Who Will Be With You When I Go Away? : When I\u27m Far Away From You

https://digitalcommons.library.umaine.edu/mmb-vp/4828/thumbnail.jp

Lucy : Dancing Around The Cabin Door

https://digitalcommons.library.umaine.edu/mmb-vp/5190/thumbnail.jp

Cootie Trot De-Gink

Illustration of two men fighting in front of hotelhttps://scholarsjunction.msstate.edu/cht-sheet-music/4355/thumbnail.jp

De-Gink

Portrait of man with illustration of two men in backgroundhttps://scholarsjunction.msstate.edu/cht-sheet-music/12653/thumbnail.jp

Lunar Surface Electric Potential Changes Associated with Traversals through the Earth's Foreshock

We report an analysis of one year of Suprathermal Ion Detector Experiment (SIDE) Total Ion Detector (TID) resonance events observed between January 1972 and January 1973. The study includes only those events during which upstream solar wind conditions were readily available. The analysis shows that these events are associated with lunar traversals through the dawn flank of the terrestrial magnetospheric bow shock. We propose that the events result from an increase in lunar surface electric potential effected by secondary electron emission due to primary electrons in the Earth's foreshock region (although primary ions may play a role as well). This work establishes (1) the lunar surface potential changes as the Moon moves through the terrestrial bow shock, (2) the lunar surface achieves potentials in the upstream foreshock region that differ from those in the downstream magnetosheath region, (3) these differences can be explained by the presence of energetic electron beams in the upstream foreshock region and (4) if this explanation is correct, the location of the Moon with respect to the terrestrial bow shock influences lunar surface potential

White Paper on Research Opportunities and CUNY Library Faculty: The Need for Annual Leave Parity

This White Paper provides an exposition and analysis of how annual leave disparity has arisen for Library Faculty at the City University of New York (CUNY) as compared to other CUNY faculty, its effects on librarians, and what a positive solution to the problem would look like

Observations and Models of the Lunar Sodium Exosphere 1988 - 1999

Sodium in the lunar exosphere is easily observed from the Earth's surface due to its strong resonance emission lines in the visible region of the spectrum. Although sodium is a trace element, it is easily ejected from the surface by a number of processes. The variation of this exospheric constituent both spatially and temporally can help to constrain these sources and the loss processes and their timescales. Due to a revival of interest in the Moon and its volatiles, observations of the lunar exosphere obtained at the McMath-Pierce solar telescope in 1998 and 1999 have recently been reduced and analyzed. In addition, observations of the lunar sodium exosphere obtained with the Mt. Lemmon Lunar Coronagraph on Mt. Lemmon, Arizona, have also been published. We combine these new data with data previously published and reanalyzed by Sarantos et al. This comprehensive data set will be modeled using both a simple Chamberlain exosphere model and a comprehensive Monte Carlo model

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

Elucidating how the brain's serotonergic network mediates diverse behavioral actions over both relatively short (minutes–hours) and long period of time (days–weeks) remains a major challenge for neuroscience. Our relative ignorance is largely due to the lack of technologies with robustness, reversibility, and spatio-temporal control. Recently, we have demonstrated that our chemogenetic approach (eg, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)) provides a reliable and robust tool for controlling genetically defined neural populations. Here we show how short- and long-term activation of dorsal raphe nucleus (DRN) serotonergic neurons induces robust behavioral responses. We found that both short- and long-term activation of DRN serotonergic neurons induce antidepressant-like behavioral responses. However, only short-term activation induces anxiogenic-like behaviors. In parallel, these behavioral phenotypes were associated with a metabolic map of whole brain network activity via a recently developed non-invasive imaging technology DREAMM (DREADD Associated Metabolic Mapping). Our findings reveal a previously unappreciated brain network elicited by selective activation of DRN serotonin neurons and illuminate potential therapeutic and adverse effects of drugs targeting DRN neurons

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine

RationaleThe sacred lotus (Nelumbo nucifera) contains many phytochemicals and has a history of human use. To determine which compounds may be responsible for reported psychotropic effects, we used in silico predictions of the identified phytochemicals. Nuciferine, an alkaloid component of Nelumbo nucifera and Nymphaea caerulea, had a predicted molecular profile similar to antipsychotic compounds. Our study characterizes nuciferine using in vitro and in vivo pharmacological assays.MethodsNuciferine was first characterized in silico using the similarity ensemble approach, and was followed by further characterization and validation using the Psychoactive Drug Screening Program of the National Institute of Mental Health. Nuciferine was then tested in vivo in the head-twitch response, pre-pulse inhibition, hyperlocomotor activity, and drug discrimination paradigms.ResultsNuciferine shares a receptor profile similar to aripiprazole-like antipsychotic drugs. Nuciferine was an antagonist at 5-HT2A, 5-HT2C, and 5-HT2B, an inverse agonist at 5-HT7, a partial agonist at D2, D5 and 5-HT6, an agonist at 5-HT1A and D4 receptors, and inhibited the dopamine transporter. In rodent models relevant to antipsychotic drug action, nuciferine blocked head-twitch responses and discriminative stimulus effects of a 5-HT2A agonist, substituted for clozapine discriminative stimulus, enhanced amphetamine induced locomotor activity, inhibited phencyclidine (PCP)-induced locomotor activity, and rescued PCP-induced disruption of prepulse inhibition without induction of catalepsy.ConclusionsThe molecular profile of nuciferine was similar but not identical to that shared with several approved antipsychotic drugs suggesting that nuciferine has atypical antipsychotic-like actions