1,581 research outputs found

    Bioreactors in Tissue Engineering

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    The Algebraic Bethe Ansatz and Tensor Networks

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    We describe the Algebraic Bethe Ansatz for the spin-1/2 XXX and XXZ Heisenberg chains with open and periodic boundary conditions in terms of tensor networks. These Bethe eigenstates have the structure of Matrix Product States with a conserved number of down-spins. The tensor network formulation suggestes possible extensions of the Algebraic Bethe Ansatz to two dimensions

    CARMA Large Area Star Formation Survey: Project Overview with Analysis of Dense Gas Structure and Kinematics in Barnard 1

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    We present details of the CARMA Large Area Star Formation Survey (CLASSy), while focusing on observations of Barnard 1. CLASSy is a CARMA Key Project that spectrally imaged N2H+, HCO+, and HCN (J=1-0 transitions) across over 800 square arcminutes of the Perseus and Serpens Molecular Clouds. The observations have angular resolution near 7" and spectral resolution near 0.16 km/s. We imaged ~150 square arcminutes of Barnard 1, focusing on the main core, and the B1 Ridge and clumps to its southwest. N2H+ shows the strongest emission, with morphology similar to cool dust in the region, while HCO+ and HCN trace several molecular outflows from a collection of protostars in the main core. We identify a range of kinematic complexity, with N2H+ velocity dispersions ranging from ~0.05-0.50 km/s across the field. Simultaneous continuum mapping at 3 mm reveals six compact object detections, three of which are new detections. A new non-binary dendrogram algorithm is used to analyze dense gas structures in the N2H+ position-position-velocity (PPV) cube. The projected sizes of dendrogram-identified structures range from about 0.01-0.34 pc. Size-linewidth relations using those structures show that non-thermal line-of-sight velocity dispersion varies weakly with projected size, while rms variation in the centroid velocity rises steeply with projected size. Comparing these relations, we propose that all dense gas structures in Barnard 1 have comparable depths into the sky, around 0.1-0.2 pc; this suggests that over-dense, parsec-scale regions within molecular clouds are better described as flattened structures rather than spherical collections of gas. Science-ready PPV cubes for Barnard 1 molecular emission are available for download.Comment: Accepted to The Astrophysical Journal (ApJ), 51 pages, 27 figures (some with reduced resolution in this preprint); Project website is at http://carma.astro.umd.edu/class

    The Loss of Telomerase Activity in Highly Differentiated CD8+CD28−CD27− T Cells Is Associated with Decreased Akt (Ser473) Phosphorylation

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    The enzyme telomerase is essential for maintaining the replicative capacity of memory T cells. Although CD28 costimulatory signals can up-regulate telomerase activity, human CD8 + T cells lose CD28 expression after repeated activation. Nevertheless, telomerase is still inducible in CD8 + CD28 − T cells. To identify alternative costimulatory pathways that may be involved, we introduced chimeric receptors containing the signaling domains of CD28, CD27, CD137, CD134, and ICOS in series with the CD3 zeta (ζ) chain into primary human CD8 + T cells. Although CD3 ζ-chain signals alone were ineffective, triggering of all the other constructs induced proliferation and telomerase activity. However, not all CD8 + CD28 − T cells could up-regulate this enzyme. The further fractionation of CD8 + CD28 − T cells into CD8 + CD28 − CD27 + and CD8 + CD28 − CD27 − subsets showed that the latter had significantly shorter telomeres and extremely poor telomerase activity. The restoration of CD28 signaling in CD8 + CD28 − CD27 − T cells could not reverse the low telomerase activity that was not due to decreased expression of human telomerase reverse transcriptase, the enzyme catalytic subunit. Instead, the defect was associated with decreased phosphorylation of the kinase Akt, that phosphorylates human telomerase reverse transcriptase to induce telomerase activity. Furthermore, the defective Akt phosphorylation in these cells was specific for the Ser 473 but not the Thr 308 phosphorylation site of this molecule. Telomerase down-regulation in highly differentiated CD8 + CD28 − CD27 − T cells marks their inexorable progress toward a replicative end stage after activation. This limits the ability of memory CD8 + T cells to be maintained by continuous proliferation in vivo

    Episodic molecular outflow in the very young protostellar cluster Serpens South

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    The loss of mass from protostars, in the form of a jet or outflow, is a necessary counterpart to protostellar mass accretion. Outflow ejection events probably vary in their velocity and/or in the rate of mass loss. Such `episodic´ ejection events have been observed during the Class 0 protostellar phase (the early accretion stage), and continue during the subsequent class I phase that marks the first one million years of star formation. Previously observed episodic-ejection sources were relatively isolated; however, the most common sites of star formation are clusters. Outflows link protostars with their environment and provide a viable source of turbulence that is necessary for regulating star formation in clusters, but it is not known how an accretion-driven jet or outflow in a clustered environment manifests itself in its earliest stage. This early stage is important in establishing the initial conditions for momentum and energy transfer to the environment as the protostar and cluster evolve. Here we report that an outflow from a very young class 0 protostar, at the hub of the very active and filamentary Serpens South protostellar cluster, shows unambiguous episodic events. The 12CO (J=2-1) emission from the protostar reveals 22 distinct features of outflow ejecta, the most recent having the highest velocity. The outflow forms bipolar lobes --- one of the first detectable signs of star formation --- which originate from the peak of 1-mm continuum emission. Emission from the surrounding C18O envelope shows kinematics consistent with rotation and an infall of material onto the protostar. The data suggest that episodic accretion-driven outflow begins in the earliest phase of protostellar evolution, and that the outflow remains intact in a very clustered environment, probably providing efficient momentum transfer for driving turbulence. Fil: Plunkett, Adele L. . Yale University. Astronomy Department.; Estados UnidosFil: Arce, Héctor G.. Yale University. Astronomy Department.; Estados UnidosFil: Mardones, Diego . Universidad de Chile. Departamento de Astronomía; ChileFil: van Dokkum, Pieter . Yale University. Astronomy Department.; Estados UnidosFil: Dunham, Michael M. . Harvard-Smithsonian Center for Astrophysics; Estados UnidosFil: Fernandez Lopez, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto Argentino de Radioastronomia (i); ArgentinaFil: Gallardo, José. Joint ALMA Observatory; ChileFil: Cordero, Stuartt A. . Joint ALMA Observatory; Chil

    Physics at a Neutrino Factory

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    In response to the growing interest in building a Neutrino Factory to produce high intensity beams of electron- and muon-neutrinos and antineutrinos, in October 1999 the Fermilab Directorate initiated two six-month studies. The first study, organized by N. Holtkamp and D. Finley, was to investigate the technical feasibility of an intense neutrino source based on a muon storage ring. This design study has produced a report in which the basic conclusion is that a Neutrino Factory is technically feasible, although it requires an aggressive R&D program. The second study, which is the subject of this report, was to explore the physics potential of a Neutrino Factory as a function of the muon beam energy and intensity, and for oscillation physics, the potential as a function of baseline.Comment: 133 pages, 64 figures. Report to the Fermilab Directorate. Available from http://www.fnal.gov/projects/muon_collider/ This version fixes some printing problem

    Identification of plastic constitutive parameters at large deformations from three dimensional displacement fields

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    The aim of this paper is to provide a general procedure to extract the constitutive parameters of a plasticity model starting from displacement measurements and using the Virtual Fields Method. This is a classical inverse problem which has been already investigated in the literature, however several new features are developed here. First of all the procedure applies to a general three-dimensional displacement field which leads to large plastic deformations, no assumptions are made such as plane stress or plane strain although only pressure-independent plasticity is considered. Moreover the equilibrium equation is written in terms of the deviatoric stress tensor that can be directly computed from the strain field without iterations. Thanks to this, the identification routine is much faster compared to other inverse methods such as finite element updating. The proposed method can be a valid tool to study complex phenomena which involve severe plastic deformation and where the state of stress is completely triaxial, e.g. strain localization or necking occurrence. The procedure has been validated using a three dimensional displacement field obtained from a simulated experiment. The main potentialities as well as a first sensitivity study on the influence of measurement errors are illustrated

    Labels direct infants’ attention to commonalities during novel category learning

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    Recent studies have provided evidence that labeling can influence the outcome of infants’ visual categorization. However, what exactly happens during learning remains unclear. Using eye-tracking, we examined infants’ attention to object parts during learning. Our analysis of looking behaviors during learning provide insights going beyond merely observing the learning outcome. Both labeling and non-labeling phrases facilitated category formation in 12-month-olds but not 8-month-olds (Experiment 1). Non-linguistic sounds did not produce this effect (Experiment 2). Detailed analyses of infants’ looking patterns during learning revealed that only infants who heard labels exhibited a rapid focus on the object part successive exemplars had in common. Although other linguistic stimuli may also be beneficial for learning, it is therefore concluded that labels have a unique impact on categorization
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