234 research outputs found
SR 2D micro-XRF imaging on entire rat thin sections in view of a pharmacokinetic study of a new bromine containing drug agains tuberculosis
Tuberculosis (TB) is a common and often deadly infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis in humans. Because of population growth, the absolute number of new cases is still increasing. Multi-drug-resistant tuberculosis (MDR-TB) is defined as resistance to the two most effective first-line TB drugs and is a public health issue in many developing countries, as treatment is longer and requires more expensive drugs. Recently, a new experimental diarylquinoline anti-tuberculosis drug was discovered at Janssen Pharmaceutica, referred to as TMC207 and shown in Fig. 1. Before TMC207 can be made commercially available, one of the necessary investigations is a thorough pharmacokinetic study to investigate its absorption, distribution, metabolism and excretion (ADME)
Investigation of Daphnia magna genotypes with different Zn tolerance using micro-XRF under cryogenic conditions
3D elemental imaging of the crustacean Ceriodaphnia by means of SR confocal micro-XRF
Daphnia is a freshwater crustacean (0.2-5 mm height) used for investigating the toxic effects of toxins (e.g. metals) on an ecosystem. Synchrotron radiation based micro X-ray fluorescence (SR micro-XRF) allows the investigation of the trace level metal distribution within these organisms in an essentially non-destructive manner. Several two-dimensional (2D), computed tomography (CT) and confocal micro-XRF experiments under conventional and cryogenic environments have been performed on Daphnia magna previously. However, due to its larger size (3 mm height) full three-dimensional (3D) imaging of the metal distributions is not practically feasible. In this contribution, we therefore report on the full 3D elemental imaging on Ceriodaphnia which is a smaller variant (1 mm height) by means of 3D confocal micro-XRF
Cryomapping on Daphnia magna at Beamline L using a cryostream : experimental setup and comparison
Elemental bio-imaging of uranium and plutonium in tissues from occupationally exposed former nuclear workers
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Non-destructive characterization of CoTSPc electrochemically deposited on gold electrodes by means of synchrotron X-ray microfluorescence
Synchrotron XRF Analysis Identifies Cerium Accumulation Colocalized with Pharyngeal Deformities in CeO2 NP-Exposed Caenorhabditis elegans
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Cryogenic analysis of frozen hydrated biological tissue at the Hard X-ray Micro-Probe Beamline at PETRA III
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Cryogenic synchrotron radiation X-ray fluorescence analysis of biological model organisms using a state-of-the-art cryochamber at P06, PETRA III
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