Chemical compound and therapeutic effects of Hypericum perforatum

Hypericum perforatum is native to parts of Europe and Asia but has spread worldwide as a cosmopolitan invasive weed, including to temperate regions of India, China, Canada, Africa, and the United States. The aim of this study was to overview its therapeutic effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases. The initial search strategy identified about 98 references. In this study, 42 studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Hypericum perforatum and dated mainly from the year 1987 to 2016.The search terms were "Hypericum perforatum", lemon balm, "therapeutic properties", "pharmacological effects". It is commonly used for antimicrobial effect, neuroprotective effect, anti-depressive effect, antioxidant effect, menopause, dental practice, anti-inflammatory, wound healing effect, anti-cancer effect, anti-herpes effect, phototoxicological effect. Hypericum perforatum is widely used for therapeutic and non-therapeutic purposes that trigger its significant value. Various combinations and numerous medicinal properties of its extract, oil, and leaves demand further and more studies about the other useful and unknown properties of this multipurpose plant

Rare Diseases and COVID-19: How are the Patients?

Dear Editor, When searching the scientific literature COVID-19-associated syndromes in addition to syndromes middle eastern respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), some cardiovascular syndromes and post intensive care syndrome [1,2], we found the syndromes of Guillain-Barré, Miller Fisher, polyneuritis cranialis, Kawasaki, Inflammatory multisystem syndrome, and syndrome of inappropriate antidiuretic hormone secretion [3-29]. Of these, only Guillain-Barré syndrome and Miller Fisher syndrome, Kawasaki diseases and Inflammatory multisystem syndrome have currently present cranio-facial manifestation (Table 1), but possibly others will become know when the damage of COVID-19 becomes known.Although there is no standardized definition of rare diseases, the classification of rare diseases is closely related to a definition according to point prevalence in the current political and legislative context, and such definitions are based on a prevalence threshold directly or implied. According to the World Health Organization (WOS) and adopted by the Ministry of Health of Brazil, a rare disease affects up to 65 per 100,000 individuals [30]. Each rare disease, taken separately, affects a limited number of people. Considering, however, that there are up to 8,000 types of rare diseases worldwide, when grouped under a single category, their epidemiological impact may become quite significant. About 80% of those are caused by genetic factors, and the rest by other factors, such as environmental, infectious and immunologicalones [31]. Thus, rare diseases are a global challenge that must be overcome. A multi-professional and interdisciplinary team, including pediatric dentistry, oral medicine and pathology, is essential for success throughout the process

Refractive outcome in preterm newborns with ROP after propranolol treatment. A retrospective observational cohort study

Background: Recent explorative studies suggest that propranolol reduces retinopathy of prematurity (ROP) progression, but the short-term effects of propranolol treatment at 1 year of corrected age have not been extensively evaluated. Methods: A multi-center retrospective observational cohort study was conducted to assess the physical development and the refractive outcome of infants with prior ROP treated with propranolol. Forty-nine infants treated with propranolol were compared with an equal number of patients who did not receive any propranolol therapy and represent the control group, with comparable anthropometrical characteristics and stages of ROP. Results: The weight, length, and head circumference at 1 year of corrected age were similar between infants who had been treated, or not, with propranolol, without any statistically significant differences. Refractive evaluation at 1 year showed spherical equivalent values decreasing with the progression of ROP toward more severe stages of the disease, together with an increasing number of infants with severe myopia. On the contrary, no differences were observed between infants who had been treated with propranolol and those who had not. Conclusion: This study confirms that the progression of ROP induces an increase of refractive errors and suggests that propranolol itself does not affect the refractive outcome. Therefore, if the efficacy of propranolol in counteracting ROP progression is confirmed by further clinical trials, the conclusion will be that propranolol might indirectly improve the visual outcome, reducing the progression of ROP

The One Hundred and Seventh Commencement 1970

Issued for the Commencement of 1970https://digitalcommons.lasalle.edu/commencement_programs/1038/thumbnail.jp

Feasibility of Intestinal MR Elastography in Inflammatory Bowel Disease

Background: While MR enterography allows detection of inflammatory bowel disease (IBD), the findings continue to be of limited use in guiding treatment-medication vs. surgery. Purpose: To test the feasibility of MR elastography of the gut in healthy volunteers and IBD patients. Study type: Prospective pilot. Population: Forty subjects (healthy volunteers: n = 20, 37 ± 14 years, 10 women; IBD patients: n = 20 (ulcerative colitis n = 9, Crohn's disease n = 11), 41 ± 15 years, 11 women). Field strength/sequence: Multifrequency MR elastography using a single-shot spin-echo echo planar imaging sequence at 1.5 T with drive frequencies of 40, 50, 60, and 70 Hz. Assessment: Maps of shear-wave speed (SWS, in m/s) and loss angle (φ, in rad), representing stiffness and solid-fluid behavior, respectively, were generated using tomoelastography data processing. Histopathological analysis of surgical specimens was used as reference standard in patients. Statistical tests: Unpaired t-test, one-way analysis of variance followed by Tukey post hoc analysis, Pearson's correlation coefficient and area under the receiver operating characteristic curve (AUC) with 95%-confidence interval (CI). Significance level of 5%. Results: MR elastography was feasible in all 40 subjects (100% technical success rate). SWS and φ were significantly increased in IBD by 21% and 20% (IBD: 1.45 ± 0.14 m/s and 0.78 ± 0.12 rad; healthy volunteers: 1.20 ± 0.14 m/s and 0.65 ± 0.06 rad), whereas no significant differences were found between ulcerative colitis and Crohn's disease (P = 0.74 and 0.90, respectively). In a preliminary assessment, a high diagnostic accuracy in detecting IBD was suggested by an AUC of 0.90 (CI: 0.81-0.96) for SWS and 0.84 (CI: 0.71-0.95) for φ. Data conclusion: In this pilot study, our results demonstrated the feasibility of MR elastography of the gut and showed an excellent diagnostic performance in predicting IBD. Evidence level: 1 TECHNICAL EFFICACY: Stage 1

Performance of Soft Asphalt and Double Otta Seal within First Three Years

Gravel roads play an important role in the transport infrastructure. However, their maintenance (especially the control of dustiness using chemical dust suppressants) is expensive. Besides, the condition of gravel roads results in low driving comfort, longer travelling time, faster vehicle amortization, and so forth. Typically, these problems are solved by paving gravel roads with asphalt wearing layer. However, north countries practice had shown pavement structure high susceptibility to frost due to insufficient thickness of frost resistance layer. The construction of thicker frost resistant layer increases road construction cost by 25% and, in most cases, there is no need to increase bearing capacity by increasing total thickness of pavement structure. In 2012 19 gravel roads were constructed using cost effective rehabilitation technologies—soft asphalt and double Otta Seal in Lithuania. This paper focuses on those two technologies’ performance within first three years of constructed roads exploitation. The implemented experimental research consisted of three parts by evaluating constructed roads base layers bearing capacity; pavement roughness; and pavement distresses and defects. As a result, the acceptable performance indicators were determined for both technologies—soft asphalt and double Otta Seal. Also recommendations for construction and exploitation improvement were defined

Society and the state in the pandemic context

Based on the importance of an unprecedented new reality, the authors were tasked with studying and analyzing the problems of interaction between the State and society in the context of the pandemic and the introduction of state measures to prevent the spread of viral infection, which to a degree or another limit the rights and freedoms of a person and citize

INDEPENDENT COMPONENT ANALYSIS AND DISCRETE WAVELET TRANSFORM FOR ARTIFACT REMOVAL IN BIOMEDICAL SIGNAL PROCESSING

Recent works have shown that artifact removal in bi omedical signals can be performed by using Discrete Wavelet Transform (DWT) or Independent Component Analysis (ICA). It results often very difficult to remove some artifacts because they could be superimposed on the recordings and they could corrupt the signals in the frequency domain. The two conditions could compromise the performance of both DWT and ICA methods. In this study we show that if the two methods are jointly implemented, it is possible to improve the performances for the artifact rejection procedure. We discuss in detail the new method and we also show how this method provides advantages with respect to DWT of ICA procedure. Finally, we tested the new approach on real data

The EFSUMB Guidelines and Recommendations for the Clinical Practice of Elastography in Non-Hepatic Applications: Update 2018

This manuscript describes the use of ultrasound elastography, with the exception of liver applications, and represents an update of the 2013 EFSUMB (European Federation of Societies for Ultrasound in Medicine and Biology) Guidelines and Recommendations on the clinical use of elastography

Explorer 1970

https://digitalcommons.lasalle.edu/explorer/1026/thumbnail.jp