Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma

Ependymal tumors constitute a clinicopathologically heterogeneous group of brain tumors. They vary in regard to their age at first symptom, localization, morphology and prognosis. Genetic data also suggests heterogeneity. We define a newly recognized subset of ependymal tumors, the trisomy 19 ependymoma. Histologically, they are compact lesions characterized by a rich branched capillary network amongst which tumoral cells are regularly distributed. When containing clear cells they are called clear cell ependymoma. Most trisomy 19 ependymomas are supratentorial WHO grade III tumors of the young. Genetically, they are associated with trisomy 19, and frequently with a deletion of 13q21.31-31.2, three copies of 11q13.3-13.4, and/or deletions on chromosome 9. These altered chromosomal regions are indicative of genes and pathways involved in trisomy 19 ependymoma tumorigenesis. Recognition of this genetico-histological entity allows better understanding and dissection of ependymal tumors

Impact de l'urbanisation sur le cycle hydrologique dans un bassin versant periurbain. Application au bassin de l’Yzeron - ouest lyonnais, France

International audienceL’urbanisation croissante, en particulier dans les zones périphériques aux grandes villes (zones périurbaines) a des conséquences sur le cycle hydrologique en modifiant l’infiltrabilité des sols, la recharge des nappes, ainsi que les chemins naturels de l’eau via les différents réseaux (routiers, eau potable, assainissement). Une modélisation à l'aide du modèle hydrologique distribué J2000 est mise en ½uvre sur le bassin versant de l’Yzeron, en périphérie de Lyon, représentatif des bassins périurbains français. Nous montrons en particulier que l’urbanisation modifie les composantes des écoulements en accroissant le ruissellement de surface au détriment des écoulements de base ou de sub-surface (comparaison de simulations s’appuyant sur des cartes d’occupation du sol de 1990, 1999, 2008). La prise en compte des réseaux d’assainissement et des déversoirs d’orage dans la modélisation permettra d’améliorer la simulation des bilans hydrologiques dans le bassin. / Urban growth, in particular close to big cities impacts the hydrological cycle by modifying soil infiltration capacity, groundwater recharge, but also by modifying natural water pathways due to the various networks associated with urbanization (roads, drinkable and sewer networks). The distributed hydrological model J2000 is set up in the Yzeron catchment, close to Lyon city. We show that urban growth modifies the flow components by increasing surface runoff and decreasing base and sub-surface flows (comparison of simulations based on past land use mapping of 1990, 1999, 2008). The inclusion of sewer networks and sewer overflow devices in the model will improve the water balance simulations of the catchment

Investigating the impact of two decades of urbanization on the water balance of the Yzeron peri-urban catchment, France

International audienceThis paper addresses the impact of 18 years of urbanization (1990-2008) on the Yzeron meso-scale peri-urban catchment (150 km²), located close to Lyon, France. A simplified version of the distributed hydrological model J2000 was used to perform long term simulations at a daily time step for several land use scenarios. These scenarios were derived from satellite SPOT images from years 1990, 1999 and 2008. The corresponding land use maps were classified into 5 classes depending on the percentage of impervious surfaces and the dominant non-impervious land use (agriculture or forest). The paper presents the methodology for the model setup and the simulation results for the main water balance components of the catchment: total runoff, runoff components, evapotranspiration and soil moisture. The results highlight the change of the catchment seasonal response from 1990 to 2008, mainly due to a change of the respective contributions of groundwater flow / surface runoff (+ 92% / - 28%, respectively). Monthly mean summer discharge unexpectedly appears to be higher in summer. It is provided by intermittent surface runoff generated by summer storm events. As surface runoff generated on urban surfaces is likely to carry a wide range of contaminants, this has a potential large impact on water quality

Highly selective recovery of Ni(II) in neutral and acidic media using a novel Ni(II)-ion imprinted polymer

In this work, an original ion-imprinted polymer (IIP) was synthetized for the highly selective removal of Ni(II) ions in neutral and acidic media. First a novel functional monomer (AMP-MMA) was synthetized through the amidation of 2-(aminomethyl)pyridine (AMP) with methacryloylchloride. Following Ni(II)/AMP-MMA complex formation study, the Ni(II)-IIP was produced via inverse suspension polymerization (DMSO in mineral oil) and characterized with solid state 13C CPMAS NMR, FT-IR, SEM and nitrogen adsorption/desorption experiments. The Ni(II)-IIP was then used in solid-phase extraction of Ni(II) exploring a wide range of pH (from neutral to strongly acidic solution), several initial concentrations of Ni(II) (from 0.02 to 1 g/L), and the presence of competitive ions (Co(II), Cu(II), Cd(II), Mn(II), and Mg(II)). The maximum Ni(II) adsorption capacity at pH 2 and pH 7 reached values of 138.9 mg/g and 169.5 mg/g, that are among the best reported in literature. The selectivity coefficients toward Cd(II), Mn(II), Co(II), Mg(II) and Cu(II) are also very high, with values up to 38.6, 32.9, 25.2, 23.1 and 15.0, respectively. The Ni(II)-IIP showed good reusability of up to 5 cycles both with acidic and basic Ni(II) eluents.Peer reviewe

Impact of land use on the hydraulic properties of the topsoil in a small French catchment

The hydraulic properties of the topsoil control the partition of rainfall into infiltration and runoff at the soil surface. They must be characterized for distributed hydrological modelling. This study presents the results of a field campaign documenting topsoil hydraulic properties in a small French suburban catchment (7 km2) located near Lyon, France. Two types of infiltration tests were performed: single ring infiltration tests under positive head and tension disk infiltration using a mini-disk. Both categories were processed using the BEST Beerkan Estimation of Soil Transfer parameters- method to derive parameters describing the retention and hydraulic conductivity curves. Dry bulk density and particle size data were also sampled. Almost all the topsoils were found to belong to the sandy loam soil class. No significant differences in hydraulic properties were found in terms of pedologic units, but the results showed a high impact of land use on these properties. The lowest dry bulk density values were obtained in forested soils with the highest organic matter content. Permanent pasture soils showed intermediate values, whereas the highest values were encountered in cultivated lands. For saturated hydraulic conductivity, the highest values were found in broad leaved forests and small woods. The complementary use of tension disk and positive head infiltration tests highlighted a sharp increase of hydraulic conductivity between near saturation and saturated conditions, attributed to macroporosity effect. The ratio of median saturated hydraulic conductivity to median hydraulic conductivity at a pressure of -20 mm of water, was about 50. The study suggests that soil texture, such as used in most pedo-transfer functions, might not be sufficient to properly map the variability of soil hydraulic properties. Land use information should be considered in the parameterizations of topsoil within hydrological models to better represent in situ conditions, as illustrated in the paper

Three very high resolution optical images for land use mapping of a suburban catchment: input to distributed hydrological models

International audienceUrbanization and other modifications of land use affect the hydrological cycle of suburban catchments. In order to quantify these impacts, the AVuPUR project (Assessing the Vulnerability of Peri-Urban Rivers) is currently developing a distributed hydrological model that includes anthropogenic features. The case study is the Yzeron catchment (150 km2), located close to Lyon city, France. This catchment experiences a growing of urbanization and a modification of traditional land use since the middle of the 20th century, resulting in an increase of flooding, water pollution and river banks erosion. This contribution discusses the potentials of automated data processing techniques on three different VHR images, in order to produce appropriate and detailed land cover data for the models. Of particular interest is the identification of impermeable surfaces (buildings, roads, and parking places) and permeable surfaces (forest areas, agricultural fields, gardens, trees. . . ) within the catchment, because their infiltration capacity and their impact on runoff generation are different. Three aerial and spatial images were acquired: (1) BD Ortho IGN aerial images, 0.50 m resolution, visible bands, may 5th 2008; (2) QuickBird satellite image, 2.44 m resolution, visible and near-infrared bands, august 29th 2008; (3) Spot satellite image, 2.50 m resolution, visible and near-infrared bands, September 22nd 2008. From these images, we developed three image processing methods: (1) a pixel-based method associated to a segmentation using Matlab®, (2) a pixel-based method using ENVI®, (3) an object-based classification using Definiens®. We extracted six land cover types from the BD Ortho IGN (visible bands) and height classes from the satellite images (visible and near infrared bands). The three classified images are resampled in the same low resolution of 2.5 m and compared in order to evaluate the accuracy of different image processing methods and to determine for each cover type, the more appropriate image and/or method. This comparison provides hydrologists with a synthetic land cover map. Four parameters affect the accuracy of land cover mapping: firstly the addition of the NIR band improves vegetation classification such as the distinction between coniferous forest and broad-leaved forest. Moreover the intensity of chlorophyllian activity allows us to characterize the use of agricultural fields. Secondly, the images were taken at three dates in the agricultural calendar. This multi-date data allows the discrimination between permanently vegetalized pastures, and temporarily bare crops, a useful information for hydrologists who study surfaces hydraulic properties. Thirdly, the high resolution of the BD Ortho IGN image emphasizes the heterogeneity inside the spatial entities. Thus, in urbanised areas, high-resolution imagery allows the precise identification of objects > 5 m2 and consequently the quantification of impervious and pervious surfaces. However, the continuity of forest areas is not maintained because of the presence of small entities with sparser tree cover that were classified as herbaceous areas. Finally, image characteristics are more crucial than classification methods for the accuracy of land cover mapping. However, object based approach improves the classification of mixed pixels on the edge between different objects. It's particularly true for buildings and roads