Existence of Equilibrium in Common Agency Games with Adverse Selection

We establish the existence of sequential equilibria in general menu games, known to be su±cient to analyze common agency problems. In particular, we show that our result solves some unpleasant features of early approaches.

Confiabilidad de taludes de suelo no saturado expuestos a precipitaciones pluviales

El procedimiento es probabilístico y es útil para valorar la falla de taludes críticos sujetos a lluvias intensas. Se incluyen incertidumbres en propiedades del suelo y las características de las lluvias. Los patrones de presiones de poro y resistencia al corte de los suelos son cruciales para poder comparar este nivel de seguridad con el límite aceptable para decidir si las condiciones de estabilidad del talud son aceptables y para generar recomendaciones de mitigación, en su caso.Se propone un procedimiento para evaluar la probabilidad de falla de taludes críticos sujetos a lluvias intensas. El procedimiento incluye incertidumbres en propiedades del suelo y las características de las lluvias. El patrón de presiones de poro y resistencia al corte de los suelos es fundamental en la evaluación del nivel de seguridad de la trayectoria crítica de falla. Se incluye la comparación con el nivel aceptable de probabilidad de falla para decidir si las condiciones de seguridad del talud y generar recomendaciones de mitigación, en su caso

Transport Protocol Performance and Impact on QoS while on the Move in Current and Future Low Latency Deployments

Transport protocols and mobile networks have evolved independently leading to a lack of adaptability and quality of service (QoS) degradation while running under the variability circumstances present in cellular access. This chapter evaluates the performance of state-of-the-art transmission control protocol (TCP) implementations in challenging mobility scenarios under 4G latencies and low delays that model the proximity service provisioning of forthcoming 5G networks. The evaluation is focused on selecting the most appropriate TCP flavor for each scenario taking into account two metrics: (1) the goodput-based performance and (2) a balanced performance metric that includes parameters based on goodput, delay and retransmitted packets. The results show that mobility scenarios under 4G latencies require more aggressive TCP solutions in order to overcome the high variability in comparison with low latency conditions. Bottleneck Bandwidth and Round-Trip Time-RTT (BBR) provides better scalability than others and Illinois is more capable of sustaining the goodput with big variability between consecutive samples. Besides, CUBIC performs better in lower available capacity scenarios and regarding the balanced metric. In reduced end-to-end latencies, the most suitable congestion control algorithms (CCAs) to maximize the goodput are NewReno (low available capacity) and CUBIC (high available capacity) when moving with continuous capacity increases. Additionally, BBR shows a balanced and controlled behavior in most of the scenarios

A role for antizyme inhibitor 2 in the biosynthesis and content of serotonin and histamine in mouse mast cells

Polyamines (putrescine, spermidine and spermine; PAs) are essential for the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine decarboxylase and PA uptake. In addition to PAs, mast cells (MC) synthesize and store in their granules histamine (Hia) and serotonin (5-HT), which are critical for their function. Our previous studies have indicated a metabolic interplay among PAs, Hia and 5-HT in this cell type. For instance, we showed that PAs affect Hia synthesis during early stages of IL-3-induced bone marrow cell differentiation into bone marrow derived MCs (BMMCs) and demonstrated that PAs are present in MC secretory granules and are important for granule homeostasis, including Hia storage and 5-HT levels. A few years ago, a novel antizyme inhibitor (AZIN2) was described whose expression is restricted to a few tissues and cell types including brain, testis and MCs. In MCs, it was recently proposed that AZIN2 could act as a local regulator of PA biosynthesis in association with 5-HT-containing granules and with 5-HT release following MC activation. To gain insight into the role of AZIN2 in the biosynthesis and storage of 5-HT and also Hia, we have generated BMMCs from both wild-type and transgenic mice with severe Azin2 hypomorphism, and have analyzed the content of PAs, 5-HT and Hia, and some elements of their metabolisms. Spermine and 5-HT levels were reduced in Azin2 hypomorphic BMMCs compared with wild-type controls, whereas the amount of Hia was increased. Accordingly, the level of tryptophan hydroxylase 1 (the key enzyme for 5-HT biosynthesis) was reduced and the amount of enzymatic activity of histidine decarboxylase (the enzyme responsible for Hia biosynthesis) was increased in Azin2 hypomorphic BMMCs. Taken together, our results show evidence that AZIN2 has an important role in the regulation of 5-HT and Hia biosynthesis and storage in MCsUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This work was supported by SAF2011-26518 (MINECO, Spain) and P10-CVI-6585 and Bio-267 (Junta de Andalucia, Spain). CIBERER is an iniciative of Instituto de Salud Carlos III (Spain)

Quality of Service (QoS) oriented management system in 5G cloud enabled RAN

[EN] This paper analyze techniques to implement QoS/QoE on multi-tenant 5G networks. Describes the ar- chitecture of the next generation mobile network based on cloud-enabled small cell deployments and also proposes an hybrid-cloud solution coexisting with centralized cloud RAN(C-RAN), in order to achieve a gradual implementation of the technology. In this context, the work here presented deals with the challenges of preserving the quality of ex- perience in a multi-tenant cloud enable RAN bearing in mind the Key Performance Indicator(KPI) agreed in the SLA. To achieve this goal, QoS should be managed at different levels of the architecture. Feedback should be given between learning modules in order to analyze the results and infer enhanced decision rules which may conclude in an architecture replacement.The research leading to these results has been supported by the EU funded H2020 5G-PPP projects SESAME (Grant Agreement n 671596) and ESSENCE project (Grant Agreement no 761592) and by the Spanish Ministerio de Economia y Competitividad (MINECO) under grant TEC2016-80090-C2-2-R (5RANVIR).Solozabal, R.; Fajardo, JO.; Blanco, B.; Liberal, F. (2018). Quality of Service (QoS) oriented management system in 5G cloud enabled RAN. En XIII Jornadas de Ingeniería telemática (JITEL 2017). Libro de actas. Editorial Universitat Politècnica de València. 170-175. https://doi.org/10.4995/JITEL2017.2017.6587OCS17017

A role for antizyme inhibitor 2 in the biosynthesis and content of histamine and serotonin in mouse mast cells

Polyamines (putrescine, spermidine and spermine; PAs) are required for the survival of the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine decarboxylase, the rate-limiting biosynthetic enzyme, and PA uptake. In addition to PA, mast cells (MC) synthesize and store in their granules the biogenically active amines histamine (Hia) and serotonin (5-HT), which are of critical importance for their function. Previously, we have performed several studies in this cell type regarding the interplay between the metabolisms of PAs and Hia and 5-HT. Our results showed that PAs affect Hia synthesis during early stages of IL-3-induced bone marrow cell differentiation into bone marrow derived MCs (BMMCs) and demonstrated that PAs are present in MC secretory granules and are important for granule homeostasis, including Hia storage and 5-HT levels. A few years ago, a novel antizyme inhibitor (AZIN2) was described. In contrast to AZIN1, AZIN2 expression is restricted to a few tissues and cell types including brain, testis and MCs. In MCs, it was recently described that AZIN2 could act as a local regulator of PA biosynthesis in association with the 5-HT granule content and release. At present, our aim is to gain further insight into the role of AZIN2 in the biosynthesis, storage and release of both Hia and 5-HT. In this study, we have generated BMMCs from both wild-type and transgenic mice with severe Azin2 hypomorphism, and have analyzed the content of PAs, Hia and 5-HT, and some elements of their metabolisms. Both PAs and 5-HT levels were reduced in Azin2 hypomorphic BMMCs compared with wild-type controls, whereas the amount of Hia was increased. Accordingly, the level of tryptophan hydroxylase 1 (the key enzyme for 5-HT biosynthesis) was reduced and the amount of enzymatic activity of histidine decarboxylase (the enzyme responsible for histamine biosynthesis) was increased in Azin2 hypomorphic BMMCs. Taken together, our results show evidence that AZIN2 has an important role in the regulation of Hia and 5-HT biosynthesis and storage in MCs. Department of Molecular Biology and Biochemistry, and CIBER de Enfermedades Raras (CIBER-ER), Faculty of Sciences, University of Málaga, Málaga 29071, Spain. Corresponding author: I. Fajardo ([email protected]) This work was supported by SAF2011-26518 (MINECO, Spain) and P10-CVI-6585 and Bio-267 (Junta de Andalucia, Spain). CIBERER is an iniciative of Instituto de Salud Carlos III (Spain).Universidad de Málaga. Campus de Excelencia Internacional Andalucía-Tech. SAF2011-26518 (MINECO, Spain) and P10-CVI-6585 and Bio-267 (Junta de Andalucia, Spain. CIBERER is an iniciative of Instituto de Salud Carlos III (Spain)

System architecture and deployment scenarios for SESAME: small cEllS coordinAtion for Multi-tenancy and Edge services

The surge of the Internet traffic with exabytes of data flowing over operators’ mobile networks has created the need to rethink the paradigms behind the design of the mobile network architecture. The inadequacy of the 4G UMTS Long term Evolution (LTE) and even of its advanced version LTE-A is evident, considering that the traffic will be extremely heterogeneous in the near future and ranging from 4K resolution TV to machine-type communications. To keep up with these changes, academia, industries and EU institutions have now engaged in the quest for new 5G technology. In this paper we present the innovative system design, concepts and visions developed by the 5G PPP H2020 project SESAME (Small cEllS coordinAtion for Multi-tenancy and Edge services). The innovation of SESAME is manifold: i) combine the key 5G small cells with cloud technology, ii) promote and develop the concept of Small Cells-as-a-Service (SCaaS), iii) bring computing and storage power at the mobile network edge through the development of non-x86 ARM technology enabled micro-servers, and iv) address a large number of scenarios and use cases applying mobile edge computing

Valor diagnóstico ecográfico de adenomiosis en mujeres histerectomizadas en el Hospital Nacional Arzobispo Loayza 2016-2019

Determina el valor diagnóstico de la ecografía transvaginal en el diagnóstico de adenomiosis en mujeres histerectomizadas en el Hospital Nacional Arzobispo Loayza durante el periodo 2016-2019, a través de un estudio cuantitativo, observacional y analítico de corte transversal. La población incluye mujeres sometidas a histerectomía en el Hospital Nacional Arzobispo Loayza entre 2016 y 2019, evaluadas previamente con ecografía transvaginal. Los datos se obtiene de historias clínicas antiguas y se analiza en SPSS v26.0. Las variables son el diagnóstico ecográfico e histopatológico para calcular la sensibilidad, especificidad y valor predictivo positivo y negativo. Se evalúan 270 mujeres de las cuales la adenomiosis se presenta con mayor frecuencia entre los 40 y 50 años y en quienes tenían 3 embarazos. Se encontra una prevalencia del 38,9% de adenomiosis confirmada por análisis histopatológico. La sensibilidad de la ecografía es del 9,52%, la especificidad del 98,18%, el valor predictivo positivo del 76,92% y el valor predictivo negativo del 63,03%. Estos hallazgos resaltan la importancia de considerar pruebas diagnósticas más sensibles, como la resonancia. Se concluye que la ecografía transvaginal presenta sensibilidad limitada (9,52%) en el diagnóstico de adenomiosis en mujeres histerectomizadas. Se recomienda complementarla con pruebas más sensibles como la resonancia magnética o la biopsia para mejorar la precisión diagnóstica

Teacher identity construction : exploring the nature of becoming a primary school language teacher

Central to this study is the question of how teachers construct their professional identity. This research explores the process of becoming a teacher and consequently of the construction of identity in terms of three specific components: belonging to a teacher community, the relationship between systems of knowledge and beliefs and classroom practice, and professional expectations for the future. A group of six Colombian preservice teachers in the final stage of their five-year teacher education programme were research participants. This case study used interviews, stimulated recall and on-line blogs as methods of data collection, and content analysis as the analytical approach. The findings reveal that while the process of learning to teach is individually constructed and experienced, it is socially negotiated. A teacher’s identity not only comprises personal knowledge and action, but is also influenced by the ideological, political and cultural interests and circumstances surrounding teachers’ lives and work. The research participants exhibited a permanent struggle between developing a personal professional style and coping with the restrictions imposed by living in a particular type of society that has already defined what teachers should do. Nevertheless, they manifested wellgrounded principles and theories of language teaching and learning and the purpose of education, and awareness of their potential as a new generation of teachers. This suggests that they had developed a sense of professional identity; a way to see themselves as teachers. This evolving identity sometimes conflicted with experience once they had faced the reality of classrooms, assumed institutional roles or negotiated modes of participation within a teacher community. The findings could be used as a point of departure in order to introduce changes into the curricula of teacher education programmes. The study has relevance for policymakers in planning action promoting professional development in pre-service and in-service teacher education.EThOS - Electronic Theses Online ServiceColfuturoGBUnited Kingdo

Optimal Consumption and Investment with Levy Processes

This paper study the intertemporal consumption and investment problem in a continuous time setting when the secutity prices follow a Geometric Levy Process. Using stochastic calculus for semimartingals we obtain sufficient conditions for the existence of optimal consump- tion and investment policies.