Identification of Mullerian Chromosomal Elements in Hawaiian Drosophila by in situ DNA Hybridization

We have hybridized Drosophila melanogaster DNA sequences to polytene chromosomes of D. silvestris. The results support Muller's hypothesis that the chromosomal elements have been largely conserved in the evolution of the genus Drosophila. As originally suggested by Carson, D. melanogaster elements X, 2L, 2R, 3L, and 3R appear to correspond to chromosomes X, 3, 2, 5, and 4, respectively, in D. silvestris and the Hawaiian picture-winged species

Examining the Responsibilities of Faculty Senates

Faculty senates function to preserve and represent the interest of the faculty during the decision-making process. The purpose of this article is to initiate dialogue focused on increasing the influence of the faculty senates in an era of declining power

P-cymenesulphonyl chloride : A bio-based activating group and protecting group for greener organic synthesis

A bio-derived protecting/activating group has been synthesized by introducing a sulphonyl chloride group to the aromatic ring of p-cymene derived from citrus peel waste. The resulting p-cymenesulphonyl chloride was evaluated as an activating group by reacting with 1-octanol, 2-octanol, phenol and piperidine, and further reactions of the activated alcohols. The comparison to tosyl chloride demonstrates that the bio-based alternative can be effectively utilized as a direct replacement for the current fossil derived equivalent

Structure of the southern Keweenawan rift from COCORP surveys across the Midcontinent Geophysical Anomaly in northeastern Kansas

This is the published version. Copyright 1984 American Geophysical Union. All Rights Reserved.COCORP profiling across the midcontinent geophysical anomaly in northeastern Kansas reveals structural basins and other features of the Precambrian Keweenawan rift buried beneath the Phanerozoic cover. The 40-km-wide main basin is asymmetric, with a maximum depth of 3 km on the east and 8 km on the west. The basin fill is characterized by a lower layered sequence of strong continuous west dipping reflectors which may be correlated with Middle Keweenawan interbedded volcanic and clastic rocks exposed along the MGA in the Lake Superior region. Overlying this layered sequence is a zone of weak, discontinuous reflectors correlated here with the predominantly clastic rocks characteristic of the Upper Keweenawan sequence near Lake Superior. A second tilted but shallower basin lies to the east of the main basin and appears to be filled predominantly with clastic sedimentary rocks. The character of the seismic data, the seismic velocity distribution, and gravity modeling suggest that mafic intrusions lie beneath the main rift basin. Normal faults associated with the rift dip at moderate angles to the east. Palinspastic reconstruction indicates that the rift basin formed by the rotation of fault bounded blocks during crustal extension. Although reactivation of preexisting structures appears to have occurred in many other rifts profiled by COCORP, the evidence is inconclusive on this point in the case of the Kansas data. The structures mapped by COCORP surveys in Kansas and elsewhere suggest that asymmetric sequences of layered reflectors are characteristic, and perhaps diagnostic, of rift basin deposits in general

Using Latent Profile Regression to Explore the Relationship between Religiosity and Work-related Ethical Judgments

Utilizing social structural symbolic interactionist theorizing about self-identity as presented by Weaver and Agle (2002) we obtained data related to five key measures of religiosity believed to be critical for understanding religiosity’s influence on ethical judgments. Using our five key religiosity measures we then fit a latent profile regression model to explore whether and how these constructs related to one another and to work-related ethical judgments. Results revealed that both our analytic and theoretical frameworks (latent profile regression and symbolic interactionism) were helpful in identifying religious profiles which are helpful for understanding the relationship between religiosity and work-related ethical judgments. More specifically, results indicated that extrinsic religious motivation orientation (RMO) may represent a ‘dark side’ to religiosity given higher levels of extrinsic RMO were found in a subgroup who judged unethical situations more favorably than those with lower levels of extrinsic RMO

Recent advances in the application of stable isotope ratio analysis in forensic chemistry

This review paper updates the previous literature in relation to the continued and developing use of stable isotope ratio analysis in samples which are relevant to forensic science. Recent advances in the analysis of drug samples, explosive materials, and samples derived from human and animal samples are discussed. The paper also aims to put the use of isotope ratio mass spectrometry into a forensic context and discuss its evidential potential

Assessment of High-Sensitivity C-Reactive Protein Levels as Diagnostic Discriminator of Maturity-Onset Diabetes of the Young Due to HNF1A Mutations

OBJECTIVE: Despite the clinical importance of an accurate diagnosis in individuals with monogenic forms of diabetes, restricted access to genetic testing leaves many patients with undiagnosed diabetes. Recently, common variation near the HNF1 homeobox A (HNF1A) gene was shown to influence C-reactive protein levels in healthy adults. We hypothesized that serum levels of high-sensitivity C-reactive protein (hs-CRP) could represent a clinically useful biomarker for the identification of HNF1A mutations causing maturity-onset diabetes of the young (MODY). RESEARCH DESIGN AND METHODS: Serum hs-CRP was measured in subjects with HNF1A-MODY (n = 31), autoimmune diabetes (n = 316), type 2 diabetes (n = 240), and glucokinase (GCK) MODY (n = 24) and in nondiabetic individuals (n = 198). The discriminative accuracy of hs-CRP was evaluated through receiver operating characteristic (ROC) curve analysis, and performance was compared with standard diagnostic criteria. Our primary analyses excluded approximately 11% of subjects in whom the single available hs-CRP measurement was >10 mg/l. RESULTS: Geometric mean (SD range) hs-CRP levels were significantly lower (

Unidirectional pulmonary airflow patterns in the savannah monitor lizard

The unidirectional airflow patterns in the lungs of birds have long been considered a unique and specialized trait associated with the oxygen demands of flying, their endothermic metabolism1 and unusual pulmonary architecture2, 3. However, the discovery of similar flow patterns in the lungs of crocodilians indicates that this character is probably ancestral for all archosaurs—the group that includes extant birds and crocodilians as well as their extinct relatives, such as pterosaurs and dinosaurs4, 5, 6. Unidirectional flow in birds results from aerodynamic valves, rather than from sphincters or other physical mechanisms7, 8, and similar aerodynamic valves seem to be present in crocodilians4, 5, 6. The anatomical and developmental similarities in the primary and secondary bronchi of birds and crocodilians suggest that these structures and airflow patterns may be homologous4, 5, 6, 9. The origin of this pattern is at least as old as the split between crocodilians and birds, which occurred in the Triassic period10. Alternatively, this pattern of flow may be even older; this hypothesis can be tested by investigating patterns of airflow in members of the outgroup to birds and crocodilians, the Lepidosauromorpha (tuatara, lizards and snakes). Here we demonstrate region-specific unidirectional airflow in the lungs of the savannah monitor lizard (Varanus exanthematicus). The presence of unidirectional flow in the lungs of V. exanthematicus thus gives rise to two possible evolutionary scenarios: either unidirectional airflow evolved independently in archosaurs and monitor lizards, or these flow patterns are homologous in archosaurs and V. exanthematicus, having evolved only once in ancestral diapsids (the clade encompassing snakes, lizards, crocodilians and birds). If unidirectional airflow is plesiomorphic for Diapsida, this respiratory character can be reconstructed for extinct diapsids, and evolved in a small ectothermic tetrapod during the Palaeozoic era at least a hundred million years before the origin of birds