452 research outputs found
Gauge Dependence of the Effective Average Action in Einstein Gravity
We study the gauge dependence of the effective average action Gamma_k and
Newtonian gravitational constant using the RG equation for Gamma_k. Then we
truncate the space of action functionals to get a solution of this equation. We
solve the truncated evolution equation for the Einstein gravity in the De
Sitter background for a general gauge parameter alpha and obtain a system of
equations for the cosmological and the Newtonian constants. Analyzing the
running of the gravitational constant we find that the Newtonian constant
depends strongly on the gauge parameter. This leads to the appearance of
antiscreening and screening behavior of the quantum gravity. The resolution of
the gauge dependence problem is suggested. For physical gauges like the
Landau-De Witt gauge the Newtonian constant shows an antiscreening.Comment: 19 pages, LaTeX, 1 figure, misprints correcte
Ocean acidification and human health
The ocean provides resources key to human health and well-being, including food, oxygen, livelihoods, blue spaces, and medicines. The global threat to these resources posed by accelerating ocean acidification is becoming increasingly evident as the world’s oceans absorb carbon dioxide emissions. While ocean acidification was initially perceived as a threat only to the marine realm, here we argue that it is also an emerging human health issue. Specifically, we explore how ocean acidification affects the quantity and quality of resources key to human health and well-being in the context of: (1) malnutrition and poisoning, (2) respiratory issues, (3) mental health impacts, and (4) development of medical resources. We explore mitigation and adaptation management strategies that can be implemented to strengthen the capacity of acidifying oceans to continue providing human health benefits. Importantly, we emphasize that the cost of such actions will be dependent upon the socioeconomic context; specifically, costs will likely be greater for socioeconomically disadvantaged populations, exacerbating the current inequitable distribution of environmental and human health challenges. Given the scale of ocean acidification impacts on human health and well-being, recognizing and researching these complexities may allow the adaptation of management such that not only are the harms to human health reduced but the benefits enhanced.publishedVersio
Effective Average Action in N=1 Super-Yang-Mills Theory
For N=1 Super-Yang-Mills theory we generalize the effective average action
Gamma_k in a manifest supersymmetric way using the superspace formalism. The
exact evolution equation for Gamma_k is derived and, introducing as an
application a simple truncation, the standard one-loop beta-function of N=1 SYM
theory is obtained.Comment: 17 pages, LaTeX, some remarks added, misprints corrected, to appear
in Phys. Rev.
One-loop f(R) gravity in de Sitter universe
Motivated by the dark energy issue, the one-loop quantization approach for a
family of relativistic cosmological theories is discussed in some detail.
Specifically, general gravity at the one-loop level in a de Sitter
universe is investigated, extending a similar program developed for the case of
pure Einstein gravity. Using generalized zeta regularization, the one-loop
effective action is explicitly obtained off-shell, what allows to study in
detail the possibility of (de)stabilization of the de Sitter background by
quantum effects. The one-loop effective action maybe useful also for the study
of constant curvature black hole nucleation rate and it provides the plausible
way of resolving the cosmological constant problem.Comment: 25 pages, Latex file. Discussion enlarged, new references added.
Version accepted in JCA
Casimir effect: running Newton constant or cosmological term
We argue that the instability of Euclidean Einstein gravity is an indication
that the vacuum is non perturbative and contains a condensate of the metric
tensor in a manner reminiscent of Yang-Mills theories. As a simple step toward
the characterization of such a vacuum the value of the one-loop effective
action is computed for Euclidean de Sitter spaces as a function of the
curvature when the unstable conformal modes are held fixed. Two phases are
found, one where the curvature is large and gravitons should be confined and
another one which appears to be weakly coupled and tends to be flat. The
induced cosmological constant is positive or negative in the strongly or weakly
curved phase, respectively. The relevance of the Casimir effect in
understanding the UV sensitivity of gravity is pointed out.Comment: Final, slightly extended version, to appear in Classical and Quantum
Gravit
Solar Influence on Nuclear Decay Rates: Constraints from the MESSENGER Mission
We have analyzed Cs-137 decay data, obtained from a small sample onboard the
MESSENGER spacecraft en route to Mercury, with the aim of setting limits on a
possible correlation between nuclear decay rates and solar activity. Such a
correlation has been suggested recently on the basis of data from Mn-54 decay
during the solar flare of 13 December 2006, and by indications of an annual and
other periodic variations in the decay rates of Si-32, Cl-36, and Ra-226. Data
from five measurements of the Cs-137 count rate over a period of approximately
5.4 years have been fit to a formula which accounts for the usual exponential
decrease in count rate over time, along with the addition of a theoretical
solar contribution varying with MESSENGER-Sun separation. The indication of
solar influence is then characterized by a non-zero value of the calculated
parameter \xi, and we find \xi=(2.8+/-8.1)x10^{-3} for Cs-137. A simulation of
the increased data that can hypothetically be expected following Mercury orbit
insertion on 18 March 2011 suggests that the anticipated improvement in the
determination of \xi could reveal a non-zero value of \xi if present at a level
consistent with other data.Comment: Accepted for publication in Astrophysics and Space Science, 2011. 7
pages, 5 figures. Version 2 has corrected Figure 1, since Fig. 1 did not
appear correctly in Version
Allelic Expression Imbalance Promoting a Mutant PEX6 Allele Causes Zellweger Spectrum Disorder
Zellweger spectrum disorders (ZSDs) are autosomal-recessive disorders that are caused by defects in peroxisome biogenesis due to bi-allelic mutations in any of 13 different PEX genes. Here, we identified seven unrelated individuals affected with an apparent dominant ZSD in whom a heterozygous mutant PEX6 allele (c.2578C>T [p.Arg860Trp]) was overrepresented due to allelic expression imbalance (AEI). We demonstrated that AEI of PEX6 is a common phenomenon and is correlated with heterozygosity for a frequent variant in the 3' untranslated region (UTR) of the mutant allele, which disrupts the most distal of two polyadenylation sites. Asymptomatic parents, who were heterozygous for PEX c.2578C>T, did not show AEI and were homozygous for the 3' UTR variant. Overexpression models confirmed that the overrepresentation of the pathogenic PEX6 c.2578T variant compared to wild-type PEX6 c.2578C results in a peroxisome biogenesis defect and thus constitutes the cause of disease in the affected individuals. AEI promoting the overrepresentation of a mutant allele might also play a role in other autosomal-recessive disorders, in which only one heterozygous pathogenic variant is identified.</p
Renormalization and asymptotic safety in truncated quantum Einstein gravity
A perturbative quantum theory of the 2-Killing vector reduction of general
relativity is constructed. Although non-renormalizable in the standard sense,
we show that to all orders of the loop expansion strict cut-off independence
can be achieved in a space of Lagrangians differing only by a field dependent
conformal factor. In particular the Noether currents and the quantum
constraints can be defined as finite composite operators. The form of the field
dependence in the conformal factor changes with the renormalization scale and a
closed formula is obtained for the beta functional governing its flow. The flow
possesses a unique fixed point at which the trace anomaly is shown to vanish.
The approach to the fixed point adheres to Weinberg's ``asymptotic safety''
scenario, both in the gravitational wave/cosmological sector and in the
stationary sector.Comment: 67 pages, Latex; v3: improved discussion of stationary sector; agrees
with published versio
The use of aortic balloon occlusion in traumatic shock : first report from the ABO trauma registry
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a technique for temporary stabilization of patients with non-compressible torso hemorrhage. This technique has been increasingly used worldwide during the past decade. Despite the good outcomes of translational studies, clinical studies are divided. The aim of this multicenter-international study was to capture REBOA-specific data and outcomes. REBOA practicing centers were invited to join this online register, which was established in September 2014. REBOA cases were reported, both retrospective and prospective. Demographics, injury patterns, hemodynamic variables, REBOA-specific data, complications and 30-days mortality were reported. Ninety-six cases from 6 different countries were reported between 2011 and 2016. Mean age was 52 +/- 22 years and 88% of the cases were blunt trauma with a median injury severity score (ISS) of 41 (IQR 29-50). In the majority of the cases, Zone I REBOA was used. Median systolic blood pressure before balloon inflation was 60 mmHg (IQR 40-80), which increased to 100 mmHg (IQR 80-128) after inflation. Continuous occlusion was applied in 52% of the patients, and 48% received non-continuous occlusion. Occlusion time longer than 60 min was reported as 38 and 14% in the non-continuous and continuous groups, respectively. Complications, such as extremity compartment syndrome (n = 3), were only noted in the continuous occlusion group. The 30-day mortality for non-continuous REBOA was 48%, and 64% for continuous occlusion. This observational multicenter study presents results regarding continuous and non-continuous REBOA with favorable outcomes. However, further prospective studies are needed to be able to draw conclusions on morbidity and mortality.Peer reviewe
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