On normalisation

Using a characterisation of strongly normalising $lambda$-terms, we give new and simple proofs of the following: all developments and superdevelopments are finite, a certain rewrite strategy is perpetual, a certain rewrite strategy is maximal and thus perpetual, simply typed $lambda$-calculus is strongly normalising

On normalisation

Using a characterisation of strongly normalising $lambda$-terms, we give new and simple proofs of the following: all developments and superdevelopments are finite, a certain rewrite strategy is perpetual, a certain rewrite strategy is maximal and thus perpetual, simply typed $lambda$-calculus is strongly normalising

Volcanic synchronization of Dome Fuji and Dome C Antarctic deep ice cores over the past 216 kyr

Abstract. Two deep ice cores, Dome Fuji (DF) and EPICA Dome C (EDC), drilled at remote dome summits in Antarctica, were synchronized to better understand their chronology. A total of 1401 volcanic tie points were identified covering the past 216 kyr. DFO2006, the chronology for the DF core characterized by strong constraining by the O2/N2 age markers, was compared with AICC2012, the chronology for 5 cores including the EDC core, and characterized by glaciological approaches combining ice flow modelling with various age markers. The age gaps between the two chronologies are within 2 kyr, except at Marine Isotope Stage (MIS) 5. DFO2006 gives ages older than AICC2012, with peak values of the gap of 4.5 and 3.1 kyr at MIS 5d and MIS 5b, respectively. Accordingly, ratios of duration DFO2006/AICC2012 are 85% at a period from the late stage of MIS 6 to MIS 5d and 114% at a period from MIS 5d to 5b. We then compared the DFO2006 with another chronology of the DF core, DFGT2006, characterized by glaciological approaches with weaker constraining by age markers. Features of the DFO2006/DFGT2006 age gaps are very similar to those of the DFO2006/AICC2012 age gaps. This fact lead us to hypothesize that a cause of the systematic DFO2006/AICC2012 age gaps at MIS 5 are associated with differences in the dating approaches. Besides, ages of speleothem records from China agreed well with DFO2006 at MIS 5c and 5d but not at MIS 5b. Thus, we hypothesize at least at MIS 5c and 5d, major sources of the gaps are systematic errors in surface mass balance estimation in the glaciological approach. Compatibility of the age markers should be carefully assessed in future. This work is a contribution to the European Project for Ice Coring in Antarctica (EPICA), a joint European Science Foundation/European Commission scientific program, funded by the European Union and by national contributions from Belgium, Denmark, France, Germany, Italy, the Netherlands, Norway, Sweden, Switzerland and the United Kingdom. This study was supported in part by a Grant-in-Aid for Scientific Research (A) (20241007) from the Japan Society for the Promotion of Science (JSPS).This is the final version of the article. It first appeared from Copernicus Publications via http://dx.doi.org/10.5194/cpd-11-407-201

Myelodysplastic syndromes: the pediatric point of view.

Myelodysplastic syndromes (MDS) are clonal disorders of the multipotent hematopoietic stem cell characterized by ineffective hematopoiesis and associated with marrow hypercellularity, increased intramedullary cell death and peripheral cytopenias of varying severity. Patients with myelodysplasia have a propensity (20% to 30% of cases) to undergo transformation into acute myeloid leakemia (AML), and a large body of evidence indicates that MDS represent steps in the multiphasic evolution of AML. Progression of the disease is characterized by expansion of the abnormal clone and inhibition of normal hematopoiesis leading to deterioration of the blood cell count and/or development of AML. MDS are relatively unusual in childhood, representing only 3% of pediatric hematological malignancies, although it has been reported that up to 17% of pediatric AML cases may have a previous myelodysplastic phase. The first systematic attempt at morphological classification of MDS was provided by the French-American-British (FAB) group. However, the FAB classification of MDS is only partially applicable in children. Some variants are extremely rare or absent (refractory anemia with ring sideroblasts and chronic myelomonocytic leukemia), and other peculiar pediatric disorders, represented by juvenile chronic myelogenous leukemia (JCML) and the monosomy 7 syndrome, are not included. Moreover, since there is a partial overlap between pediatric MDS and myeloproliferative disorders and the variants occurring in young children have rather specific features, some confusion still surrounds the nosographical definition of childhood MDS, so that none of the proposed classifications are widely accepted and used. Characteristically, some genetic conditions such as Fanconi's anemia, Shwachman's and Down's syndromes predispose to the development of MDS in childhood. The most common variants of childhood MDS are represented by JCML and the monosomy 7 syndrome, both disorders typically occurring in young children. JCML is characterized by a spontaneous growth of granulocyte-macrophage progenitors that show a striking hypersensitivity to granulocyte-macrophage colony-stimulating factor. Clinical presentation resembles that of some myeloproliferative disorders, with massive organomegaly usually not observed in the classically reported variants of MDS. Clinical features of the monosomy 7 syndrome resemble those observed in JCML and a differential diagnosis between these two entities relies upon the higher percentage of fetal hemoglobin, the more pronounced decrease in platelet count and, in some cases, the lack of the peculiar cytogenetic abnormality in the latter. With the number of children being cured of cancer constantly rising, a significant increase in secondary or chemotherapy-related myelodysplasia is being observed, and these disorders represent a formidable challenge for pediatric hematologists due to their poor response to chemotherapy. As a matter of fact, owing to their biological heterogeneity and aggressive clinical course in childhood, all MDS variants pose serious difficulties for successful management. If a compatible donor is available, allogeneic bone marrow transplantation (BMT) becomes the treatment of choice and should be performed during the early stages of the disease. Supportive therapy, differentiative treatments and low-dose chemotherapy, while valuable alternative therapeutic options in adults, have limited application in pediatric patients. The role of intensive chemotherapy and autologous BMT has not yet been clearly defined, and the use of hematopoietic growth factors does not seem to have a significant influence on the natural history of the disease. In the future, new insights into the events leading to progressive genetic changes in the clonal population and into the molecular basis of these genetic lesions could result in interesting new therapeutic approaches directed either at the oncogenes involved in the pathogenesis of the disease, or at the cytokines and/or their receptors causing the abnormal differentiation and proliferation of the myelodysplastic clone

Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas

The bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin. Consequently, preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular, histological and pathophysiological features. Intraepithelial neoplasms are reported in biliary tract, as biliary intraepithelial neoplasm (BilIN), and in pancreas, as pancreatic intraepithelial neoplasm (PanIN). Both can evolve to invasive carcinomas, respectively cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC). Intraductal papillary neoplasms arise in biliary tract and pancreas. Intraductal papillary neoplasm of the biliary tract (IPNB) share common histologic and phenotypic features such as pancreatobiliary, gastric, intestinal and oncocytic types, and biological behavior with the pancreatic counterpart, the intraductal papillary mucinous neoplasm of the pancreas (IPMN). All these neoplastic lesions exhibit similar immunohistochemical phenotypes, suggesting a common carcinogenic process. Indeed, CCA and PDAC display similar clinic-pathological features as growth pattern, poor response to conventional chemotherapy and radiotherapy and, as a consequence, an unfavorable prognosis. The objective of this review is to discuss similarities and differences between the neoplastic lesions of the pancreas and biliary tract with potential implications on a common origin from similar stem/progenitor cells

Volcanic synchronization of Dome Fuji and Dome C Antarctic deep ice cores over the past 216 kyr

第6回極域科学シンポジウム[OM] 極域気水圏11月16日（月）　国立極地研究所１階交流アトリウ

Employment of an auto-regressive model for knock detection supported by 1D and 3D analyses

In this work, experimental data, carried out on a twin-cylinder turbocharged engine at full load operations and referred to a spark advance of borderline knock, are used to characterize the effects of cyclic dispersion on knock phenomena. 200 consecutive incylinder pressure signals are processed through a refined Auto-Regressive Moving Average (ARMA) mathematical technique, adopted to define the percentage of knocking cycles, through a prefixed threshold level. The heuristic method used for the threshold selection is then verified by 1D and 3D analyses. In particular, a 1D model, properly accounting for cycle-by-cycle variations, and coupled to a reduced kinetic sub-model, is used to reproduce the measured cycles, in terms of statistical distribution of a theoretical knock index. In addition, few individual cycles, representative of the whole dataset, are selected in a single operating condition in order to perform a more detailed knock analysis by means of a 3D CFD approach, coupled to a tabulated chemistry technique for auto-ignition modeling. Outcomes of 1D and 3D models are compared to the ARMA results and a substantial coherence of the numerical and experimental results is demonstrated. The integrated 1D and 3D analyses can hence help in supporting the choice of the experimental threshold level for knock identification, following a more standardized theoretical approach

Volcanic synchronization of Dome Fuji and Dome C Antarctic deep ice cores over the past 216 kyr

Two deep ice cores, Dome Fuji (DF) and EPICA Dome C (EDC), drilled at remote dome summits in Antarctica, were volcanically synchronized to improve our understanding of their chronologies. Within the past 216 kyr, 1401 volcanic tie points have been identified. DFO2006 is the chronology for the DF core that strictly follows O2/N2 age constraints with interpolation using an ice flow model. AICC2012 is the chronology for five cores, including the EDC core, and is characterized by glaciological approaches combining ice flow modelling with various age markers. A precise comparison between the two chronologies was performed. The age differences between them are within 2 kyr, except at Marine Isotope Stage (MIS) 5. DFO2006 gives ages older than AICC2012, with peak values of 4.5 and 3.1 kyr at MIS 5d and MIS 5b, respectively. Accordingly, the ratios of duration (AICC2012/DFO2006) range between 1.4 at MIS 5e and 0.7 at MIS 5a. When making a comparison with accurately dated speleothem records, the age of DFO2006 agrees well at MIS 5d, while the age of AICC2012 agrees well at MIS 5b, supporting their accuracy at these stages. In addition, we found that glaciological approaches tend to give chronologies with younger ages and with longer durations than age markers suggest at MIS 5d-6. Therefore, we hypothesize that the causes of the DFO2006-AICC2012 age differences at MIS 5 are (i) overestimation in surface mass balance at around MIS 5d-6 in the glaciological approach and (ii) an error in one of the O2/N2 age constraints by ∼ 3 kyr at MIS 5b. Overall, we improved our knowledge of the timing and duration of climatic stages at MIS 5. This new understanding will be incorporated into the production of the next common age scale. Additionally, we found that the deuterium signals of ice, δDice, at DF tends to lead the one at EDC, with the DF lead being more pronounced during cold periods. The lead of DF is by +710 years (maximum) at MIS 5d, -230 years (minimum) at MIS 7a and +60 to +126 years on average

Treatment of perinfarction recurrent ventricular fibrillation by percutaneous pharmacological block of left stellate ganglion

A patient suffering from an acute myocardial infarction presented on the seventh and eighth days of hospitalization recurrent episodes of ventricular fibrillation refractory to antiarrhythmic treatment. The life-threatening ventricular fibrillation was suppressed by percutaneous pharmacological block of the left stellate ganglion