24 research outputs found
Lower NPAS3 expression during the later stages of abnormal lung development in rat congenital diaphragmatic hernia
- Author
- AR McIntosh
- Barbara M. Iwasiow
- BS Pickard
- C Erbel-Sieler
- D Kamnasaran
- EE Morrisey
- EW Brunskill
- EW Brunskill
- FO Peixoto
- G Kempermann
- GB Kamm
- J Correia-Pinto
- J Huang
- Jorge Correia-Pinto
- JR Gosche
- L Leeuwen
- Meghan Higgins
- MJ Baptista
- P Gould
- Patrícia Pereira-Terra
- Ramin Kholdebarin
- Richard Keijzer
- RJ Metzger
- RS Moura
- S Montedonico
- S Zhoua
- T Doi
- V Chi
- Y Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/07/2015
- Field of study
Purpose
Congenital diaphragmatic hernia (CDH) is characterized by a developmental defect in the diaphragm, pulmonary hypoplasia and pulmonary hypertension. NPAS3 is a PAS domain transcription factor regulating Drosophila tracheogenesis. NPAS3 null mice develop pulmonary hypoplasia in utero and die after birth due to respiratory failure. We aimed to evaluate NPAS3 expres- sion during normal and abnormal lung development due to CDH.
Methods
CDH was induced by administering 100 mg/ml nitrofen to time-pregnant dams on embryonic day (E) 9 of gestation. Lungs were isolated on E15, E18 and E21 and NPAS3 localization was determined by immunohisto- chemistry and quantified using Western blotting.
Results
We found that only E21 hypoplastic CDH lungs have reduced expression of NPAS3 in the terminal sac- cules. Western blotting confirmed the down-regulation of NPAS3 protein in the nitrofen-induced hypoplastic lungs.
Conclusions
We demonstrate for the first time that ni- trofen-induced hypoplastic CDH lungs have reduced NPAS3 expression in the terminal saccules during the later stages of abnormal lung development. Our findings suggest that NPAS3 is associated with pulmonary hypoplasia in CDH.Supported by the Children’s Hospital Research Institute of Manitoba; RK is the recipient of a Career Enhancement Award from the Canadian Child Health Clinician Scientist Program and a New Investigator Salary Award from the Canadian Institutes of Health Research, Manitoba Lung Association and the Children’s Hospital Research Institute
A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells
- Author
- Publication venue
- CUNY Academic Works
- Publication date
- 21/03/2013
- Field of study
Previous studies proposed that myosin-Va regulates apoptosis by sequestering pro-apoptotic Bmf to the actin cytoskeleton through dynein light chain-2 (DLC2). Adhesion loss or other cytoskeletal perturbations would unleash Bmf, allowing it to bind and inhibit pro-survival Bcl2 proteins. Here, we demonstrated that over expression of a myosin-Va medial tail fragment (MVaf) harboring the binding site for DLC2 dramatically decreased melanoma cell viability. Morphological and molecular changes, including surface blebbing, mitochondrial outer membrane permeabilization, cytochrome-c and Smac release, as well as caspase-9/-3 activation and DNA fragmentation indicated that melanoma cells died of apoptosis. Immobilized MVaf interacted directly with DLCs, but complexed MVaf/DLCs did not interact with Bmf. Overexpression of DLC2 attenuated MVaf-induced apoptosis. Thus, we suggest that, MVaf induces apoptosis by sequestering DLC2 and DLC1, thereby unleashing the pair of sensitizer and activator BH3-only proteins Bmf and Bim. Murine embryonic fibroblasts (MEFs) lacking Bim and Bmf or Bax and Bak were less sensitive to apoptosis caused by MVaf expression than wild-type MEFs, strengthening the putative role of the intrinsic apoptotic pathway in this response. Finally, MVaf expression attenuated B16-F10 solid tumor growth in mice, suggesting that this peptide may be useful as an apoptosis-inducing tool for basic and translational studies
Concentração de propriedade e desempenho: um estudo nas empresas brasileiras de capital aberto do setor de energia elétrica
- Author
- Alchian A.
- Almeida J. E. F.
- Almeida R. S.
- Andrade A.
- Assunção T. N.
- Bahnemann W.
- Barbedo C. H.
- Berle A. A.
- Bernardino F. F. M.
- Bernardino F. F. M.
- Brigham E. F.
- Brugni T. V.
- Caio Peixoto Chain
- Caixe D. F.
- Campos T. L. C.
- Chhaochharia V.
- Chung K.
- Claessens S.
- Correia L. F.
- Damasceno D. D.
- Eisenhardt K. M.
- Fama E. F.
- Famá R.
- Frentrop P.
- Gugler K.
- Gujarati D.
- Jensen M. C.
- Jensen M. C.
- João Paulo Calembo Batista Menezes
- Kronbauer C. A.
- La Porta R.
- Leal R. P. C.
- Leech D.
- Lima A. A. P.
- Maddala G. S.
- Miller D.
- Morck R. K.
- Naiara Leite dos Santos Sant'Ana
- Natália Carolina Duarte de Medeiros
- Oliveira I. G. S.
- Pedersen T.
- Renders A.
- Rossoni L.
- Sabrina Amélia de Lima e Silva
- Shin H.
- Shleifer A.
- Siffert Fo N. F.
- Silva C. L.
- Silva E. C.
- Silvestre B. S.
- Smith A.
- Souza G. H. S.
- Sánchez‐Ballesta J. P.
- Teixeira E. A.
- Ventura Fo A
- Wooldridge J. M.
- Young M. N.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Microbial Diversity of a Brazilian Coastal Region Influenced by an Upwelling System and Anthropogenic Activity
- Author
- A Chao
- A Chao
- AE Murray
- AK Hamilton
- Alberto M. R. Dávila
- Alexandre S. Rosado
- B Diez
- B Ewing
- BJ Tibbles
- C Lovejoy
- CE Shannon
- CEL Ferreira
- CL Moyer
- CS Jebaraj
- D Marie
- D Marie
- D Woebken
- DA Walsh
- DC Smith
- DL Kirchman
- E Durisch-Kaiser
- E Gonzalez-Rodriguez
- E Gonzalez-Rodriguez
- E Lim
- E Pruesse
- EF DeLong
- EF DeLong
- EJD Campos
- Fabio V. Araujo
- FO Glockner
- GB Dubelaar
- GB McManus
- GB McManus
- GC Pereira
- GC Pereira
- GC Pereira
- H Heuer
- Henrique F. Santos
- HF Santos
- HJ Mills
- HJM Op den Camp
- IJ Good
- IJ Good
- J Sambrook
- JA Fuerst
- JA Fuhrman
- Jack Gilbert
- JD Thompson
- JL Valentin
- JL Valentin
- JL Valentin
- JL Valentin
- Joana A. L. Oliveira
- JP Felsenstein
- JR Cole
- Juliano C. Cury
- JV McArthur
- K Koch
- K Tamura
- KE Ashelford
- L Alonso-Sáez
- L Hansson
- L Herfort
- L Ovreas
- LA Codispoti
- M Garren
- M Guenther
- M Hamady
- M Simon
- MB Karner
- MC Savin
- ME Vinogradov
- MJ Church
- MK Cheung
- MM Varela
- MMM Kuypers
- N Bano
- NN Perreault
- P Cury
- P Del Giorgio
- P Lam
- P Yarza
- PD Schloss
- PE Galand
- PK Hershberger
- Q Wang
- R Massana
- R Massana
- R Terrado
- Raquel S. Peixoto
- RM Castelão
- RR Rodrigues
- Sergio A. Coelho-Souza
- SF Altschul
- SJ Cathrine
- SJ Giovannoni
- SYM Staay
- T Nagata
- T Stoeck
- T Stoeck
- T Stoeck
- TH Jukes
- VP Edgcomb
- WF Carvalho
- WL Marshall
- YI Sorokin
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
BACKGROUND: Upwelling systems are characterised by an intense primary biomass production in the surface (warmest) water after the outcrop of the bottom (coldest) water, which is rich in nutrients. Although it is known that the microbial assemblage plays an important role in the food chain of marine systems and that the upwelling systems that occur in southwest Brazil drive the complex dynamics of the food chain, little is known about the microbial composition present in this region. METHODOLOGY/PRINCIPAL FINDINGS: We carried out a molecular survey based on SSU rRNA gene from the three domains of the phylogenetic tree of life present in a tropical upwelling region (Arraial do Cabo, Rio de Janeiro, Brazil). The aim was to analyse the horizontal and vertical variations of the microbial composition in two geographically close areas influenced by anthropogenic activity (sewage disposal/port activity) and upwelling phenomena, respectively. A lower estimated diversity of microorganisms of the three domains of the phylogenetic tree of life was found in the water of the area influenced by anthropogenic activity compared to the area influenced by upwelling phenomena. We observed a heterogenic distribution of the relative abundance of taxonomic groups, especially in the Archaea and Eukarya domains. The bacterial community was dominated by Proteobacteria, Cyanobacteria and Bacteroidetes phyla, whereas the microeukaryotic community was dominated by Metazoa, Fungi, Alveolata and Stramenopile. The estimated archaeal diversity was the lowest of the three domains and was dominated by uncharacterised marine Crenarchaeota that were most closely related to Marine Group I. CONCLUSIONS/SIGNIFICANCE: The variety of conditions and the presence of different microbial assemblages indicated that the area of Arraial do Cabo can be used as a model for detailed studies that contemplate the correlation between pollution-indicating parameters and the depletion of microbial diversity in areas close to anthropogenic activity; functional roles and geochemical processes; phylogeny of the uncharacterised diversity; and seasonal variations of the microbial assemblages
Diálise planejada e a utilização regular da atenção primária à saúde entre os pacientes diabéticos do Município de Belo Horizonte, Minas Gerais, Brasil
- Author
- Andrade MV
- Araújo RB
- Arora P
- Astor BC
- Barros AJD
- Bastos MG
- Batista LKC
- Bello AK
- Cabral ALLV
- Cass A
- Cherchiglia ML
- Ciconelli RM
- Duarte PS
- Elaine Leandro Machado
- Eli Iola Gurgel Andrade
- Eline Rezende de Morais Peixoto
- Finkelstein FO
- Francisco de Assis Acurcio
- Gorriz JL
- Heatley SA
- Ilka Afonso Reis
- Khan IH
- Lameire N
- Lorenzo V
- Machado EL
- Mariângela Leal Cherchiglia
- Marrón B
- Mendelssohn DC
- Mendelssohn DC
- Monteiro CA
- Nesrallah G
- Pereira RPA
- Pisoni RL
- Roderick P
- Romão Jr JE
- Romão Jr JE
- Roubicek C
- Sesso R
- Silva GM
- Wauters JP
- Wavamunno MD
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Efeito da desnutrição neonatal sobre o recrutamento celular e a atividade oxidante-antioxidante de macrófagos em ratos adultos endotoxêmicos
- Author
- Amersfoort ESV
- Andrade Júnior DR
- Anstead GM
- Ben Baruch A
- Boles JM
- Borelli P
- Borelli P
- Chan J
- Chandra RK
- Chandra RK
- Cunningham-Rundles S
- Célia Maria Machado Barbosa de Castro
- De Castro CM
- De Castro CMMB
- Dong W
- Feder LS
- Ferreira HS
- Guedes RCA
- Gupta P
- Guzmán-Silva MA
- Ikeda S
- Jimoh FO
- Johnston Jr RB
- Juliana Félix de Melo
- Klasing KC
- Leite HP
- Lowry OH
- Marcelo Tavares Viana
- Meyer J
- Morgan G
- Prazeres FG
- Queiros-Santos A
- Rebecca Peixoto Paes Silva
- Redmond HP
- Revillard JP
- Shaaban SY
- Souza IP
- Teodósio NR
- Welbourn CRB
- Wylla Tatiana Ferreira e Silva
- Érika Michelle Correia de Macedo
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
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The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud A Abed
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo P Martinez
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen J Von
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FL Lucio
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparo MA
- Aranda C Padilla
- Aranzabal N
- Araya S Tapia
- Arcangeletti C
- Arce ATH
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asawatavonvanich T
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Atmasiddha PA
- Augsten K
- Austrup VA
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Backman F
- Bagnaia P
- Bahilo JJ Lozano
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Bakos E
- Balaji S
- Balasubramanian R
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barron U
- Barsov S
- Bartels F
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley John
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer P
- Bawa HS
- Bayirli A
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beisiegel F
- Belfkir M
- Bella G
- Bella L Aperio
- Bellagamba L
- Bellerive A
- Bello FA Di
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bethke S
- Betti A
- Bevan AJ
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
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- Bianchi RM
- Biebel O
- Biedermann D
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- Bierwagen K
- Biesuz NV
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- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birch-sykes CJ
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- Bitadze A
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- Blazek T
- Bloch I
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- Blumenschein U
- Blumenthal J
- Bobbink GJ
- Bobrovnikov VS
- Boeriu OE Vickey
- Bogavac D
- Bogdanchikov AG
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- Boisvert V
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- Bolanos G Rabanal
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- Bomben M
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- Bonilla JS
- Boonekamp M
- Booth CD
- Borbely AG
- Borecka-Bielska HM
- Borgna LS
- Borisov A
- Borissov G
- Bortoletto D
- Bosca S Rodriguez
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- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
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- Bullard BA
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- Burgard CD
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- Burr Jon
- Burton CD
- Burzynski JC
- Buscher V
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- Buttinger W
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- Chevalerias TJA
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- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov MV
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- Chomont AR
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- Chow YS
- Christopher LD
- Chu MC
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- Chwastowski JJ
- Ciaccio A Di
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- Collaboration ATLAS
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- Correia AM Henriques
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- Czurylo MM
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- D'Amico V
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- D'onofrio A
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- D'uffizi M
- Da Costa AM Mendes Jacques
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- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Daalen TR Van
- Dabrowski W
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- Davidek T
- Davis DR
- Dawson I
- de Andrade Filho L Manhaes
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- De Beurs M
- De Carvalho AL Moreira
- De Castro S
- De Groot N
- de Jong P
- de la Hoz S Gonzalez
- de la Torre H
- De Lima R Teixeira
- De Maria A
- De Pedis D
- de Renstrom PA Bruckman
- De Sa R Coelho Lopes
- De Salvo A
- De Sanctis U
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- De Santo A
- De Vivie De Regie JB
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- Delporte C
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- Demontigny G
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
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- Desch K
- Dette K
- Deutsch C
- Deviveiros PO
- Diaconu C
- Dias FA
- Diaz L Pedraza
- Diaz MA
- Diaz Y Delabat
- Dickinson J
- Didenko M
- Diehl EB
- Dietrich J
- Dimitrievska A
- Ding W
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- Dittmeier SJ
- Dittus F
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- Djuvsland JI
- Dobre M
- Dodsworth D
- Doglioni C
- Dolejsi J
- Dolezal Z
- Dominguez L Pascual
- Don M Madugoda Ralalage
- Donadelli M
- Donaldson C Pitman
- Donato C Di
- Donell DM Mac
- Dong B
- Donini J
- Donszelmann T Cuhadar
- Dopke J
- Doria A
- Dova MT
- Doyle AT
- Drechsler E
- Dreyer E
- Dreyer T
- Drobac AS
- Du D
- Duan Y
- Dubinin F
- Dubovsky M
- Dubreuil A
- Duchovni E
- Duckeck G
- Ducu OA
- Duda D
- Dudarev A
- Dudder AC
- Duflot L
- Duhrssen M
- Dulsen C
- Dumancic M
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- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 08/03/2022
- Field of study
The design and performance of the inner detector trigger for the high level
trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18
data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector
recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of
proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to
deal with the very high interaction multiplicities per bunch crossing expected
with the 13 TeV collisions the inner detector trigger was redesigned during the
long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of
these developments is provided and the performance of the tracking in the
trigger for the muon, electron, tau and b-jet signatures is discussed. The
high performance of the inner detector trigger with these extreme interaction
multiplicities demonstrates how the inner detector tracking continues to lie at
the heart of the trigger performance and is essential in enabling the ATLAS
physics programme
The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud A Abed
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo P Martinez
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen J Von
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
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- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
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- Zwalinski L
- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 01/01/2022
- Field of study
The design and performance of the inner detector trigger for the high level
trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18
data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector
recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of
proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to
deal with the very high interaction multiplicities per bunch crossing expected
with the 13 TeV collisions the inner detector trigger was redesigned during the
long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of
these developments is provided and the performance of the tracking in the
trigger for the muon, electron, tau and b-jet signatures is discussed. The
high performance of the inner detector trigger with these extreme interaction
multiplicities demonstrates how the inner detector tracking continues to lie at
the heart of the trigger performance and is essential in enabling the ATLAS
physics programme
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gómez L
- Abdeen ZA
- Abdrakhmanova S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Lahou B
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
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- Alkerwi A
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- Amarapurkar DN
- Amoah J
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.</jats:p
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Aarestrup J
- Abarca-Gómez L
- Abbasi-Kangevari M
- Abdeen ZA
- Abdrakhmanova S
- Abdul Ghaffar S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abu-Rmeileh NM
- Abubakar Garba J
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
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- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Asfoor D
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Hinai H
- Al-Lahou B
- Al-Lawati JA
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
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- Alomirah HF
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- Publication venue
- Elsevier
- Publication date
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining https://researchonline.ljmu.ac.uk/images/research_banner_face_lab_290.jpgunderweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity