80 research outputs found
Quiet Clean Short-haul Experimental Engine (QCSEE). Aerodynamic and aeromechanical performance of a 50.8 cm (20 inch) diameter 1.34 PR variable pitch fan with core flow
The fan aerodynamic and aeromechanical performance tests of the quiet clean short haul experimental engine under the wing fan and inlet with a simulated core flow are described. Overall forward mode fan performance is presented at each rotor pitch angle setting with conventional flow pressure ratio efficiency fan maps, distinguishing the performance characteristics of the fan bypass and fan core regions. Effects of off design bypass ratio, hybrid inlet geometry, and tip radial inlet distortion on fan performance are determined. The nonaxisymmetric bypass OGV and pylon configuration is assessed relative to both total pressure loss and induced circumferential flow distortion. Reverse mode performance, obtained by resetting the rotor blades through both the stall pitch and flat pitch directions, is discussed in terms of the conventional flow pressure ratio relationship and its implications upon achievable reverse thrust. Core performance in reverse mode operation is presented in terms of overall recovery levels and radial profiles existing at the simulated core inlet plane. Observations of the starting phenomena associated with the initiation of stable rotor flow during acceleration in the reverse mode are briefly discussed. Aeromechanical response characteristics of the fan blades are presented as a separate appendix, along with a description of the vehicle instrumentation and method of data reduction
Unsteady Flow and Whirl-Inducing Forces in Axial-Flow Compressors: Part I—Experiment
An experimental and theoretical investigation has been conducted to evaluate the effects seen in axial-flow compressors when the centerline of the rotor is displaced from the centerline of the static structure of the engine. This creates circumferentially nonuniform rotor-tip clearances, unsteady flow, and potentially increased clearances if the rotating and stationary parts come in contact. The result not only adversely affects compressor stall margin, pressure rise capability, and efficiency, but also generates an unsteady, destabilizing, aerodynamic force, called the Thomas/Alford force, which contributes significantly to rotor whirl instabilities in turbomachinery. Determining both the direction and magnitude of this force in compressors, relative to those in turbines, is especially important for the design of mechanically stable turbomachinery components. Part I of this two-part paper addresses these issues experimentally and Part II presents analyses from relevant computational models. Our results clearly show that the Thomas/Alford force can promote significant backward rotor whirl over much of the operating range of modern compressors, although some regions of zero and forward whirl were found near the design point. This is the first time that definitive measurements, coupled with compelling analyses, have been reported in the literature to resolve the long-standing disparity in findings concerning the direction and magnitude of whirl-inducing forces important in the design of modern axial-flow compressors
Results from a Large, Multinational Sample Using the Childhood Trauma Questionnaire
Childhood maltreatment has diverse, lifelong impact on morbidity and
mortality. The Childhood Trauma Questionnaire (CTQ) is one of the most
commonly used scales to assess and quantify these experiences and their
impact. Curiously, despite very widespread use of the CTQ, scores on its
Minimization-Denial (MD) subscale—originally designed to assess a positive
response bias—are rarely reported. Hence, little is known about this measure.
If response biases are either common or consequential, current practices of
ignoring the MD scale deserve revision. Therewith, we designed a study to
investigate 3 aspects of minimization, as defined by the CTQ’s MD scale: 1)
its prevalence; 2) its latent structure; and finally 3) whether minimization
moderates the CTQ’s discriminative validity in terms of distinguishing between
psychiatric patients and community volunteers. Archival, item-level CTQ data
from 24 multinational samples were combined for a total of 19,652
participants. Analyses indicated: 1) minimization is common; 2) minimization
functions as a continuous construct; and 3) high MD scores attenuate the
ability of the CTQ to distinguish between psychiatric patients and community
volunteers. Overall, results suggest that a minimizing response bias—as
detected by the MD subscale—has a small but significant moderating effect on
the CTQ’s discriminative validity. Results also may suggest that some prior
analyses of maltreatment rates or the effects of early maltreatment that have
used the CTQ may have underestimated its incidence and impact. We caution
researchers and clinicians about the widespread practice of using the CTQ
without the MD or collecting MD data but failing to assess and control for its
effects on outcomes or dependent variables
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Subgrouping the autism "spectrum": reflections on DSM-5
DSM-5 has moved autism from the level of subgroups ("apples and oranges") to the prototypical level ("fruit"). But making progress in research, and ultimately improving clinical practice, will require identifying subgroups within the autism spectrum
Proton Magnetic Resonance Spectroscopy in 22q11 Deletion Syndrome
OBJECTIVE: People with velo-cardio-facial syndrome or 22q11 deletion syndrome (22q11DS) have behavioral, cognitive and psychiatric problems. Approximately 30% of affected individuals develop schizophrenia-like psychosis. Glutamate dysfunction is thought to play a crucial role in schizophrenia. However, it is unknown if and how the glutamate system is altered in 22q11DS. People with 22q11DS are vulnerable for haploinsufficiency of PRODH, a gene that codes for an enzyme converting proline into glutamate. Therefore, it can be hypothesized that glutamatergic abnormalities may be present in 22q11DS. METHOD: We employed proton magnetic resonance spectroscopy ((1)H-MRS) to quantify glutamate and other neurometabolites in the dorsolateral prefrontal cortex (DLPFC) and hippocampus of 22 adults with 22q11DS (22q11DS SCZ+) and without (22q11DS SCZ-) schizophrenia and 23 age-matched healthy controls. Also, plasma proline levels were determined in the 22q11DS group. RESULTS: We found significantly increased concentrations of glutamate and myo-inositol in the hippocampal region of 22q11DS SCZ+ compared to 22q11DS SCZ-. There were no significant differences in levels of plasma proline between 22q11DS SCZ+ and 22q11DS SCZ-. There was no relationship between plasma proline and cerebral glutamate in 22q11DS. CONCLUSION: This is the first in vivo(1)H-MRS study in 22q11DS. Our results suggest vulnerability of the hippocampus in the psychopathology of 22q11DS SCZ+. Altered hippocampal glutamate and myo-inositol metabolism may partially explain the psychotic symptoms and cognitive impairments seen in this group of patients
The importance of understanding individual differences in Down syndrome
In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences at every level of description. We argue that, in the context of significant increases in DS life expectancy, a focus on individual differences in trisomy 21 at all levels—genetic, cellular, neural, cognitive, behavioral, and environmental—constitutes one of the best approaches for understanding genotype/phenotype relations in DS and for exploring risk and protective factors for Alzheimer’s disease in this high-risk population
Syndromic Autism: progressing beyond current levels of description
Genetic syndrome groups at high risk of autism comorbidity, like Down syndrome and fragile X syndrome, have been presented as useful models for understanding risk and protective factors involved in the emergence of autistic traits. Yet despite reaching clinical thresholds, these ‘syndromic’ forms of autism appear to differ in significant ways from the idiopathic or ‘non-syndromic’ autism profile. We explore alternative mechanistic explanations for these differences and propose a developmental interpretation of syndromic autism that takes into account the character of the genetic disorder. This interpretation anticipates syndrome-specific autism phenotypes, since the neurocognitive and behavioural expression of the autism is coloured by syndromically defined atypicalities. To uncover the true nature of comorbidities and of autism per se, we argue that it is key to extend definitions of autism to include the perceptual and neurocognitive characteristics of the disorder and then apply this multilevel conceptualization to the study of syndromic autism profiles
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