence survey of antimicrobial use during the COVID-19 pandemic among different hospitals in Pakistan : findings and implications

The COVID-19 pandemic has significantly influenced antimicrobial use in hospitals raising concerns regarding increased antimicrobial resistance (AMR) through their overuse. The objective of this study was to assess patterns of antimicrobial prescribing during the current COVID-19 pandemic among hospitals in Pakistan, including the prevalence of COVID-19. A point prevalence survey (PPS) was performed among 11 different hospitals from November 2020 to January 2021. The study included all hospitalized patients receiving an antibiotic on the day of the PPS. The Global-PPS web-based application was used for data entry and analysis. Out of 1024 hospitalized patients, 662 (64.64%) received antimicrobials. The top three most common indications for antimicrobial use were pneumonia (13.3%), central nervous system infections (10.4%) and gastrointestinal indications (10.4%). Ceftriaxone (26.6%), metronidazole (9.7%) and vancomycin (7.9%) were the top three most commonly prescribed antimicrobials among surveyed patients, with the majority of antibiotics administered empirically (97.9%). Most antimicrobials for surgical prophylaxis were given for more than one day, which is a concern. Overall, a high percentage of antimicrobial use, including broad-spectrums, was seen among the different hospitals in Pakistan during the current COVID-19 pandemic. Multifaceted interventions are needed to enhance rational antimicrobial prescribing including limiting their prescribing post-operatively for surgical prophylaxis

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

Index testing among HIV-positive patients is feasible and successful in identifying additional HIV infections in Pakistan

Objective: To assess the feasibility of index testing approach to test the parents and siblings of human immunodeficiency virus (HIV)-positive children, and identify HIV-positive individuals. Methods: The study was conducted at Ratodero, Pakistan. Study participants were enrolled from September 2019 to February 2020.  The list of HIV-positive persons was provided by the Provincial Acquired Immunodeficiency Syndrome (AIDS) Control Programme. Families of 706 HIV-positive persons were approached and all of them agreed to participate. The first test was performed by trained outreach workers. All those with a reactive first test were transported to the nearest health facility for further testing and confirmation. Mothers and siblings were tested at home while additional visits were carried out to reach the fathers.  Results: A total of 1766 persons were tested through HIV index testing. Biological siblings accounted for 81% of the contacts. We were able to test 413/463 (89.2%) mothers, 232/413 (56.2%) fathers and 1121/1392 (80.5%) siblings. Out of these, 7 mothers (1.7%) and 22 siblings (2.0%) were confirmed to be HIV-positive, while no one was found to be positive among the fathers. The overall HIV prevalence was 1.6% (29/1766). All HIV-positive persons were guided for treatment and care.  Conclusion: Results indicate that index-testing approach is feasible in Pakistan to expand HIV testing services through home visits.  Key words: Human immunodeficiency virus, HIV, HIV testing, Pakistan, Index testing, HIV outbreak, Prevalence

Baseline assessment of therapeutic injection practices in Pakistan in 2020: a cross-sectional study

Objective: To assess the magnitude of the problem of injection safety in public and private health facilities in two districts of Sindh and Punjab provinces of Pakistan. Methods: A cross-sectional observational study was conducted between October and December 2020 among public and private health facilities of two districts of Pakistan: Gujarat in Punjab and Larkana in Sindh provinces. A convenient sample size of 60 healthcare facilities (30 from each district) was taken due to time and resource constraint. Six data collection tools were used which included structured observations and interviews with injection prescribers and providers based on WHO Revised Tool C, which were finalised after piloting. Results: Reuse of injection equipment was not observed in any of the 60 health facilities. In exit interviews of 120 patients, it was found that 27 (22.5%) patients reported receiving an injection, while 11 (9.2%) were prescribed intravenous (IV) drips. More injections and drips were prescribed in the private sector (n=15; 25.0%) in comparison with the public sector (n=12; 20.0%). Slightly higher proportion of IV drips were prescribed by the private providers when compared to public sector healthcare providers: 6 (10.0%) vs 5 (8.3%) respectively. Most of the prescribers (n=58; 96.7%) reported that patients who attended public and private health facilities demanded injectable medicines. Used syringes and drips were noted to be visible in open containers and buckets for final disposal in 20 (33.3%) assessed health facilities. Continuou..

Community engagement following a human immunodeficiency virus (HIV) outbreak in rural Pakistan: challenges and lessons learned

Introduction The lives of the residents of a small rural community in taluka Ratodero near the town of Larkana in Sindh province of Pakistan was rattled when an unprecedented human immunodeficiency virus (HIV) outbreak was discovered in April 2019. The problem of HIV is not new to Larkana which has already experienced multiple outbreaks among key population at risk for HIV as well as among dialysis patients.(1-3) However, in Ratodero, a town of 150,000-200,000 persons which is 40 kilometres away from Larkana, no such event had occurred in the past. Continuous..