Klauwgezondheid bij varkens

Kreupelheid is één van de belangrijkste gezondheidsproblemen bij de huisvesting van zeugen in Nederland. Met name in groepshuisvesting komt dit tot uiting. Hierbij blijkt het vooral om klauwkreupelheden te gaan

Zeugen gezond houden in groepshuisvesting

Uit onderzoek naar gezondheidsproblemen bij zeugen die tijdens de dracht in groepshuisvesting worden gehouden, kwam als voornaamste probleem kreupelheid naar voren. Daarnaast komen ook huid- en vulvabeschadigingen regelmatig voor

Isolated limb perfusion with actinomycin D and TNF-alpha results in improved tumour response in soft-tissue sarcoma-bearing rats but is accompanied by severe local toxicity

Previously we demonstrated that addition of Tumour Necrosis Factor-α to melphalan or doxorubicin in a so-called isolated limb perfusion results in synergistic antitumour responses of sarcomas in both animal models and patients. Yet, 20 to 30% of the treated tumours do not respond. Therefore agents that synergise with tumour necrosis factor alpha must be investigated. Actinomycin D is used in combination with melphalan in isolated limb perfusion in the treatment of patients with melanoma in-transit metastases and is well known to augment tumour cell sensitivity towards tumour necrosis factor alpha in vitro. Both agents are very toxic, which limits their systemic use. Their applicability may therefore be tested in the isolated limb perfusion setting, by which the tumours can be exposed to high concentrations in the absence of systemic exposure. To study the beneficial effect of the combination in vivo, BN-175 soft tissue sarcoma-bearing rats were perfused with various concentrations of actinomycin D and tumour necrosis factor alpha. When used alone the drugs had only little effect on the tumour. Only when actinomycin D and tumour necrosis factor alpha were combined a tumour response was achieved. However, these responses were accompanied by severe, dose limiting, local toxicity such as destruction of the muscle tissue and massive oedema. Our results show that isolated limb perfusion with actinomycin D in combination with tumour necrosis factor alpha leads to a synergistic anti-tumour response but also to idiosyncratic locoregional toxicity to the normal tissues. Actinomycin D, in combination with tumour necrosis factor alpha, should not be explored in the clinical setting because of this. The standard approach in the clinic remains isolated limb perfusion with tumour necrosis factor alpha in combination with melphalan

Low radiographic muscle density is associated with lower overall and disease-free survival in early-stage colorectal cancer patients

Contains fulltext : 197390.pdf (Publisher’s version ) (Open Access

Liver Resection for Hepatic Metastases from Soft Tissue Sarcoma:A Nationwide Study

Contains fulltext : 209467pub.pdf (publisher's version ) (Open Access

The Lantern Vol. 2, No. 1, December 1933

• Petition • Keep it Burning! • Jes\u27 Before Christmas • Noel: Translation from Theophile Gautier • A Young Jew Meets Jesus • Book Review: Little Man, What Now? • Book Review: Thunder and Dawn • Continuity • La Veille de Noel (Reflexions d\u27un Provincial) • Noel Sceptique par Jules LaFargue • Horizon • Winter Night • Linoleum Cutshttps://digitalcommons.ursinus.edu/lantern/1001/thumbnail.jp