ECLAS CONFERENCE GHENT 2018 Landscapes of Conflict

Producción CientíficaThroughout the twentieth century, Friuli Venezia Giulia, the north-eastern region of Italy that borders Austria and Slovenia, played a strategic wartime role. From the Great War to the Cold War, the installation of defensive works including barracks, fortifications and infrastructure distinguished the territory. A significant rationalization in the territory and modification in the organizational structure of the Armed Forces took place from the end of the Cold War, through the EU expansion to the countries located on the north-eastern border of Italy, and up to the Army’s transformation from conscription to voluntary service. The town of Casarsa della Delizia represents a case of important significance due to the presence of the “Trieste” barracks, a settlement of extensive and significant environmental impact, a part of which has not been used for years, becoming over time a landscape-abandonment issue, on which action is needed. The paper focuses on the proposals to recover this former military area as a new integrated part of the city, merging the necessity of saving the past heritage and developing a new landscape vision, bringing together the historical and contemporary ways of living and promoting urban regeneration complex operations.European Joint Doctorate “urbanHIST”. European Union. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 721933

How 15-min City, Tactical Urbanism, and Superblock Concepts Are Affecting Major Cities in the Post-Covid-19 Era?

Producción CientíficaThis chapter analyses three strategies proposed to redefine current urban policies to deal with issues inherited from the contemporary city evolution. The case study analysis focuses on applying the concepts of 15-min City, Tactical Urbanism, and Superblock in global cities such as Barcelona, Shanghai, and Milan. Have these cities changed the urban environment and mobility patterns dealing with health, social, and economic inequities? Which have been the impacts of urban regeneration, governance, and inclusion towards achieving the Sustainable Development Goal 11, emphasizing the need for inclusivity and equitability in urban areas? These questions find the answer in three main aspects. First, the regeneration of the existing built environment; second, short-, medium-, and long-term governance issues; third, the concerns about the possible risk of gentrification. An introductive part explains the adopted methodology, follows an analysis of the three case studies, and, eventually, remarks on what we learned. Two are the primary outcomes: a comparison between different global cities and diverse ways to deal with the impacts of people-centered solutions for urban environments and an evaluation of 15-min City, Tactical Urbanism, and Superblocks feasible solutions for sustainable urban transition

Challenges of recovery and resilience: ArhiBau.hr 2022 scientific conference proceedings

Producción CientíficaSince introducing the new urban planning instruments in 2012 – Piano del Governo del Territorio (PGT) – Milan has commenced a new approach to the definition of its urban environment, the services availability, and the redevelopment of the public spaces. The PGT aims to improve citizens’ and city users’ life quality by implementing various tools addressing the contemporary urban agenda’s ecological, mobility, and cultural challenges. In particular, Milan is trying to align with the global metropolitan vision of the 15-minute City concept and to cope with this objective by applying traditional tools (long-term planning process) and smart city strategies (tactical urbanism). In a context of an emerging global ecological and socioeconomic crisis driven by the pandemic and the war, this paper aims to evaluate the PGT ten years after its introduction by interrogating how public spaces have changed in quantitative and qualitative terms and the perspective for 2030 goals introduced by the PGT update in 2020. Green corridors and tactical urbanism plans may be an interpretative key to illustrate elements of success, weakness, and threats for the future development of the metropolitan city

Urban Voids After the Pandemic. A New Chance for Greenway

Our proposal deals with the meaning of urban voids in the post-COVID-19 period to suggest new understandings of how urban green corridors can positively affect design for healthier and more sustainable cities. According to Secchi (1986), planning through the void involves a profound revision of the way we think about the city, reversing the points of interest, proposing as polarities the spaces that do not usually emerge. The void thus becomes an opportunity, a chance to improve the structure of our urban landscape (Lopez-Pineiro, 2020). A city is a powerful place, always in motion and transformation. It has an artificial spirit full of surprises and vague limits. It is the scene of remarkable transformations that in their wildness are partially ungovernable by the designers themselves. The desire to control them leaves a series of abandoned and unfinished spaces, “holes” that live from their discontinuity with the surroundings (Labriola, 2021). During a period of crisis, like the one that we are still living with COVID-19 (Fabris et al, 2020), it is common to re-think our cities to create better places for the community. After the long period of forced distance that we lived, an evolution of public space is recommended. During the pandemic, the emptiness of our cities permitted Nature to re-appropriate its spaces. Following this trend and thinking about a new kind of public space where Nature and its inside processes are the protagonists, it is possible to intervene in our cities. The porosity of the urban fabric in towns without humans, blocked at home by the never-ending lockdowns, became a new green corridor that revealed the presence of wildlife (both fauna and flora) as part of a forgotten urban layer that turned visible again. The preservation of this new asset should be possible. The spaces to allow this change can be the abandoned and empty areas present in the contemporary city’s sick body that we can finally heal. The so-called wastelands, voids, or terrain vague, have a significant value independent from the environment in which they are inserted, showing a relationship with the contemporary city extraneous to its rhythms. For this reason, they are the perfect place for experimentation in terms of greenways, a possible starting point to re-think how green can be part of the urban texture and how to conceive public and open spaces after the nowadays crisis. The paper considers the Metropolitan City of Milan as a remarkable case study to understand the pivotal role played by urban voids in the formation of greenways and their capacity of reshaping the environmental, aesthetic and healthy dimensions of urban landscapes

Fábos Conference on Landscape and Greenway Planning

Producción CientíficaOur proposal deals with the meaning of urban voids in the post-COVID-19 period to suggest new understandings of how urban green corridors can positively affect design for healthier and more sustainable cities. According to Secchi (1986), planning through the void involves a profound revision of the way we think about the city, reversing the points of interest, proposing as polarities the spaces that do not usually emerge. The void thus becomes an opportunity, a chance to improve the structure of our urban landscape (Lopez-Pineiro, 2020). A city is a powerful place, always in motion and transformation. It has an artificial spirit full of surprises and vague limits. It is the scene of remarkable transformations that in their wildness are partially ungovernable by the designers themselves. The desire to control them leaves a series of abandoned and unfinished spaces, “holes” that live from their discontinuity with the surroundings (Labriola, 2021). During a period of crisis, like the one that we are still living with COVID-19 (Fabris et al, 2020), it is common to re-think our cities to create better places for the community. After the long period of forced distance that we lived, an evolution of public space is recommended. During the pandemic, the emptiness of our cities permitted Nature to re-appropriate its spaces. Following this trend and thinking about a new kind of public space where Nature and its inside processes are the protagonists, it is possible to intervene in our cities. The porosity of the urban fabric in towns without humans, blocked at home by the never-ending lockdowns, became a new green corridor that revealed the presence of wildlife (both fauna and flora) as part of a forgotten urban layer that turned visible again. The preservation of this new asset should be possible. The spaces to allow this change can be the abandoned and empty areas present in the contemporary city’s sick body that we can finally heal. The so-called wastelands, voids, or terrain vague, have a significant value independent from the environment in which they are inserted, showing a relationship with the contemporary city extraneous to its rhythms. For this reason, they are the perfect place for experimentation in terms of greenways, a possible starting point to re-think how green can be part of the urban texture and how to conceive public and open spaces after the nowadays crisis. The paper considers the Metropolitan City of Milan as a remarkable case study to understand the pivotal role played by urban voids in the formation of greenways and their capacity of reshaping the environmental, aesthetic and healthy dimensions of urban landscapes

Binding and Uptake into Human Hepatocellular Carcinoma Cells of Peptide-Functionalized Gold Nanoparticles

One of the most daunting challenges of nanomedicine is the finding of appropriate targeting agents to deliver suitable payloads precisely to cells affected by malignancies. Even more complex is to achieve the ability to ensure the nanosystems enter those cells. Here we use 2 nm (metal core) gold nanoparticles to target human hepatocellular carcinoma (HepG2) cells stably transfected with the SERPINB3 (SB3) protein. The nanoparticles were coated with a 85:15 mixture of thiols featuring, respectively, a phosphoryl choline, to ensure water solubility and biocompatibility, and a 28-mer peptide corresponding to the amino acid sequence 21-47 of the hepatitis B virus-PreS1 protein (PreS1(21-47)). Conjugation of the peptide was performed via the maleimide-thiol reaction in methanol allowing the use of a limited amount of the targeting molecule. This is an efficient procedure also in the perspective of selecting libraries of new targeting agents. The rationale behind the selection of the peptide is that SB3, which is undetectable in normal hepatocytes, is over-expressed in hepatocellular carcinoma and in hepatoblastoma and has been proposed as a target of the hepatitis B virus (HBV). For the latter the key recognition element is the PreS1(21-47) peptide, which is a fragment of one of the proteins composing the viral envelope. The ability of the conjugated nanoparticles to bind the target protein SB3, expressed in liver cancer cells, was investigated by surface plasmon resonance analysis and in vitro via cellular uptake analysis followed by atomic absorption analysis of digested samples. The results showed that the PreS1(21-47) peptide is a suitable targeting agent for cells overexpressing the SB3 protein. Even more important is the evidence that the gold nanoparticles are internalized by the cells. The comparison between the surface plasmon resonance analysis and the cellular uptake studies suggests the presentation of the protein on cell surface is critical for efficient recognition

ANÁLISIS DE COMPORTAMIENTO DE CUENTAS CORRIENTES EN ENTIDADES BANCARIAS MEDIANTE EL USO DE FUZZY CLUSTERING Y ANÁLISIS DISCRIMINANTE PARA LA ADMINISTRACIÓN DE RIESGO CREDITICIO

Cada entidad bancaria tiene sus propios parámetros de evaluación de clientes y aplica sus propios métodos para hacerlo. Esto forma parte de su política de administración de riesgos. El análisis del comportamiento de la cuenta corriente de cada cliente es de suma importancia en este caso, ya que describe la conducta del cliente en relación a sus deudas y ayuda a evaluar los riesgos que el banco asume. A su vez, este análisis permite la descripción de la evolución de los riesgos mediante el hallazgo de un patrón de conducta de cada cliente. Una vez descripta esta evolución, la entidad podrá definir su política crediticia de corto plazo en cuenta corriente, pudiendo hacer un seguimiento de las cuentas que entran en zonas que el banco evaluaría como indeseables. En el presente trabajo se desarrolla, mediante un modelo simple con datos generados en forma aleatoria, una aplicación referida a estos métodos de evaluación. Se presenta, fundamentalmente, el método de Fuzzy Clustering, utilizando los programas SPSS® y R para desarrollar los cálculos. Además, se hace un análisis discriminante canónico para la asignación de nuevos individuos a los grupos definidos y la reasignación en caso de cambio de las características. Palabras Clave: Fuzzy clustering, validación, Clustering, análisis discriminante. Abstract Each bank has its own parameters to evaluate its clients and applies its own methods to do that. This belongs to its management risk policy. The behavioural analysis of the current accounts of each client is of great importance in this case, since it describes the client’s behaviour related to his debts and helps to evaluate the risks that the bank deals with. In the same way, this analysis permit to describe the risk’s evolution through the gathering of behavioural patterns. Once one has described this evolution, the institution can define its short term credit policy in current account, being able to follow the ones that enter the zones which the bank has defined as unwishable. Over the present paper, an application referred to those methods of evaluation is developed with a simple model using simulated data. Fundamentally, the method of Fuzzy Clustering is shown using SPSS and R software to make the calculations. Additionally, we make a canonical discriminant analysis to assign new individuals to the defined groups and the reorganization in the case of characteristic’s changes. Keywords: Fuzzy clustering, Validation, Clustering, Discriminant analysis, Risk management, Fuzzy theory

Direct oral Xa inhibitors versus warfarin in patients with cancer and atrial fibrillation: a meta-analysis

Patients with cancer are at higher risk of atrial fibrillation, thromboembolic complications and bleeding events compared with the general population. The aim of the present meta-analysis was to compare the efficacy and safety of direct oral Xa inhibitor anticoagulants versus warfarin in patients with cancer and atrial fibrillation

The impact of COVID-19 on myocardial infarctions, strokes and out-of-hospital cardiopulmonary arrests: an observational retrospective study on time-sensitive disorders in the Friuli Venezia Giulia region (Italy)

The COVID-19 global pandemic has changed considerably the way time-sensitive disorders are treated. Home isolation, people's fear of contracting the virus and hospital reorganisation have led to a significant decrease in contacts between citizens and the healthcare system, with an expected decrease in calls to the Emergency Medical Services (EMS) of the Friuli-Venezia Giulia (FVG) region. However, mortality in clinical emergencies like acute ST-elevation myocardial infarction (STEMI), stroke and out-of-hospital cardiopulmonary arrest (OHCA) remained high. An observational retrospective cross-sectional study was carried out in FVG, taking into account the period between March 1, 2020, and May 31, 2020, the first wave of the COVID-19 pandemic, and comparing it with the same period in 2019. The flow of calls to the EMS was analysed and COVID-19 impact on time-sensitive disorders (STEMIs, ischemic strokes and OHCPAs) was measured in terms of hospitalisation, treatment and mortality. Despite a -8.01% decrease (p value ˂0.001) in emergency response, a 10.89% increase in calls to the EMS was observed. A lower number of advanced cardiopulmonary resuscitations (CPR) (75.8 vs 45.2%, p=0.000021 in April) and ROSC (39.1 vs 11.6%, p=0.0001 in April) was remarked, and survival rate dropped from 8.5 to 5%. There were less strokes (-27.5%, p value=0.002) despite a more severe onset of symptoms at hospitalisation with NHISS˃10 in 38.47% of cases. Acute myocardial infarctions decreased as well (-20%, p value=0.05), but statistical significances were not determined in the variables considered and in mortality. Despite a lower number of emergency responses, the number of calls to the EMS was considerably higher. The number of cardiac arrests treated with advanced CPR (ALS) was lower, but mortality was higher. The number of strokes decreased as well, but at the time of hospitalisation the clinical picture of the patient was more severe, thus affecting the outcome when the patient was discharged. Finally, STEMI patients decreased; however, no critical issues were observed in the variables taken into account, neither in terms of response times nor in terms of treatment times