LOCAL CULTURE EXPERIENCE AND NOVELTY SEEKING: A COMPARISON ON ISTANBUL AND ANTALYA TOURISM DESTINATIONS

Distinguishing the society from others, cultural assets create a unique local culture experience for tourists and lead to satisfaction by influencing the novelty seeking motivation. Based on this hypothesis, the aims of this research are as follows; a) to examine the effect of the local cultural experience on novelty seeking behavior, b) to examine the influence of the local culture experience on tourist satisfaction, and c) to assess the mediating role of novelty seeking between local cultural experience and satisfaction. Using structural equation modeling, a comparative study was carried out on Turkey's most-tourist attracting destinations which have distinctive DNA's in accordance with their specific positioning strategies. Findings revealed that local culture experience, novelty seeking and tourist satisfaction variables are associated with each other in both destinations. The SEM suggests that the novelty seeking variable have the mediating role between local culture experience and satisfaction.&nbsp

Interdisciplinary orthognathic treatment of high angle class III malocclusion

For Class III adult patients, combined treatment strategy must be followed which includes either further dentoalveolar compensation or orthognathic surgery following decompensation of the teeth. This case report presents the interdisciplinary approach of a skeletal Class III malocclusion with increased vertical facial dimension, occlusal cant, extracted posterior teeth on the right upper and left lower segments, extensive restorations, and total circular crossbite. The orthodontic alignment took 10 months. LeFort 1 osteotomy with 7 mm advancement, 5 mm impaction on the left side, 3 mm impaction on the right side and 2 mm rotation for midline correction toward the left side, 3 mm set.back of mandible with bilateral sagittal split osteotomy were done. The surgery simulation, postoperative and 2 year follow up records were compatible. The treatment was finalized in a straight profile with stable occlusion and good smile characteristics without airway disturbance.Key words: Interdisciplinary treatment, orthognathic surgery, skeletal Class II

BK Channels – Focus on Polyamines, Ethanol/Acetaldehyde and Hydrogen Sulfide (H2S)

(VLID)386021

Higher Education As a Tool to Build the Cultural and Intellectual Potential of Managers

The article reveals the methodological aspects of training a new generation of managers in universities. In modern conditions in higher education theoretical and practical education of managers is required, as well as formation of their professional culture demonstrated in developed soft skills. However, in Russian society the traditional type of managerial culture prevails, which is demonstrated in spontaneous recruitment. As a scientific-theoretical and methodological basis of this research, the authors use system, dialectical, activity, phenomenological approaches, methods of applied sociological research. The article justifies that the effectiveness of management is associated with the level of development of intellectual potential of managerial personnel and its improvement is carried out through the implementation of professional, innovative, moral, information sub potential. Modern university training of managerial personnel reflects the contradiction between the traditional model of education and new requirements of the society, connected with modernization processes. Growing public intellectual activity requires managers to create new forms, methods and mechanisms of management. In these conditions, one of the mechanisms of management is a purposeful construction of managerial culture of young people as a future subject of management in the system of higher education. The development of the ability to improve internally is an important task of modern Russian management. The principle of subject-subject vertical and horizontal relations in knowledge management implies a shift of emphasis to self-organization. Therefore, it is necessary to take into account not only learning opportunities, but also self-learning. Academic training for management activities includes a combination of research and applied activities supplemented by the study of disciplines with a social and humanitarian orientation. In this connection, there is a need to train a new generation of professional managers capable of innovations, creative, constructive management activities, which are based on a fundamentally different culture of education management and personnel policy. Keywords: intellectual potential, culture, knowledge, management, higher education, professional training of manager

Cardiac Auscultatory Skills of Academic Family Physicians: Strength of Association with an Academic Pediatric Cardiologist

Aim. Heart murmur is common in children, and it is one of the main reasons for referral among children in primary care. The aim of this study is to evaluate agreement and consistency of normal, innocent, and pathologic murmur decision between academic family physicians and academic pediatric cardiologist. Methods. Seven hundred fifteen primary school children were examined by family physicians and paediatric cardiologist. Auscultatory examination was performed. Intensity, frequency, duration, quality, location, and radiation of the murmur were described if present. Agreement of normal, innocent, and pathologic murmur classification decision between family physician and paediatric cardiologist was analyzed by using kappa statistic. Results. Normal, innocent and pathologic murmurs were reported for 419, 228, and 54 children in family physicians' reports, respectively. Paediatric cardiologist agreed on 383 (91.4%) children as normal, 191 (83.7%) children having innocent murmur, and 19 (35.2%) children having pathologic murmur among family physician's reports. There was good consistency between family physicians and paediatric cardiologist (κ value = 0.679, 95% CI 0.630–0.727, P < .001). They agreed on the majority of normal and innocent murmur decisions. However family physicians reported pathologic murmur more frequently. Conclusion. Cardiac auscultatory skills of academic family physicians may be concordant with paediatric cardiologist

Phosphorylation of BK channels modulates the sensitivity to hydrogen sulfide (H2S)

Introduction: Gases, such as nitric oxide (NO), carbon monoxide (CO) or hydrogen sulfide (H2S), termed gasotransmitters, play an increasingly important role in understanding of how electrical signaling of cells is modulated. H2S is well known to act on various ion channels and receptors. In a previous study we reported that H2S increased calcium-activated potassium (BK) channel activity. Aims: The goal of the present study is to investigate the modulatory effect of BK channel phosphorylation on the action of H2S on the channel as well as to recalculate and determine the H2S concentrations in aqueous sodium hydrogen sulfide (NaHS) solutions.Methods: Single channel recordings of GH3, GH4 and GH4 STREX cells were used to analyze channel open probability, amplitude and open dwell times. H2S was measured with ananion selective electrode. Results: The concentration of H2S produced from NaHS was recalculated taking pH, temperature salinity of the perfusate and evaporation of H2S into account. The results indicate that from a concentration of 300 µM NaHS, only11-13%, i.e. 34-41 µM is effective as H2S in solution. GH3, GH4 and GH4 STREX cells respond differently to phosphorylation. BK channel open probability (Po) of all cells lines used was increased by H2S in ATP containing solutions. PKA prevented the action of H2S on channel Po in GH4 and GH4 STREX, but not in GH3 cells. H2S, high significantly increased Po of all PKG pretreated cells. In the presence of PKC, which lowers channel activity, H2S increased channel Po of GH4 and GH4 STREX, but not those of GH3 cells. H2S increased open dwell times of GH3 cells in the absence of ATP significantly. A significant increase of dwell times with H2S was also observed in the presence of okadaic acid.Conclusions: Our results suggest that phosphorylation by PKG primes the channels for H2S activation and indicate that channel phosphorylation plays an important role in the response to H2S

Computed tomography depiction of normal inguinal lymph nodes in children

Background: The aim of the study was to establish computed tomography (CT) characteristics, distribution and provide normative data about size of normal inguinal lymph nodes in a paediatric population. Materials and methods: Four hundred eighty-one otherwise healthy children (147 girls, mean age: 8.87, range 0–17 years) underwent pelvic CT in the setting of high-energy trauma were included in the study. Both axial and coronal 1.25-mm reconstructions were evaluated for the presence, location (deep or superficial), number, presence of fat attenuation, and shape of the lymph nodes, short-axis diameter of the biggest lymph node for each of right and left inguinal regions. Results: A total of 7556 lymph nodes were detected in 481 subjects (the mean count of superficial and deep inguinal lymph nodes was 13.35 [range 6–23] and 2.36 [range 0–7] per subject, respectively): 15% (1135/7556) deep located, 85% (6421/7556) superficially located, 86.6% (6547/7556) with fat attenuation, 99.2% (7496/7556) oval in shape, 0.8% (60/7556) spherical. The short-axis diameter of the lymph nodes increased with age. Pearson’s correlation coefficient for superficial and deep lymph nodes in boys and girls, respectively: 0.538 (p &lt; 0.001), 0.504 (p &lt; 0.001), 0.452 (p &lt; 0.001) and 0.268 (p &lt; 0.001). The mean maximum short-axis diameters in different age groups and gender varied between 6.33 ± 0.85 mm and 8.68 ± 1.33 mm for superficial, 3.62 ± 1.16 mm and 5.83 ± 1.05 mm for deep inguinal lymph nodes. Conclusions: Inguinal lymph nodes were multiple, commonly contained fat, and were oval in shape. The data determined about inguinal lymph node size in different paediatric age groups may be applicable as normative data in daily clinical CT evaluation practice

IMECE2005-79838 ENERGY DISSIPATION WITH SLOSHING FOR ABSORBER DESIGN

ABSTRACT Sloshing is the low frequency oscillation of the free surface of a liquid in a partially full container. Due to its detrimental effects, efforts are usually made in the direction of suppressing sloshing. In addition, intentionally induced sloshing may be employed as an effective energy sink to provide protection for resonant structures exposed to excessive vibration levels. It is generally reported that sloshing absorbers with shallow levels of liquid are more effective energy dissipators than those with deep levels. However, there has not yet been a study to reveal the mechanism of energy dissipation for practical applications, although there has been ample empirical proof for effectiveness. One of the limitations from a numerical perspective lies with the difficulty in predicting extreme free surface behaviour by traditional grid based computational methods. The objective of this paper is to report initial observations in this direction using Smoothed Particle Hydrodynamics (SPH). SPH is a Lagrangian method of solving the equations for fluid flow, that is suitable for modeling free surface phenomena such as sloshing due to its grid-free nature. Results are reported in this paper in the form of numerical case studies

Economic Evaluation of the Efficiency of Supply Chain Management in Agricultural Production Based on Multidimensional Research Methods

The article studies the system of indicators characterizing the efficiency of supply chain management in agricultural production. The hierarchical classification of the subjects of the Russian Federation according to the indicators characterizing the results of the activity of the agricultural sector has been carried out. Clusters with high, medium and low levels of supply chains management’s efficiency have been identified. Regions for selected clusters are set. A comparative analysis of the regions on the performance of the agricultural sector has been carried out. Regularities are revealed, prospects for further development are defined. For each cluster promising areas of effective development of agriculture were identified