651 research outputs found

    Language Learning Strategies Used by Thai Students in Learning English and Indonesian

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    Penelitian ini bertujuan untuk mengetahui strategi pembelajaran bahasa yang digunakan oleh mahasiswa Thailand dalam memperlajari Bahasa Inggris dan Bahasa Indonesia. Penelitian ini merupakan penelitian kualitatif deskriptif. Hasil dari data penelitian menemukan bahwa strategi belajar yang dipakai oleh mahasiswa Thailand dalam mempelajari bahasa Inggris lebih rendah dari pada bahasa Indonesia. Dari hasil ini dapat disimpulkan bahwa pembelajar bahasa akan menggunakan strategi pembelajaran yang berbeda pada seting yang berbeda pula. Seting pembelajaran yang tidak formal akan dapat memberikan kesempatan yang lebih untuk memberikan pembelajaran yang alami dari pada pembelajaran formal. Oleh karena itu, guru bahasa Inggris sebaiknya menjadikan strategi pembelajaran bahasa sebagai bahan pertimbangan dalam menyusun materi pengajaran dan latihan bahasa agar pembelajaran bahasa dapat lebih dioptimalkan.The objective of this research is to investigate the language learning strategies used by Thai students in learning English and Indonesian. This research used the descriptive qualitative method in collecting and analyzing the data. The result showed that average mean score of the use of language learning strategies in English is lower than in Indonesian and there are significant differences in language strategies used by the Thai students in learning English and Indonesian. Therefore, it can be concluded that the students used different language strategies in different setting. The informal setting in which language learning can naturally happen will give more chance for language learning to use language strategies than in formal setting. Therefore, it is better for English teachers and the students to consider the use of the language learning strategies and design the teaching instruction and activities based on the use of language learning strategies so that the teaching learning process can be optimized

    Exosome levels in human body fluids: A tumor marker by themselves?

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    Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up

    Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia : implication for therapy

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    This work was supported by: Associazione Italiana Ricerca sul Cancro (AIRC) Grant 5 x mille n.9980, (to M.F., F.M. A. N., P.T. and M.N.) ; AIRC I.G. n. 14326 (to M.F.), n.10136 and 16722 (A.N.), n.15426 (to F.F.). AIRC and Fondazione CaRiCal co-financed Multi Unit Regional Grant 2014 n.16695 (to F.M.). Italian Ministry of Health 5x1000 funds (to S.Z. and F.F). A.G R. was supported by Associazione Italiana contro le Leucemie-Linfomi-Mielomi (AIL) Cosenza - Fondazione Amelia Scorza (FAS). S.M. C.M., M.C., L.E., S.B. were supported by AIRC.Peer reviewedPostprin

    Impact of Transformational Leadership on Psychological Empowerment and Job Satisfaction Relationship: a Case of Yemeni Banking

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    The banking sector of Yemen is under threat due to the lack of confidence and trust of the prospective clients that hindered economic development of the country. The study aimed to measure a moderating effect of transformational leadership on employees\u27 psychological empowerment and job satisfaction relationship so that attitudes of the Yemeni can be bumped towards banking. In this study, 160 employees were surveyed in different branches of four banks in Yemen. The data were analyzed in four stages namely, reliability and validity analysis, descriptive analysis, multivariate analysis, and hypotheses testing analysis. The study revealed a significant positive relationship between employees\u27 psychological empowerment and transformational leadership towards their job satisfaction level. If the policy makers consider the findings and undertake necessary measures, the Yemeni banking is expected to be accelerated which will contribute to the economy of the country

    Opening the black box of energy modelling: Strategies and lessons learned

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    The global energy system is undergoing a major transition, and in energy planning and decision-making across governments, industry and academia, models play a crucial role. Because of their policy relevance and contested nature, the transparency and open availability of energy models and data are of particular importance. Here we provide a practical how-to guide based on the collective experience of members of the Open Energy Modelling Initiative (Openmod). We discuss key steps to consider when opening code and data, including determining intellectual property ownership, choosing a licence and appropriate modelling languages, distributing code and data, and providing support and building communities. After illustrating these decisions with examples and lessons learned from the community, we conclude that even though individual researchers' choices are important, institutional changes are still also necessary for more openness and transparency in energy research

    Biological Potential of Asphodelus microcarpus Extracts: α-Glucosidase and Antibiofilm Activities In Vitro

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    Type 2 diabetes (T2D), characterized by insulin resistance and β-cell dysfunction, requires continuous advancements in management strategies, particularly in controlling postprandial hyperglycemia to prevent complications. Current antidiabetics, which have α-amylase and α-glucosidase inhibitory activities, have side effects, prompting the search for better alternatives. In addition, diabetes patients are particularly vulnerable to yeast infections because an unusual sugar concentration promotes the growth of Candida spp. in areas like the mouth and genitalia. Asphodelus microcarpus contains bioactive flavonoids with potential enzyme inhibitory properties. This study investigates α-amylase and α-glucosidase inhibitory activities and antioxidant and antimycotic capacity of ethanolic extracts from different parts of A. microcarpus. Results show that extracts significantly inhibit α-glucosidase, with the IC50 value being up to 25 times higher than for acarbose, while exerting low α-amylase activity. The extracts also demonstrated strong antioxidant properties and low cytotoxicity. The presence of phenolic compounds is likely responsible for the observed biological activities. Molecular docking analysis of 11 selected compounds identified emodin and luteolin as significant inhibitors of α-glucosidase. Additionally, the extracts demonstrated significant antibiofilm action against an MDR strain of Candida albicans. These findings suggest that A. microcarpus is a promising source of natural compounds for T2D management

    Novel experimental and theoretical study on the synthesis and use of microalgae-derived silver nanomaterials for water purification

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    A green procedure involving metabolites of the microalga Haematococcus pluvialis is proposed to synthesize silver nanoparticles (Ag NPs) capable of removing the polluting dye brilliant blue R (BBR) from water. The X-ray diffraction (XRD) analysis revealed the crystalline nature of the product with Ag2O and Ag phases with a crystallite size of 14.27 nm. Fourier Transform Infrared Spectroscopy (FTIR) showed abundant functional groups from the extract on Ag NPs. Scanning Electron Microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX) and Thermogravimetric (TGA) analyses further corroborated the involvement of microalgal metabolites from the extract. Experiments were performed to assess BBR removal under different conditions, including varying light intensities, concentration of Ag NPs and BBR, and pH levels. Removal efficiency close to 70 % was achieved under visible light and using specific operating conditions. A novel mathematical model considering both BBR adsorption on the Ag NPs surface and its photocatalytic reaction dynamics was also developed. Simulation results were successfully compared with experimental data, thus demonstrating the reliability of the proposed model. Model results also suggest that, under the investigated conditions, the main mechanism underlying the BBR removal is adsorption rather than photocatalysis. Based on the model and experimental data, it was found that enhancing photocatalytic degradation would likely require more energetic light, prompting further research into optimizing light sources for better efficiency and sustainability

    Homicide or suicide? A probabilistic approach for the evaluation of the manner of death in sharp force fatalities

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    The role of forensic science can be defined as providing relevant opinions to assist investigators and courts of law in answering questions. The Likelihood Ratio (LR) provides a quantitative and logical approach to communicating the strength of expert evidence. We reviewed existing forensic literature on sharp force fatalities, focusing on studies reporting the manner of death and the frequency of some characteristics that are traditionally assessed. Four studies were included, resulting in a database of 173 suicides and 354 homicides. The LR of each of the characteristic under both hypotheses (suicide and homicide) was obtained. Subsequently, the LR was computed in six fatalities with known manner of death, three suicides and three homicides, by multiplying the corresponding LR of each individual characteristic. LR ranged from 115 to 140,250 in suicidal cases and from 9 to 2728 in homicidal cases. Compared to other fields of forensic science where LR is used extensively, the values obtained in our cases of sharp force fatalities is low. However, in forensic pathology there is evidence that is outside the expert's opinion, and it is for the trier of fact, such as the judge or jury, to draw conclusions. Nevertheless, the LR serves as a tool for interpreting and weighing evidence while maintaining the distinct roles of the trier of fact and the expert. To comprehensively apply the LR in the field of sharp force deaths, it will be necessary to standardize the methodology of investigation and data collection in descriptive studies

    Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation

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    Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus of extensive research in the development of novel preventive and therapeutic strategies. However, their health benefits are often limited by low bioavailability. Nanoparticle delivery systems can represent a solution to such limitations. Euphorbia characias is a Mediterranean shrub known to have biological activities, such as inhibiting tyrosinase and showing a potential role as a skin-whitening agent. In this study, an ethanolic extract from E. characias leaves was tested for its inhibitory activity on skin-related enzymes, such as elastase, collagenase, and hyaluronidase, and for sun protection factors. Moreover, the extract was formulated in phospholipid vesicles to improve its local bioavailability and applicability. The vesicles were characterized by size, surface charge, storage stability, and entrapment efficiency. The nanoformulation was also evaluated for antioxidant activity and assayed for cytocompatibility and anti-tyrosinase activity in melanoma cells. Our findings demonstrated that the extract has a photo-protective effect and enzyme-inhibitory properties. E. characias nanoformulation was also cytocompatible and improved the extract’s activity in the cells, suggesting a potential skin application for antimelanogenic treatments and confirming the key role of nanotechnological approaches to maximize plant extract’s potentialities

    Anti-aging potential of extracts from Washingtonia filifera seeds

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    The aim of this study was to test the inhibitory effect of fruit extracts from Washingtonia filifera on skin aging-related enzymes. The pulp extracts did not exert a significant enzyme inhibition while seed extracts from W. filifera exhibit anti-elastase, anti-collagenase, and anti-tyrosinase activities. Tyrosinase was mildly inhibited while a stronger effect was observed with respect to elastase and collagenase inhibition. Alcoholic extracts provided better results than aqueous extracts. Among them, methanol extracts showed the prominent enzyme inhibitory activities being IC50 value for elastase and collagenase comparable and even better than the reference compound. The inhibition mode of the most active extracts was investigated by Lineweaver-Burk plot analysis. Seed extracts from W. filifera were also investigated for their photo-protective effect by Mansur equation and the antioxidant activity of W. filifera extract was evaluated in oxidative-stressed cells. To evaluate the safety of the extract, the effect on cell viability of human keratinocytes cells was analyzed. Methanol extract presented the best photo-protective effect and exerted an antioxidant activity in a cellular system with no cytotoxic effect. The overall results demonstrate that W. filifera extracts are promising sources of bioactive compounds that could be used in cosmetic and pharmaceutical preparation
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