7 research outputs found

    How is the surface Atlantic water inflow through the Gibraltar Strait forecasted? A lagrangian validation of operational oceanographic services in the Alboran Sea and the Western Mediterranean

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    IV Encuentro Oceanografía Física Española, celebrado del 20 al 22 de julio de 2016 en Alicante,España.-- 2 pages, 7 figuresAn exhaustive validation of operational ocean forecast products available in the Gibraltar Strait and the Alboran Sea is presented. The skill of two ocean model solutions (i.e. the regional CMEMS IBI and the local PdE SAMPA ones) in reproducing the complex surface dynamics in the above areas is evaluated. To this aim, in-situ measurements from 35 drifter buoys (the MEDESS-GIB database) are used as observational reference. A Lagrangian separation distance and a skill score have been applied to evaluate the performance of the modeling systems in reproducing the observed trajectories. Furthermore, the SST validation with in-situ data is carried out by means of validating the model solutions with L3 satellite SST products. The IBI products are evaluated in an extended domain, beyond the Alboran Sea, covering western Mediterranean waters. This analysis reveals some strengths of the regional solution (i.e. realistic values of the Atlantic Jet in the Strait, realistic simulation of the Algerian Current), together with some shortcomings (the major one related to the simulated geographical position and intensity of the Alboran Gyres, particularly the western one). On the other hand, the SAMPA system shows a more accurate model performance and it realistically reproduces the observed surface circulation in the area. The results reflect the effectiveness of the dynamical downscaling performed through the SAMPA system with respect to the regional IBI solution (in which SAMPA is nested), providing an objective measure of the potential added values introduced by the SAMPA downscaling solution in the Alboran SeaPeer Reviewe

    Strategies to reengage patients lost to follow up in HIV care in high income countries, a scoping review

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    Background: Despite remarkable achievements in antiretroviral therapy (ART), losses to follow-up (LTFU) might prevent the long-term success of HIV treatment and might delay the achievement of the 90-90-90 objectives. This scoping review is aimed at the description and analysis of the strategies used in high-income countries to reengage LTFU in HIV care, their implementation and impact. Methods: A scoping review was done following Arksey & O'Malley's methodological framework and recommendations from Joanna Briggs Institute. Peer reviewed articles were searched for in Pubmed, Scopus and Web of Science; and grey literature was searched for in Google and other sources of information. Documents were charted according to the information presented on LTFU, the reengagement procedures used in HIV units in high-income countries, published during the last 15 years. In addition, bibliographies of chosen articles were reviewed for additional articles. Results: Twenty-eight documents were finally included, over 80% of them published in the United States later than 2015. Database searches, phone calls and/or mail contacts were the most common strategies used to locate and track LTFU, while motivational interviews and strengths-based techniques were used most often during reengagement visits. Outcomes like tracing activities efficacy, rates of reengagement and viral load reduction were reported as outcome measures. Conclusions: This review shows a recent and growing trend in developing and implementing patient reengagement strategies in HIV care. However, most of these strategies have been implemented in the United States and little information is available for other high-income countries. The procedures used to trace and contact LTFU are similar across reviewed studies, but their impact and sustainability are widely different depending on the country studied

    Mechanism and Inhibition of Matrix Metalloproteinases

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    Human immunodeficiency virus continuum of care in 11 european union countries at the end of 2016 overall and by key population: Have we made progress?

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    Background. High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods. A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved viral suppression at their last visit. Results. We estimated that 87% of PLHIV were diagnosed; 92% of those diagnosed had ever initiated ART; and 91% of those ever on ART, or 73% of all PLHIV, were virally suppressed. Corresponding figures for men having sex with men were: 86%, 93%, 93%, 74%; for people who inject drugs: 94%, 88%, 85%, 70%; and for heterosexuals: 86%, 92%, 91%, 72%. The proportion suppressed of all PLHIV ranged from 59% to 86% across countries. Conclusions. The EU is close to the 90-90-90 target and achieved the UNAIDS target of 73% of all PLHIV virally suppressed, significant progress since 2013 when 60% of all PLHIV were virally suppressed. Strengthening of testing programs and treatment support, along with prevention interventions, are needed to achieve HIV epidemic control
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