Solitary fibrous tumor of the tongue

Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm originally described in pleura with a rare presentation in the oral cavity. Herein, we report a case of a 28-year-old male patient who presented an asymptomatic slow-growing mass in the anterior part of the tongue. Intraoral examination revealed a well-circumscribed mass covered by normal mucosa with a fibrous consistency. Due to non-specific clinical findings, the initial diagnostic hypotheses include benign submucosal neoplasms such as leiomyoma, neurofibroma, SFT, and others. An excisional biopsy was performed. Microscopically, the tumor was surrounded by a thick fibrous capsule; hypo and hypercellular areas were arranged in a storiform pattern with a stroma formed by collagen and abundant vascularization. Tumor cells showed immunopositivity for CD34 and STAT-6 and no expression of CD99, AML, S-100, and Ki-67. According to these findings, the diagnosis of SFT was established. After 24 months, the patient is asymptomatic and has no evidence of recurrence. Although oral involvement is rare, SFT should be included in the differential diagnosis of oral submucosal lesions

Satisfaction level of phisicians working in a social health organization of Unified Health System In Brazil

Introduction: The evaluation of a work system is based on the ability to adapt work to the man and the man to the work. One of the aspects that interfere in the capacity of adaptation is the satisfaction in the work as the integration, the autonomy, the motivation, the involvement and the utilization of the physical and mental capacities.Objective: To analyze the level of satisfaction of medical professionals regar ding their work environment in a Social Health Organization of Brazilian Unified Health System.Methods: It is a cross-sectional, exploratory and descriptive study. For data collection, we used a questionnaire mailed  through the Google Docs platform, containing 36 questions about indicators: material, personnel, quality and social.Results: A total of 51 physicians participated in the study. The findings showed significant associations between their satisfaction of work environment and relationship with their work team, unit manager and performance recognition.Conclusion: The satisfaction in the work environment of the medical professional in the Social Health Organization is associated with internal factors, as well as the need for their performance recognition by the management policy. The external factors studied, such as multiple job sites

Dental status, salivary flow, and sociodemographic aspects in Sheehan Syndrome patients

Sheehan?s syndrome (SS) is one of the leading causes of hypopituitarism in developing countries. It occurs after postpartum necrosis of the pituitary gland, and it is considered a significant public health problem. This paper, apparently unpublished, aimed to perform an analysis on oral aspects in patients with SS. A cross-sectional study was performed with 23 women diagnosed with SS at the Division of Endocrinology and Diabetes (Walter Cantídio University Hospital, Fortaleza, Brazil). Data on sociodemographic, dental and salivary flow aspects were collected through a clinical approach and a panoramic radiograph request. The mean age was 64 ± 11.5 years old, with the sample consisting mainly of married women (56.5%), socioeconomic class C2 or D / E (78.2%) and years of education up to 8 years (69.5%). The presence of horizontal bone loss (p<0.001) and bilateral pneumatization of the maxillary sinus (p=0.015) were significant data. The mean number of absent teeth considering all subjects was 23.17±9.7, being statistically significant (p<0.001). In relation to age, the mean number of missing teeth was higher in individuals over 65 years old (p=0.048). Reduced salivary flow was observed in 78.3% of the patients. In a bivariate analysis, considering the outcome variables ?missing teeth? and ?reduced salivary flow?, it was observed that economic class (p< 0.001), family income (0.037) and maxillary sinus pneumatization (0.032) were statistically significant. In brief, patients with SS showed severe teeth loss, reduced salivary flow, and low educational status. This study addressed important aspects regarding oral findings in SS and highlighted the importance of researches in oral medicine

Avaliação da atividade antimicrobiana da esponja marinha Ectyoplasia ferox de Fernando de Noronha / Evaluation of antimicrobial activity of Ectyoplasia ferox marine sponge from Fernando de Noronha

Os oceanos cobrem mais de 70% da superfície terrestre e por isso são reservatórios de inúmeras espécies e estruturas químicas que podem ser potencialmente bioativas. Nos últimos anos o ambiente marinho recebeu maior atenção das indústrias farmacêuticas e biotecnológicas devido à diversidade de novas substâncias que podem ser descobertas. Estudos já demostraram que esponjas marinhas possuem algum tipo de defesa contra infecções microbianas em seu habitat. Nesse sentido esses organismos são uma fonte promissora de substâncias com potencial antibiótico que devem ser investigadas como alternativas terapêuticas para a problemática da resistência aos fármacos atuais.  Nesse trabalho avaliamos a atividade antimicrobiana de amostras da esponja Ectyoplasia ferox coletadas em diferentes locais do arquipélago de Fernando de Noronha (PE/Brasil). O ensaio antimicrobiano dos seis extratos brutos obtidos foi realizado através do método de micro diluição em caldo para determinar a Concentração Inibitória Mínima (CIM) contra Staphylococcus aureus HU25, Staphylococcus epidermidis ATCC 12228, e Escherichia coli ATCC 11775. Dois extratos demonstraram atividade moderada: FN98-009 coletada na região da Ressureta (S. aureus: CIM = 64 µg/mL; S. epidermidis: CIM = 128 µg/mL) e FN98-063 coletada na região de Pedras Secas (S. epidermidis: CIM = 128 µg/mL). A partição por gradiente de polaridade da amostra com menor CIM (FN98-009) forneceu uma fração butanólica com atividade menor que seu extrato bruto, levando à hipótese de sinergismo entre as substâncias das diferentes frações. Como estratégia para investigar o possível efeito sinérgico e restaurar a atividade, as quatro frações foram combinadas duas a duas, originando seis amostras. Nenhuma das combinações demonstrou atividade até 512 µg/mL. Dessa forma, acredita-se que a atividade observada no extrato bruto esteja relacionada ao conjunto da maioria de seus constituintes em um efeito sinérgico e que um fracionamento biomonitorado do extrato não permitirá identificar as substâncias mais ativas, mas o potencial do extrato deve ser considerado para maiores estudos

Radix entomolaris: relatos de série de casos / Radix entomolaris: case series reports

O conhecimento anatômico é um dos fatores que irão influenciar diretamente no prognóstico do tratamento endodôntico e um dos grandes desafios consiste em dominar as possíveis variações anatômicas internas dos grupos dentais. Uma destas encontradas nos molares inferiores é a presença de uma raiz supranumerária, podendo ser mais lingualizada ou mesiovestibularizada quando comparada com a raiz distal, sendo chamadas de radix entomolaris e radix paramolaris, respectivamente. O objetivo desses três relatos de casos é abordar diferentes variações anatômicas da posição e conformação do radix entomolaris em consonância com a prevalência na literatura. E assim, demonstrar que o correto diagnóstico e o conhecimento da anatomia do sistema de canais radiculares, juntamente com auxílio de magnificação são fundamentais para determinar o sucesso do tratamento endodôntico. Conclusão: é fundamental o Cirurgião Dentista ter conhecimento das possíveis variações anatômicas, a magnificação na endodontia proporciona uma desinfecção mais adequada, a exploração inicial prévia pode ser realizada de forma mecanizada, mas a exploração manual prévia influência diretamente na diminuição dos índices de fraturas e as limas de abertura de orifício diminuem tensões das limas de modelagem

Análise da anatomia interna do segundo pré-molar superior por tomografia computadorizada cone beam / Ex vivo analysis of the internal anatomy of maxilary second premolar by cone beam computerized tomography

O sucesso do tratamento endodôntico é resultado de uma série de passos técnicos que vão desde a seleção correta do caso a tratar à obturação do canal, porém o conhecimento anatômico torna-se essencial para um início promissor desse tratamento. O objetivo desse estudo foi analisar, através de imagens tomográficas, a anatomia interna do segundo pré-molar superior de dentes humanos. A anatomia endodôntica de 280 segundos pré-molares superiores foi avaliada através de exames tomográficos. As imagens foram avaliaram a quantidade e forma dos canais em terços cervical, médio e apical. 48,2% terminavam em um único conduto radicular, enquanto 51,8% pré-molares terminavam com dois condutos radiculares. Apenas 41,4%   apresentavam a mesma quantidade de canais do início ao fim do trajeto, sendo 23,9% com um canal e 17,5% com dois condutos. Com relação ao formato transversal dos canais radiculares, entre os 280 dentes, 194 apresentavam um canal em terço cervical, e destes, 98,4% tinham formato achatado e 1,6% eram circulares, enquanto 86 dentes apresentavam 2 canais nessa região, sendo 30,2% achatados e 69,8% circulares. Baseado na metodologia empregada concluiu-se que 48,2% dos dentes analisados terminaram em um único conduto radicular, enquanto 51,8% terminavam em dois; 41,4% apresentaram a mesma quantidade de canais do início ao fim do trajeto; canais únicos apresentam forte tendência, em corte axial, de a luz do canal apresentar-se achatada

Development and validation of the Brazilian Version of Lay Persons’ Social Judgements about Cleft-lip Scale (B-LSojCleft-S)

Abstract The aim of this study was to develop and analyze the psychometric properties of the Brazilian Version of Lay Person's Social Judgement about Cleft-lip Scale (B-LSojCleft-S). A standardized photograph of a 16-year-old girl was manipulated by using photo editing software, to simulate different cleft-lip situations. The cleft-free image was used as a control. The researchers structured an initial questionnaire that was evaluated by experts and a sample of the target population to evaluate the construct. After analysis by the researchers, a final version of the B-LSojCleft-S containing 14 items was generated. Each answer was awarded score from 1 to 3 points, yielding a total score of 14 to 42 points. Higher scores represented better social judgements. The B-LSojCleft-S was applied online to 103 test participants and 73 retest participants with an interval of 20 days between application. Aspects of acceptability, discriminant property, internal consistency, reliability and construct validity were evaluated. Construct validity was assessed using the Friedman test (p 0.70, and internal consistency using Cronbach's alpha > 0.81. The B-LSojCleft-S showed high acceptability, strong discriminant property, excellent internal consistency and reliability, but had a floor and ceiling effect. The instrument reached valid and reliable scores and had acceptable psychometric properties to evaluate the social judgments of lay persons about different cleft lip situations in a Brazilian population

Análise genética de características produtivas e reprodutivas em populações multirraciais de bovinos leiteiros

The objective of this work was to determine whether the random regression model using linear splines (RRMLS) is suitable to estimate the genetic parameters for productive and reproductive traits of a multiple-breed dairy cattle population, as well as to investigate the effect of the genetic group of the progeny on the genetic merit of the sire. The multiple-trait model (MTM) and the RRMLS with one knot fitted for every genetic group were used to obtain the genetic parameters. Records of 1/2 Holstein + 1/2 Gyr (1/2HG), 5/8 Holstein + 3/8 Gyr (5/8HG), and 3/4 Holstein + 1/4 Gyr (3/4HG) crossbreed dams were considered. The RRMLS showed better fitting. The additive and residual variances estimated by the MTM and the RRMLS were similar. Heritability varied from 0.20 to 0.33 for age at first calving, from 0.09 to 0.22 for first lactation length, and from 0.15 to 0.35 for first lactation 305-day milk yield, according to the genetic composition of the dams. The RRMLS is suitable to estimate the genetic parameters for productive and reproductive traits of multiple-breed dairy cattle populations. The genetic merit of the sires is affected by the genetic group of the progeny by which they are evaluated.O objetivo deste trabalho foi verificar se o modelo de regressão aleatória com polinômios lineares do tipo spline (MRAPLS) é adequado para estimar os parâmetros genéticos de características produtivas e reprodutivas em uma população multirracial de bovinos leiteiros, bem como investigar o efeito do grupo genético da progênie sobre o mérito genético do touro. Foram utilizados o modelo multicaracterístico (Mult) e o MRAPLS com nós ajustados aos grupos genéticos, para obtenção dos parâmetros genéticos. Foram considerados os registros de vacas 1/2 Holandesa + 1/2 Gir (1/2HG), 5/8 Holandesa + 3/8 Gir (5/8HG) e 3/4 Holandesa + 1/4 Gir (3/4HG). O MRAPLS apresentou os melhores ajustes. As variâncias aditivas e residuais estimadas por Mult e MRAPLS foram semelhantes. As herdabilidades variaram de 0,20 a 0,33 para idade ao primeiro parto, de 0,09 a 0,22 para duração da primeira lactação e de 0,15 a 0,35 para produção de leite em até 305 dias na primeira lactação, de acordo com a composição genética das vacas. O MRAPLS é adequado para estimar parâmetros genéticos de características produtivas e reprodutivas em populações multirraciais de bovinos leiteiros. O mérito genético do touro é influenciado pelo grupo genético da progênie por meio do qual ele é avaliado

Development and validation of a rabbit model of Pseudomonas aeruginosa non-ventilated pneumonia for preclinical drug development

BackgroundNew drugs targeting antimicrobial resistant pathogens, including Pseudomonas aeruginosa, have been challenging to evaluate in clinical trials, particularly for the non-ventilated hospital-acquired pneumonia and ventilator-associated pneumonia indications. Development of new antibacterial drugs is facilitated by preclinical animal models that could predict clinical efficacy in patients with these infections.MethodsWe report here an FDA-funded study to develop a rabbit model of non-ventilated pneumonia with Pseudomonas aeruginosa by determining the extent to which the natural history of animal disease reproduced human pathophysiology and conducting validation studies to evaluate whether humanized dosing regimens of two antibiotics, meropenem and tobramycin, can halt or reverse disease progression.ResultsIn a rabbit model of non-ventilated pneumonia, endobronchial challenge with live P. aeruginosa strain 6206, but not with UV-killed Pa6206, caused acute respiratory distress syndrome, as evidenced by acute lung inflammation, pulmonary edema, hemorrhage, severe hypoxemia, hyperlactatemia, neutropenia, thrombocytopenia, and hypoglycemia, which preceded respiratory failure and death. Pa6206 increased &gt;100-fold in the lungs and then disseminated from there to infect distal organs, including spleen and kidneys. At 5 h post-infection, 67% of Pa6206-challenged rabbits had PaO2 &lt;60 mmHg, corresponding to a clinical cut-off when oxygen therapy would be required. When administered at 5 h post-infection, humanized dosing regimens of tobramycin and meropenem reduced mortality to 17-33%, compared to 100% for saline-treated rabbits (P&lt;0.001 by log-rank tests). For meropenem which exhibits time-dependent bactericidal activity, rabbits treated with a humanized meropenem dosing regimen of 80 mg/kg q2h for 24 h achieved 100% T&gt;MIC, resulting in 75% microbiological clearance rate of Pa6206 from the lungs. For tobramycin which exhibits concentration-dependent killing, rabbits treated with a humanized tobramycin dosing regimen of 8 mg/kg q8h for 24 h achieved Cmax/MIC of 9.8 ± 1.4 at 60 min post-dose, resulting in 50% lung microbiological clearance rate. In contrast, rabbits treated with a single tobramycin dose of 2.5 mg/kg had Cmax/MIC of 7.8 ± 0.8 and 8% (1/12) microbiological clearance rate, indicating that this rabbit model can detect dose-response effects.ConclusionThe rabbit model may be used to help predict clinical efficacy of new antibacterial drugs for the treatment of non-ventilated P. aeruginosa pneumonia