190 research outputs found
Erratum to: CDOM fluorescence as a proxy of DOC concentration in natural waters: a comparison of four contrasting tropical systems
Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
published_or_final_versio
Lavoisier: A Low Altitude Balloon Network for Probing the Deep Atmosphere and Surface of Venus
The in-situ exploration of the low atmosphere and surface of Venus is clearly the next step of Venus exploration. Understanding the geochemistry of the low atmosphere, interacting with rocks, and the way the integrated Venus system evolved, under the combined effects of inner planet cooling and intense atmospheric greenhouse, is a major challenge of modern planetology. Due to the dense atmosphere (95 bars at the surface), balloon platforms offer an interesting means to transport and land in-situ measurement instruments. Due to the large Archimede force, a 2 cubic meter He-pressurized balloon floating at 10 km altitude may carry up to 60 kg of payload. LAVOISIER is a project submitted to ESA in 2000, in the follow up and spirit of the balloon deployed at cloud level by the Russian Vega mission in 1986. It is composed of a descent probe, for detailed noble gas and atmosphere composition analysis, and of a network of 3 balloons for geochemical and geophysical investigations at local, regional and global scales
Paraoxonase-1 Is Not a Major Determinant of Stent Thrombosis in a Taiwanese Population
BACKGROUND: Clopidogrel is a prodrug that undergoes in vivo bioactivation to show its antiplatelet effects. Recent studies have shown that cytochrome P450 (CYP), ATP-binding cassette transporters (ABCB1), and paraoxonase-1 (PON1) play crucial roles in clopidogrel bioactivation. Here, we aim to determine the effects of genetic polymorphisms of CYP (CYP 2C19*2, CYP 2C19*3, and CYP 2C19*17), ABCB1 (ABCB1 3435C>T, ABCB1 129T>C, and ABCB1 2677G>T/A), and PON1 (PON1 Q192R, PON1 L55M, and PON1 108C>T) on the development of stent thrombosis (ST) in patients receiving clopidogrel after percutaneous coronary intervention (PCI). METHODS AND RESULTS: We evaluated the incidence of ST (0.64%) in 4964 patients who were recruited in the CAPTAIN registry (Cardiovascular Atherosclerosis and Percutaneous TrAnsluminal INterventions). The presence of genetic polymorphisms was assessed in 20 subjects who developed ST after aspirin and clopidogrel therapy and in 40 age- and sex-matched control subjects who did not develop ST, which was documented after 9 months of angiographic follow-up. ST was acute in 5 subjects, subacute in 7, late in 7, and very late in 1. The presence of CYP 2C19*2 allele was significantly associated with ST (adjusted odds ratio [ORadj]: 4.20, 95% confidence interval [CI], 1.263-9.544; P = 0.031). However, genetic variations in PON1 and ABCB1 showed no significant association with ST. CONCLUSION: We conclude that in a Taiwanese population, PON1 Q192R genotype is not associated with ST development after PCI. However, the presence of CYP 2C19*2 allele is a risk factor for ST development after PCI
International Geomagnetic Reference Field: the eleventh generation
The eleventh generation of the International Geomagnetic Reference Field (IGRF) was adopted in December 2009 by the International Association of Geomagnetism and Aeronomy Working Group V-MOD. It updates the previous IGRF generation with a definitive main field model for epoch 2005.0, a main field model for epoch 2010.0, and a linear predictive secular variation model for 2010.0-2015.0. In this note the equations defining the IGRF model are provided along with the spherical harmonic coefficients for the eleventh generation. Maps of the magnetic declination, inclination and total intensity for epoch 2010.0 and their predicted rates of change for 2010.0-2015.0 are presented. The recent evolution of the South Atlantic Anomaly and magnetic pole positions are also examine
International Geomagnetic Reference Field: the eleventh generation
The eleventh generation of the International Geomagnetic Reference Field (IGRF)was adopted in December 2009 by the International Association of Geomagnetism and AeronomyWorking Group V-MOD. It updates the previous IGRF generation with a definitive main field model for epoch 2005.0, a main field model for epoch 2010.0, and a linear predictive secular variation model for 2010.0–2015.0. In this note the equations defining the IGRF model are provided along with the spherical harmonic coefficients for the eleventh generation. Maps of the magnetic declination, inclination and total intensity for epoch 2010.0 and their predicted rates of change for 2010.0–2015.0 are presented. The recent evolution of the South Atlantic Anomaly and magnetic pole positions are also examined
Magnetic signatures of ionospheric and magnetospheric current systems during geomagnetic quiet conditions - An overview
Thermal Evolution and Magnetic Field Generation in Terrestrial Planets and Satellites
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