Magnetization pinning in modulated nanowires: from topological protection to the "corkscrew" mechanism

Diameter-modulated nanowires offer an important paradigm to design the magnetization response of 3D magnetic nanostructures by engineering the domain wall pinning. With the aim to understand its nature and to control the process, we analyze the magnetization response in FeCo modulated polycrystalline two-segment nanowires varying the minor diameter. Our modelling indicates a very complex behavior with a strong dependence on the disorder distribution and an important role of topologically non-trivial magnetization structures. We demonstrate that modulated nanowires with a small diameter difference are characterized by an increased coercive field in comparison to the straight ones which is explained by a formation of topologically protected walls formed by two 3D skyrmions with opposite chiralities. For a large diameter difference we report the occurrence of a novel pinning type called here the "corkscrew": the magnetization of the large diameter segment forms a skyrmion tube with a core position in a helical modulation along the nanowire. This structure is pinned at the constriction and in order to penetrate the narrow segments the vortex/skyrmion core size should be reduced

Analysis of a long-duration AR throughout five solar rotations: Magnetic properties and ejective events

Coronal mass ejections (CMEs), which are among the most magnificent solar eruptions, are a major driver of space weather and can thus affect diverse human technologies. Different processes have been proposed to explain the initiation and release of CMEs from solar active regions (ARs), without reaching consensus on which is the predominant scenario, and thus rendering impossible to accurately predict when a CME is going to erupt from a given AR. To investigate AR magnetic properties that favor CMEs production, we employ multi-spacecraft data to analyze a long duration AR (NOAA 11089, 11100, 11106, 11112 and 11121) throughout its complete lifetime, spanning five Carrington rotations from July to November 2010. We use data from the Solar Dynamics Observatory to study the evolution of the AR magnetic properties during the five near-side passages, and a proxy to follow the magnetic flux changes when no magnetograms are available, i.e. during far-side transits. The ejectivity is studied by characterizing the angular widths, speeds and masses of 108 CMEs that we associated to the AR, when examining a 124-day period. Such an ejectivity tracking was possible thanks to the multi-viewpoint images provided by the Solar-Terrestrial Relations Observatory and Solar and Heliospheric Observatory in a quasi-quadrature configuration. We also inspected the X-ray flares registered by the GOES satellite and found 162 to be associated to the AR under study. Given the substantial number of ejections studied, we use a statistical approach instead of a single-event analysis. We found three well defined periods of very high CMEs activity and two periods with no mass ejections that are preceded or accompanied by characteristic changes in the AR magnetic flux, free magnetic energy and/or presence of electric currents. Our large sample of CMEs and long term study of a single AR, provide further evidence relating AR magnetic activity to CME and Flare production.Fil: Iglesias, Francisco Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina. Universidad Tecnológica Nacional. Facultad Regional de Mendoza; ArgentinaFil: Cremades Fernandez, Maria Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina. Universidad Tecnológica Nacional. Facultad Regional de Mendoza; ArgentinaFil: Merenda, Luciano A.. Universidad Tecnológica Nacional. Facultad Regional de Mendoza; ArgentinaFil: Mandrini, Cristina Hemilse. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Lopez Fuentes, Marcelo Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Lopez Fuentes, Marcelo Claudio. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Ugarte Urra, Ignacio. Spece Sciences División. Naval Research Laboratory; Estados Unido

A near-infrared study of the multi-phase outflow in the type-2 quasar J1509+0434

Based on new near-infrared spectroscopic data from the instrument EMIR on the 10.4 m Gran Telescopio Canarias (GTC) we report the presence of an ionized and warm molecular outflow in the luminous type-2 quasar J150904.22+043441.8 (z = 0.1118). The ionized outflow is faster than its molecular counterpart, although the outflow sizes that we derive for them are consistent within the errors (1.34±0.18 kpc and 1.46±0.20 kpc respectively). We use these radii, the broad emission-line luminosities and in the case of the ionized outflow, the density calculated from the trans-auroral [OII] and [SII] lines, to derive mass outflow rates and kinetic coupling efficiencies. Whilst the ionized and warm molecular outflows represent a small fraction of the AGN power (≤0.033% and 0.0001% of Lbol respectively), the total molecular outflow, whose mass is estimated from an assumed warm-to-cold gas mass ratio of 6× 10−5, has a kinetic coupling efficiency of ∼1.7%Lbol. Despite the large uncertainty, this molecular outflow represents a significant fraction of Lbol and it could potentially have a significant impact on the host galaxy. In addition, the quasar spectrum reveals bright and patchy narrow Paα emission extending out to 4″ (8 kpc) South-East and North-West from the active nucleus.Includes Horizon 202

The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance

Adaptive immune responses depend on the capacity of T cells to target specific antigens. As similar antigens can be expressed by pathogens and host cells, the question naturally arises of how can T cells discriminate friends from foes. In this work, we suggest that T cells tolerate cells whose proliferation rates remain below a permitted threshold. Our proposal relies on well-established facts about T-cell dynamics during acute infections: T-cell populations are elastic (they expand and contract) and they display inertia (contraction is delayed relative to antigen removal). By modelling inertia and elasticity, we show that tolerance to slow-growing populations can emerge as a population-scale feature of T cells. This result suggests a theoretical framework to understand immune tolerance that goes beyond the self versus non-self dichotomy.M.A.H. has been partially supported by MINECO grant no. MTM2014-53156. The rest of the authors have not received any particular financial support for this work

Hydrogeologic controls on groundwater discharge and nitrogen loads in a coastal watershed

© The Author(s), 2016. This is the author's version of the work and is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Journal of Hydrology 538 (2016): 783–793, doi:10.1016/j.jhydrol.2016.05.013.Submarine groundwater discharge (SGD) is a small portion of the global water budget, but a potentially large contributor to coastal nutrient budgets due to high concentrations relative to stream discharge. A numerical groundwater flow model of the Inland Bays Watershed, Delaware, USA, was developed to identify the primary hydrogeologic factors that affect groundwater discharge rates and transit times to streams and bays. The distribution of groundwater discharge between streams and bays is sensitive to the depth of the water table below land surface. Higher recharge and reduced hydraulic conductivity raised the water table and increased discharge to streams relative to bays compared to the Reference case (in which 66% of recharge is discharged to streams). Increases to either factor decreased transit times for discharge to both streams and bays compared to the Reference case (in which mean transit times are 56.5 and 94.3 years, respectively), though sensitivity to recharge is greater. Groundwaterborne nitrogen loads were calculated from nitrogen concentrations measured in discharging fresh groundwater and modeled SGD rates. These loads combined with long SGD transit times suggest groundwater-borne nitrogen reductions and estuarine water quality improvements will lag decades behind implementation of efforts to manage nutrient sources. This work enhances understanding of the hydrogeologic controls on and uncertainties in absolute and relative rates and transit times of groundwater discharge to streams and bays in coastal watersheds.This work was funded by the National Science Foundation (EAR-0910756 and EAR- 0911805).2017-05-1

Iberian cured-ham consumption improves endothelial function in healthy subjects

Objectives: Previous studies have shown that dietary components such as oleic acid or polyphenols exert beneficial effects on endothelium. We aimed to assess the impact of regular consumption of Iberian cured-ham (ICH) on endothelial function. Design: An open-label, randomized controlled parallel study. Setting: Volunteers recruited through advertisements at a hospital in Madrid, Spain. Participants: 102 Caucasian adults (76.8% females) aged 25-55 years, and free from cardiometabolic disease. Intervention: Participants were randomized to an ICH-enriched ad libitum diet or an ad libitum diet without ICH for 6 weeks. Subjects in ICH group were randomly provided with either acorn- or mixed-fed ICH, and followed up for an additional 6-week period under their usual diet. Measurements: Clinical parameters, biomarkers of endothelial function and oxidative stress, microvascular vasodilatory response to hyperemia and arterial stiffness were measured before and after the intervention. Results: After 6 weeks, a larger decrease in PAI-1 was observed in subjects consuming ICH compared to the Control group (-6.2±17.7 vs. 0.3±1.4 ng/ml; p=0.020). Similarly, microvascular vasodilatory response to hyperemia showed a significant increase (112.4±391.7 vs. -56.0±327.9%; p=0.007). However, neither oxidative stress, hemodynamic nor clinical parameters differed significantly over the study. Additionally, after stopping ICH consumption, improvements in PAI-1 remained for 6 additional weeks with respect to baseline (p=0.006). Conclusion: The present study demonstrates, for the first time, that regular consumption of ICH improves endothelial function in healthy adults. Strategies aimed to preserve or improve the endothelial function may have implications in vascular aging beyond the prevention of the atherothrombotic disease

Muscle, functional and cognitive adaptations after flywheel resistance training in stroke patients : a pilot randomized controlled trial

Resistance exercise (RE) improves neuromuscular function and physical performance after stroke. Yet, the effects of RE emphasizing eccentric (ECC; lengthening) actions on muscle hypertrophy and cognitive function in stroke patients are currently unknown. Thus, this study explored the effects of ECC-overload RE training on skeletal muscle size and function, and cognitive performance in individuals with stroke. Thirty-two individuals with chronic stroke (≥6 months post-stroke) were randomly assigned into a training group (TG; n = 16) performing ECC-overload flywheel RE of the more-affected lower limb (12 weeks, 2 times/week; 4 sets of 7 maximal closed-chain knee extensions; <2 min of contractile activity per session) or a control group (CG; n = 16), maintaining daily routines. Before and after the intervention, quadriceps femoris volume, maximal force and power for each leg were assessed, and functional and dual task performance, and cognitive functions were measured. Quadriceps femoris volume of the more-affected leg increased by 9.4 % in TG. Muscle power of the more-affected, trained (48.2 %), and the less-affected, untrained limb (28.1 %) increased after training. TG showed enhanced balance (8.9 %), gait performance (10.6 %), dual-task performance, executive functions (working memory, verbal fluency tasks), attention, and speed of information processing. CG showed no changes. ECC-overload flywheel resistance exercise comprising 4 min of contractile activity per week offers a powerful aid to regain muscle mass and function, and functional performance in individuals with stroke. While the current intervention improved cognitive functions, the cause-effect relationship, if any, with the concomitant neuromuscular adaptations remains to be explored. Clinical Trial

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart

This is the final version. It was first published by Wiley in The Journal of Physiology at http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.275263/abstract.Hypoxic exposure is associated with impaired cardiac energetics in humans and altered mitochondrial function, with suppressed complex I-supported respiration, in rat heart. This response might limit reactive oxygen species (ROS) generation, but at the cost of impaired electron transport chain (ETC) activity. Dietary nitrate supplementation improves mitochondrial efficiency and can promote tissue oxygenation by enhancing blood flow. We therefore hypothesised that ETC dysfunction, impaired energetics and oxidative damage in the hearts of rats exposed to chronic hypoxia could be alleviated by sustained administration of a moderate dose of dietary nitrate. Male Wistar rats (n=40) were given water supplemented with 0.7 mmol/L NaCl (as control) or 0.7 mmol/L NaNO3, elevating plasma nitrate levels by 80%, and were exposed to 13% O2 (hypoxia) or normoxia (n=10 per group) for 14 days. Respiration rates, ETC protein levels, mitochondrial density, ATP content and protein carbonylation were measured in cardiac muscle. Complex I respiration rates and protein levels were 33% lower in hypoxic/NaCl rats compared with normoxic/NaCl controls. Protein carbonylation was 65% higher in hearts of hypoxic rats compared with controls, indicating increased oxidative stress, whilst ATP levels were 62% lower. Respiration rates, complex I protein and activity, protein carbonylation and ATP levels were all fully protected in the hearts of nitrate-supplemented hypoxic rats. Both in normoxia and hypoxia, dietary nitrate suppressed cardiac arginase expression and activity and markedly elevated cardiac L-arginine concentrations, unmasking a novel mechanism of action by which nitrate enhances tissue NO bioavailability. Dietary nitrate therefore alleviates metabolic abnormalities in the hypoxic heart, improving myocardial energetics

Plant diversity of a cattle field in the northwest of San Luis (Argentina)

En este trabajo se da a conocer la diversidad de la flora vascular del establecimiento privado "Lomas Blancas", situado en el noroeste de la provincia de San Luis, con mención de las familias y géneros representados, su status, como así también el número y riqueza de especies relevadas según el hábito y estado de conservación.This paper describes the composition of the vascular flora of the private establishment "Lomas Blancas", located in the northwestern of the San Luis province. Families and genera represented, their status, as well as the number and species richness surveyed according to the habit and conservation status are put forward.Fil: Carosio, Maria Cristina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Junqueras, Maria J.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Fernandez Belmonte, María Cecilia. Universidad Nacional de San Luis. Facultad de Ingeniería y Ciencias Económico Sociales. Departamento de Ciencias Agropecuarias; ArgentinaFil: Chiofalo, Sergio David. Universidad Nacional de San Luis. Facultad de Ingeniería y Ciencias Económico Sociales. Departamento de Ciencias Agropecuarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; ArgentinaFil: Manrique, Marcela A.. Universidad Nacional de San Luis. Facultad de Ingeniería y Ciencias Económico Sociales. Departamento de Ciencias Agropecuarias; Argentin

Rigid urea and self-healing thiourea ethanolamine monolayers

A series of long-tail alkyl ethanolamine analogs containing amide-, urea-, and thiourea moieties was synthesized and the behavior of the corresponding monolayers was assessed on the Langmuir–Pockels trough combined with grazing incidence X-ray diffraction experiments and complemented by computer simulations. All compounds form stable monolayers at the soft air/water interface. The phase behavior is dominated by strong intermolecular headgroup hydrogen bond networks. While the amide analog forms well-defined monolayer structures, the stronger hydrogen bonds in the urea analogs lead to the formation of small three-dimensional crystallites already during spreading due to concentration fluctuations. The hydrogen bonds in the thiourea case form a two-dimensional network, which ruptures temporarily during compression and is recovered in a self-healing process, while in the urea clusters the hydrogen bonds form a more planar framework with gliding planes keeping the structure intact during compression. Because the thiourea analogs are able to self-heal after rupture, such compounds could have interesting properties as tight, ordered, and self-healing monolayers