661 research outputs found
Accuracy of a method based on atomic absorption spectrometry to determine inorganic arsenic in food : Outcome of the collaborative trial IMEP-41
Peer reviewedPublisher PD
Current oscillations in a metallic ring threaded by a time-dependent magnetic flux
We study a mesoscopic metallic ring threaded by a magnetic flux which varies
linearly in time PhiM(t)=Phi t with a formalism based in Baym-Kadanoff-Keldysh
non-equilibrium Green functions. We propose a method to calculate the Green
functions in real space and we consider an experimental setup to investigate
the dynamics of the ring by recourse to a transport experiment. This consists
in a single lead connecting the ring to a particle reservoir. We show that
different dynamical regimes are attained depending on the ratio hbar Phi/Phi0
W, being Phi0=h c/e and W, the bandwidth of the ring. For moderate lengths of
the ring, a stationary regime is achieved for hbar Phi/Phi0 >W. In the opposite
case with hbar Phi/Phi0 < W, the effect of Bloch oscillations driven by the
induced electric field manifests itself in the transport properties of the
system. In particular, we show that in this time-dependent regime a tunneling
current oscillating in time with a period tau=2piPhi0/Phi can be measured in
the lead. We also analyze the resistive effect introduced by inelastic
scattering due to the coupling to the external reservoir.Comment: 17 pages, 13 figure
Tuning a Resonance in the Fock Space: Optimization of Phonon Emission in a Resonant Tunneling Device
Phonon-assisted tunneling in a double barrier resonant tunneling device can
be seen as a resonance in the electron-phonon Fock space which is tuned by the
applied voltage. We show that the geometrical parameters can induce a symmetry
condition in this space that can strongly enhance the emission of longitudinal
optical phonons. For devices with thin emitter barriers this is achieved by a
wider collector's barrier.Comment: 4 pages, 3 figures. Figure 1 changed, typos correcte
Quantum transport and momentum conserving dephasing
We study numerically the influence of momentum-conserving dephasing on the
transport in a disordered chain of scatterers. Loss of phase memory is caused
by coupling the transport channels to dephasing reservoirs. In contrast to
previously used models, the dephasing reservoirs are linked to the transport
channels between the scatterers, and momentum conserving dephasing can be
investigated. Our setup provides a model for nanosystems exhibiting conductance
quantization at higher temperatures in spite of the presence of phononic
interaction. We are able to confirm numerically some theoretical predictions.Comment: 7 pages, 4 figure
Time evolution of stimulated Raman scattering and two-plasmon decay at laser intensities relevant for shock ignition in a hot plasma
Laserâplasma interaction (LPI) at intensities 1015â1016 W cm2 is dominated by parametric instabilities which can be
responsible for a significant amount of non-collisional absorption and generate large fluxes of high-energy nonthermal
electrons. Such a regime is of paramount importance for inertial confinement fusion (ICF) and in particular for the
shock ignition scheme. In this paper we report on an experiment carried out at the Prague Asterix Laser System (PALS)
facility to investigate the extent and time history of stimulated Raman scattering (SRS) and two-plasmon decay (TPD)
instabilities, driven by the interaction of an infrared laser pulse at an intensity 1:2 1016 W cm2 with a 100 mm
scalelength plasma produced from irradiation of a flat plastic target. The laser pulse duration (300 ps) and the high
value of plasma temperature (4 keV) expected from hydrodynamic simulations make these results interesting for a
deeper understanding of LPI in shock ignition conditions. Experimental results show that absolute TPD/SRS, driven at
a quarter of the critical density, and convective SRS, driven at lower plasma densities, are well separated in time, with
absolute instabilities driven at early times of interaction and convective backward SRS emerging at the laser peak and
persisting all over the tail of the pulse. Side-scattering SRS, driven at low plasma densities, is also clearly observed.
Experimental results are compared to fully kinetic large-scale, two-dimensional simulations. Particle-in-cell results,
beyond reproducing the framework delineated by the experimental measurements, reveal the importance of filamentation
instability in ruling the onset of SRS and stimulated Brillouin scattering instabilities and confirm the crucial role of
collisionless absorption in the LPI energy balance
Seasonal effects on reconciliation in Macaca Fuscata Yakui
Dietary composition may have profound effects on the activity budgets, levelof food competition, and social behavior of a species. Similarly, in seasonally breeding species, the mating season is a period in which competition for mating partners increases, affecting amicable social interactions among group members. We analyzed the importance of the mating season and of seasonal variations in dietary composition and food competition on econciliation
in wild female Japanese macaques (Macaca fuscata yakui) on Yakushima Island, Japan. Yakushima macaques are appropriate subjects because they are seasonal breeders and their dietary composition significantly changes among the seasons. Though large differences occurred between the summer months and the winter and early spring months in activity budgets and the consumption of the main food sources, i.e., fruits, seeds, and leaves, the level
of food competition and conciliatory tendency remained unaffected. Conversely,conciliatory tendency is significantly lower during the mating season than in the nonmating season. Moreover, conciliatory tendency is lower when 1 or both female opponents is in estrous than when they are not. Thus the mating season has profound effects on reconciliation, whereas seasonal changes in activity budgets and dietary composition do not. The detrimental effects of the mating season on female social relationships and reconciliation may be due to the importance of female competition for access to male partners in multimale, multifemale societies
Comparison of mid-latitude single- And mixed-phase cloud optical depth from co-located infrared spectrometer and backscatter lidar measurements
The long-wave downwelling spectral radiance measurements performed by means of the Far-Infrared Radiation Mobile Observation System (FIRMOS) spectrometer at the summit of the Zugspitze (German Alps) in the winter 2018/19 allowed the retrieval of the optical and micro-physical properties of ice and mixed clouds, showing a good agreement of the statistical relationship between the ice water path and the ice optical depth with the ones from previous works. In this paper the optical depths retrieved from FIRMOS are initially compared with selected cases calculated from backscattering light detection and ranging (lidar) data by using a transmittance method. Then, in order to compare the whole FIRMOS dataset, the power-law relationship between backscattering and extinction is used to apply the Klett method and automatize the routine. Minimizing the root mean square differences, the exponent k of the power-law relationship is assessed to be 0.85 with a variability in the range of 0.60â1.10 for ice clouds and 0.50 with a variability within 0.30â0.70 for mixed clouds
A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
20siBruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in colon carcinoma cell lines and tumour tissue samples. p65BTK protein is expressed, through heterogeneous nuclear ribonucleoprotein K (hnRNPK)-dependent and internal ribosome entry site-driven translation, from a transcript containing an alternative first exon in the 5'-untranslated region, and is post-transcriptionally regulated, via hnRNPK, by the mitogen-activated protein kinase (MAPK) pathway. p65BTK is endowed with strong transforming activity that depends on active signal-regulated protein kinases-1/2 (ERK1/2) and its inhibition abolishes RAS transforming activity. Accordingly, p65BTK overexpression in colon cancer tissues correlates with ERK1/2 activation. Moreover, p65BTK inhibition affects growth and survival of colon cancer cells. Our data reveal that BTK, via p65BTK expression, is a novel and powerful oncogene acting downstream of the RAS/MAPK pathway and suggest that its targeting may be a promising therapeutic approach.openopenGrassilli, Emanuela; Pisano, Fabio; Cialdella, Annamaria; Bonomo, Sara; Missaglia, Carola; Cerrito, Maria Grazia; Masiero, Laura; Ianzano, Leonarda; Giordano, Federica; Cicirelli, Vittoria; Narloch, Robert; D'Amato, Filomena; Noli, Barbara; Ferri, Gian Luca; Leone, Biagio; Stanta, Giorgio; Bonin, Serena; Helin, Kristian; Giovannoni, Roberto; Lavitrano, MarialuisaGrassilli, Emanuela; Pisano, Fabio; Cialdella, Annamaria; Bonomo, Sara; Missaglia, Carola; Cerrito, Maria Grazia; Masiero, Laura; Ianzano, Leonarda; Giordano, Federica; Cicirelli, Vittoria; Narloch, Robert; D'Amato, Filomena; Noli, Barbara; Ferri, Gian Luca; Leone, Biagio; Stanta, Giorgio; Bonin, Serena; Helin, Kristian; Giovannoni, Roberto; Lavitrano, Marialuis
A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
Brutonâs tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in colon carcinoma cell lines and tumor tissue samples. p65BTK protein is expressed, through hnRNPK-dependent and IRES-driven translation, from a transcript containing an alternative first exon in the 5âUTR, and is post-transcriptionally regulated, via hnRNPK, by the MAPK pathway. p65BTK is endowed with strong transforming activity that depends on active ERK1/2 and its inhibition abolishes RAS transforming activity. Accordingly, p65BTK overexpression in colon cancer tissues correlates with ERK1/2 activation. Moreover, p65BTK inhibition affects growth and survival of colon cancer cells. Our data reveal that BTK, via p65BTK expression, is a novel and powerful oncogene acting downstream of the RAS/MAPK pathway and suggest that its targeting may be a promising therapeutic approac
Measurement of the atmospheric muon depth intensity relation with the NEMO Phase-2 tower
The results of the analysis of the data collected with the NEMO Phase-2
tower, deployed at 3500 m depth about 80 km off-shore Capo Passero (Italy), are
presented. Cherenkov photons detected with the photomultipliers tubes were used
to reconstruct the tracks of atmospheric muons. Their zenith-angle distribution
was measured and the results compared with Monte Carlo simulations. An
evaluation of the systematic effects due to uncertainties on environmental and
detector parameters is also included. The associated depth intensity relation
was evaluated and compared with previous measurements and theoretical
predictions. With the present analysis, the muon depth intensity relation has
been measured up to 13 km of water equivalent.Comment: submitted to Astroparticle Physic
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