The Herschel Lensing Survey (HLS): Overview

The Herschel Lensing Survey (HLS) will conduct deep PACS and SPIRE imaging of ∼40 massive clusters of galaxies. The strong gravitational lensing power of these clusters will enable us to penetrate through the confusion noise, which sets the ultimate limit on our ability to probe the Universe with Herschel. Here we present an overview of our survey and a summary of the major results from our science demonstration phase (SDP) observations of the Bullet cluster (z = 0.297). The SDP data are rich and allow us to study not only the background high-redshift galaxies (e.g., strongly lensed and distorted galaxies at z = 2.8 and 3.2) but also the properties of cluster-member galaxies. Our preliminary analysis shows a great diversity of far-infrared/submillimeter spectral energy distributions (SEDs), indicating that we have much to learn with Herschel about the properties of galaxy SEDs. We have also detected the Sunyaev-Zel’dovich (SZ) effect increment with the SPIRE data. The success of this SDP program demonstrates the great potential of the Herschel Lensing Survey to produce exciting results in a variety of science areas

High-density molecular characterization and association mapping in Ethiopian durum wheat landraces reveals high diversity and potential for wheat breeding

Durum wheat (Triticum turgidum subsp. durum) is a key crop worldwide, and yet, its improvement and adaptation to emerging environmental threats is made difficult by the limited amount of allelic variation included in its elite pool. New allelic diversity may provide novel loci to international crop breeding through quantitative trait loci (QTL) mapping in unexplored material. Here, we report the extensive molecular and phenotypic characterization of hundreds of Ethiopian durum wheat landraces and several Ethiopian improved lines. We test 81 587 markers scoring 30 155 single nucleotide polymorphisms and use them to survey the diversity, structure, and genome-specific variation in the panel. We show the uniqueness of Ethiopian germplasm using a siding collection of Mediterranean durum wheat accessions. We phenotype the Ethiopian panel for ten agronomic traits in two highly diversified Ethiopian environments for two consecutive years and use this information to conduct a genome-wide association study. We identify several loci underpinning agronomic traits of interest, both confirming loci already reported and describing new promising genomic regions. These loci may be efficiently targeted with molecular markers already available to conduct marker-assisted selection in Ethiopian and international wheat. We show that Ethiopian durum wheat represents an important and mostly unexplored source of durum wheat diversity. The panel analysed in this study allows the accumulation of QTL mapping experiments, providing the initial step for a quantitative, methodical exploitation of untapped diversity in producing a better wheat

A critical review on the role of food and nutrition in the energy balance

The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure

A Large Mass of H2 in the Brightest Cluster Galaxy in Zwicky 3146

We present the Spitzer/IRS mid-infrared spectrum of the infrared-luminous (L_{IR}=4e11 L_sun) brightest cluster galaxy (BCG) in the X-ray-luminous cluster Z3146 (z=0.29). The spectrum shows strong aromatic emission features, indicating that the dominant source of the infrared luminosity is star formation. The most striking feature of the spectrum, however, is the exceptionally strong molecular hydrogen (H2) emission lines, which seem to be shock-excited. The line luminosities and inferred warm H2 gas mass (~1e10 M_sun) are 6 times larger than those of NGC 6240, the most H2-luminous galaxy at z <~ 0.1. Together with the large amount of cold H2 detected previously (~1e11 M_sun), this indicates that the Z3146 BCG contains disproportionately large amounts of both warm and cold H2 gas for its infrared luminosity, which may be related to the intracluster gas cooling process in the cluster core.Comment: 13 pages, 3 figures, 1 table; Accepted for publication in ApJ

Spitzer Mid-Infrared Spectroscopy of Infrared Luminous Galaxies at z~2 II: Diagnostics

We present mid-IR spectral decomposition of a sample of 48 Spitzer-selected ULIRGs spanning z~1-3 and likely L_IR~10^12-10^13Lsun. Our study aims at quantifying the star-formation and AGN processes in these sources which recent results suggest have evolved strongly between the observed epoch and today. To do this, we study the mid-IR contribution of PAH emission, continuum, and extinction. About 3/4 of our sample are continuum- (i.e. AGN) dominated sources, but ~60% of these show PAH emission, suggesting the presence of star-formation activity. These sources have redder mid-IR colors than typical optically-selected quasars. About 25% of our sample have strong PAH emission, but none are likely to be pure starbursts as reflected in their relatively high 5um hot dust continua. However, their steep 30um-to-14um slopes suggest that star-formation might dominate the total infrared luminosity. Six of our z~2 sources have EW6.2>~0.3um and L_14um>~10^12Lsun (implying L_IR>~10^13Lsun). At these luminosities, such high EW6.2 ULIRGs do not exist in the local Universe. We find a median optical depth at 9.7um of =1.4. This is consistent with local IRAS-selected ULIRGs, but differs from early results on SCUBA-selected z~2 ULIRGs. Similar to local ULIRGs about 25% of our sample show extreme obscuration (tau_9.7>~3) suggesting buried nuclei. In general, we find that our sources are similar to local ULIRGs, but are an order of magnitude more luminous. It is not clear whether our z~2 ULIRGs are simply scaled-up versions of local ULIRGs, or subject to fundamentally different physical processes.Comment: 60 pages, 15 figures, accepted for publication in Ap

Genome wide association study to identify the genetic base of smallholder farmer preferences of Durum wheat traits

Smallholder agriculture involves millions of farmers worldwide. A methodical utilization of their traditional knowledge in modern breeding efforts may help the production of locally adapted varieties better addressing their needs. In this study, a combination of participatory approaches, genomics, and quantitative genetics is used to trace the genetic basis of smallholder farmer preferences of durum wheat traits. Two smallholder communities evaluated 400 Ethiopian wheat varieties, mostly landraces, for traits of local interest in two locations in the Ethiopian highlands. For each wheat variety, farmers provided quantitative evaluations of their preference for flowering time, spike morphology, tillering capacity, and overall quality. Ten agronomic and phenology traits were simultaneously measured on the same varieties, providing the means to compare them with farmer traits. The analysis of farmer traits showed that they were partially influenced by gender and location but were repeatable and heritable, in some cases more than metric traits. The durum wheat varieties were genotyped for more than 80,000 SNP markers, and the resulting data was used in a genome wide association (GWA) study providing the molecular dissection of smallholder farmers' choice criteria

ISO investigates the nature of extremely-red hard X-ray sources responsible for the X-ray background

We analyse very deep X-ray and mid-IR surveys in common areas of the Lockman Hole and the HDF North to study the sources of the X-ray background (XRB) and to test the standard obscured accretion paradigm. We detect with ISO a rich population of X-ray luminous sources with red optical colours, including a fraction identified with Extremely Red Objects (R-K > 5) and galaxies with SEDs typical of normal massive ellipticals or spirals at z ~ 1. The high 0.5-10 keV X-ray luminosities of these objects (1E43-1E45 erg/s) indicate that the ultimate energy source is gravitational accretion, while the X-ray to IR flux ratios and the X-ray spectral hardness show evidence of photoelectric absorption at low X-ray energies. An important hint on the physics comes from the mid-IR data at 6.7 and 15 um, well reproduced by model spectra of completely obscured quasars under standard assumptions and l.o.s. optical depths tau ~ 30-40. Other predictions of the standard XRB picture, like the distributions of intrinsic bolometric luminosities and the relative fractions of type-I and -II objects (1:3), are also consistent with our results. Obscured gravitational accretion is then confirmed as being responsible for the bulk of the X-ray background, since we detect in the IR the down-graded energy photoelectrically absorbed in X-rays: 63% of the faint 5-10 keV XMM sources are detected in the mid-IR by Fadda et al. (2001). However, although as much as 90% of the X-ray energy production could be converted to IR photons, no more than 20% of the Cosmic IR Background can be attributed to X-ray loud AGNs.Comment: 7 pages, 5 postscript figures, ApJ submitte

Nanosuspensions and microneedles roller as a combined approach to enhance diclofenac topical bioavailability

Topical application of the anti-inflammatory drug diclofenac (DCF) reduces the severity of systemic unwanted effects compared to its oral administration. A number of transdermal formulations are available on the market and routinely used in clinical and home-care settings. However, the amount of DCF delivered across the skin remains limited and often insufficient, thus making the oral route still necessary for achieving sufficient drug concentration at the inflamed site. In attempting to improve the transdermal penetration, we explored the combined use of DCF nanosuspensions with a microneedle roller. Firstly, DCF nanosuspensions were prepared by a top-down media milling method and characterized by spectroscopic, thermal and electron microscopy analyses. Secondly, the pore-forming action of microneedle rollers on skin specimens (ex vivo) was described by imaging at different scales. Finally, DCF nanosuspensions were applied on newborn pig skin (in vitro) in combination with microneedles roller treatment, assessing the DCF penetration and distribution in the different skin layers. The relative contribution of microneedle length, nanosuspension stabilizer and application sequence could be identified by systemically varying these parameters