A descriptive model of the offence chain for imprisoned adult male firesetters (descriptive model of adult male firesetting)

Purpose: Firesetting has devastating consequences. Although some theoretical efforts have been made to explain firesetting (i.e., a small number of multi- and single-factor theories), little effort has been devoted to understand how deliberate firesetting unfolds across time (i.e., micro or offence chain theories). This research aimed to produce the first descriptive offence chain theory for incarcerated adult male firesetters.Methods: Thirty-eight adult male firesetters—recruited from prison establishments in England and Wales—were interviewed about the events, thoughts and feelings leading up to, surrounding, and immediately following a deliberate incident of firesetting. Results: Using Grounded Theory analysis, the Descriptive Model of Adult male Firesetting (DMAF) was developed documenting the cognitive, behavioural, affective and contextual factors leading to a single incident of deliberate firesetting. Conclusions: New information generated from the DMAF is presented and its contributions to the current evidence base are highlighted. Clinical implications, limitations and future research directions are also discussed

A Social Security Forecasting and Simulation Model

This paper presents and validates a multiregional neoclassical economic- demographic growth model developed by the IIASA Social Security Reform Project. This model is intended to study linkages between population age distribution, the macroeconomy, the nature of pension arrangements, the intergenerational distribution of income and wealth, and international capital flows. In this paper, we concentrate on the model in single-region form, showing that: (i) reasonable exogenous assumptions give rise to a reasonable long-run model solution; (ii) when exogenous assumptions or model parameters are changed, the model performs sensibly on a baseline-vs.-alternative basis; and (iii) model projection results are reasonably robust to selection of demographic scenario and exogenous assumptions regarding household saving and labor supply; they are sensitive, however, to the selection of the parameters of the core production function

New resource axes for deposit feeders?

Recent work on selectivity in deposit feeders has focused on the importance of particle size. In field experiments with exotic sediments of known characteristics (glass beads), we demonstrate that selective ingestion in a multitentaculate, surface deposit feeding ampharetid polychaete depends upon particle specific gravities and surface textures. The degree of selectivity for specific gravity is shown to be dependent upon worm size...

Neurocognitive and neurophysiological endophenotypes in Schizophrenia: an overview

Schizophrenia (SCZ) is a severe psychotic disorder that affects up to 1% of the US population and it is associated with progressive impairment in social functioning and cognition. Nonetheless, despite its high burden, the pathophysiology of SCZ, including the genetic and biological mechanisms underlying the development and manifestation of the disorder, remains largely elusive. Endophenotypes are subtypes of biological markers that are more closely related to the genetic vulnerability for a disorder (e.g., SCZ). Recently, research on endophenotypes has identified several parameters that may prove useful in shedding light over the underlying neurobiology of SCZ. In this article, we provide an overview of the most established SCZ endophenotypes in the domains of neurocognition (attention deficits, working and verbal declarative memory dysfunctions) and neurophysiology (pre-pulse inhibition, anti-saccade impairment, event-related potential deficits) along with some novel, sleep-based measures (reduced sleep spindles and sleep slow waves). We also discuss recent conceptual advances in the field that may lead to novel, personalized treatment interventions for patients affected by this devastating mental illness

Signature of small rings in the Raman spectra of normal and compressed amorphous silica: A combined classical and ab initio study

We calculate the parallel (VV) and perpendicular (VH) polarized Raman spectra of amorphous silica. Model SiO2 glasses, uncompressed and compressed, were generated by a combination of classical and ab initio molecular-dynamics simulations and their dynamical matrices were computed within the framework of the density functional theory. The Raman scattering intensities were determined using the bond-polarizability model and a good agreement with experimental spectra was found. We confirm that the modes associated to the fourfold and threefold rings produce most of the Raman intensity of the D1 and D2 peaks, respectively, in the VV Raman spectra. Modifications of the Raman spectra upon compression are found to be in agreement with experimental data. We show that the modes associated to the fourfold rings still exist upon compression but do not produce a strong Raman intensity, whereas the ones associated to the threefold rings do. This result strongly suggests that the area under the D1 and D2 peaks is not directly proportional to the concentration of small rings in amorphous SiO2.Comment: 21 pages, 8 figures. Phys. Rev. B, in pres

Randall's plaque: Pathogenesis and role in calcium oxalate nephrolithiasis

The purpose of these studies was to test the hypothesis that Randall's plaque develops in unique anatomical sites of the kidney and their formation is conditioned by specific stone-forming pathophysiologies. We performed intraoperative papillary biopsies from kidneys of idiopathic-calcium oxalate (CaOx), intestinal bypass for obesity, brushite (BR) and cystine stone formers (SF) during percutaneous nephrolithotomy. Tissues were examined by infrared analysis and light and electron microscopy. Our analysis revealed a distinct pattern of mineral deposition and papillary pathology for each type of SF. CaOx SF had interstitial apatite crystals beginning at thin loops of Henle. These deposits termed Randall's plaque are thought to serve as sites for stone attachment. No tubular injury was noted. Intestinal bypass patients possessed intraluminal apatite deposits in inner medullary collecting ducts (IMCD) with associated cell injury. BR SF showed the most severe form of cortical and medullary changes with sites of Randall's plaque, and yellowish intraluminal deposits of apatite in IMCD. Cystine SF had plugging of ducts of Bellini with cystine crystals and apatite deposits in IMCD and loops of Henle. Intratubular sites of crystalline deposits were always associated to adjacent regions of interstitial fibrosis. The metabolic, anatomic, and surgical pathologic findings in four distinct groups of SF clearly show that ‘the histology of the renal papilla from a stone former, is particular to the clinical setting’. We believe our approach to studying stone disease will provide insights into the pathogenesis of stone formation for each type of SF that will lead to improved clinical treatment

First evidence of contourite drifts in the north-western sicilian active continental margin (Southern tyrrhenian sea)

We present the results of an integrated geomorphological and seismo-stratigraphic study based on high resolution marine data acquired in the north-western Sicilian continental margin. We document for the first time five contourite drifts (marked as EM1a, EM2b, EM2, EM3a, and EM3b), located in the continental slope at depths between ca. 400 and 1500 m. EM1a,b have been interpreted as elongated mounded drifts. EM1a,b are ca. 3 km long, 1.3 km wide, and have a maximum thickness of 36 m in their center that thins northwards, while EM1b is smaller with a thickness up to 24 m. They are internally characterized by mounded seismic packages dominated by continuous and parallel reflectors. EM2 is located in the upper slope at a depth of ca. 1470 m, and it is ca. 9.3 km long, more than 3.9 km wide, and has a maximum thickness of ca. 65 m. It consists of an internal aggradational stacking pattern with elongated mounded packages of continuous, moderate to high amplitude seismic reflectors. EM2 is internally composed by a mix of contourite deposits (Holocene) interbedded with turbiditic and/or mass flow deposits. EM1a,b and EM2 are deposited at the top of an erosional truncation aged at 11.5 ka, so they mostly formed during the Holocene. EM3a,b are ca. 16 km long, more than 6.7 km wide, and have a thickness up to 350 m. Both EM2 and EM3a,b have been interpreted as sheeted drift due to their morphology and seismic features. The spatial distribution of the contourite drifts suggests that the drifts are likely generated by the interaction of the LIW, and deep Tyrrhenian water (TDW) on the seafloor, playing an important role in the shaping this continental margin since the late Pleistocene-Holocene. The results may help to understand the deep oceanic processes affecting the north-western Sicilian continental margin

Removing data and using metafounders alleviates biases for all traits in Lacaune dairy sheep predictions

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Resistance Exercise Improves Metabolic Parameters And Changes Adipocyte-derived Leptin: A Comparison Between Genders In Untrained Adults

This study examined gender differences after resistance exercise (RE) by measuring fasting plasma levels of creatine kinase, lipid profile, blood glucose, adiponectin, tumor necrosis factor alpha (TNF-α), and leptin. Thirteen women (23.6 ± 7.3 years) and 11 men (29.5 ± 9 years) were enrolled in the study. Two bouts of RE were performed on two different occasions separated by 48 h each. Blood samples were collected and analyzed at baseline and 15 h after the last RE session. Increased creatine kinase levels and improvements in lipid profile and blood glucose were found for both genders. No changes in adiponectin and TNF-α levels were observed for both genders, but leptin levels were reduced (p < 0.05) only for women after RE. Collectively, our findings clearly show that RE was effective in lowering blood glucose and that this effect was not accompanied by changes in adiponectin levels in healthy subjects, indicating that RE is still an important tool for the prevention of metabolic diseases. Furthermore, two sessions of RE promoted a reduction in leptin levels in women, even though no changes in body weight were found, showing that RE is an interesting approach to study obese patients and metabolic regulation.22321722