The comparative study of resolving parameters for a family of ladder networks

For a simple connected graph $G = (V, E)$, a vertex $x\in V$ distinguishes two elements (vertices or edges) $x_1\in V, y_1 \in E$ if $d(x, x_1)\neq d(x, y_1).$ A subset $Q_m\subset V$ is a mixed metric generator for $G,$ if every two distinct elements (vertices or edges) of $G$ are distinguished by some vertex of $Q_m.$ The minimum cardinality of a mixed metric generator for $G$ is called the mixed metric dimension and denoted by $dim_m(G).$ In this paper, we investigate the mixed metric dimension for different families of ladder networks. Among these families, we consider Möbius ladder, hexagonal Möbius ladder, triangular Möbius ladder network and conclude that all these families have constant-metric, edge metric and mixed metric dimension

Web Design Attributes in Building User Trust, Satisfaction, and Loyalty for a High Uncertainty Avoidance Culture

In this study, we attempt to evaluate the user pref6 erences for web design attributes (i.e., typography, color, content 7 quality, interactivity, and navigation) to determine the trust, sat8 isfaction, and loyalty for uncertainty avoidance cultures. Content 9 quality and navigation have been observed as strong factors in 10 building user trust with e-commerce websites. In contrast, inter11 activity, color, and typography have been observed as strong de12 terminants of user satisfaction. The most relevant and interesting 13 finding is related to typography, which has been rarely discussed 14 in e-commerce literature. A questionnaire was designed to collect 15 data to corroborate the proposed model and hypotheses. Further16 more, the partial least-squares method was adopted to analyze the 17 collected data from the students who participated in the test (n 18 = 558). Finally, the results of this study provide strong support to 19 the proposed model and hypotheses. Therefore, all the web design 20 attributes were observed as important design features to develop 21 user trust and satisfaction for uncertainty avoidance cultures. Al22 though both factors seem to be relevant, the relationship between 23 trust and loyalty was observed to be stronger than between satis24 faction and loyalty; thus, trust seems to be a stronger determinant 25 of loyalty for risk/high uncertainty avoidance culture

Brain Abscesses in Children: A Study of Microbiological Spectrum and Outcome of 80 Cases

Objective:  Brain abscess is a focus of pus in the brain due to infection somewhere else in the body. It is common in males than females and the average age in children ranges from 4 to 7 years. It develops by skull trauma or contiguous or hematogenous spread of infection. The study aimed to identify the pattern of microbiological involvement in the etiology of pediatric brain abscesses and the outcome so as to enable us to ensure definitive treatment with the appropriate and specific antimicrobial regimen. Materials and Methods:  A prospective study was conducted in 80 pediatric patients of brain abscess admitted to the Pediatric Neurosurgery Department, Children Hospital, Lahore, Pakistan. Results:  The median age was 5.2 years with a predominance of males (60%). The most common presentation was fever (72.5%) and then fits (35%). Congenital heart disease was the commonest factor in 32% of cases. Streptococcus was a commonly isolated pathogen in 17% cases out of 70% of culture positive cases. Recovery was seen in 70% of cases and the mortality was 7.5%. Conclusion:  Congenital heart disease is the most common causative factor in pediatric brain abscesses and most of the abscesses were found culture negative. There is a pressing need to carry out multicenter studies over a large sample size over extended study duration in developing countries to help establish guidelines in treating pediatric brain abscesses

Hamltonian Connectedness and Toeplitz Graphs

A square matrix of order n is called Toeplitz matrix if it has constant elements along all diagonals parallel to the main diagonal and a graph is called Toeplitz graph if its adjacency matrix is Toeplitz. In this paper we proved that the Toeplitz graphs , for   and  are Hamiltonian  connected

Probabilistic Model for Free-Space Optical Links Under Continental Fog Conditions

The error characteristics of a free-space optical (FSO) channel are significantly different from the fiber based optical links and thus require a deep physical understanding of the propagation channel. In particular different fog conditions greatly influence the optical transmissions and thus a channel model is required to estimate the detrimental fog effects. In this paper we shall present the probabilistic model for radiation fog from the measured data over a 80 m FSO link installed at Graz, Austria. The fog events are classified into thick fog, moderate fog, light fog and general fog based on the international code of visibility range. We applied some probability distribution functions (PDFs) such as Kumaraswamy, Johnson SB and Logistic distribution, to the actual measured optical attenuations. The performance of each distribution is evaluated by Q-Q and P-P plots. It is found that Kumaraswamy distribution is the best fit for general fog, while Logistic distribution is the optimum choice for thick fog. On the other hand, Johnson SB distribution best fits the moderate and light fog related measured attenuation data. The difference in these probabilistic models and the resultant variation in the received signal strength under different fog types needs to be considered in designing an efficient FSO system

Climate, population, and vulnerability in Pakistan: Exploring evidence of linkages for adaptation

The global discussion of climate change and its impacts and causes has changed completely in the past quarter century. Scientific opinion now accepts that rapid warming is occurring and that greenhouse gases (GHG) emitted as a result of human activities are largely to blame. The consequences of taking no action will be catastrophic. Unfortunately, the burden of impact will fall disproportionately on the poor and most vulnerable people who rely heavily on agriculture in countries where average temperatures are already high. Climate change is particularly harmful because it increasingly threatens food security in these countries. Pakistan is one of the most vulnerable countries in the world. This monograph uses diverse data sources to initiate an interdisciplinary conversation on the interlinkages of climate change and demography through contributions from national experts in meteorology, migration, and agriculture. The aim is to provide a regionally nuanced perspective of the climatic changes to which the population is exposed; the key demographic and socioeconomic trends that have a bearing on vulnerability, resilience, and adaptation; internal migration; and the expected combined impact of these dynamics on the country’s food and economic mainstay—agriculture

In vitro Studies on Anti-diabetic and Anti-ulcer Potentials of Jatropha gossypifolia (Euphorbiaceae)

Purpose: To evaluate α-glucosidase and α-chymotrypsin enzyme inhibitory activity of Jatropha gossypifolia as a probable remedy for the management of diabetes and ulcer.Methods: Different extracts and fractions of the root, leaf and stem bark of the plant were screened for their α-glucosidase and α-chymotrypsin inhibitory activity using standard in vitro inhibition assays. Acarbose and chymostatin were used as positive control, respectively.Results: n-Butanol and ethyl acetate fraction showed maximum enzyme inhibition for α-glucosidase with 67.93 ± 0.66 and 67.67 ± 0.71 % and half maximal concentration (IC50) of 218.47 ± 0.23 and 213.45 ± 0.12 μg/ml, respectively. Dichloromethane and ethyl acetate leaf fractions exhibited maximum α-chymotrypsin inhibition activity of 85.08 ± 0.38 and 83.87 ± 0.70 %, and IC50 of 133.1 ± 0.68 and 134.5 ± 0.12 μg/ml, respectively, Acarbose exhibited enzyme inhibition activity of 92.14 ± 0.38 % with IC50 of 38.24 ± 0.1 μg/ml, while chymostatin exhibited 93.67 ± 0.38 % enzyme inhibition and IC50 of 8.24 ± 0.11 μg/ml.Conclusion: The presence of bioactive secondary metabolities with enzyme-inhibiting activity lends some support for the traditional use of this plant in the management of diabetes and ulcer. However, further investigation of the plant including identification of its active components is required.Keywords: α-Chymotrypsin, α-Glucosidase, Inhibition, Jatropha gossypifolia, Anti-diabetic, Anti-ulce

Cardiopulmonary resuscitation: outcome and its predictors among hospitalized adult patients in Pakistan.

Introduction:Our aim was to study the outcomes and predictors of in-hospital cardiopulmonary resuscitation (CPR) among adult Patients at a tertiary care centre in Pakistan.Methods:We conducted a retrospective chart review of all adult Patients (age \u3e or =14 years), who underwent CPR following cardiac arrest, in a tertiary care hospital during a 5-year study period (June 1998 to June 2003). We excluded Patients aged 14 years or less, those who were declared dead on arrival and Patients with a do not resuscitate order. The 1- and 6-month follow-ups of discharged Patients were also recorded.Results:We found 383 cases of adult in-hospital cardiac arrest that underwent CPR. Pulseless electrical activity was the most common initial rhythm (50%), followed by asystole (30%) and ventricular tachycardia/fibrillation (19%). Return of spontaneous circulation was achieved in 72% of Patients with 42% surviving more than 24 h, and 19% survived to discharge from hospital. On follow-up, 14% and 12% were found to be alive at 1 and 6 months, respectively. Multivariable logistic regression identified three independent predictors of better outcome (survival \u3e24 h): non-intubated status [adjusted odds ratio (aOR): 3.1, 95% confidence interval (CI): 1.6-6.0], location of cardiac arrest in emergency department (aOR: 18.9, 95% CI: 7.0-51.0) and shorter duration of CPR (aOR: 3.3, 95% CI: 1.9-5.5).Conclusion:Outcome of CPR following in-hospital cardiac arrest in our setting is better than described in other series. Non-intubated status before arrest, cardiac arrest in the emergency department and shorter duration of CPR were independent predictors of good outcome

A state-of-the-art review on topologies and control techniques of solid-state transformers for electric vehicle extreme fast charging

Electrical vehicle (EV) technology has gained popularity due to its higher efficiency, less maintenance, and lower dependence on fossil fuels. However, a longer charging time is a significant barrier to its complete adaptation. Solid state transformer (SST) based extreme fast charging schemes have emerged as an appealing idea with an ability to provide a refuelling capability analogous to that of gasoline vehicles. Therefore, this paper reviews the EV charger requirements, specifications, and design criteria for high power applications. At first, the key barriers of using a traditional low frequency transformer (LFT) are discussed, and potential solutions are suggested by replacing the conventional LFT with high frequency SST at extreme fast-charging (XFC) stations. Then, various SST-based converter topologies and their control for EV fast-charging stations are described. The reviewed control strategies are compared while considering several factors such as harmonics, voltage drop under varying loading conditions, dc offset load unbalances, overloads, and protection against system disturbances. Furthermore, the realization of SST for EV charging is comprehensively discussed, which facilitates understanding the current challenges, based on which potential solutions are also suggested.This publication was made possible by UREP grant # [27-021-2-010] from the Qatar National Research Fund (a member of the Qatar Foundation). The statements made herein are solely the responsibility of the authors. The Article Processing Fee of this article is paid by the Qatar National Library.Scopu

Surveillance of molecular markers of antimalarial drug resistance in Plasmodium falciparum and Plasmodium vivax in Federally Administered Tribal Area (FATA), Pakistan

This molecular epidemiological study was designed to determine the antimalarial drug resistance pattern, and the genetic diversity of malaria isolates collected from a war-altered Federally Administered Tribal Area (FATA), in Pakistan. Clinical isolates were collected from Bajaur, Mohmand, Khyber, Orakzai and Kurram agencies of FATA region between May 2017 and May 2018, and they underwent DNA extraction and amplification. The investigation of gene polymorphisms in drug resistance genes (dhfr, dhps, crt, and mdr1) of Plasmodium falciparum and Plasmodium vivax was carried out by pyrosequencing and Sanger sequencing, respectively. Out of 679 PCR-confirmed malaria samples, 523 (77%) were P. vivax, 121 (18%) P. falciparum, and 35 (5%) had mixed-species infections. All P. falciparum isolates had pfdhfr double mutants (C59R+S108N), while pfdhfr/pfdhps triple mutants (C59R+S108N+A437G) were detected in 11.5% of the samples. About 97.4% of P. falciparum isolates contained pfcrt K76T mutation, while pfmdr1 N86Y and Y184F mutations were present in 18.2% and 10.2% of the samples. P. vivax pvdhfr S58R mutation was present in 24.9% of isolates and the S117N mutation in 36.2%, while no mutation in the pvdhps gene was found. Pvmdr1 F1076L mutation was found in nearly all samples, as it was observed in 98.9% of isolates. No significant anti-folate and chloroquine resistance was observed in P. vivax; however, mutations associated with antifolate-resistance were found, and the chloroquine-resistant gene has been observed in 100% of P. falciparum isolates. Chloroquine and sulphadoxine-pyrimethamine resistance were found to be high in P. falciparum and low in P. vivax. Chloroquine could still be used for P. vivax infection but need to be tested in vivo, whereas a replacement of the artemisinin combination therapy for P. falciparum appears to be justified