Surface Conditions Drive Changes In Groundfish Species\u27 Populations Along California Coast

Oceans display physical variability over a range of temporal and spatial scales, influencing factors such as larval dispersal, nutrient availability, species migration, and biodiversity. Such variability is vulnerable to the effects of climate change. Larvae and juveniles are particularly susceptible to changes in ocean variability, and changes in the early life stages of species populations ultimately impacts the adult stages. Physical consequences stemming from climate driven variability, including a loss of key prey species and changes in depth distributions of vulnerable fish species, could ultimately impact ecosystem services and threaten human food security and fisheries. The deep sea benthopelagic groundfish play significant roles in biogeochemical and ecological processes on a global scale. Macrourids, the most common benthopelagic fish in the deep sea, are important benthic and midwater predators; making it critical to understand changes in their population structures over time. Macrourid larvae reside in surface waters, where they are more vulnerable to climate driven variability. Merluccius productus (M. productus) is a commercially important benthopelagic groundfish species with a life history similar to Macrourids. The combination of surface waters exhibiting more changes in physical variability compared to the deep sea and the vulnerability of larvae to oceanographic variability makes observing these benthopelagic species particularly important for understanding the full-depth interactions and climate-related changes. This project focuses on studying correlations between changes in the life stages of Macrourid species\u27 and M. productus\u27 populations over time in relation to changes in climate and surface ocean conditions. Four research questions are addressed; Q1 & Q2) Has groundfish (specifically Macrourid spp. (Q1) and M. productus (Q2)) population structure changed over time in relation to changing climate and surface-ocean conditions?; and Q3 & Q4) Has the depth range of groundfish species (specifically Macrourid spp. (Q3) and M. productus (Q4)) changed over time with changing climate and surface-ocean conditions? With increasing changes in climate and surface-ocean conditions over time, there is a significant change in both Macrourid species\u27 population structure and M. productus population structure over time (Q1 and Q2). With increasing changes in climate and surface-ocean conditions over time, there is no significant change in M. productus\u27 depth distribution over time (Q4). Regarding potential changes in Macrourid species\u27 depth distributions, Q3 couldn\u27t be answered due to insufficient data. This study increases our understanding of how potential impacts of changing climate and surface-ocean conditions on M. productus\u27 population structure and depth distribution could affect Macrourid populations. Findings also provide valuable insight for: 1) predicting and managing consequences of climate change and 2) management of coastal and marine resources and fisheries in the future

Talking green business: A qualitative study on the use of digital storytelling in sustainability communication to influence corporate success

Sustainability is one of the most urgent and relevant topics today, permeating social and economic spheres alike. Especially corporations are faced with high stakeholder expectations, not least to be economically sustainable. To communicate a firms' efforts on ESG issues, a well-known but still underrated way is storytelling - nowadays mostly digital. Answers to the question how digital storytelling in sustainability communication of profit corporations influences their strategic success are provided within this study by the analysis of qualitative data from 14 semi-structured interviews across different communication practitioners of globally operating companies in Germany. As the study found out, digital storytelling in sustainability communication mainly contributes to intangible success factors, fulfilling its goal to foster an improvement of corporate reputation. The study provides evidence that this could further lead to a significant influence on the creation of tangible values, since even the outflow as the highest level of value creation could be traced back to communicative efforts. The findings contribute to the research on value creation through digital storytelling as a method in sustainability communication. They are the first of their kind that combine those three aspects empirically and stimulate the debate on communicative value creation providing an adaption of the DPRG/ICV Framework. Furthermore, the study gives practical implications for corporate communication professionals on the emerging format of storytelling

Aplicação de recursos midiáticos para apreensão do conteúdo da aula de Parada Cárdio-Respiratoria / Ressuscitação Cardiopulmonar no curso Técnico em Enfermagem

Orientador : Roberto de Fino BentesArtigo (especialização) - Universidade Federal do Paraná, Setor de Educação Profissional e Tecnológica, Curso de Especialização em Mídias Integradas na Educação.Inclui referência

A triarylated 1,2,3-triazol-5-ylidene ligand with a redox-active ferrocenyl substituent for rhodium(I)-catalyzed hydroformylation of 1-octene

A series of rhodium(I)–1,2,3-triazol-5-ylidene (trz) complexes are described, containing either a novel triarylated trz ligand A′ (N1, N3-arylated, C4-ferrocenyl) {complexes 1, [Rh(A′)Cl(cod)]; 4, [Rh(A′)Cl(CO)2]}, or N3-alkylated triazolylidenes with a C4-ferrocenyl {2, [Rh(B′)Cl(cod)]; 5, [Rh(B′)Cl(CO)2]} or C4-phenyl substituent {3, [Rh(C′)Cl(cod)]; 6, [Rh(C′)Cl(CO)2]}. The free mesoionic carbene (MIC) A′ is structurally characterized and its electronic properties evaluated by employing the complex [Pd(Br)2(iPr2-bimy)(A′)] (7) in an NMR spectroscopic analysis method. The redox activity of A′ is exploited, and the chemically oxidized precursor Aox and complex 4ox are isolated. The mesoionic carbene complexes 1– 3, as well as in situ oxidized 1ox, are used as homogeneous catalysts for the hydroformylation of 1-octene for the first time, and the influence of chemical oxidation of the catalyst on the activity and chemo- and regioselectivity of the catalyst precursor 1 is evaluated.F.D. and T.W. gratefully acknowledge financial support from the Fonds der Chemischen Industrie (FCI). G.S.S. gratefully acknowledges financial support from the University of Cape Town and the NRF-DST Centre of Excellence in Catalysis (C*Change). D.I.B. and D.A. gratefully acknowledge the National Research Foundation, South Africa (NRF 87890, 97202 and 104205), and Sasol Technology R&D Pty. Ltd., South Africa for financial support.http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0682c2018-03-31hb2017Chemistr

Grand Challenges in Immersive Analytics

The definitive version will be published in CHI 2021, May 8–13, 2021, Yokohama, JapanInternational audienceImmersive Analytics is a quickly evolving field that unites several areas such as visualisation, immersive environments, and humancomputer interaction to support human data analysis with emerging technologies. This research has thrived over the past years with multiple workshops, seminars, and a growing body of publications, spanning several conferences. Given the rapid advancement of interaction technologies and novel application domains, this paper aims toward a broader research agenda to enable widespread adoption. We present 17 key research challenges developed over multiple sessions by a diverse group of 24 international experts, initiated from a virtual scientific workshop at ACM CHI 2020. These challenges aim to coordinate future work by providing a systematic roadmap of current directions and impending hurdles to facilitate productive and effective applications for Immersive Analytics

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be extremely potent against Mycobacterium tuberculosis. To ensure compound supply for further development, we studied myxovalargin biosynthesis in detail enabling production via fermentation of a native producer. Feeding experiments as well as functional genomics analysis suggested a structural revision, which was eventually corroborated by the development of a concise total synthesis. The ribosome was identified as the molecular target based on resistant mutant sequencing, and a cryo-EM structure revealed that myxovalargin binds within and completely occludes the exit tunnel, consistent with a mode of action to arrest translation during a late stage of translation initiation. These studies open avenues for structure-based scaffold improvement toward development as an antibacterial agent

The development of a HAMstring InjuRy (HAMIR) index to mitigate injury risk through innovative imaging, biomechanics, and data analytics : Protocol for an observational cohort study

Background The etiology of hamstring strain injury (HSI) in American football is multi-factorial and understanding these risk factors is paramount to developing predictive models and guiding prevention and rehabilitation strategies. Many player-games are lost due to the lack of a clear understanding of risk factors and the absence of effective methods to minimize re-injury. This paper describes the protocol that will be followed to develop the HAMstring InjuRy (HAMIR) index risk prediction models for HSI and re-injury based on morphological, architectural, biomechanical and clinical factors in National Collegiate Athletic Association Division I collegiate football players. Methods A 3-year, prospective study will be conducted involving collegiate football student-athletes at four institutions. Enrolled participants will complete preseason assessments of eccentric hamstring strength, on-field sprinting biomechanics and muscle–tendon volumes using magnetic-resonance imaging (MRI). Athletic trainers will monitor injuries and exposure for the duration of the study. Participants who sustain an HSI will undergo a clinical assessment at the time of injury along with MRI examinations. Following completion of structured rehabilitation and return to unrestricted sport participation, clinical assessments, MRI examinations and sprinting biomechanics will be repeated. Injury recurrence will be monitored through a 6-month follow-up period. HAMIR index prediction models for index HSI injury and re-injury will be constructed. Discussion The most appropriate strategies for reducing risk of HSI are likely multi-factorial and depend on risk factors unique to each athlete. This study will be the largest-of-its-kind (1200 player-years) to gather detailed information on index and recurrent HSI, and will be the first study to simultaneously investigate the effect of morphological, biomechanical and clinical variables on risk of HSI in collegiate football athletes. The quantitative HAMIR index will be formulated to identify an athlete’s propensity for HSI, and more importantly, identify targets for injury mitigation, thereby reducing the global burden of HSI in high-level American football players. Trial Registration The trial is prospectively registered on ClinicalTrials.gov (NCT05343052; April 22, 2022)

A large-scale genome-wide association study meta-analysis of cannabis use disorder

Summary Background Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50–70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. Methods To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations. Findings We identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07–1·15, p=1·84 × 10−9) and the previously identified chromosome 8 locus (near CHRNA2 and EPHX2, lead SNP rs4732724; OR 0·89, 95% CI 0·86–0·93, p=6·46 × 10−9). Cannabis use disorder and cannabis use were genetically correlated (rg 0·50, p=1·50 × 10−21), but they showed significantly different genetic correlations with 12 of the 22 traits we tested, suggesting at least partially different genetic underpinnings of cannabis use and cannabis use disorder. Cannabis use disorder was positively genetically correlated with other psychopathology, including ADHD, major depression, and schizophrenia. Interpretation These findings support the theory that cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder. Funding National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; Center for Genomics and Personalized Medicine and the Centre for Integrative Sequencing; The European Commission, Horizon 2020; National Institute of Child Health and Human Development; Health Research Council of New Zealand; National Institute on Aging; Wellcome Trust Case Control Consortium; UK Research and Innovation Medical Research Council (UKRI MRC); The Brain & Behavior Research Foundation; National Institute on Deafness and Other Communication Disorders; Substance Abuse and Mental Health Services Administration (SAMHSA); National Institute of Biomedical Imaging and Bioengineering; National Health and Medical Research Council (NHMRC) Australia; Tobacco-Related Disease Research Program of the University of California; Families for Borderline Personality Disorder Research (Beth and Rob Elliott) 2018 NARSAD Young Investigator Grant; The National Child Health Research Foundation (Cure Kids); The Canterbury Medical Research Foundation; The New Zealand Lottery Grants Board; The University of Otago; The Carney Centre for Pharmacogenomics; The James Hume Bequest Fund; National Institutes of Health: Genes, Environment and Health Initiative; National Institutes of Health; National Cancer Institute; The William T Grant Foundation; Australian Research Council; The Virginia Tobacco Settlement Foundation; The VISN 1 and VISN 4 Mental Illness Research, Education, and Clinical Centers of the US Department of Veterans Affairs; The 5th Framework Programme (FP-5) GenomEUtwin Project; The Lundbeck Foundation; NIH-funded Shared Instrumentation Grant S10RR025141; Clinical Translational Sciences Award grants; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences.Peer reviewe

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Individual response to stress is correlated with neuroticism and is an important predictor of both neuroticism and the onset of major depressive disorder (MDD). Identification of the genetics underpinning individual differences in response to negative events (stress-sensitivity) may improve our understanding of the molecular pathways involved, and its association with stress-related illnesses. We sought to generate a proxy for stress-sensitivity through modelling the interaction between SNP allele and MDD status on neuroticism score in order to identify genetic variants that contribute to the higher neuroticism seen in individuals with a lifetime diagnosis of depression compared to unaffected individuals. Meta-analysis of genome-wide interaction studies (GWIS) in UK Biobank (N = 23,092) and Generation Scotland: Scottish Family Health Study (N = 7,155) identified no genome-wide significance SNP interactions. However, gene-based tests identified a genome-wide significant gene, ZNF366, a negative regulator of glucocorticoid receptor function implicated in alcohol dependence (p = 1.48x10-7; Bonferroni-corrected significance threshold p < 2.79x10-6). Using summary statistics from the stress-sensitivity term of the GWIS, SNP heritability for stress-sensitivity was estimated at 5.0%. In models fitting polygenic risk scores of both MDD and neuroticism derived from independent GWAS, we show that polygenic risk scores derived from the UK Biobank stress-sensitivity GWIS significantly improved the prediction of MDD in Generation Scotland. This study may improve interpretation of larger genome-wide association studies of MDD and other stress-related illnesses, and the understanding of the etiological mechanisms underpinning stress-sensitivity