Optimization of 125-mu m Heterogeneous Multi-Core Fibre Design Using Artificial Intelligence

We propose an automated heterogeneous trench-assisted multi-core fibre (MCF) design method. This method uses neural networks to speed up coating loss estimation by ∼ 10^{6} times and using particle swarm optimization (PSO) algorithm to explore the optimal MCF design under various objectives and properties constraints. The latter reduces the permutation evaluations by ten orders of magnitude compared with the brute force method. The artificial intelligence (AI)-based method is used to design MCFs on two objectives: minimizing crosstalk (XT) and maximizing effective mode area ( A_{eff} ). By optimizing XT with different A_{eff} and cutoff wavelength constraints combinations for 6-core fibres, we achieved −92.1 dB/km ultra-low XT for C+L band fibre and −64 dB/km for E+S+C+L-band fibre. Meanwhile, we explored the upper limit of A_{eff} given different bandwidth constraints resulting in a 6.82 relative core multiplicity factor. We performed capacity analysis of fibres for two transmission lengths. It is shown that bandwidth is the dominant factor while the increase brought by A_{eff} and the penalty caused by XT are relevantly small. Our fibres exceed the cutoff-limited capacity of the 7-core fibre in literature by 35.1% and 84.8% for 1200 km and 6000 km transmission respectively

Design Optimization of Uncoupled Six-core Fibers in Standard Cladding Diameter Using Artificial Intelligence

We report on ultra-wide-band and long-haul compatible 125µm six-core trench-assisted fiber designs. The AI-optimization process considers crosstalk, effective area, and bandwidth. We show that homogeneous cores can lead to low complexity yet high capacity fiber

Design and transmission analysis of trench-assisted multi-core fibre in standard cladding diameter

6-core and 8-core trench-assisted heterogeneous fibres in standard cladding diameter are designed using artificial intelligence-based techniques including a cut-off wavelength regressor. The designs proposed here, for the first time, suppress crosstalk at 1550 nm of 8-core fibre to as low as −55 dB/km covering the whole S+C+L band while keeping coating loss below 0.001 dB/km. We compare them to reveal the influence of the additional cores in the 125 µm cladding diameter scenario. We report on the transmission characteristics and performance of the MCFs in terms of capacity and spatial spectral efficiency, including the influence of bandwidth, effective mode area, distance and crosstalk, for a range of transmission distances. The artificial intelligence-based method and insights given can be used to significantly speed up and tailor designs for a variety of telecom and datacom applications

S?ndrome de burnout en el personal de enfermer?a de un hospital de referencia Ibagu? 2014.

94 P?ginasRecurso Electr?nicoIntroducci?n: El S?ndrome de Burnout (SB) se define como la respuesta al estr?s laboral caracterizado por el cansancio emocional, la despersonalizaci?n y la baja realizaci?n personal, la desmotivaci?n, el desinter?s, el malestar interno o la insatisfacci?n laboral. Objetivo: Determinar la prevalencia del SB en el personal de enfermer?a de un hospital de referencia de una ciudad colombiana y su relaci?n con variables sociodemogr?ficas. Materiales y m?todos: Se llev? a cabo un estudio de corte transversal en una muestra aleatoria y representativa de 174 enfermeras(os), estratificada seg?n si la enfermera era profesional o auxiliar, en un hospital de referencia de una ciudad colombiana. Se utiliz? como instrumento para la determinaci?n del evento la escala validada en Colombia del MBI (Maslach Burnout Inventory). Para la obtenci?n de los resultados se utilizaron pruebas ji-cuadrado de independencia, t para diferencia de promedios en muestras independientes y an?lisis de la varianza de una v?a o de Kruskal Wal?s seg?n si las variables en los grupos de comparaci?n proven?an de una poblaci?n con distribuci?n normal. En an?lisis multivariado, se seleccionaron como variables candidatas a ingresar al modelo de regresi?n log?stica, aquellas que cumplieran con el criterio de Hosmer Lemeshow. En la construcci?n del modelo se tom? como medida de la asociaci?n el OR acompa?ado de su respectivo intervalo de confianza del 95%. Resultados: La prevalencia de Burnout fue del 20.1% (IC 95%: 13,9 26,4) y adem?s el 52,3% est?n a riesgo de padecerlo. Quienes afirmaron ser solteros/viudos/separados, las profesionales de enfermer?a, los que al momento de la encuesta ten?an una vinculaci?n temporal o de supernumerario, quienes laboraban en servicios administrativos/oncolog?a/camillero/esterilizaci?n y los 11 hombres y aquellos que afirmaron tener m?s de un contrato, fueron quienes presentaron indicadores de la proporci?n de Burnout mayores del 20,1%.En el an?lisis multivariado, los factores conjuntos que probablemente tienen mayor incidencia en la presencia del Burnout son el n?mero de hijos y ser hombre. Conclusiones: Con respecto a otros estudios, este estudio revela que la prevalencia del s?ndrome de Burnout en el hospital de referencia es mayor.Introduction: Burnout Syndrome (BS) is defined as the response to occupational stress characterized by emotional exhaustion, depersonalization and reduced personal accomplishment, discouragement, disinterest, internal discomfort or dissatisfaction labor. Objective: To determine the prevalence of BS nurses in a hospital reference a Colombian city and its relationship with sociodemographic variables. Materials and methods: A cross sectional study was conducted in a random and representative sample of 174 nurses, stratified according to whether they were professional or nurse assistant in a referral hospital of a Colombian city, was used as an instrument for determining the scale of the event in Colombia validated MBI (Maslach Burnout Inventory). To obtain the results chi- square test of independence, t-tests for mean differences in independent samples and analysis of variance or one-way Kruskal Wallis were used depending on whether the variables in the comparison groups were drawn from a population with normal distribution. In multivariate analysis, were selected as candidate variables to enter the logistic regression model those that met the criteria of Hosmer-Lemeshow. In building the model was taken as the measure of association OR accompanied by its respective confidence interval 95 %. Results: The prevalence of burnout was 201.1 % (95 % CI: 13.9 26.4) and also the 52.3 % are at risk for suffering. Who claimed to be single / widowed / separated, nursing professionals, which at the time of the survey had a temporary or temporary bonding, who worked in administrative / oncology / orderly / sterilization services and those men who reported having more than a contract, who presented were indicators of burnout higher proportion of 20.1%. In the multivariate analysis, the factors that sets probably have a greater incidence in the presence of burnout are the number of children and be a man. 13 Conclusions: With respect to other studies, this study reveals that the prevalence of burnout syndrome in the referral hospital is greater.RESUMEN 10 ABSTRACT 12 INTRODUCCI?N 14 1. PLANTEAMIENTO DEL PROBLEMAS Y JUSTIFICACION 16 2. MARCO TE?RICO 19 2.1 ESTR?S LABORAL 19 2.2 CONCEPTUALIZACI?N DEL S?NDROME DE BURNOUT 20 2.2.1 Caracter?sticas del s?ndrome de Burnout 22 2.2.2 Consecuencias del s?ndrome de Burnout 23 2.2.3 Instrumento de medici?n del s?ndrome de Burnout 25 2.2.4 Prevenci?n del s?ndrome de Burnout 27 2.2.5 Tratamiento del s?ndrome de Burnout 30 2.3 DEFINICI?N DE ENFERMER?A 35 2.4 GENERALIDADES DEL HOSPITAL DE REFERENCIA 39 2.5 LEGISLACI?N LABORAL EN COLOMBIA 40 3. OBJETIVOS 43 3.1 OBJETIVO GENERAL 43 3.2 OBJETIVOS ESPEC?FICOS 43 4. METODOLOG?A 44 4.1 TIPO DE ESTUDIO 44 4.2 POBLACI?N DE ESTUDIO 44 4.3 MUESTREO 44 5 4.4 CRITERIOS DE INCLUSI?N Y EXCLUSI?N 47 4.5. INSTRUMENTO DE RECOLECCI?N DE INFORMACI?N 47 4.6 CONTROL DE SESGOS 48 4.7 CONSIDERACIONES ?TICAS 49 5. RESULTADOS 50 5.1 CARACTERISTICAS SOCIODEMOGRAFICAS DEL 50 PERSONAL ENCUESTADO 5.1.1 Variables cualitativas 50 5.1.2 Variables cuantitativas 51 5.2 MASLASCH BURNOUT INVENTORY (MBI) 52 5.2.1 An?lisis de los ?tems 53 5.2.2 Grados del Burnout 55 5.2.3 An?lisis por patrones: Niveles del Burnout 56 5.2.4 Prevalencia del Burnout 59 5.2.5 Descripci?n de las dimensiones del MBI 62 5.3 ANALISIS BIVARIADO 65 5.4 ANALISIS MULTIVARIADO 69 6. DISCUSI?N 72 7. CONCLUSIONES 77 8. RECOMENDACIONES 78 9. LIMITACIONES 79 REFERENCIAS 8

Individual variation in susceptibility or exposure to SARS-CoV-2 lowers the herd immunity threshold

Individual variation in susceptibility and exposure is subject to selection by natural infection, accelerating the acquisition of immunity, and reducing herd immunity thresholds and epidemic final sizes. This is a manifestation of a wider population phenomenon known as “frailty variation”. Despite theoretical understanding, public health policies continue to be guided by mathematical models that leave out considerable variation and as a result inflate projected disease burdens and overestimate the impact of interventions. Here we focus on trajectories of the coronavirus disease (COVID-19) pandemic in England and Scotland until November 2021. We fit models to series of daily deaths and infer relevant epidemiological parameters, including coefficients of variation and effects of non-pharmaceutical interventions which we find in agreement with independent empirical estimates based on contact surveys. Our estimates are robust to whether the analysed data series encompass one or two pandemic waves and enable projections compatible with subsequent dynamics. We conclude that vaccination programmes may have contributed modestly to the acquisition of herd immunity in populations with high levels of pre-existing naturally acquired immunity, while being crucial to protect vulnerable individuals from severe outcomes as the virus becomes endemic

Dynamics for a complex-valued heat equation with an inverse nonlinearity

[[abstract]]We study the Cauchy problem for a parabolic system which is derived from a complex-valued heat equation with an inverse nonlinearity. First, we provide some criteria for the global existence of solutions. Then we consider the case when the initial data are asymptotically constants and obtain that, depending on the asymptotic limits, the solution quenches at space infinity or exists globally in time.[[journaltype]]國外[[incitationindex]]SCI[[ispeerreviewed]]Y[[countrycodes]]US

Comparative population structure of <i>Plasmodium malariae</i> and <i>Plasmodium falciparum</i> under different transmission settings in Malawi

&lt;b&gt;Background:&lt;/b&gt; Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P. malariae is more common than previously thought, and is frequently in sympatry and co-infection with P. falciparum, making its study increasingly important. This study compares the population parameters of the two species in two districts of Malawi with different malaria transmission patterns - one seasonal, one perennial - to explore the effects of transmission on population structures. &lt;BR/&gt; &lt;b&gt;Methods:&lt;/b&gt; Six species-specific microsatellite markers were used to analyse 257 P. malariae samples and 257 P. falciparum samples matched for age, gender and village of residence. Allele sizes were scored to within 2 bp for each locus and haplotypes were constructed from dominant alleles in multiple infections. Analysis of multiplicity of infection (MOI), population differentiation, clustering of haplotypes and linkage disequilibrium was performed for both species. Regression analyses were used to determine association of MOI measurements with clinical malaria parameters. &lt;BR/&gt; &lt;b&gt;Results:&lt;/b&gt; Multiple-genotype infections within each species were common in both districts, accounting for 86.0% of P. falciparum and 73.2% of P. malariae infections and did not differ significantly with transmission setting. Mean MOI of P. falciparum was increased under perennial transmission compared with seasonal (3.14 vs 2.59, p = 0.008) and was greater in children compared with adults. In contrast, P. malariae mean MOI was similar between transmission settings (2.12 vs 2.11) and there was no difference between children and adults. Population differentiation showed no significant differences between villages or districts for either species. There was no evidence of geographical clustering of haplotypes. Linkage disequilibrium amongst loci was found only for P. falciparum samples from the seasonal transmission setting. &lt;BR/&gt; &lt;b&gt;Conclusions:&lt;/b&gt; The extent of similarity between P. falciparum and P. malariae population structure described by the high level of multiple infection, the lack of significant population differentiation or haplotype clustering and lack of linkage disequilibrium is surprising given the differences in the biological features of these species that suggest a reduced potential for out-crossing and transmission in P. malariae. The absence of a rise in P. malariae MOI with increased transmission or a reduction in MOI with age could be explained by differences in the duration of infection or degree of immunity compared to P. falciparum

Continuity as a computational effect

The original purpose of component-based development was to provide techniques to master complex software, through composition, reuse and parametrisation. However, such systems are rapidly moving towards a level in which software becomes prevalently intertwined with (continuous) physical processes. A possible way to accommodate the latter in component calculi relies on a suitable encoding of continuous behaviour as (yet another) computational effect. This paper introduces such an encoding through a monad which, in the compositional development of hybrid systems, may play a role similar to the one played by 1+, powerset, and distribution monads in the characterisation of partial, nondeterministic and probabilistic components, respectively. This monad and its Kleisli category provide a universe in which the effects of continuity over (different forms of) composition can be suitably studied.This work is financed by the ERDF - European Regional Development Fund through the Operational Programme for Competitiveness and Internationalisation - COMPETE 2020 Programme and by National Funds through the Portuguese funding agency, FCT - Fundacao para a Ciencia e a Tecnologia within project POCI-01-0145-FEDER-016692.The first author is also sponsored by FCT grant SFRH/BD/52234/2013, and the second one by FCT grant SFRH/BSAB/113890/2015. Moreover, D. Hofmann and M. Martins are supported by the EU FP7 Marie Curie PIRSES-GA-2012-318986 project GeTFun: Generalizing Truth-Functionality and FCT project UID/MAT/04106/2013 through CIDMA