1,335 research outputs found
Impact of diabetes mellitus on long-term outcome after unstable angina and non-ST-segment elevation myocardial infarction treated with a very early invasive strategy
Aims/hypothesis: We sought to evaluate the impact of diabetes mellitus on long-term outcome in patients with unstable angina and non-ST-segment elevation myocardial infarction treated with a very early invasive strategy. Methods: We carried out a prospective cohort study in 270 diabetic and 1163 non-diabetic patients with unstable angina and non-ST-segment elevation myocardial infarction. All patients underwent coronary angiography and, if appropriate, subsequent revascularisation within 24 hours of admission. The primary endpoint was all-cause mortality during follow-up for up to 60 months. Results: Diabetic patients had less favourable baseline characteristics including more advanced coronary artery disease and more severe unstable angina and non-ST-segment elevation myocardial infarction. Percutaneous coronary intervention was performed in 53% of diabetic patients and 56% of non-diabetic patients. Coronary artery bypass grafting was done in 21% of diabetic patients and 12% of non-diabetic patients. In-hospital mortality (4.1% vs 1.3%; hazard ratio 3.47; 95% CI: 1.57 to 7.64; p=0.002) and long-term mortality (9.7% vs 4.9%; hazard ratio 2.11; 95% CI: 1.33 to 3.36; p=0.002) were significantly higher in diabetic patients. After adjustment for differences in baseline characteristics, diabetes mellitus was no longer an independent predictor of long-term mortality (hazard ratio 1.43; 95% CI: 0.74 to 2.78; p=0.292). Conclusions/interpretation: Diabetic patients treated with a very early invasive strategy for unstable angina and non-ST-segment elevation myocardial infarction have a higher in-hospital and long-term mortality that is largely explained by their less favourable baseline characteristics including more advanced coronary artery disease and more severe unstable angina and non-ST-segment elevation myocardial infarctio
Expressing Measurement Uncertainty in OCL/UML Datatypes
Uncertainty is an inherent property of any measure or estimation performed in any physical setting, and therefore it needs to
be considered when modeling systems that manage real data. Although several modeling languages permit the representation of measurement uncertainty for describing certain system attributes, these aspects are not normally incorporated into their type systems. Thus, operating with uncertain values and propagating uncertainty are normally cumbersome processes, di cult to achieve at the model level. This paper proposes an extension of OCL and UML datatypes to incorporate data uncertainty coming from physical measurements or user estimations into the models, along with the set of operations de ned for the values of these types.Universidad de Málaga. Campus de Excelencia Internacional AndalucĂa Tech
Investigation of the Dzyaloshinskii-Moriya interaction and room temperature skyrmions in W/CoFeB/MgO thin films and microwires
Recent studies have shown that material structures, which lack structural
inversion symmetry and have high spin-orbit coupling can exhibit chiral
magnetic textures and skyrmions which could be a key component for next
generation storage devices. The Dzyaloshinskii-Moriya Interaction (DMI) that
stabilizes skyrmions is an anti-symmetric exchange interaction favoring
non-collinear orientation of neighboring spins. It has been shown that material
systems with high DMI can lead to very efficient domain wall and skyrmion
motion by spin-orbit torques. To engineer such devices, it is important to
quantify the DMI for a given material system. Here we extract the DMI at the
Heavy Metal (HM) /Ferromagnet (FM) interface using two complementary
measurement schemes namely asymmetric domain wall motion and the magnetic
stripe annihilation. By using the two different measurement schemes, we find
for W(5 nm)/Co20Fe60B20(0.6 nm)/MgO(2 nm) the DMI to be 0.68 +/- 0.05 mJ/m2 and
0.73 +/- 0.5 mJ/m2, respectively. Furthermore, we show that this DMI stabilizes
skyrmions at room temperature and that there is a strong dependence of the DMI
on the relative composition of the CoFeB alloy. Finally we optimize the layers
and the interfaces using different growth conditions and demonstrate that a
higher deposition rate leads to a more uniform film with reduced pinning and
skyrmions that can be manipulated by Spin-Orbit Torques
Parthenium Weed (Parthenium hysterophorus L.) Research in Ethiopia: Impacts on Food Production, Plant Biodiversity and Human Health
The highly competitive, adaptable and allergenic weed Parthenium hysterophorus (Compositae) is an invasive annual weed believed to be introduced to Ethiopia in 1970s. Field surveys, plant biodiversity impacts, and analysis of secondary plant compounds in P. hysterophorus and its possible impact on human health have been studied in Ethiopia since 1998. The weed has invaded a variety of habitats ranging from roadsides to grasslands and crop fields. Infestations were found to be greater than 20 plants per m2 and yield losses in sorghum reached 46-97% depending on the location and year. In grasslands dominated by parthenium, native plant species composition and abundance was found to be low. Manual control of parthenium by farmers resulted in the development of skin allergies, itching, fever, and asthma. These reactions could be attributed to the presence of secondary plant compounds (parthenin, chlorogenic acid, isocholorogenic acid, vanilic acid and caffeic acid) which were found in parthenium with significant variation in their concentrations among the different plant parts, dependent on plant locality, moisture content and plant size. The social cost of parthenium in Ethiopia was measured by Disability Adjusted Life Years and its equivalence in terms of monetary value was estimated at US$ 2,535,887 - 4,365,057. More resources have to be invested to tackle the parthenium problem as the estimated loss is disproportionate to the cost of investment in parthenium research and development activities
Field-free deterministic ultra fast creation of skyrmions by spin orbit torques
Magnetic skyrmions are currently the most promising option to realize
current-driven magnetic shift registers. A variety of concepts to create
skyrmions were proposed and demonstrated. However, none of the reported
experiments show controlled creation of single skyrmions using integrated
designs. Here, we demonstrate that skyrmions can be generated deterministically
on subnanosecond timescales in magnetic racetracks at artificial or natural
defects using spin orbit torque (SOT) pulses. The mechanism is largely similar
to SOT-induced switching of uniformly magnetized elements, but due to the
effect of the Dzyaloshinskii-Moriya interaction (DMI), external fields are not
required. Our observations provide a simple and reliable means for skyrmion
writing that can be readily integrated into racetrack devices
FGF2 inhibits early pancreatic lineage specification during differentiation of human embryonic stem cells
Selforganized 3-band structure of the doped fermionic Ising spin glass
The fermionic Ising spin glass is analyzed for arbitrary filling and for all
temperatures. A selforganized 3-band structure of the model is obtained in the
magnetically ordered phase. Deviation from half filling generates a central
nonmagnetic band, which becomes sharply separated at T=0 by (pseudo)gaps from
upper and lower magnetic bands. Replica symmetry breaking effects are derived
for several observables and correlations. They determine the shape of the
3-band DoS, and, for given chemical potential, influence the fermion filling
strongly in the low temperature regime.Comment: 13 page
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