Changing patterns of child labor around the world since 1950 : the roles of income growth, parental literacy, and agriculture

Using country-level data, this report lays out the broad stylized facts regarding the relationship between child labor and per capita GDP, adult literacy, and the share of agriculture in the economy. The relationship between child labor force participation and per capita income is convex and stable over time. The implication is that as a country develops, child labor will decrease, but at a decreasing rate. At some point, further reductions in child labor may require more than just increasing per capita income. Child labor also is affected by the perceived return to child time in the labor market relative to child time in school. The strength of demand for child labor is highly correlated with the share of agriculture in the economy. Parental perception of the importance of education is highly correlated with the parents'own education. A 10 percent decrease in agriculture's share of GDP, decreases child labor by about 20 percent. A 10 percent decrease in adult illiteracy also decreases child labor by 20 percent. In Latin America, all three of these factors have contributed to decreases in child labor since 1950. Increases in per capita income have lowered the child labor participation rate by 2.9 percentage points. The reduction in adult illiteracy was responsible for a 4.2 percentage point reduction in child labor participation and reductions in agriculture's share of production, lowered child labor by an additional 1.2 percentage points. It is possible that income redistribution may lead to lower incidence of child labor, even if increases in average income will not. However, child labor is still found even at the upper end of the income distribution in Latin America. Consequently, income transfer programs alone will not eliminate child labor.

How does working as a child affect wage, income, and poverty asan adult?

The authors use a unique data set on adult earnings in Brazil to study how child labor affects adult earnings through its impacts on work experience, years of schooling, and human capital attained per year of schooling. Adding up these positive and negative effects, their empirical findings suggest that adults who entered the labor market before age 13 earn 20 percent less per hour, have 26 percent lower incomes, and are 14 percent more likely to be in the lowest two income quintiles. Overall, child labor raises the probability of being poor later in life by 13 percent to 31percent. These magnitudes are large. On the other hand, while child labor reduces the productivity of schooling, the net effect of an additional year of schooling on adult wages is still positive, even if the child works while in school. Consequently, policies which delay dropping out of school, even as the child works, appear to be effective at mitigating adult poverty. This report is a promising first step toward a better understanding of the theoretically ambiguous impact of early labor market entry on lifetime labor market outcomes and the dynastic poverty traps discussed below.

Combined SEM-FIB-SPM-TOF-EDX-EBSD as a Multifunctional Tool

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 - August 2, 201

Intronic determinants coordinate charme lncRNA nuclear activity through the interaction with MATR3 and PTBP1

Chromatin architect of muscle expression (Charme) is a muscle-restricted long noncoding RNA (lncRNA) that plays an important role in myogenesis. Earlier evidence indicates that the nuclear Charme isoform, named pCharme, acts on the chromatin by assisting the formation of chromatin domains where myogenic transcription occurs. By combining RNA antisense purification (RAP) with mass spectrometry and loss-of-function analyses, we have now identified the proteins that assist these chromatin activities. These proteins—which include a sub-set of splicing regulators, principally PTBP1 and the multifunctional RNA/DNA binding protein MATR3—bind to sequences located within the alternatively spliced intron-1 to form nuclear aggregates. Consistent with the functional importance of pCharme interactome in vivo, a targeted deletion of the intron-1 by a CRISPR-Cas9 approach in mouse causes the release of pCharme from the chromatin and results in cardiac defects similar to what was observed upon knockout of the full-length transcript

Commentary and Worked Examples to EN 1993-1-10 "Material Toughness and Through Thickness Properties" and Other Toughness Oriented Rules in EN 1993

This commentary gives explanations and worked examples to the design rules in Eurocode 3 that are influenced by the strength and toughness properties of the structural steels used. It is a commentary and background document to EN 1993-1-10 "Material toughness and through thickness properties" and its extension in EN 1993-1-12 "Design rules for high-strength steels", where toughness properties are explicitly addressed. It however provides also background to other parts of EN 1993, e.g. to EN 1993-1-1 "Design of steel structures - Basic rules and rules for buildings", where the design rules are related only to strength properties as the yield strength and the tensile strength without explicitly mentioning the role of toughness that is hidden behind the resistance formulae. Finally it gives some comments to chapter 6 of EN 1998-1: "Design of structures for earthquake resistance - Part 1: General rules, seismic actions and rules for buildings".JRC.G.5-European laboratory for structural assessmen

Effects of Cyclin Dependent Kinase 9 inhibition on zebrafish larvae

CDK9 is a known regulator of cellular transcription, growth and proliferation. Small molecule inhibitors are currently being developed and assessed in clinical trials as anti-cancer drugs. The zebrafish embryo provides an ideal model to explore the effects of CDK9 inhibition in-vivo. This has not been adequately explored previously at the level of a whole organism. We have compared and contrasted the effects of pharmacological and molecular inhibition of CDK9 on somatic growth, apoptosis and cellular proliferation in zebrafish larvae between 0 to 120 hours post fertilisation (hpf) using flavopiridol, a selective CDK9 antagonist, and CDK9-targeting morpholino. We demonstrate that the inhibition of CDK9 diminishes cellular proliferation and increases apoptosis. Subsequently, it affects somatic growth and development of a number of key embryonic structures including the brain, heart, eye and blood vessels. For the first time, we have localized CDK9 at a subcellular level in whole-mounted larvae. This works shows, at a high-throughput level, that CDK9 clearly plays a fundamental role in early cellular growth and proliferation

Design of floor structures for human induced vibrations

In recent years, the introduction of new structural materials and innovative construction processes, associated to architectural and space arrangement requirements, in multi-storey buildings construction have produced significantly more flexible floor structural systems. The design of these floor systems is usually controlled by serviceability criteria, deflections or vibrations. Recognizing a gap in the design codes, this report gives a procedure for the determination and assessment of floor response for human induced vibrations. First, the proposed procedure is presented, giving particular attention to the human induced loading characterization, dynamic properties and the comfort criteria for the verification of floor structural systems. Design charts are derived. Finally, it is presented a guidance manual to use the simplified procedure proposed for the design of building floors for human induced vibrations. Two worked examples of the proposed design procedure are given, namely a filigree slab with ACB-composite beams and a composite slab with steel beams.JRC.DG.G.5-European laboratory for structural assessmen

Impact of conditioning regimen on outcomes for children with acute myeloid leukemia undergoing transplantation in first complete remission. An analysis on behalf of the Pediatric Disease Working Party of the European Group for Blood and Marrow Transplantation

Hematopoietic stem cell transplantation (HSCT) represents the cornerstone of treatment in pediatric high-risk and relapsed acute myeloid leukemia (AML). The aim of the present study was to compare outcomes of pediatric patients with AML undergoing HSCT using 3 different conditioning regimens: total body irradiation (TBI) and cyclophosphamide (Cy); busulfan (Bu) and Cy; or Bu, Cy, and melphalan (Mel). In this retrospective study, registry data for patients > 2 and <18 years age undergoing matched allogeneic HSCT for AML in first complete remission (CR1) in 204 European Group for Blood and Marrow Transplantation centers between 2000 and 2010 were analyzed. Data were available for 631 patients; 458 patients received stem cells from a matched sibling donor and 173 from a matched unrelated donor. For 440 patients, bone marrow was used as stem cell source, and 191 patients received peripheral blood stem cells. One hundred nine patients received TBICy, 389 received BuCy, and 133 received BuCyMel as their preparatory regimen. Median follow-up was 55 months. Patients receiving BuCyMel showed a lower incidence of relapse at 5 years (14.7% versus 31.5% in BuCy versus 30% in TBICy, P < .01) and higher overall survival (OS) (76.6% versus 64% versus 64.5%, P = .04) and leukemia-free survival (LFS) (74.5% versus 58% versus 61.9%, P < .01), with a comparable nonrelapse mortality (NRM) (10.8% versus 10.5% versus 8.1%, P = .79). Acute graft-versus-host disease (GVHD) grades III and IV but not chronic GVHD, was higher in patients receiving BuCyMel. Older age at HSCT had an adverse impact on NRM and the use of peripheral blood as stem cell source was associated with increased chronic GVHD and NRM as well as lower LFS and OS. Among pediatric patients receiving HSCT for AML in CR1, the use of BuCyMel conditioning proved superior to TBICy and BuCy in reducing relapse and improving LFS