Blood pressure distribution in microvascular networks

This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.Blood rheology is complex and nonlinear. The effective viscosity variations are important due to red blood cells packing inside capillaries, the socalled FåhræusLindquist effect, whilst concomitantly phase segregation appears in bifurcations. We have performed direct numerical simulations of different nonlinear rheological models of the blood on realistic threedimensional microvascular networks. These simulations point out two significant results. First, various rheological models lead to very similar pressure distributions over the whole range of physiologically relevant hematocrits. Secondly, different models for phase segregation lead to very distinct hematocrit distributions in the microvascular network. Moreover, for all the investigated rheological models, the hematocrit distribution very weakly affects the pressure distribution, when prescribing uniform pressure boundary conditions.The research was supported by GDR n° 2760 Biomécanique des fluides et des transferts Interaction fluide/structure biologique, the ASUPS A03 and A05 of Paul Sabatier University, Toulouse, France and the ANR project ANR06BLAN023801

Fasti Ecclesiae Gallicanae (1200-1500). XIV: Diocèse de Châlons-en-Champagne

This is a prosopographical repertory of bishops, canons and office-holders of the French dioceses from 1200 to 1500, giving for each a biographical and a bibliographical entry. The geographical limits are those of present-day France.  Each volume presents the central institutions of the bishopric, and, depending on the availability of sources or research, gives a description of the cathedral borough, books, treasure, relics and ornaments

Motivic Milnor fibre for nondegenerate function germs on toric singularities

We study function germs on toric varieties which are nondegenerate for their Newton diagram. We express their motivic Milnor fibre in terms of their Newton diagram. We extend a formula for the motivic nearby fibre to the case of a toroidal degeneration. We illustrate this by some examples.Comment: 14 page

A photometric catalogue of galaxies in the cluster Abell 85

We present two catalogues of galaxies in the direction of the rich cluster \a85. The first one includes 4,232 galaxies located in a region $\pm 1^\circ$ from the cluster centre. It has been obtained from a list of more than 25,000 galaxy candidates detected by scanning a Schmidt photographic plate taken in the \bj band. Positions are very accurate in this catalogue but magnitudes are not. This led us to perform CCD imaging observations in the V and R bands to calibrate these photographic magnitudes. A second catalogue (805 galaxies) gives a list of galaxies with CCD magnitudes in the V and R bands for a much smaller region in the centre of the cluster. These two catalogues will be combined with a redshift catalogue of 509 galaxies (Durret et al. 1997; astro-ph/9709298) to investigate the cluster properties at optical wavelengths (Durret et al. in preparation), as a complement to our previous X-ray studies (Pislar et al. 1997, Lima-Neto et al. 1997).Comment: accepted for publication in A&AS; 7 pages, including 8 figures, Tables are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5

DENIS-P J104814.7-395606.1: An M9 dwarfs at about 4 pc

We present the discovery of a previously unknown member of the immediate solar neighbourhood, DENIS-P J104814.7-395606.1 (hereafter DENIS 1048-39), identified while mining the DENIS database for new nearby stars. A HIRES echelle spectrum obtained with the 10-m Keck telescope shows that it is an M9 dwarf. DENIS 1048-39 has a very bright apparent magnitude (I=12.67) for its spectral type and colour (I-J=3.07), and is therefore very nearby. If it is single its distance is only 4.1 +- 0.6pc, ranking it as between our twelfth and fortyth closest neighbour. It is also the closest star or brown dwarf with a spectral type later than M7V. Its proper motion was determined through comparison of Sky atlas Schmidt plates, scanned by the MAMA microdensitometer, with the DENIS images. At 1.53"/yr it further attests the closeness of DENIS 1048-39, and hence its dwarf status. These characteristics make it an obvious target for further detailed studies.Comment: In press in A&A Letter

Pharmacokinetics and dosage adjustment of cefotiam in renal impaired patients

The pharmacokinetics of cefotiam were investigated after intravenous administration of 1 g to 2 healthy volunteers with normal renal function and to 16 patients whose creatinine clearance ranged from 4.7 to 0.11/h (78 to 1.66 ml/min). The elimination half-life varied from 1.1 h in normal subjects to 13 h in patients and the total plasma clearance from 21 to 0.6 1/h (350 to 10 ml/min). The urinary recovery decreased from 62% of the dose in normal subjects to 1.1% in patients, and the renal clearance from 15 to 0.03 l/h (250 to 0.5 ml/min). Plasma and renal clearances of cefotiam correlated well with the creatinine clearance. The dosage schedule for cefotiam in patients with normal renal function can be used in the presence of renal failure when the creatinine clearance is equal to or greater than 1 1/h (16.6 ml/min). For patients whose creatinine clearance is less than 1 1/h, the dose must be decreased to 75% of that for a patient with normal renal function only when it is given every 6 or 8

Cohort study of an outbreak of viral gastroenteritis in a nursing home for elderly, Majorca, Spain, February 2008.

An outbreak of acute gastroenteritis occurred in a nursing home for elderly in Majorca between 4 and 23 February 2008. To know its aetiology and mechanism of transmission a retrospective cohort study was conducted with a fixed cohort including 146 people (96 residents and 50 employees). The data were collected from clinical histories and through a survey by questionnaire. In total 71 cases were identified (53 residents, 18 employees), corresponding to an overall attack rate (AR) of 48.6%

Tendencias bibliométricas de las publicaciones sobre resistencia a antimicrobianos en Escherichia coli en Perú de 2009-2019.

Antibiotic resistance is a growing problem worldwide. While the most visible aspect is the direct effect of antimicrobial resistance in clinical settings, this problem affects all microorganisms in all environments. Nevertheless, most of the data available on antibiotic resistance outside clinical settings are from high-income countries, with the current situation in most low- and middle-income countries remaining under-reported. Escherichia coli is considered a good marker of “antibiotic pressure” due to its cosmopolitan distribution. In this scenario, we selected E. coli as an appropriate microorganism to perform an initial bibliometric analysis of publications focused on antimicrobial resistance outside disease-causing microorganisms. Thus, the present manuscript performs an analysis of the studies reporting measurable levels of antibiotic resistance of E. coli not causing human disease in Peru published during the period from 2009-2019. Following a search in PubMed and Google, 35 documents were selected as reporting measurable data of antibiotic resistance. Of these, 8 (22.8%) were reported in thesis format. The mean delay between sampling and publishing in article format was 3.7 years, with one study having been published 18 years after sampling. The number of publications developed in Peru describing antimicrobial resistance levels in E. coli out of hospital settings in the period 2009-2019 is scarce. Of these, a relevant number is of unpublished thesis. These findings showing the gap of knowledge and lack of accessible data about antimicrobial resistance out of hospital environments. Efforts and strategies must be developed to fill this knowledge gap.La resistencia a antibióticos es un problema creciente a nivel mundial. Aunque el aspecto más visible es el efecto de la resistencia a antimicrobianos en ambientes hospitalarios, este problema afecta todos los ambientes. No obstante, la mayoría de los datos sobre resistencia antimicrobiana allende ambientes hospitalarios son de países de alta renta, siendo escasa la información sobre la situación en países de baja y media renta. Escherichia coli se considera un buen marcador de "presión antibiótica" debido a su distribución cosmopolita. En este escenario seleccionamos E. coli como microorganismo ideal para realizar un análisis bibliométrico de publicaciones, del periodo 2009-2019, que se centrasen en el estudio de la resistencia a antimicrobianos en E. coli no causantes de enfermedad en humanos en Perú. Tras una búsqueda en PubMed y Google, se seleccionaron 35 documentos que reportasen datos cuantificables de resistencia a antimicrobianos. De estos, 8 (22.8%) fueron tesis. La media de tiempo entre muestreo y publicación de artículo fue de 3.7 años, con un estudio habiéndose publicado 18 años después del muestreo. El número de publicaciones realizadas en Perú en el periodo 2009-2019 describiendo la resistencia a antimicrobianos de E. coli fuera del ámbito clínico es escaso. De estas, reseñar la presencia de un elevado número de tesis. Estos hechos muestran un vacío de conocimiento y una falta de datos accesibles sobre resistencia a antimicrobianos fuera de ámbitos hospitalarios. Se han de desarrollar esfuerzos y estrategias para acabar con este vacío de conocimiento