Percutaneous coronary intervention driven by combined use of intracoronary anatomy and physiology Towards a tailored therapy for coronary artery disease

Coronary angiography classically allows a bidimensional evaluation of the vascular lumen, however with many limitations in the case of eccentric lesions, irregular contour or tortuosity of the vessel.Moreover, it does not enable to assess neither the features of the vessel wall, nor the functional significance of a lesion [1]. Newer technologies are available to overcome these limitations.We present a case of percutaneous coronary revascularization optimized by combined use of two of the most widely used techniques

Twenty years of experience in juvenile nasopharyngeal angiofibroma (JNA) preoperative endovascular embolization: An effective procedure with a low complications rate

Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor of the nasal cavity that predominantly affects young boys. Surgical removal remains the gold standard for the management of this disease. Preoperative intra-arterial embolization (PIAE) is useful for reductions in intraoperative blood loss and surgical complications. In our series of 79 patients who underwent preoperative embolization from 1999 to 2020, demographics, procedural aspects, surgical management and follow-up outcome were analyzed. Embolization was performed in a similar fashion for all patients, with a superselective microcatheterization of external carotid artery (ECA) feeders and an injection of polyvinyl alcohol (PVA) particles, followed, in some cases, by the deployment of coils. Procedural success was reached in 100% of cases, with no complications such as bleeding or thromboembolic occlusion, and surgical intraoperative blood loss was significantly decreased. In conclusion, PIAE is a safe and effective technique in JNA treatment, minimizing intraoperative bleeding

3D-Printed transmit-array antenna for broadband backhaul 5G links at V band

The low cost and compactness of transmit-array antennas (TAs) make them attractive for 5G backhaul links. However, the TA advantage is less obvious when considering the broadband operation requirement. Two main factors influence the bandwidth performance, namely: 1) the bandwidth of the unit cells, and 2) the number of 360° phase wrapping zones in the aperture, which are designed for a specific frequency. Herein, we overcome these limitations by using all-dielectric unit cells (inherently broadband) and by developing a general method to quantify and manage the intricate relation between antenna gain, bandwidth, and antenna height. Based on this framework we optimize, as an example, a TA design (focal distance, F=63 mm and aperture diameter D=80 mm ) to comply with typical gain specification for 5G backhaul links (>30 dBi) in the WiGiG band (from 57 to 66 GHz). The feed is a dedicated compact horn (8 ×5×22 mm3) that provides a proper illumination of the aperture. Additive manufacturing is used to simplify the manufacturing process of the antenna. A very good agreement between simulations and experimental results is obtained, achieving good aperture efficiency for this type of antenna (42%), which rivals with existing solutions based on more expensive manufacturing techniques.info:eu-repo/semantics/acceptedVersio

Transmit-array antenna design for broadband backhaul 5G communications at WiGiG band

A cost-effective transmit-array (TA) antenna design framework is presented and experimentally validated for a 5G backhaul application at the WiGiG band. The antenna is composed of a discrete dielectric lens (DDL) fed by a horn, specifically designed for this application. Both the TA and feed are fabricated using additive manufacturing. Metal coating and Fuse Deposition Modeling are employed for the horn and TA fabrication, respectively. Simple design rules are devised to quantify the bandwidth of this type of antennas as function of the aperture dimension and focal distance . Based on this framework a compact TA antenna ( ⁄=.) than can comply with typical specifications for 5G backhaul links at WiGiG band (minimum gain of 30 dBi from 57 to 66 GHz) is designed.info:eu-repo/semantics/acceptedVersio

Sifting the debris : patterns in the SNR population with unsupervised ML methods

Context. Supernova remnants (SNRs) carry vast amounts of mechanical and radiative energy that heavily influence the structural, dynamical, and chemical evolution of galaxies. To this day, more than 300 SNRs have been discovered in the Milky Way, exhibiting a wide variety of observational features. However, existing classification schemes are mainly based on their radio morphology. Aims. In this work, we introduce a novel unsupervised deep learning pipeline to analyse a representative subsample of the Galactic SNR population ( 50% of the total) with the aim of finding a connection between their multi-wavelength features and their physical properties. Methods. The pipeline involves two stages: (1) a representation learning stage, consisting of a convolutional autoencoder that feeds on imagery from infrared and radio continuum surveys (WISE 22 m, Hi-GAL 70 m and SMGPS 30 cm) and produces a compact representation in a lower-dimensionality latent space; and (2) a clustering stage that seeks meaningful clusters in the latent space that can be linked to the physical properties of the SNRs and their surroundings. Results. Our results suggest that this approach, when combined with an intermediate uniform manifold approximation and projection (UMAP) reprojection of the autoencoded embeddings into a more clusterable manifold, enables us to find reliable clusters. Despite a large number of sources being classified as outliers, most clusters relate to the presence of distinctive features, such as the distribution of infrared emission, the presence of radio shells and pulsar wind nebulae, and the existence of dust filaments.peer-reviewe

reference architecture and framework

M. Adorni, F. Arcelli, S. Bandini, L. Baresi, C. Batini, A. Bianchi, D. Bianchini, M. Brioschi, A. Caforio, A. Cali, P. Cappellari, C. Cappiello, T. Catarci, A. Corallo, V. De Antonellis, C. Franza, G. Giunta, A. Limonta, G. Lorenzo, P. Losi, A. Maurino, M. Melideo, D. Micucci, S. Modafferi, E. Mussi, L. Negri, C. Pandolfo, B. Pernici, P. Plebani, D. Ragazzi, C. Raibulet, M. Riva, N. Simeoni, C. Simone, G. Solazzo, F. Tisato, R. Torlone, G. Vizzari, and A. Zill

Percutaneous treatments of acute myocardial infarction and major stroke: Two parallel roads

Neurological and cardiovascular ischemic diseases represent the main causes of morbidity and mortality in the world. Physiopathological mechanisms present several similarities, based on "thromboembolic" events, as well as the pharmacological and percutaneous treatment options. We report a case of contemporary presentation of acute coronary and cerebral syndromes, successfully managed with a combined percutaneous intervention driven by the emergency setting. Whereas invasive revascularization represents nowadays the "gold standard" therapy for acute coronary syndromes, catheter-based treatment of acute stroke is not yet widespread and still under debate