Modeling MIRV Footprint Constraints in the Weapons Assignment Model

US Strategic Command (USSTRATCOM) is developing a new linear programming model called the Weapons Assignment Model (WAM) to perform weapons assignment for the Strategic Integrated Operations Plan (SIOP). One of the major improvements WAM will have over its predecessor is the ability to include Multiple Independently Targetable Reentry Vehicle (MIRV) footprinting constraints in the optimization process. In order to include MIRV footprint constraints in WAM, a methodology is needed to model the MIRV footprints in a manner that is consistent with the limitations of linear programming. Two techniques for modeling MIRV footprints were developed. The first, Geometric Approximation (GA), uses a carefully positioned and sized ellipse on the earth\u27s surface to model the capabilities of a Post Boost Vehicle (PBV) to disperse MIRVs. Any combination of targets within the ellipse is considered to constitute a feasible targeting plan for a missile. The second model is called Energy Space Transformation (EST). This model scales the distance each MIRV is displaced from the missile aimpoint to account for the PBV energy required to maneuver for each MIRV. The sum of the maneuvering energy for each MIRV is used to calculate the fraction of the PBV energy required to strike a particular combination of targets. Any combination where the fraction is less than one is considered feasible. These two models were tested and verified using 120 missile sorties. Both models were approximately 85 percent accurate

DNA methylation dynamics during oocyte and embryo development and its association with environmental induced alterations

Abstract Epigenetic mechanisms are fundamental to successful gametogenesis and development. The fertilized egg undergoes global DNA demethylation to facilitate remodelling from two differentiated gametespecific states to a pluripotent embryonic state. Maintenance of appropriate levels of DNA methylation during preimplantation development is essential to embryo viability. Recent advances in epigenetic research have highlighted the susceptibility of foetal epigenetic programming to maternal health and nutritional status, particularly, at the time of conception. There is much evidence that maternal stress impacts on ovarian function, leading to compromised oocytes presented for fertilization in a suboptimal environment. Similarly, declining fertility has become a substantive issue in western countries, where it is primarily associated with high mean ages at childbearing. Thus the use of assisted reproduction technologies (ART) interventions to overcome low fertility is increasing steadily across the globe. In addition, the use of prolonged in vitro culture following the removal and storage of oocytes and/or ovarian tissue in advance of cancer treatment, or to circumvent ovarian aging, is increasing rapidly. ART is associated with compromised pre and post -natal outcomes, including premature birth, low birth weight, congenital abnormalities and elevated risk of epigenetic disorders. There is extensive evidence from studies in cattle that embryos produced by conventional ART protocols are susceptible to errors in epigenetic programming. The present review discusses the impact of intrinsic physiological status and external environments on oocyte and embryo DNA methylation with regard to data available from mouse, human and bovine models

ADCP Observations of Currents and Suspended Sediment in the Macrotidal Gulf of Martaban, Myanmar

The Ayeyarwady and Thanlwin Rivers, which drain Myanmar, together form one of the largest point sources of freshwater and sediment to the global ocean. Combined, these rivers annually deliver an estimated 485 Mt of sediment to the northern Andaman Sea. This sediment contributes to a perennially muddy zone within the macro-tidal Gulf of Martaban, but little is known about the processes that dominate dispersal and trapping of sediment there, as very few water column observations are available. A research cruise in December 2017 provided a rare opportunity to obtain Acoustic Doppler Current Profiler (ADCP) data along transects from the Gulf of Martaban and adjacent continental shelf. Two transects were obtained from the outer portion of the Gulf of Martaban in water depths that ranged from about 20–35 m. These showed very fast currents, especially during flood tide conditions, exceeding 1.5 m/s. The backscatter record from the ADCP indicated asymmetries in distribution of suspended sediment during the ebb versus flood phase of the tide. During ebb tidal conditions, the backscatter record indicated that sediment was transported in either a surface advected layer, or fairly well-mixed throughout the water column. In contrast, during flood tidal conditions, sediment was confined to the bottom boundary layer, even though the velocities were faster during flood than the ebb conditions. The vertical structure of the currents during flood tide conditions indicated the presence of sediment–induced stratification because currents within the near-bed turbid layers were relatively slow, but speeds increased markedly above these layers. This albeit limited dataset provides an exciting glimpse into the dynamics of sediment transport within the muddy, macrotidal Gulf of Martaban, and implies the importance of tidal straining and bottom nepheloid layer formation there

The ontology of causal process theories

There is a widespread belief that the so-called process theories of causation developed by Wesley Salmon and Phil Dowe have given us an original account of what causation really is. In this paper, I show that this is a misconception. The notion of "causal process" does not offer us a new ontological account of causation. I make this argument by explicating the implicit ontological commitments in Salmon and Dowe's theories. From this, it is clear that Salmon's Mark Transmission Theory collapses to a counterfactual theory of causation, while the Conserved Quantity Theory collapses to David Fair's phsyicalist reduction of causation

Genetic merit for fertility traits in Holstein cows: VI. Oocyte developmental competence and embryo development

peer-reviewedThe hypothesis of this study was that cows with good genetic merit for fertility traits (Fert+) would produce oocytes and embryos of greater quality than cows with poor genetic merit for fertility traits (Fert−) and that mRNA expression of candidate genes would reflect the observed differences in quality. The aim of the study, therefore, was to determine the effect of genetic merit for fertility traits on morphological classification and mRNA abundance of key genes in immature oocytes and cumulus cells following ovum pick-up and in embryos following superovulation, artificial insemination (AI), and uterine flushing. In experiment 1, 17 Fert+ and 11 Fert− cows, ranging from 54 to 84 d in milk, were submitted to ovum pick-up on 4 occasions during a 2-wk period. Recovered cumulus–oocyte complexes (COC) were morphologically graded. Oocytes and cumulus cells were separated, and mRNA abundance of genes associated with oocyte developmental competence was measured. There was no effect of genotype on the distribution of COC grades or on the mRNA abundance of the candidate genes in grade 1 COC. In experiment 2, 20 Fert+ and 19 Fert− cows, ranging from 71 to 189 d in milk, were submitted to superovulation and AI. The uteri of cows that responded to the superovulation protocol (17 Fert+ and 16 Fert− cows) were nonsurgically flushed 7 d postovulation. Recovered embryos were morphologically graded, and mRNA abundance of genes associated with embryo development was measured in grade 1 blastocysts. The response to the superovulation protocol was assessed by counting the number of codominant follicles on the day of AI, which was similar for both genotypes (22.0 ± 9.7 and 19.8 ± 8.2 for Fert+ and Fert− cows, respectively). There was no effect of genotype on the proportion of transferable embryos recovered or on the mRNA abundance of the candidate genes tested in the grade 1 blastocysts. Of the total embryos classified as blastocysts, however, the Fert+ cows tended to have a greater proportion of grade 1 blastocysts compared with Fert− cows (90% vs. 64%, respectively). In conclusion, genetic merit for fertility traits had a no effect on mRNA abundance of the candidate genes that were examined in immature oocytes and cumulus cells and in embryos recovered after superovulation. The observed differences in morphological blastocyst quality following superovulation would suggest that the superior reproductive performance of Fert+ cows could arise during the later stages of embryo development from d 7 until maternal recognition of pregnancy

Fluency Assistance Device (FAD): Masker Upgrades

There are around seventy million people internationally who have a stutter, a form of fluency disorder. Some fluency assistance devices are available to the public, but most are highly expensive or unreliable. The Fluency Assistive Device (FAD) team seeks to assist a niche community of these individuals for whom therapy has not worked, and who currently rely on a device known as the Edinburgh Masker. To best reach this community, FAD is partnering with Dave Germeyer, who has invaluable experience repairing these masker devices for his clientele. FAD is redesigning the masker to increase its portability, functionality, and cost-effectiveness by developing an improved analog and new digital version. The Analog Masker v1.3 focuses on updated components and consolidated circuitry to eliminate troublesome wiring of the original. The Digital Masker v1.0 employs a Bluetooth-enabled microcontroller to achieve masker functionality, offering the flexibility of alternative fluency assistance algorithms to assist a broader group of users. An updated prototype of the Analog Masker v1.3 was fabricated and tested for power consumption and overall functional output characteristics versus the original Edinburgh version. The Analog Masker v1.3 has also been fully packaged and enclosed to produce a client testable unit. Bluetooth audio output for the Digital Masker has almost been completed, and two of the alternative algorithms have been coded for the masking output. One of these algorithms, Delayed Altered Feedback (DAF), now produces the expected output in response to an audio test input. Clarity and integrity of the DAF signal output have also been improved. The Masking Altered Feedback (MAF) algorithm that emulates the behavior of the Edinburgh original on the Digital Masker v1.0 is under development. Funding for this work provided by The Collaboratory for Strategic Partnerships and Applied Research.https://mosaic.messiah.edu/engr2022/1006/thumbnail.jp

Practice characteristics of Emergency Department extracorporeal cardiopulmonary resuscitation (eCPR) programs in the United States: The current state of the art of Emergency Department extracorporeal membrane oxygenation (ED ECMO).

PURPOSE: To characterize the current scope and practices of centers performing extracorporeal cardiopulmonary resuscitation (eCPR) on the undifferentiated patient with cardiac arrest in the emergency department. METHODS: We contacted all US centers in January 2016 that had submitted adult eCPR cases to the Extracorporeal Life Support Organization (ELSO) registry and surveyed them, querying for programs that had performed eCPR in the Emergency Department (ED ECMO). Our objective was to characterize the following domains of ED ECMO practice: program characteristics, patient selection, devices and techniques, and personnel. RESULTS: Among 99 centers queried, 70 responded. Among these, 36 centers performed ED ECMO. Nearly 93% of programs are based at academic/teaching hospitals. 65% of programs are less than 5 years old, and 60% of programs perform ≤3 cases per year. Most programs (90%) had inpatient eCPR or salvage ECMO programs prior to starting ED ECMO programs. The majority of programs do not have formal inclusion and exclusion criteria. Most programs preferentially obtain vascular access via the percutaneous route (70%) and many (40%) use mechanical CPR during cannulation. The most commonly used console is the Maquet Rotaflow(®). Cannulation is most often performed by cardiothoracic (CT) surgery, and nearly all programs (\u3e85%) involve CT surgeons, perfusionists, and pharmacists. CONCLUSIONS: Over a third of centers that submitted adult eCPR cases to ELSO have performed ED ECMO. These programs are largely based at academic hospitals, new, and have low volumes. They do not have many formal inclusion or exclusion criteria, and devices and techniques are variable

Real-time motion analytics during brain MRI improve data quality and reduce costs

Head motion systematically distorts clinical and research MRI data. Motion artifacts have biased findings from many structural and functional brain MRI studies. An effective way to remove motion artifacts is to exclude MRI data frames affected by head motion. However, such post-hoc frame censoring can lead to data loss rates of 50% or more in our pediatric patient cohorts. Hence, many scanner operators collect additional 'buffer data', an expensive practice that, by itself, does not guarantee sufficient high-quality MRI data for a given participant. Therefore, we developed an easy-to-setup, easy-to-use Framewise Integrated Real-time MRI Monitoring (FIRMM) software suite that provides scanner operators with head motion analytics in real-time, allowing them to scan each subject until the desired amount of low-movement data has been collected. Our analyses show that using FIRMM to identify the ideal scan time for each person can reduce total brain MRI scan times and associated costs by 50% or more