Fair Hearing in Administrative Rule-Making: A Recent Experience Under the Federal Food, Drug, and Cosmetic and Fair Packaging and Labeling Acts

In promulgating regulations to govern the labeling of foods under the Fair Packaging and Labeling Act, the Commissioner of Food and Drugs, despite the objections of adversely affected parties, denied all requests for a public hearing. In this article the author reviews the hearing provisions of the Act, analyzes the position taken by the Food and Drug Administration, and concludes that the failure to grant a trial-type hearing on the labeling regulations was legally indefensible

Mapping the galaxy NGC 4486 (M87) through its Globular Cluster System

As shown in previous works, globular clusters can be used to trace the overall structure of the diffuse stellar populations in early type galaxies if the number of clusters per unit stellar mass depends on metallicity. In this paper we further test this assumption in the galaxy NGC 4486 (M 87), by combining several data sources. The results show that globular clusters allow the mapping of the galaxy in terms of the surface brightness profile, integrated colour gradient, chemical abundance, and mass to luminosity ratios up to 1000 arcsec (or 80.4 kpc) from its centre (i.e. some 10 effective radii). The analysis indicates the presence of a dominant high metallicity bulge associated with the red globulars, whose ellipticity increases outwards, and of a more flattened low metallicity halo connected with the blue globulars. The chemical abundance gradient of the composite stellar population is remarkably similar to that inferred from X ray observations of hot gas. The mass-metallicity spectrum of the stellar population can, in principle, be understood in terms of inhomogeneous enrichment models. In turn, the distribution of the bluest GCs, and lowest metallicity halo stars, has an intriguing similarity with that of dark matter, a feature shared with NGC 1399. Also, in these two galaxies, the number of blue GCs per dark mass unit is identical within the errors, \approx 1.0(\pm0.3) \times 10^{-9} . The total stellar mass derived for NGC 4486 is 6.8(\pm1.1) \times 10^{11} M\odot with a baryonic mass fraction fb = 0.08(\pm 0.01).Comment: 18 pages, 23 figure

Applications of DFT to the theory of twentieth-century harmony

Music theorists have only recently, following groundbreaking work by Quinn, recognized the potential for the DFT on pcsets, initially proposed by Lewin, to serve as the foundation of a theory of harmony for the twentieth century. This paper investigates pcset “arithmetic” – subset structure, transpositional combination, and interval content – through the lens of the DFT. It discusses relationships between interval classes and DFT magnitudes, considers special properties of dyads, pcset products, and generated collections, and suggest methods of using the DFT in analysis, including interpreting DFT magnitudes, using phase spaces to understand subset structure, and interpreting the DFT of Lewin’s interval function. Webern’s op. 5/4 and Bartok’s String Quartet 4, iv, are discussed.Accepted manuscrip

Field-induced Orbital Patterns in Ferromagnetic Layered Ruthenates

We study the evolution of orbital patterns in ferromagnetic layered ruthenates due to the competition of Coulomb interactions, compressive c axis and orthorhombic distortions in the presence of a polarizing orbital field coupled to the angular momentum. By means of the exact diagonalization on a 2x2 cluster and a cluster embedded analysis where inter-plaquette interaction is treated on mean field level, we determine the ground-state phase diagram. Specifically, we demonstrate that, via the activation of two or three of t_2g local orbital configurations, an external field applied along different symmetry directions can lead to inequivalent orbital correlated states. Starting from an antiferro-orbital pattern, for the easy axis case an orbital ordered phase is induced, having strong next nearest neighbors ferro-orbital correlations. Otherwise, a field applied along the hard axis leads a reduction of local orbital moment in a way to suppress the orbital order.Comment: 11 page

Small Angle Polarization in High Energy P--P Scattering Through Nonperturbative Chiral Symmetry Breaking

We show that a large anomalous contribution due to nonperturbative instanton-like gluonic field configurations to the axial charge of the proton implies high-energy spin effects in $p-p$ elastic scattering. This is the same mechanism which is responsible for anomalous baryon number violation at high energy in the standard model. We compute the proton polarization due to these effects and we show that it is proportional to the center-of-mass scattering angle with a universal (energy-independent) slope of order unity.Comment: (13 pages, 2 figures

The globular clusters-stellar haloes connection in early type galaxies

This paper explores if, and to what an extent, the stellar populations of early type galaxies can be traced through the colour distribution of their globular cluster systems. The analysis, based on a galaxy sample from the Virgo ACS data, is an extension of a previous approach that has been successful in the cases of the giant ellipticals NGC 1399 and NGC 4486, and assumes that the two dominant GC populations form along diffuse stellar populations sharing the cluster chemical abundances and spatial distributions. The results show that a) Integrated galaxy colours can be matched to within the photometric uncertainties and are consistent with a narrow range of ages; b) The inferred mass to luminosity ratios and stellar masses are within the range of values available in the literature; c) Most globular cluster systems occupy a thick plane in the volume space defined by the cluster formation efficiency, total stellar mass and projected surface mass density. The formation efficiency parameter of the red clusters shows a dependency with projected stellar mass density that is absent for the blue globulars. In turn, the brightest galaxies appear clearly detached from that plane as a possible consequence of major past mergers; d) The stellar mass-metallicity relation is relatively shallow but shows a slope change at $M_*\approx 10^{10} M_\odot$. Galaxies with smaller stellar masses show predominantly unimodal globular cluster colour distributions. This result may indicate that less massive galaxies are not able to retain chemically enriched intestellar matter.Comment: 19 pages, 10 figure

Globular Clusters: DNA of Early-Type galaxies?

This paper explores if the mean properties of Early-Type Galaxies (ETG) can be reconstructed from "genetic" information stored in their GCs (i.e., in their chemical abundances, spatial distributions and ages). This approach implies that the formation of each globular occurs in very massive stellar environments, as suggested by some models that aim at explaining the presence of multi-populations in these systems. The assumption that the relative number of globular clusters to diffuse stellar mass depends exponentially on chemical abundance, [Z/H], and the presence of two dominant GC sub-populations blue and red, allows the mapping of low metallicity halos and of higher metallicity (and more heterogeneous) bulges. In particular, the masses of the low-metallicity halos seem to scale up with dark matter mass through a constant. We also find a dependence of the globular cluster formation efficiency with the mean projected stellar mass density of the galaxies within their effective radii. The analysis is based on a selected sub-sample of galaxies observed within the ACS Virgo Cluster Survey of the {\it Hubble Space Telescope}. These systems were grouped, according to their absolute magnitudes, in order to define composite fiducial galaxies and look for a quantitative connection with their (also composite) globular clusters systems. The results strengthen the idea that globular clusters are good quantitative tracers of both baryonic and dark matter in ETGs.Comment: 20 pages, 28 figures and 5 table

The potential for liquid biopsies in the precision medical treatment of breast cancer.

Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary tumor biology. Circulating biomarkers, such as circulating tumor DNA (ctDNA) or circulating tumor cells (CTCs) may enhance our treatment options by focusing on the very cells that are the direct precursors of distant metastatic disease, and probably inherently different than the primary tumor's biology. To shift the current clinical paradigm, assessing tumor biology in real time by molecularly profiling CTCs or ctDNA may serve to discover therapeutic targets, detect minimal residual disease and predict response to treatment. This review serves to elucidate the detection, characterization, and clinical application of CTCs and ctDNA with the goal of precision treatment of breast cancer