Constraints on the Equation-of-State of neutron stars from nearby neutron star observations

We try to constrain the Equation-of-State (EoS) of supra-nuclear-density matter in neutron stars (NSs) by observations of nearby NSs. There are seven thermally emitting NSs known from X-ray and optical observations, the so-called Magnificent Seven (M7), which are young (up to few Myrs), nearby (within a few hundred pc), and radio-quiet with blackbody-like X-ray spectra, so that we can observe their surfaces. As bright X-ray sources, we can determine their rotational (pulse) period and their period derivative from X-ray timing. From XMM and/or Chandra X-ray spectra, we can determine their temperature. With precise astrometric observations using the Hubble Space Telescope, we can determine their parallax (i.e. distance) and optical flux. From flux, distance, and temperature, one can derive the emitting area - with assumptions about the atmosphere and/or temperature distribution on the surface. This was recently done by us for the two brightest M7 NSs RXJ1856 and RXJ0720. Then, from identifying absorption lines in X-ray spectra, one can also try to determine gravitational redshift. Also, from rotational phase-resolved spectroscopy, we have for the first time determined the compactness (mass/radius) of the M7 NS RBS1223. If also applied to RXJ1856, radius (from luminosity and temperature) and compactness (from X-ray data) will yield the mass and radius - for the first time for an isolated single neutron star. We will present our observations and recent results.Comment: refereed NPA5 conference proceedings, in pres

On identifying the neutron star that was born in the supernova that placed 60Fe onto the Earth

Recently, 60Fe was found in the Earth crust formed in a nearby recent supernova (SN). If the distance to the SN and mass of the progenitor of that SN was known, then one could constrain SN models. Knowing the positions, proper motions, and distances of dozens of young nearby neutron stars, we can determine their past flight paths and possible kinematic origin. Once the birth place of a neutron star in a SN is found, we would have determined the distance of the SN and the mass of the SN progenitor star.Comment: refereed NPA5 conference proceedings, in pres

Patching in reversed-phase high-performance liquid chromatographic materials studied by solid-state NMR spectrometry

The distribution of silane chains over the silica gel surface in reversed-phase high-performance liq. chromatog. (RP-HPLC) phases was studied with special attention being paid to surface homogeneity: there might be areas with high coverage and areas with low coverage of silane chains, hence clustering or patching of the silane chains can occur. Two RP phases were studied before and after well conditioned aging, together with 4 silylated silica gels (serving as models). Two solid-state NMR techniques (e.g.,1H-29Si dipolar dephasing 29Si cross-polarization magic angle spinning NMR and 13C spin-lattice relaxation in the rotating frame) were used. For the 4 model compds. with varying degrees of coverage, only differences in the NMR time consts. were obsd. between the maximally covered phase and the 3 less densely covered silica gels. This proves that silane chains on an RP phase with max. coverage are restricted in their mobilities with respect to the less densely packed materials. For the 2 non-aged RP phases, the silane chains are probably homogeneously distributed over the silica gel surface. Further, the non-aged RP phases were compared with their counterparts, aged under well defined exptl. conditions. After aging, no differences were found between the original and the aged phases, now indicating however, that patching had developed upon agein

The continued spectral and temporal evolution of RX J0720.4-3125

RX J0720.4-3125 is the most peculiar object among a group of seven isolated X-ray pulsars (the so-called "Magnificent Seven"), since it shows long-term variations of its spectral and temporal properties on time scales of years. This behaviour was explained by different authors either by free precession (with a seven or fourteen years period) or possibly a glitch that occurred around $\mathrm{MJD=52866\pm73 days}$. We analysed our most recent XMM-Newton and Chandra observations in order to further monitor the behaviour of this neutron star. With the new data sets, the timing behaviour of RX J0720.4-3125 suggests a single (sudden) event (e.g. a glitch) rather than a cyclic pattern as expected by free precession. The spectral parameters changed significantly around the proposed glitch time, but more gradual variations occurred already before the (putative) event. Since $\mathrm{MJD\approx53000 days}$ the spectra indicate a very slow cooling by $\sim$2 eV over 7 years.Comment: seven pages, three figures, three tables; accepted by MNRA

The effects of customer equity drivers on loyalty across services industries and firms

Customer equity drivers (CEDs)—value equity, brand equity, and relationship equity—positively affect loyalty intentions, but this effect varies across industries and firms. We empirically examine potential industry and firm characteristics that explain why the CEDs–loyalty link varies across services industries and firms in the Netherlands. The results show that (1) some previously assumed industry and firm characteristics have moderating effects while others do not and (2) firm-level advertising expenditures constitute the most crucial moderator because they influence all three loyalty strategies (significant for value equity and brand equity; marginally significant for relationship equity), while three industry contexts (i.e., innovative markets, visibility to others, and complexity of purchase decisions) each influence two of the three loyalty strategies. Our results clearly show that specific industry and firm characteristics affect the effectiveness of specific loyalty strategies

Epigenetic modulators as therapeutic targets in prostate cancer

Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management.info:eu-repo/semantics/publishedVersio

Referenzmethoden zur quantitativen Bestimmung von Peptid- und Proteohormonen mit Mikro-HPLC

14 figs.SIGLETIB Hannover: FR 3481+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman