A pilot study on effectiveness of visual arts mediation in Cognitive Activation Therapy (CAT) on biological ageing and cognitive/functional status

openAgeing is one of the most significant phenomenons of the 21 st century with important consequences on all sectors of society. It’s also the greatest risk factor for the development of dementia, which is a complex clinic syndrome that gradually and irreversibly impairs cognitive functions and functional abilities. In this pilot study we analyse whether Cognitive Activation Therapy (CAT) with visual arts influences biological aging and cognition/functional. Twenty patients affected by major neurocognitive disorder in the mild to moderate phase of the disease (mainly Alzheimer's disease) were recruited at the Regional Center for the Study and Treatment of Cerebral Aging (CRIC). Patients aged between 47 and 85 years underwent a cycle of Cognitive Activation Therapy (CAT) mediated by the visual arts and a pre- and post-treatment neuropsychological and functional evaluation with 17 sessions of which 14 at the CRIC and 3 at the the Eremitani Civic Museums of Padua. The biological aging performed on blood samples at the beginning and at the end of the cognitive activation cycle mediated by the visual arts involved the evaluation of biological aging indicators: epigenetic age (DNAmAge) and telomere length. The preliminary statistical analysis of the data shows that the duration of the treatment, through the mediation of the visual arts in the use of a structured and standardized rehabilitation protocol (CAT), influences biological aging. The simple linear regression analysis showed a significant correlation (p=0.035) treatment days and an increased age acceleration DNAmAge (T1-T0). A multiple linear regression shows that the determinants in LTL elongation are being female and days of treatment. In particular, a prolonged duration of the rehabilitation protocol seems to significantly slow down biological aging. Standardizing this rehabilitation model would mean increasing the therapeutic options for people affected by neurocognitive disorders and identifying rehabilitation paradigms capable, not only of positively influencing cognition, but also of leveraging the person's potential, of creating social inclusion, modifying the social perception of disease and to combat stigma.Ageing is one of the most significant phenomenons of the 21 st century with important consequences on all sectors of society. It’s also the greatest risk factor for the development of dementia, which is a complex clinic syndrome that gradually and irreversibly impairs cognitive functions and functional abilities. In this pilot study we analyse whether Cognitive Activation Therapy (CAT) with visual arts influences biological aging and cognition/functional. Twenty patients affected by major neurocognitive disorder in the mild to moderate phase of the disease (mainly Alzheimer's disease) were recruited at the Regional Center for the Study and Treatment of Cerebral Aging (CRIC). Patients aged between 47 and 85 years underwent a cycle of Cognitive Activation Therapy (CAT) mediated by the visual arts and a pre- and post-treatment neuropsychological and functional evaluation with 17 sessions of which 14 at the CRIC and 3 at the the Eremitani Civic Museums of Padua. The biological aging performed on blood samples at the beginning and at the end of the cognitive activation cycle mediated by the visual arts involved the evaluation of biological aging indicators: epigenetic age (DNAmAge) and telomere length. The preliminary statistical analysis of the data shows that the duration of the treatment, through the mediation of the visual arts in the use of a structured and standardized rehabilitation protocol (CAT), influences biological aging. The simple linear regression analysis showed a significant correlation (p=0.035) treatment days and an increased age acceleration DNAmAge (T1-T0). A multiple linear regression shows that the determinants in LTL elongation are being female and days of treatment. In particular, a prolonged duration of the rehabilitation protocol seems to significantly slow down biological aging. Standardizing this rehabilitation model would mean increasing the therapeutic options for people affected by neurocognitive disorders and identifying rehabilitation paradigms capable, not only of positively influencing cognition, but also of leveraging the person's potential, of creating social inclusion, modifying the social perception of disease and to combat stigma

Stress on Cold Mass Due to the Supporting System of the CMS Coil in the Vacuum Tank

This report contains a verification analysis of the stress on cold mass coming from the supporting system of the CMS coil in the vacuum tank. The need to carry out this analysis is related to the high mechanical requirements for $9 Al-alloy mandrels (218 MPa yield at cryogenic temperature), demanding accurate analysis of the impact of supporting system on cylinder stress

Detailed Field Distribution in CMS Winding

The CMS winding has now arrived at its constructive phase. This means that some practical aspects regarding the winding itself have to be considered, such as the minimum requirement of conductor performance for each layer of each $9 module. Several magnetic calculations have been already performed, but the winding has been never analyzed in detail, in order to understand the impact of the self-field on its performances. This analysis and its implications are$9 reported in this paper

Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis.

Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption that may be therapeutically targetable. Among them, glucose metabolism and glycolytic intermediaries seem to have an important role in fibroblast-like synoviocytes (FLS) phenotype and might contribute to early stage disease pathogenesis. RA FLS are transformed from quiescent to aggressive and metabolically active cells and several works have shown that glucose metabolism is increased in activated FLS. Glycolytic inhibitors reduce not only FLS aggressive phenotype in vitro but also decrease bone and cartilage damage in several murine models of arthritis. Essential glycolytic enzymes, including hexokinase 2 (HK2) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB) enzymes, have important roles in FLS behavior. Of interest, HK2 is an inducible enzyme present only in the inflamed rheumatic tissues compared to osteoarthritis synovium. It is a contributor to glucose metabolism that could be selectively targeted without compromising systemic homeostasis as a novel approach for combination therapy independent of systemic immunosuppression. More information about metabolic targets that do not compromise global glucose metabolism in normal cells is needed

A Proposal for the IAXO Magnet System

The note describes a proposal for a superconducting toroidal magnet for the IAXO axion helioscope obtained assembling several canted solenoid dipoles. Respect to toroids made with racetrack coils, having the same average field, it has lower stored energy, lower peak magnetic field at the conductor and lower cold mass

Magnetic field, Lorentz forces and stored energy of multipole cos(nθ) and sector magnets with and without iron yoke

When approaching the design of a multipole magnet, such as a dipole, quadrupole, sextupole, and so on, it is highly advantageous to initiate the process by establishing the fundamental parameters. These parameters include conductor size, current density, inner and outer radius of the iron yoke, and more. This preliminary dimensioning enables the acquisition of the necessary specifications for the design. Within this report, analytical expressions for the magnetic field, Lorentz forces, and stored energy of multipole magnets with the cos(nθ) and sector coil configurations, both with and without the presence of an iron yoke, are derived. These derivations are based on the vector potential of a current line

Unambiguous identification and investigation of uranium projectile fragments & discovery of 63 new neutron-rich isotopes in the element range 61 less-than or equal to Z less-than or equal to 78 at the FRS

The research of exotic, short-lived nuclei is a main contribution of modern nuclear physics to improve the knowledge of the strong interaction and to understand the synthesis of elements in stellar media. Nature is still ahead of the laboratories since in the astrophysical r-process very neutron-rich nuclides are continuously created which we just barely reach or which still have to be discovered. For this challenge new powerful accelerators and experimental tools have been developed to expand the frontiers of discovered nuclides. Besides a high intensity primary beam efficient and very sensitive in-flight separators are needed to access new nuclides in this field. To exploit the full discovery potential also the applied particle detectors and especially the unambiguous identification have to be steadily improved and extended in the experiments. In the presented work Uranium projectile fragmentation and fission have been used to discover new neutron-rich nuclides in the Z-range above 60 at the FRS. In this region of heavy nuclides most radioactive beam facilities have clearly strong limitations.Experimente mit exotischen, kurzlebigen Kernen tragen zum besseren Verständnis der starken Wechselwirkung und der Elementsynthese in den Sternen bei. Im astrophysikalischen r-Prozess werden sehr neutronen-reiche Kerne gebildet, die nur schwer oder noch gar nicht im Labor herzustellen sind. Um sehr neutronen-reiche Kerne im Labor erzeugen zu können, werden moderne leistungsstarke Beschleuniger und neuartige Experimentiertechniken gebraucht. Eine besondere Herausforderung ist die eindeutige Identifikation von sehr schweren neutronen-reichen neuen Kernen. In dieser Arbeit wurde eine spezielle Implantationsapparatur entwickelt und eingesetzt, die eine eindeutige Identifikation der separierten Projektilfragmente aufgrund von bekannter Isomerenstrahlung erlaubt. Diese Arbeit besteht aus verschiedenen Experimenten, die alle von einer Produktion von exotischen Kernen mit einem Uran-Projektilstrahl bei relativistischen Energien am FRS ausgehen