Geotechnical properties of sewage sludge solidified with Sulphoaluminate cement

The geotechnical properties of sewage sludge solidified with sulphoaluminate cement are presented. The sludge has a high water content and organic matter which is not easy to disposal. After Solidification/Stabilization (S/S), landfill disposal of sewage sludge is widely adopted in China. However, there is little research focused on the geotechnical properties of sewage sludge after S/S treatment and the impact on the landfill site is also difficult to be evaluated. To solve this problem, this paper is aimed to evaluate the basic mechanics properties of solidified materials by means of Atterberg limit, triaxial test, consolidation test and permeability test. The result showed that the strength and the hydraulic conductivity of the modified sludge was close to that of the high organic soil. By adding suitable additives, modified sludge could not only satisfy the requirement of being landfilled but also be utilized as a construction material

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer : development of a prognostic model through a crowdsourced challenge with open clinical trial data

Background Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative allowing data from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Assessments and Methods) challenge to not only identify a better prognostic model for prediction of survival in patients with metastatic castration-resistant prostate cancer but also engage a community of international data scientists to study this disease. Methods Data from the comparator arms of four phase 3 clinical trials in first-line metastatic castration-resistant prostate cancer were obtained from Project Data Sphere, comprising 476 patients treated with docetaxel and prednisone from the ASCENT2 trial, 526 patients treated with docetaxel, prednisone, and placebo in the MAINSAIL trial, 598 patients treated with docetaxel, prednisone or prednisolone, and placebo in the VENICE trial, and 470 patients treated with docetaxel and placebo in the ENTHUSE 33 trial. Datasets consisting of more than 150 clinical variables were curated centrally, including demographics, laboratory values, medical history, lesion sites, and previous treatments. Data from ASCENT2, MAINSAIL, and VENICE were released publicly to be used as training data to predict the outcome of interest-namely, overall survival. Clinical data were also released for ENTHUSE 33, but data for outcome variables (overall survival and event status) were hidden from the challenge participants so that ENTHUSE 33 could be used for independent validation. Methods were evaluated using the integrated time-dependent area under the curve (iAUC). The reference model, based on eight clinical variables and a penalised Cox proportional-hazards model, was used to compare method performance. Further validation was done using data from a fifth trial-ENTHUSE M1-in which 266 patients with metastatic castration-resistant prostate cancer were treated with placebo alone. Findings 50 independent methods were developed to predict overall survival and were evaluated through the DREAM challenge. The top performer was based on an ensemble of penalised Cox regression models (ePCR), which uniquely identified predictive interaction effects with immune biomarkers and markers of hepatic and renal function. Overall, ePCR outperformed all other methods (iAUC 0.791; Bayes factor >5) and surpassed the reference model (iAUC 0.743; Bayes factor >20). Both the ePCR model and reference models stratified patients in the ENTHUSE 33 trial into high-risk and low-risk groups with significantly different overall survival (ePCR: hazard ratio 3.32, 95% CI 2.39-4.62, p Interpretation Novel prognostic factors were delineated, and the assessment of 50 methods developed by independent international teams establishes a benchmark for development of methods in the future. The results of this effort show that data-sharing, when combined with a crowdsourced challenge, is a robust and powerful framework to develop new prognostic models in advanced prostate cancer.Peer reviewe

Theoretical Study on the Regional Comprehensive Price of Expropriated Agricultural Land Based on the Benchmark Land Price

So far, the work of calculating the regional comprehensive price of expropriated agricultural land has been carried out for more than ten years, but in the specific calculation process, the concept and calculation method of the regional comprehensive price of expropriated land is still lack of unified standards. In this paper, from the point of view of the benchmark land price, the regional comprehensive price of expropriated agricultural land is calculated by using the relatively mature benchmark land price

Optimization technology of gas extraction pipe network based on “pipe network solving-genetic algorithm optimization”

In order to realize the intelligent decision-making of the pipe diameter optimization scheme of the mine gas extraction pipe network, the gas extraction pipe network diagram theory model is constructed based on the principle of graph theory, and the specific pipe diameter pipe network is solved based on the gas-air hybrid flow model of the pipe network. Taking the minimum pipe network investment as the target function and the pipe diameter as the decision-making variable, the pipe diameter optimization model of the gas extraction pipe network is established. Based on the genetic algorithm of integer coding, the pipe diameter optimization scheme of the extraction area on the west side of Liuzhuang Coal Mine was obtained. The results show that the combination of pipe diameter optimized by genetic algorithm is better than the flow rate method in terms of economy and extraction effect, and the negative pressure of extraction at the extractive end after optimization meets the extraction requirements, and the cost of pipe network is reduced by 483,000 yuan

Geotechnical properties of sewage sludge solidified with Sulphoaluminate cement

The geotechnical properties of sewage sludge solidified with sulphoaluminate cement are presented. The sludge has a high water content and organic matter which is not easy to disposal. After Solidification/Stabilization (S/S), landfill disposal of sewage sludge is widely adopted in China. However, there is little research focused on the geotechnical properties of sewage sludge after S/S treatment and the impact on the landfill site is also difficult to be evaluated. To solve this problem, this paper is aimed to evaluate the basic mechanics properties of solidified materials by means of Atterberg limit, triaxial test, consolidation test and permeability test. The result showed that the strength and the hydraulic conductivity of the modified sludge was close to that of the high organic soil. By adding suitable additives, modified sludge could not only satisfy the requirement of being landfilled but also be utilized as a construction material

Site Selection of Land Consolidation Project Based on Farmland Quality Evaluation in Yanjin County of Henan Province

In order to explore the effects of farmland quality evaluation on site selection of land consolidation projects, the methods of agricultural land use classification were used. Taking several project areas in Yanjin County of Henan Province as examples, the farmland quality before and after land consolidation projects was evaluated. The results indicate that under the conditions of reasonable site selection, the implementation of land consolidation projects can effectively improve the farmland quality and increase the grain productivity. Therefore, before the site selection for land consolidation projects, it is recommended to carry out pre-evaluation of farmland quality, and guide the project implementation according to the evaluation results. Besides, it is recommended to focus on medium and low level farmland with large centralized area, excellent original production conditions, but low level of development and use

Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP

YiiP from Shewanella oneidensis is a prokaryotic Zn2+/H+ antiporter that serves as a model for the Cation Diffusion Facilitator (CDF) superfamily, members of which are generally responsible for homeostasis of transition metal ions. Previous studies of YiiP as well as related CDF transporters have established a homodimeric architecture and the presence of three distinct Zn2+ binding sites named A, B, and C. In this study, we use cryo-EM, microscale thermophoresis and molecular dynamics simulations to address the structural and functional roles of individual sites as well as the interplay between Zn2+ binding and protonation. Structural studies indicate that site C in the cytoplasmic domain is primarily responsible for stabilizing the dimer and that site B at the cytoplasmic membrane surface controls the structural transition from an inward facing conformation to an occluded conformation. Binding data show that intramembrane site A, which is directly responsible for transport, has a dramatic pH dependence consistent with coupling to the proton motive force. A comprehensive thermodynamic model encompassing Zn2+ binding and protonation states of individual residues indicates a transport stoichiometry of 1 Zn2+ to 2–3 H+ depending on the external pH. This stoichiometry would be favorable in a physiological context, allowing the cell to use the proton gradient as well as the membrane potential to drive the export of Zn2+

Assessment of Coproduction of Ethanol and Methane from Pennisetum purpureum: Effects of Pretreatment, Process Performance, and Mass Balance

To overcome the structural complexity and improve the bioconversion efficiency of Pennisetum purpureum into bioethanol or/and biomethane, the effects of ensiling pretreatment, NaOH pretreatment, and their combination on digestion performance and mass flow were comparatively investigated. The coproduction of bioethanol and biomethane showed that 65.2 g of ethanol and 102.6 g of methane could be obtained from 1 kg of untreated Pennisetum purpureum, and pretreatment had significant impacts on the production; however, there is no significant difference between the results of NaOH pretreatment and ensiling-NaOH pretreatment in terms of production improvement. Among them, 1 kg of ensiling-NaOH treated Pennisetum purpureum could yield 269.4 g of ethanol and 144.5 g of methane, with a respective increase of 313.2% and 40.8% compared to that from the untreated sample; this corresponded to the final energy production of 14.5 MJ, with the energy conversion efficiency of 46.8%. In addition, for the ensiling-NaOH treated Pennisetum purpureum, the energy recovery from coproduction (process III) was 98.9% higher than that from enzymatic hydrolysis and fermentation only (process I) and 53.6% higher than that from anaerobic digestion only (process II). This indicated that coproduction of bioethanol and biomethane from Pennisetum purpureum after ensiling and NaOH pretreatment is an effective method to improve its conversion efficiency and energy output