Universal scaling of a classical impurity in the quantum Ising chain

We study finite size scaling for the magnetic observables of an impurity residing at the endpoint of an open quantum Ising chain in a transverse magnetic field, realized by locally rescaling the magnetic field by a factor $\mu \neq 1$. In the homogeneous chain limit at $\mu = 1$, we find the expected finite size scaling for the longitudinal impurity magnetization, with no specific scaling for the transverse magnetization. At variance, in the classical impurity limit, $\mu = 0$, we recover finite scaling for the longitudinal magnetization, while the transverse one basically does not scale. For this case, we provide both analytic approximate expressions for the magnetization and the susceptibility as well as numerical evidences for the scaling behavior. At intermediate values of $\mu$, finite size scaling is violated, and we provide a possible explanation of this result in terms of the appearance of a second, impurity related length scale. Finally, on going along the standard quantum-to-classical mapping between statistical models, we derive the classical counterpart of the quantum Ising chain with an impurity at its endpoint as a classical Ising model on a square lattice wrapped on a half-infinite cylinder, with the links along the first circle modified as a function of $\mu$.Comment: Update closer to published versio

X-Ray Spectral Variability of Extreme BL Lac AGN H1426+428

Between 7 March 2002 and 15 June 2002, intensive X-ray observations were carried out on the extreme BL Lac object H1426+428 with instruments on board the Rossi X-ray Timing Explorer (RXTE). These instruments provide measurements of H1426+428 in the crucial energy range that characterizes the first peak of its spectral energy distribution. This peak, which is almost certainly due to synchrotron emission, has previously been inferred to be in excess of 100 keV. By taking frequent observations over a four-month campaign, which included $\sim$450 ksec of RXTE time, studies of flux and spectral variability on multiple timescales were performed, along with studies of spectral hysteresis. The 3-24 keV X-ray flux and spectra exhibited significant variability, implying variability in the location of the first peak of the spectral energy distribution. Hysteresis patterns were observed, and their characteristics have been discussed within the context of emission models.Comment: accepted for publication in Astrophysical Journa

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells

A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldown followed by RNA sequencing, combined with in silico microRNA target prediction, we have identified two new targets of microRNA-222 involved in the regulation of myogenic differentiation, Ahnak and Rbm24. Specifically, the RNA-binding protein Rbm24 is a major regulator of muscle-specific alternative splicing and its downregulation by microRNA-222 results in defective exon inclusion impairing the production of muscle-specific isoforms of Coro6, Fxr1 and NACA transcripts. Reconstitution of normal levels of Rbm24 in cells overexpressing microRNA-222 rescues muscle-specific splicing. In conclusion, we have identified a new function of microRNA-222 leading to alteration of myogenic differentiation at the level of alternative splicing, and we provide evidence that this effect is mediated by Rbm24 protei

Fermion masses and mixings in gauge theories

The recent evidence for neutrino oscillations stimulate us to discuss again the problem of fermion masses and mixings in gauge theories. In the standard model, several forms for quark mass matrices are equivalent. They become ansatze within most extensions of the standard model, where also relations between quark and lepton sectors may hold. In a seesaw framework, these relations can constrain the scale of heavy neutrino mass, which is often related to the scale of intermediate or unification gauge symmetry. As a consequence, two main scenarios arise. Hierarchies of masses and mixings may be explained by broken horizontal symmetries.Comment: 25 pages, RevTex, no figures. Few misprints corrected and two references adde

Triangular Textures for Quark Mass Matrices

The hierarchical quark masses and small mixing angles are shown to lead to a simple triangular form for the U- and D-type quark mass matrices. In the basis where one of the matrices is diagonal, each matrix element of the other is, to a good approximation, the product of a quark mass and a CKM matrix element. The physical content of a general mass matrix can be easily deciphered in its triangular form. This parameterization could serve as a useful starting point for model building. Examples of mass textures are analyzed using this method.Comment: 10 pages, no figure

Gamma-Ray Burst long lasting X-ray flaring activity

In this paper we shed light on late time (i.e. with peak time t_{pk} \gtrsim 1000 s) flaring activity. We address the morphology and energetic of flares in the window \sim 10^3-10^6 s to put constraints on the temporal evolution of the flare properties and to identify possible differences in the mechanism producing the early and late time flaring emission, if any. This requires the complete understanding of the observational biases affecting the detection of X-ray flares superimposed on a fading continuum at t > 1000 s. We consider all the Swift GRBs that exhibit late time flares. Our sample consists of 36 flares, 14 with redshift measurements. We inherit the strategy of data analysis from Chincarini et al. (2010) in order to make a direct comparison with the early time flare properties. The morphology of the flare light curve is the same for both early time and late time flares, while they differ energetically. The width of late time flares increases with time similarly to the early time flares. Simulations confirmed that the increase of the width with time is not due to the decaying statistics, at least up to 10^4 s. The energy output of late time flares is one order of magnitude lower than the early time flare one, being \sim 1% E_{prompt}. The evolution of the peak luminosity as well as the distribution of the peak flux-to-continuum ratio for late time flares indicate that the flaring emission is decoupled from the underlying continuum, differently from early time flares/steep decay. A sizable fraction of late time flares are compatible with afterglow variability. The internal shock origin seems the most promising explanation for flares. However, some differences that emerge between late and early time flares suggest that there could be no unique explanation about the nature of late time flares.Comment: 8 pages, 6 figures, accepted for publication in Astronomy and Astrophysic

Joint Astrophysics Nascent Universe Satellite:. utilizing GRBs as high redshift probes

The Joint Astrophysics Nascent Universe Satellite (JANUS) is a multiwavelength cosmology mission designed to address fundamental questions about the cosmic dawn. It has three primary science objectives: (1) measure the massive star formation rate over 5 ≤ z ≤ 12 by discovering and observing high-z gamma-ray bursts (GRBs) and their afterglows, (2) enable detailed studies of the history of reionization and metal enrichment in the early Universe, and (3) map the growth of the first supermassive black holes by discovering and observing the brightest quasars at z ≥ 6. A rapidly slewing spacecraft and three science instruments – the X-ray Coded Aperture Telescope (XCAT), the Near InfraRed Telescope (NIRT), and the GAmma-ray Transient Experiment for Students (GATES) – make-up the JANUS observatory and are responsible for realizing the three primary science objectives. The XCAT (0.5–20 keV) is a wide field of view instrument responsible for detecting and localizing ∼60 z ≥ 5 GRBs, including ∼8 z ≥ 8 GRBs, during a 2-year mission. The NIRT (0.7–1.7 µm) refines the GRB positions and provides rapid (≤ 30 min) redshift information to the astronomical community. Concurrently, the NIRT performs a 20, 000 deg2 survey of the extragalactic sky discovering and localizing ∼300 z ≥ 6 quasars, including ∼50 at z ≥ 7, over a two-year period. The GATES provides high-energy (15 keV −1.0 MeV) spectroscopy as well as 60–500 keV polarimetry of bright GRBs. Here we outline the JANUS instrumentation and the mission science motivations

Seesaw mechanism, baryon asymmetry and neutrinoless double beta decay

A simplified but very instructive analysis of the seesaw mechanism is here performed. Assuming a nearly diagonal Dirac neutrino mass matrix, we study the forms of the Majorana mass matrix of right-handed neutrinos, which reproduce the effective mass matrix of left-handed neutrinos. As a further step, the important effect of a non diagonal Dirac neutrino mass matrix is explored. The corresponding implications for the baryogenesis via leptogenesis and for the neutrinoless double beta decay are reviewed. We propose two distinct models where the baryon asymmetry is enhanced.Comment: 21 pages, RevTex. Revise

Mortality of patients with multiple sclerosis: a cohort study in UK primary care

We aimed to estimate rates, causes and risk factors of all-cause mortality in a large population-based cohort of multiple sclerosis (MS) patients compared with patients without MS. Using data from the UK General Practice Research Database, we identified MS cases diagnosed during 2001–2006 and validated using patients’ original records where possible. We also included MS cases during 1993–2000 identified and validated in an earlier study. Cases were matched to up to ten referents without MS by age, sex, index date (date of first MS diagnosis for cases and equivalent reference date for controls), general practice and length of medical history before first MS diagnosis. Patients were followed up to identify deaths; hazard ratios (HRs) and 95 % confidence intervals (CIs) were estimated using Cox-proportional regression. MS patients (N = 1,822) had a significantly increased risk of all-cause mortality compared with referents (N = 18,211); adjusted HR 1.7 (95 % CI 1.4–2.1). Compared with referents, female MS patients had a higher but not significantly different HR for death than males; adjusted HR 1.86 (95 % CI 1.46–2.38) vs. HR 1.31 (95 % CI 0.93–1.84), respectively. The most commonly recorded cause of death in MS patients was ‘MS’ (41 %), with a higher proportion recorded among younger patients. A significantly higher proportion of referents than MS patients had cancer recorded as cause of death (40 vs. 19 %). Patients with MS have a significant 1.7-fold increased risk of all-cause mortality compared with the general population. MS is the most commonly recorded cause of death among MS patients. Electronic supplementary material The online version of this article (doi:10.1007/s00415-014-7370-3) contains supplementary material, which is available to authorized users

Irreversible Work and Inner Friction in Quantum Thermodynamic Processes

We discuss the thermodynamics of closed quantum systems driven out of equilibrium by a change in a control parameter and undergoing a unitary process. We compare the work actually done on the system with the one that would be performed along ideal adiabatic and isothermal transformations. The comparison with the latter leads to the introduction of irreversible work, while that with the former leads to the introduction of inner friction. We show that these two quantities can be treated on an equal footing, as both can be linked with the heat exchanged in thermalization processes and both can be expressed as relative entropies. Furthermore, we show that a specific fluctuation relation for the entropy production associated with the inner friction exists, which allows the inner friction to be written in terms of its cumulants.All the authors acknowledge support from COST MP1209 Action. F. P., G. F., and N. L. G. acknowledge insightful discussions with Michele Campisi, John Goold, and Mauro Paternostro. T. J. G. A. is supported by the European Commission, the European Social Fund, and the Region Calabria through the program POR Calabria FSE 2007-2013-Asse IV Capitale Umano-Obiettivo Operativo M2. F. G. and R. Z. acknowledge MINECO, CSIC, the EU commission, UIB and FEDER funding under Grants FIS2011-23526 (TIQS), postdoctoral JAE program (ESF) and Invited professors program.Peer reviewe