601 research outputs found
Determining Microscopic Viscoelasticity in Flexible and Semiflexible Polymer Networks from Thermal Fluctuations
We have developed a new technique to measure viscoelasticity in soft
materials such as polymer solutions, by monitoring thermal fluctuations of
embedded probe particles using laser interferometry in a microscope.
Interferometry allows us to obtain power spectra of fluctuating beads from 0.1
Hz to 20 kHz, and with sub-nanometer spatial resolution. Using linear response
theory, we determined the frequency-dependent loss and storage shear moduli up
to frequencies on the order of a kHz. Our technique measures local values of
the viscoelastic response, without actively straining the system, and is
especially suited to soft biopolymer networks. We studied semiflexible F-actin
solutions and, as a control, flexible polyacrylamide (PAAm) gels, the latter
close to their gelation threshold. With small particles, we could probe the
transition from macroscopic viscoelasticity to more complex microscopic
dynamics. In the macroscopic limit we find shear moduli at 0.1 Hz of G'=0.11
+/- 0.03 Pa and 0.17 +/- 0.07 Pa for 1 and 2 mg/ml actin solutions, close to
the onset of the elastic plateau, and scaling behavior consistent with G(omega)
as omega^(3/4) at higher frequencies. For polyacrylamide we measured plateau
moduli of 2.0, 24, 100 and 280 Pa for crosslinked gels of 2, 2.5, 3 and 5%
concentration (weight/volume) respectively, in agreement to within a factor of
two with values obtained from conventional rheology. We also found evidence for
scaling of G(omega) as \omega^(1/2), consistent with the predictions of the
Rouse model for flexible polymers.Comment: 16 pages, with 15 PostScript figures (to be published in
Macromolecules
VLT/SINFONI time-resolved spectroscopy of the central, luminous, H-rich WN stars of R136
Using the Very Large Telescope's Spectrograph for INtegral Field Observation
in the Near-Infrared (VLT/SINFONI), we have obtained repeated AO-assisted, NIR
spectroscopy of the six central luminous, Wolf-Rayet (WR) stars in the core of
the very young (~1 Myr), massive and dense cluster R136, in the Large
Magellanic Cloud (LMC). We also de-archived available images that were obtained
with the Hubble Space Telescope's Space Telescope Imaging Spectrograph
(HST/STIS), and extracted high-quality, differential photometry of our target
stars to check for any variability related to binary motion.
Previous studies, relying on spatially unresolved, integrated, optical
spectroscopy, had reported that one of these stars was likely to be a 4.377-day
binary. Our study set out to identify the culprit and any other short-period
system among our targets. However, none displays significant photometric
variability, and only one star, BAT99-112 (R136c), located on the outer fringe
of R136, displays a marginal variability in its radial velocities; we
tentatively report an 8.2-day period. The binary status of BAT99-112 is
supported by the fact that it is one of the brightest X-ray sources among all
known WR stars in the LMC, consistent with it being a colliding-wind system.
Follow-up observations have been proposed to confirm the orbital period of this
potentially very massive system.Comment: 9 pages, 6 figures; accepted for publication in MNRA
Collapse of a semiflexible polymer in poor solvent
We investigate the dynamics and the pathways of the collapse of a single,
semiflexible polymer in a poor solvent via 3-D Brownian Dynamics simulations.
Earlier work indicates that the condensation of semiflexible polymers
generically proceeds via a cascade through metastable racquet-shaped,
long-lived intermediates towards the stable torus state. We investigate the
rate of decay of uncollapsed states, analyze the preferential pathways of
condensation, and describe likelihood and lifespan of the different metastable
states. The simulation are performed with a bead-stiff spring model with
excluded volume interaction and exponentially decaying attractive potential.
The semiflexible chain collapse is studied as functions of the three relevant
length scales of the phenomenon, i.e., the total chain length , the
persistence length and the condensation length , where is a measure of the attractive potential per unit
length. Two dimensionless ratios, and , suffice to describe
the decay rate of uncollapsed states, which appears to scale as . The condensation sequence is described in terms of the time series
of the well separated energy levels associated with each metastable collapsed
state. The collapsed states are described quantitatively through the spatial
correlation of tangent vectors along the chain. We also compare the results
obtained with a locally inextensible bead-rod chain and with a phantom
bead-spring model. Finally, we show preliminary results on the effects of
steady shear flow on the kinetics of collapse.Comment: 9 pages, 8 figure
Two-point microrheology and the electrostatic analogy
The recent experiments of Crocker et al. suggest that microrheological
measurements obtained from the correlated fluctuations of widely-separatedprobe
particles determine the rheological properties of soft, complex materials more
accurately than do the more traditional particle autocorrelations. This
presents an interesting problem in viscoelastic dynamics. We develop an
important, simplifing analogy between the present viscoelastic problem and
classical electrostatics. Using this analogy and direct calculation we analyze
both the one and two particle correlations in a viscoelastic medium in order to
explain this observation
One- and two-particle microrheology
We study the dynamics of rigid spheres embedded in viscoelastic media and
address two questions of importance to microrheology. First we calculate the
complete response to an external force of a single bead in a homogeneous
elastic network viscously coupled to an incompressible fluid. From this
response function we find the frequency range where the standard assumptions of
microrheology are valid. Second we study fluctuations when embedded spheres
perturb the media around them and show that mutual fluctuations of two
separated spheres provide a more accurate determination of the complex shear
modulus than do the fluctuations of a single sphere.Comment: 4 pages, 1 figur
Capacity of Gaussian MIMO Bidirectional Broadcast Channels
We consider the broadcast phase of a three-node network, where a relay node
establishes a bidirectional communication between two nodes using a spectrally
efficient two-phase decode-and-forward protocol. In the first phase the two
nodes transmit their messages to the relay node. Then the relay node decodes
the messages and broadcasts a re-encoded composition of them in the second
phase. We consider Gaussian MIMO channels and determine the capacity region for
the second phase which we call the Gaussian MIMO bidirectional broadcast
channel.Comment: Proc. IEEE International Symposium on Information Theory (ISIT 2008),
Toronto, Canada, July 200
Comorbid conditions explain the association between posttraumatic stress disorder and incident cardiovascular disease
Background Posttraumatic stress disorder ( PTSD ) is associated with risk of cardiovascular disease ( CVD ). Biopsychosocial factors associated with PTSD likely account for some or all of this association. We determined whether 1, or a combination of comorbid conditions explained the association between PTSD and incident CVD . Methods and Results Eligible patients used 1 of 5 Veterans Health Affairs medical centers distributed across the United States. Data were obtained from electronic health records. At index date, 2519 Veterans Health Affairs ( VA ) patients, 30 to 70 years of age, had PTSD diagnoses and 1659 did not. Patients had no CVD diagnoses for 12 months before index date. Patients could enter the cohort between 2008 and 2012 with follow-up until 2015. Age-adjusted Cox proportional hazard models were computed before and after adjusting for comorbidities. Patients were middle aged (mean=50.1 years, SD ±11.0), mostly male (87.0%), and 60% were white. The age-adjusted association between PTSD and incident CVD was significant (hazard ratio=1.41; 95% CI : 1.21-1.63). After adjustment for metabolic conditions, the association between PTSD and incident CVD was attenuated but remained significant (hazard ratio=1.23; 95% CI : 1.06-1.44). After additional adjustment for smoking, sleep disorder, substance use disorder, anxiety disorders, and depression, PTSD was not associated with incident CVD (hazard ratio=0.96; 95% CI : 0.81-1.15). Conclusions PTSD is not an independent risk factor for CVD . Physical and psychiatric conditions and smoking that co-occur with PTSD explain why this patient population has an increased risk of CVD . Careful monitoring may limit exposure to CVD risk factors and subsequent incident CVD
Mixed Reality-Based Simulator for Training on Imageless Navigation Skills in Total Hip Replacement Procedures
Imageless navigation systems (INS) in orthopaedics have been used to improve the outcomes of several orthopaedic procedures such as total hip replacement [1, 2]. However, the increased surgical times and the associate learning curve discourage surgeons from using navigation systems in their theatres [2]. This paper presents a Mixed Reality (MR) simulator that helps surgeons acquire the infrared based navigation skills before performing it in reality. A group of 7 hip surgeons tried the application, expressing their satisfaction with all the features and confirmed that the simulator represents a cheaper and faster option to train surgeons in the use of INS than the current learning methods
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