Recommendations for the Use of Serious Games in Neurodegenerative Disorders: 2016 Delphi Panel

International audienceThe use of Serious Games (SG) in the health domain is expanding. In the field of neurodegenerative disorders (ND) such as Alzheimer’s disease, SG are currently employed both to support and improve the assessment of different functional and cognitive abilities, and to provide alternative solutions for patients’ treatment, stimulation, and rehabilitation. As the field is quite young, recommendations on the use of SG in people with ND are still rare. In 2014 we proposed some initial recommendations (Robert et al., 2014). The aim of the present work was to update them, thanks to opinions gathered by experts in the field during an expert Delphi panel. Results confirmed that SG are adapted to elderly people with mild cognitive impairment (MCI) and dementia, and can be employed for several purposes, including assessment, stimulation, and improving wellbeing, with some differences depending on the population (e.g., physical stimulation may be better suited for people with MCI). SG are more adapted for use with trained caregivers (both at home and in clinical settings), with a frequency ranging from 2 to 4 times a week. Importantly, the target of SG, their frequency of use and the context in which they are played depend on the SG typology (e.g., Exergame, cognitive game), and should be personalized with the help of a clinician

Functionnectome as a framework to analyse the contribution of brain circuits to fMRI.

International audienceIn recent years, the field of functional neuroimaging has moved away from a pure localisationist approach of isolated functional brain regions to a more integrated view of these regions within functional networks. However, the methods used to investigate functional networks rely on local signals in grey matter and are limited in identifying anatomical circuitries supporting the interaction between brain regions. Mapping the brain circuits mediating the functional signal between brain regions would propel our understanding of the brain's functional signatures and dysfunctions. We developed a method to unravel the relationship between brain circuits and functions: The Functionnectome. The Functionnectome combines the functional signal from fMRI with white matter circuits' anatomy to unlock and chart the first maps of functional white matter. To showcase this method's versatility, we provide the first functional white matter maps revealing the joint contribution of connected areas to motor, working memory, and language functions. The Functionnectome comes with an open-source companion software and opens new avenues into studying functional networks by applying the method to already existing datasets and beyond task fMRI

CONTACT : patient‐centred care questionnaire to assess care for patients treated with oral anticancer drugs : development and psychometric validation

Objective: Instruments to measure quality of patient-centred care (PCC) for the rapidly growing population of patients treated with oral anticancer drugs (OACD) are lacking. The aim of this study was to develop a valid and reliable instrument to assess PCC in the context of OACD. Methods: The CONTACT-Patient-Centred Care Questionnaire (CONTACT-PCCQ) was developed based on a validated set of key elements (KEs) for patient-centred education and counselling in patients taking OACD, and face validity was evaluated by means of cognitive interviews. In 16 Belgian hospitals, adult patients treated with OACD were asked to complete the questionnaire. Construct validity was investigated through exploratory factor analyses (EFAs) and internal consistency of the subscales was examined using Cronbach's alpha. Results: The initial 86-item instrument was completed by 464 patients. Each EFA confirmed the a priori PCC-based structure of the subscales. However, EFA revealed more than one factor for two of the subscales. Therefore, multiple subsections within these subscales were created. Based on factor loadings and item content, six items were removed. This resulted in a final 80-item instrument with seven subscales and five subsections. Cronbach's alpha for the subscales and subsections ranged between 0.732 and 0.918, which implies adequate internal consistency. Conclusion: A final instrument with 80 items divided into seven subscales, covering all six dimensions of PCC, was obtained. The CONTACT-PCCQ has acceptable psychometric properties, supporting its use as a measure to assess care experiences of patients treated with OACD

MICROSCOPE mission scenario, ground segment and data processing

International audienceTesting the weak equivalence principle to a precision of 10$^{−15}$ requires a quantity of data that give enough confidence on the final result: ideally, the longer the measurement the better the rejection of the statistical noise. The science sessions had a duration of 120 orbits maximum and were regularly repeated and spaced out to accommodate operational constraints but also in order to repeat the experiment in different conditions and to allow time to calibrate the instrument. Several science sessions were performed over the 2.5 years duration of the experiment. This paper aims to describe how the data have been produced on the basis of a mission scenario and a data flow process, driven by a tradeoff between the science objectives and the operational constraints. The mission was led by the Centre National d’Etudes Spatiales (CNES) which provided the satellite, the launch and the ground operations. The ground segment was distributed between CNES and Office National d’Etudes et de Recherches Aérospatiales (ONERA). CNES provided the raw data through the Centre d’Expertise de Compensation de Traînée (CECT: drag-free expertise centre). The science was led by the Observatoire de la Côte d’Azur (OCA) and ONERA was in charge of the data process. The latter also provided the instrument and the Science Mission Centre of MICROSCOPE (CMSM)

MICROSCOPE Mission scenario, ground segment and data processing

Testing the Weak Equivalence Principle (WEP) to a precision of $10^{-15}$ requires a quantity of data that give enough confidence on the final result: ideally, the longer the measurement the better the rejection of thestatistical noise. The science sessions had a duration of 120 orbits maximum and were regularly repeated and spaced out to accommodate operational constraints but also in order to repeat the experiment in different conditions and to allow time to calibrate the instrument. Several science sessions were performed over the 2.5 year duration of the experiment. This paper aims to describe how the data have been produced on the basis of a mission scenario and a data flow process, driven by a tradeoff between the science objectives and the operational constraints. The mission was led by the Centre National d'Etudes Spatiales (CNES) which provided the satellite, the launch and the ground operations. The ground segment was distributed between CNES and Office National d'Etudes et de Recherches Aérospatiales (ONERA). CNES provided the raw data through the Centre d'Expertise de Compensation de Traînée (CECT: Drag-free expertise centre). The science was led by the Observatoire de la Côte d'Azur (OCA) and ONERA was in charge of the data process. The latter also provided the instrument and the Science Mission Centre of MICROSCOPE (CMSM)

JEMImE: A Serious Game to Teach Children with ASD How to Adequately Produce Facial Expressions

International audienc