Epidemiological aspect of pertussis in the Czech Republic

The aim was to document the trend in pertussis in the Czech Republic (CR) with regard to the infant population under one year of age, which is at highest risk for pertussis. Another point was to answer two questions: 1) whether the recent rise in pertussis cases in the CR is caused by new lineages of B. pertussis, against which the available vaccines are not effective, and 2) whether the circulating strains of B. pertussis are susceptible to antibiotics of choice. Data on pertussis cases were derived from the surveillance programme. Two hundred and sixty-five children under one year of age with laboratory confirmed pertussis, diagnosed between 1997 and 2013, were included in the study. B. pertussis isolates obtained within the surveillance of pertussis were examined by molecular biological methods - MAST (multiantigen sequence typing), MLVA (multilocus variable-number tandem-repeat analysis), and MLST (multilocus sequence typing). B. pertussis strains isolated from patients between 1967 and 2010 were tested for susceptibility to first-line antibiotics for the treatment of pertussis. The analysis of the epidemiological situation confirmed an upward trend in pertussis in the CR since the 1990s in all age categories, including children under one year of age. Nearly 77 % of children acquired pertussis..

Epidemiological aspect of pertussis in the Czech Republic

The aim was to document the trend in pertussis in the Czech Republic (CR) with regard to the infant population under one year of age, which is at highest risk for pertussis. Another point was to answer two questions: 1) whether the recent rise in pertussis cases in the CR is caused by new lineages of B. pertussis, against which the available vaccines are not effective, and 2) whether the circulating strains of B. pertussis are susceptible to antibiotics of choice. Data on pertussis cases were derived from the surveillance programme. Two hundred and sixty-five children under one year of age with laboratory confirmed pertussis, diagnosed between 1997 and 2013, were included in the study. B. pertussis isolates obtained within the surveillance of pertussis were examined by molecular biological methods - MAST (multiantigen sequence typing), MLVA (multilocus variable-number tandem-repeat analysis), and MLST (multilocus sequence typing). B. pertussis strains isolated from patients between 1967 and 2010 were tested for susceptibility to first-line antibiotics for the treatment of pertussis. The analysis of the epidemiological situation confirmed an upward trend in pertussis in the CR since the 1990s in all age categories, including children under one year of age. Nearly 77 % of children acquired pertussis..

Role ČMZRB, a.s. v podpoře malého a středního podnikání a možnost rozvoje podnikatelské činnosti v Moravskoslezském kraji

Import 20/04/2006Prezenční výpůjčkaVŠB - Technická univerzita Ostrava. Ekonomická fakulta. Katedra (152) podnikohospodářsk

Evaluation of the Completeness and Timeliness of the Infant Pertussis Surveillance System in the Czech Republic in 2015, 2017 and 2019

The completeness and timeliness of the pertussis questionnaire-based enhanced surveillance system (ESS) among infants and reported pertussis data within the electronic nationwide notification system (NNS) in the years 2015, 2017 and 2019 were evaluated in a pilot study

Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018

International audienceIntroductionPERTINENT is a pilot active surveillance system of infants hospitalised with pertussis in six European Union/European Economic Area countries (37 hospitals, seven sites).AimThis observational study aimed to estimate annual pertussis incidence per site from 2016 to 2018 and respective trends between 2017 and 2018. Pertussis cases were described, including their severity.MethodsWe developed a generic protocol and laboratory guidelines to harmonise practices across sites. Cases were hospitalised infants testing positive for Bordetella pertussis by PCR or culture. Sites collected demographic, clinical, laboratory data, vaccination status, and risk/protective factors. We estimated sites' annual incidences by dividing case numbers by the catchment populations.ResultsFrom December 2015 to December 2018, we identified 469 cases (247 males; 53%). The median age, birthweight and gestational age were 2.5 months (range: 0-11.6; interquartile range (IQR): 2.5), 3,280 g (range: 700-4,925; IQR: 720) and 39 weeks (range: 25-42; IQR: 2), respectively. Thirty cases (6%) had atypical presentation either with cough or cyanosis only or with absence of pertussis-like symptoms. Of 330 cases with information, 83 (25%) were admitted to intensive care units including five deceased infants too young to be vaccinated. Incidence rate ratios between 2018 and 2017 were 1.43 in Czech Republic (p = 0.468), 0.25 in Catalonia (p = 0.002), 0.71 in France (p = 0.034), 0.14 in Ireland (p = 0.002), 0.63 in Italy (p = 0.053), 0.21 in Navarra (p = 0.148) and zero in Norway.ConclusionsIncidence appeared to decrease between 2017 and 2018 in all but one site. Enhanced surveillance of hospitalised pertussis in Europe is essential to monitor pertussis epidemiology and disease burden