Some q-Hypergeometric representations of the multiple Hurwitz zeta function

In this paper, The main object to give some new representations of the q-analogue of the multiple Hurwitz zeta function are derived

Sistem Informasi Tanggap Bencana Berbasis Web dengan GIS dan SMS Gateway

PMI Kota Semarang merupakan suatu organisasi independen yang bergerak dibidang kemanusiaan. Salah satu bidang kegiatan yang ditangani PMI adalah tanggap bencana. Permasalahan yang terjadi adalah belum tersedianya Sistem Informasi Tanggap Bencana untuk membantu PMI dalam merekap data bencana yang terjadi di Kota Semarang. Makalah ini menjelaskan tentang pembuatan sebuah sistem informasi kebencanaan untuk PMI Kota Semarang dengan memanfaatkan teknologi GIS untuk mengetahui lokasi bencana melalui peta dan SMS Gateway sebagai media untuk petugas satgana dalam memberikan informasi logistik di lokasi bencana. Proses pembuatan Sistem Informasi dengan menggunakan perangkat lunak Adobe Dreamweaver CS4, PHP, database MySQL, web server Xampp, Gammu, dan Google maps. Hasil pengujian tingkat kepuasan user yang didapatkan adalah sebanyak 84 % menyatakan bahwa Sistem Informasi Tanggap Bencana yang dibuat sesuai dengan yang diharapkan. Dengan menggunakan GIS dan SMS Gateway diharapkan akan mempermudah dalam penyampaian informasi dari lokasi bencana yang terjadi di Kota Semarang kepada pihak-pihak terkait

Latin hypercube sampling Jaya algorithm based strategy for T-way test suite generation

T-way testing is a sampling strategy that generates a subset of test cases from a pool of possible tests. Many t-way testing strategies appear in the literature to-date ranging from general computational ones to meta-heuristic based. Owing to its performance, man the meta-heuristic based t-way strategies have gained significant attention recently (e.g. Particle Swarm Optimization, Genetic Algorithm, Ant Colony Algorithm, Harmony Search, Jaya Algorithm and Cuckoo Search). Jaya Algorithm (JA) is a new metaheuristic algorithm, has been used for solving different problems. However, losing the search's diversity is a common issue in the metaheuristic algorithm. In order to enhance JA's diversity, enhanced Jaya Algorithm strategy called Latin Hypercube Sampling Jaya Algorithm (LHS-JA) for Test Suite Generation is proposed. Latin Hypercube Sampling (LHS) is a sampling approach that can be used efficiently to improve search diversity. To evaluate the efficiency of LHS-JA, LHS-JA is compared against existing metaheuristic-based t-way strategies. Experimental results have shown promising results as LHS-JA can compete with existing t-way strategies

Construction of gene regulatory networks using biclustering and bayesian networks

<p>Abstract</p> <p>Background</p> <p>Understanding gene interactions in complex living systems can be seen as the ultimate goal of the systems biology revolution. Hence, to elucidate disease ontology fully and to reduce the cost of drug development, gene regulatory networks (GRNs) have to be constructed. During the last decade, many GRN inference algorithms based on genome-wide data have been developed to unravel the complexity of gene regulation. Time series transcriptomic data measured by genome-wide DNA microarrays are traditionally used for GRN modelling. One of the major problems with microarrays is that a dataset consists of relatively few time points with respect to the large number of genes. Dimensionality is one of the interesting problems in GRN modelling.</p> <p>Results</p> <p>In this paper, we develop a biclustering function enrichment analysis toolbox (BicAT-plus) to study the effect of biclustering in reducing data dimensions. The network generated from our system was validated via available interaction databases and was compared with previous methods. The results revealed the performance of our proposed method.</p> <p>Conclusions</p> <p>Because of the sparse nature of GRNs, the results of biclustering techniques differ significantly from those of previous methods.</p

Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies

Iatrogenic vascular air embolism is a relatively infrequent event but is associated with significant morbidity and mortality. These emboli can arise in many clinical settings such as neurosurgery, cardiac surgery, and liver transplantation, but more recently, endoscopy, hemodialysis, thoracentesis, tissue biopsy, angiography, and central and peripheral venous access and removal have overtaken surgery and trauma as significant causes of vascular air embolism. The true incidence may be greater since many of these air emboli are asymptomatic and frequently go undiagnosed or unreported. Due to the rarity of vascular air embolism and because of the many manifestations, diagnoses can be difficult and require immediate therapeutic intervention. An iatrogenic air embolism can result in both venous and arterial emboli whose anatomic locations dictate the clinical course. Most clinically significant iatrogenic air emboli are caused by arterial obstruction of small vessels because the pulmonary gas exchange filters the more frequent, smaller volume bubbles that gain access to the venous circulation. However, there is a subset of patients with venous air emboli caused by larger volumes of air who present with more protean manifestations. There have been significant gains in the understanding of the interactions of fluid dynamics, hemostasis, and inflammation caused by air emboli due to in vitro and in vivo studies on flow dynamics of bubbles in small vessels. Intensive research regarding the thromboinflammatory changes at the level of the endothelium has been described recently. The obstruction of vessels by air emboli causes immediate pathoanatomic and immunologic and thromboinflammatory responses at the level of the endothelium. In this review, we describe those immunologic and thromboinflammatory responses at the level of the endothelium as well as evaluate traditional and novel forms of therapy for this rare and often unrecognized clinical condition

Viscoelastic Testing and Coagulopathy of Traumatic Brain Injury

A unique coagulopathy often manifests following traumatic brain injury, leading the clinician down a difficult decision path on appropriate prophylaxis and therapy. Conventional coagulation assays—such as prothrombin time, partial thromboplastin time, and international normalized ratio—have historically been utilized to assess hemostasis and guide treatment following traumatic brain injury. However, these plasma-based assays alone often lack the sensitivity to diagnose and adequately treat coagulopathy associated with traumatic brain injury. Here, we review the whole blood coagulation assays termed viscoelastic tests and their use in traumatic brain injury. Modified viscoelastic tests with platelet function assays have helped elucidate the underlying pathophysiology and guide clinical decisions in a goal-directed fashion. Platelet dysfunction appears to underlie most coagulopathies in this patient population, particularly at the adenosine diphosphate and/or arachidonic acid receptors. Future research will focus not only on the utility of viscoelastic tests in diagnosing coagulopathy in traumatic brain injury, but also on better defining the use of these tests as evidence-based and/or precision-based tools to improve patient outcomes

SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock

Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic hemostatic aberrancies afflict up to one-quarter of critically ill patients in shock. Intensivists and traumatologists have embraced the concept of SHock-INduced Endotheliopathy (SHINE) as a foundational derangement in progressive shock wherein sympatho-adrenal activation may cause systemic endothelial injury. The pro-thrombotic endothelium lends to micro-thrombosis, enacting a cycle of worsening perfusion and increasing catecholamines, endothelial injury, de-endothelialization, and multiple organ failure. The hypocoagulable/hyperfibrinolytic hemostatic phenotype is thought to be driven by endothelial release of anti-thrombogenic mediators to the bloodstream and perivascular sympathetic nerve release of tissue plasminogen activator directly into the microvasculature. In the shock state, this hemostatic phenotype may be a counterbalancing, yet maladaptive, attempt to restore blood flow against a systemically pro-thrombotic endothelium and increased blood viscosity. We therefore review endothelial physiology with emphasis on glycocalyx function, unique biomarkers, and coagulofibrinolytic mediators, setting the stage for understanding the pathophysiology and hemostatic phenotypes of SHINE in various etiologies of shock. We propose that the hyperfibrinolytic phenotype is exemplified in progressive shock whether related to trauma-induced coagulopathy, sepsis-induced coagulopathy, or post-cardiac arrest syndrome-associated coagulopathy. Regardless of the initial insult, SHINE appears to be a catecholamine-driven entity which early in the disease course may manifest as hyper- or hypocoagulopathic and hyper- or hypofibrinolytic hemostatic imbalance. Moreover, these hemostatic derangements may rapidly evolve along the thrombohemorrhagic spectrum depending on the etiology, timing, and methods of resuscitation. Given the intricate hemochemical makeup and changes during these shock states, macroscopic whole blood tests of coagulative kinetics and clot strength serve as clinically useful and simple means for hemostasis phenotyping. We suggest that viscoelastic hemostatic assays such as thromboelastography (TEG) and rotational thromboelastometry (ROTEM) are currently the most applicable clinical tools for assaying global hemostatic function—including fibrinolysis—to enable dynamic resuscitation with blood products and hemostatic adjuncts for those patients with thrombotic and/or hemorrhagic complications in shock states

Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies

Iatrogenic vascular air embolism is a relatively infrequent event but is associated with significant morbidity and mortality. These emboli can arise in many clinical settings such as neurosurgery, cardiac surgery, and liver transplantation, but more recently, endoscopy, hemodialysis, thoracentesis, tissue biopsy, angiography, and central and peripheral venous access and removal have overtaken surgery and trauma as significant causes of vascular air embolism. The true incidence may be greater since many of these air emboli are asymptomatic and frequently go undiagnosed or unreported. Due to the rarity of vascular air embolism and because of the many manifestations, diagnoses can be difficult and require immediate therapeutic intervention. An iatrogenic air embolism can result in both venous and arterial emboli whose anatomic locations dictate the clinical course. Most clinically significant iatrogenic air emboli are caused by arterial obstruction of small vessels because the pulmonary gas exchange filters the more frequent, smaller volume bubbles that gain access to the venous circulation. However, there is a subset of patients with venous air emboli caused by larger volumes of air who present with more protean manifestations. There have been significant gains in the understanding of the interactions of fluid dynamics, hemostasis, and inflammation caused by air emboli due to in vitro and in vivo studies on flow dynamics of bubbles in small vessels. Intensive research regarding the thromboinflammatory changes at the level of the endothelium has been described recently. The obstruction of vessels by air emboli causes immediate pathoanatomic and immunologic and thromboinflammatory responses at the level of the endothelium. In this review, we describe those immunologic and thromboinflammatory responses at the level of the endothelium as well as evaluate traditional and novel forms of therapy for this rare and often unrecognized clinical condition

Terrestrial gamma dose rate, radioactivity and radiological hazards in the rocks of an elevated radiation background in Juban District, Ad Dali Governorate, Yemen

This study aims to evaluate natural radiation and radioactivity in the rock and to assess the corresponding health risk in a region of elevated background radiation in Juban District, Ad Dali' Governorate, Yemen. The mean external gamma dose rate was 374 nGy h-1 which is approximately six times the world average. The measured results were used to compute annual effective dose equivalent, collective effective dose and excess lifetime cancer risk, which are 2.298 mSv, 61.95 man Sv y-1 and 8.043 × 10-3, respectively. Rocks samples from different geological formations were analyzed for quantitative determination of 226Ra, 232Th and 40K. The specific activity of the rocks samples ranges from 7 ± 1 Bq Kg-1 to 12 513 ± 329 Bq Kg-1 for 232Th, from 6 ± 1 Bq kg-1 to 3089 ± 74 Bq kg-1 for 226Ra and 702 ± 69 Bq kg-1 to 2954 ± 285 Bq kg-1 for 40K. 232Th is the main contributor to gamma dose rate from the rock samples. Indicators of radiological health impact, radium equivalent activity and external hazard index are 3738 Bq kg-1 and 10.10, respectively. The mean external hazard index was ten times unity in the studied locations in Juban District, which is higher than the recommended value

Operation and control strategies of integrated distributed energy resources: A review

Abstract Integrated distributed energy resources play a crucial role in modernized power systems. They can decrease emissions, decrease the resistive losses and add to the security and reliability of electric networks. They can be of different nature and may contain fossil-fuelled generating units, wind units, fuel cells, storage devices and solar panels. In this article, first different distributed energy resources are introduced briefly, then, the operation and control strategies of integrated distributed energy resources will be reviewed. The review of existing research works in this field and finding the research gaps can lead to useful directions for future researchers who are interested to work in this field