Imaging Radar Observations Of Normal Faults In Tibet

NASA/JPL has an ongoing program to study land processes that will lead to a better understanding of the geologic evolution of the continents and the history of global climate change. Northwestern China and Tibet are key areas for these investigations because arid regions such as these retain the record of climate change and a wide variety of large-scale structures are present throughout the area as a result of the continuing collision between the Indian and Asian plates. During the Shuttle Imaging Radar Missions (SIR-A and SIR-B) a number of image swaths were acquired over the People's Republic of China that show interesting landforms indicative of climate change and large-scale faulting in the arid regions of Tibet and northwestern China. One of the 50-km wide swaths (data-take 32-33) passed from northeastern India, through Lhasa and southern Tibet, to the Karakorum Himalaya and beyond. This swath provides a view of several active faults related to the collision between India and Asia, in particular, normal faults in the Yangbajain Valley, northeast of Lhasa. The scarps are oriented N12°E±16° and most of them dip to the west, which is generally within a few degrees of being parallel to the illumination direction of SIR-A. Since conventional interpretation of the interaction of radar signals with steep scarps predicts that they will not be visible if the illumination azimuth is nearly parallel to the scarp strike because of a lack of the "highlighting" that occurs when a scarp face is oriented normal to the incoming illumination, it is surprising they show up in such light tones on the SIR-A image. The most likely reason for the high radar returns from the scarp faces is that their surfaces are rougher than the smooth, grass-covered valley floor. Height, slope-angle, and surface-roughness measurements were obtained on several scarps and we found that scarps which were visible on the SIR-A image are higher than 5 m and are rough at the decimeter to meter scale. This result is significant since orbital radar sensors can obtain high-resolution images of large areas that are difficult to access, and it appears that they may provide an efficient means with which to survey large areas, extrapolate local observations, and derive quantitative estimates of rates of tectonic processes

Wireless recording of the calls of Rousettus aegyptiacus and their reproduction using electrostatic transducers

Bats are capable of imaging their surroundings in great detail using echolocation. To apply similar methods to human engineering systems requires the capability to measure and recreate the signals used, and to understand the processing applied to returning echoes. In this work, the emitted and reflected echolocation signals of Rousettus aegyptiacus are recorded while the bat is in flight, using a wireless sensor mounted on the bat. The sensor is designed to replicate the acoustic gain control which bats are known to use, applying a gain to returning echoes that is dependent on the incurred time delay. Employing this technique allows emitted and reflected echolocation calls, which have a wide dynamic range, to be recorded. The recorded echoes demonstrate the complexity of environment reconstruction using echolocation. The sensor is also used to make accurate recordings of the emitted calls, and these calls are recreated in the laboratory using custom-built wideband electrostatic transducers, allied with a spectral equalization technique. This technique is further demonstrated by recreating multi-harmonic bioinspired FM chirps. The ability to record and accurately synthesize echolocation calls enables the exploitation of biological signals in human engineering systems for sonar, materials characterization and imaging

Estimating the incidence, prevalence and true cost of asthma in the UK: secondary analysis of national stand-alone and linked databases in England, Northern Ireland, Scotland and Wales-a study protocol.

INTRODUCTION: Asthma is now one of the most common long-term conditions in the UK. It is therefore important to develop a comprehensive appreciation of the healthcare and societal costs in order to inform decisions on care provision and planning. We plan to build on our earlier estimates of national prevalence and costs from asthma by filling the data gaps previously identified in relation to healthcare and broadening the field of enquiry to include societal costs. This work will provide the first UK-wide estimates of the costs of asthma. In the context of asthma for the UK and its member countries (ie, England, Northern Ireland, Scotland and Wales), we seek to: (1) produce a detailed overview of estimates of incidence, prevalence and healthcare utilisation; (2) estimate health and societal costs; (3) identify any remaining information gaps and explore the feasibility of filling these and (4) provide insights into future research that has the potential to inform changes in policy leading to the provision of more cost-effective care. METHODS AND ANALYSIS: Secondary analyses of data from national health surveys, primary care, prescribing, emergency care, hospital, mortality and administrative data sources will be undertaken to estimate prevalence, healthcare utilisation and outcomes from asthma. Data linkages and economic modelling will be undertaken in an attempt to populate data gaps and estimate costs. Separate prevalence and cost estimates will be calculated for each of the UK-member countries and these will then be aggregated to generate UK-wide estimates. ETHICS AND DISSEMINATION: Approvals have been obtained from the NHS Scotland Information Services Division's Privacy Advisory Committee, the Secure Anonymised Information Linkage Collaboration Review System, the NHS South-East Scotland Research Ethics Service and The University of Edinburgh's Centre for Population Health Sciences Research Ethics Committee. We will produce a report for Asthma-UK, submit papers to peer-reviewed journals and construct an interactive map

Time evolution of a non-singular primordial black hole

There is growing notion that black holes may not contain curvature singularities (and that indeed nature in general may abhor such spacetime defects). This notion could have implications on our understanding of the evolution of primordial black holes (PBHs) and possibly on their contribution to cosmic energy. This paper discusses the evolution of a non-singular black hole (NSBH) based on a recent model [1]. We begin with a study of the thermodynamic process of the black hole in this model, and demonstrate the existence of a maximum horizon temperature T_{max}, corresponding to a unique mass value. At this mass value the specific heat capacity C changes signs to positive and the body begins to lose its black hole characteristics. With no loss of generality, the model is used to discuss the time evolution of a primordial black hole (PBH), through the early radiation era of the universe to present, under the assumption that PBHs are non-singular. In particular, we track the evolution of two benchmark PBHs, namely the one radiating up to the end of the cosmic radiation domination era, and the one stopping to radiate currently, and in each case determine some useful features including the initial mass m_{f} and the corresponding time of formation t_{f}. It is found that along the evolutionary history of the universe the distribution of PBH remnant masses (PBH-RM) PBH-RMs follows a power law. We believe such a result can be a useful step in a study to establish current abundance of PBH-MRs.Comment: To appear in Int. J. Mod. Phys.

Supplement: Going the Distance: Mapping Host Galaxies of LIGO and Virgo Sources in Three Dimensions Using Local Cosmography and Targeted Follow-up

This is a supplement to the Letter of Singer et al. (https://arxiv.org/abs/1603.07333), in which we demonstrated a rapid algorithm for obtaining joint 3D estimates of sky location and luminosity distance from observations of binary neutron star mergers with Advanced LIGO and Virgo. We argued that combining the reconstructed volumes with positions and redshifts of possible host galaxies can provide large-aperture but small field of view instruments with a manageable list of targets to search for optical or infrared emission. In this Supplement, we document the new HEALPix-based file format for 3D localizations of gravitational-wave transients. We include Python sample code to show the reader how to perform simple manipulations of the 3D sky maps and extract ranked lists of likely host galaxies. Finally, we include mathematical details of the rapid volume reconstruction algorithm.Comment: For associated data release, see http://asd.gsfc.nasa.gov/Leo.Singer/going-the-distanc

A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes.

Human botulism is most commonly caused by botulinum neurotoxin (BoNT) serotypes A, B, and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based antitoxin capable of binding and neutralizing multiple subtypes of BoNT/E. Libraries of yeast-displayed single chain Fv (scFv) antibodies were created from the heavy and light chain variable region genes of humans immunized with pentavalent-toxoid- and BoNT/E-binding scFv isolated by Fluorescence-Activated Cell Sorting (FACS). A total of 10 scFv were isolated that bound one or more BoNT/E subtypes with nanomolar-level equilibrium dissociation constants (KD). By diversifying the V-regions of the lead mAbs and selecting for cross-reactivity, we generated three scFv that bound all four BoNT/E subtypes tested at three non-overlapping epitopes. The scFvs were converted to IgG that had KD values for the different BoNT/E subtypes ranging from 9.7 nM to 2.28 pM. An equimolar combination of the three mAbs was able to potently neutralize BoNT/E1, BoNT/E3, and BoNT/E4 in a mouse neutralization assay. The mAbs have potential utility as therapeutics and as diagnostics capable of recognizing multiple BoNT/E subtypes. A derivative of the three-antibody combination (NTM-1633) is in pre-clinical development with an investigational new drug (IND) application filing expected in 2018

Low-loss criterion and effective area considerations for photonic crystal fibers

We study the class of endlessly single-mode all-silica photonic crystal fibers with a triangular air-hole cladding. We consider the sensibility to longitudinal nonuniformities and the consequences and limitations for realizing low-loss large-mode area photonic crystal fibers. We also discuss the dominating scattering mechanism and experimentally we confirm that both macro and micro-bending can be the limiting factor.Comment: Accepted for Journal of Optics A - Pure and Applied Optic

Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients

Hepatozoon canis in three imported dogs: a new tickborne disease reaching the United Kingdom

An increasing number of non-endemic vectorborne pathogens have been described in dogs imported to the UK in the past two decades. Recently, an outbreak of canine babesiosis in south-east England has raised veterinary awareness with regard to the impact of such diseases on the UK canine population. Canine hepatozoonosis, caused by Hepatozoon canis and transmitted by the ingestion of Rhipicephalus sanguineus ticks, is widespread in the Mediterranean basin. Herein we describe the first three molecularly confirmed clinical cases of canine hepatozoonosis in dogs imported into the UK. Veterinarians in the UK should be aware of H canis as a potential infection in imported dogs, especially in the face of the expanding distribution of R sanguineus ticks in Europe