179 research outputs found
The Series as Commodity: Marketing T. Fisher Unwin's Pseudonym and Autonym Libraries
This volume focuses on the publisher's series as a cultural formation - a material artefact and component of cultural hierarchies. Contributors engage with archival research, cultural theory, literary and bibliometric analysis (amongst a range of other approaches) to contextualize the publisher's series in terms of its cultural and economic work. [Book
Use of archival aerial photographs for archaeological research in the Arabian Gulf
A valuable archaeological and historical resource is contained within recently declassified aerial imagery from the UK’s Joint Aerial
Reconnaissance Intelligence Centre (JARIC), now held at the National Collection of Aerial Photography in Edinburgh (NCAP).
A project at UCL-Qatar has begun to exploit this to acquire and research the historical aerial photography of Qatar and the wider
Gulf region. The JARIC collection, comprising perhaps as many as 25 million photographs from British intelligence sources in the
twentieth century, mainly from Royal Air Force reconnaissance missions, is known to include large quantities of aerial photography
from the Gulf that have never been seen outside intelligence circles, dating from 1939 to 1989. This paper will demonstrate how
others may gain access to this valuable resource, not only for the Gulf but for the entire MENA (Middle East and North Africa)
region. We will explore the research value of these resources and demonstrate how they enrich our understanding of the area. The
archive is likely to be of equal value to archaeologists and historians of other regions
Consortia from Past to Future
This essay reviews the global history of library consortia from ancient times until the present and proposes further development of consortia to address journal costs and research distribution. The global history of consortia is reviewed, with a concentration on the early years of the American Library Association. Consortia have proved their value in making libraries more efficient and in advancing research through combined efforts in developing indexes and catalogues . The paper encourages libraries to build on their history of cooperation and extend it by linking their repositories, using their own strengths to battle excessive subscription fees, and become publishers in their own right. Consortia are encouraged to work together to build a global repository, to stand firm against predatory pricing, and to take the lead in the dissemination of scholarship. This essay proposes that libraries join in broad regional consortia to oppose unjustifiable prices imposed by the major publishers and that ibraries, with their institutions, work regionally and internationally to take control of the distribution of research
How COVID-19 Pandemic Indirectly Affected Orthopedic Patients: A Case Report of a Rescue Treatment For a Proximal Humerus Nonunion
Humeral fractures account for 5% to 8% of all fractures, whereas proximal humerus fractures represent the seventh most frequent fractures in adults..
Knowledge Integration and Diffusion: Measures and Mapping of Diversity and Coherence
I present a framework based on the concepts of diversity and coherence for
the analysis of knowledge integration and diffusion. Visualisations that help
understand insights gained are also introduced. The key novelty offered by this
framework compared to previous approaches is the inclusion of cognitive
distance (or proximity) between the categories that characterise the body of
knowledge under study. I briefly discuss the different methods to map the
cognitive dimension
Interpreting the yield of transit surveys: Are there groups in the known transiting planets population?
Each transiting planet discovered is characterized by 7 measurable
quantities, that may or may not be linked together (planet mass, radius,
orbital period, and star mass, radius, effective temperature, and metallicity).
Correlations between planet mass and period, surface gravity and period, planet
radius and star temperature have been previously observed among the known
transiting giant planets. Two classes of planets have been previously
identified based on their Safronov number. We use the CoRoTlux code to compare
simulated events to the sample of discovered planets and test the statistical
significance of these correlations. We first generate a stellar field with
planetary companions based on radial velocity discoveries and a planetary
evolution model, then apply a detection criterion that includes both
statistical and red noise sources. We compare the yield of our simulated survey
with the ensemble of 31 well-characterized giant transiting planets, using a
multivariate logistic analysis to assess whether the simulated distribution
matches the known transiting planets. Our multivariate analysis shows that our
simulated sample and observations are consistent to 76%. The mass vs. period
correlation for giant planets first observed with radial velocity holds with
transiting planets. Our model naturally explains the correlation between planet
surface gravity and period and the one between planet radius and stellar
effective temperature. Finally, we are also able to reproduce the previously
observed apparent bimodal distribution of Safronov numbers in 10% of our
simulated cases, although our model predicts a continuous distribution. This
shows that the evidence for the existence of two groups of planets with
different intrinsic properties is not statistically significant.Comment: 17 page
What is the role of public feeder markets in developing technology-based small firms? An exploration of the motivations for listing on AIM since the GFC
In the aftermath of the 2007 global financial crisis (GFC) stock markets experienced sharp decline in listings and marked reduction in Initial Public Offerings (IPOs). This paper explores the factors determining UK technology based small firm (TBSF) listings on the UK Alternative Investment Market (AIM) and whether this market has a role to play in their future development.
A case study approach is used to contrast the experiences of five recent AIM listed TBSFs with five TBSFs approaching private equity investment exit that are considering an IPO.
The paper concludes that macro market conditions, rather than managerial resource base or AIM market structural factors were most influential in TBSF pecking order preferences to undertake IPOs. From a resource based management perspective lifelong entrepreneurs were more likely than serial entrepreneurs to favour an IPO exit, as it supported their aims to continue to manage and grow UK-based companies. Additionally, with a more buoyant and sustainable AIM market TBSF investors are more likely to choose IPOs. To conclude, AIM played an important role in listed UK TBSF development. A more buoyant AIM could ease the UK finance escalator’s flow, facilitating more rapid UK TBSF growth
Mapping Patent Classifications: Portfolio and Statistical Analysis, and the Comparison of Strengths and Weaknesses
The Cooperative Patent Classifications (CPC) jointly developed by the
European and US Patent Offices provide a new basis for mapping and portfolio
analysis. This update provides an occasion for rethinking the parameter
choices. The new maps are significantly different from previous ones, although
this may not always be obvious on visual inspection. Since these maps are
statistical constructs based on index terms, their quality--as different from
utility--can only be controlled discursively. We provide nested maps online and
a routine for portfolio overlays and further statistical analysis. We add a new
tool for "difference maps" which is illustrated by comparing the portfolios of
patents granted to Novartis and MSD in 2016.Comment: Scientometrics 112(3) (2017) 1573-1591;
http://link.springer.com/article/10.1007/s11192-017-2449-
Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
BACKGROUND
The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algorithm is also established to determine how the pathophysiological condition might influence the human biological cardiac age.
RESULTS
Blood samples and cardiac auricles were collected from patients who underwent cardiac procedures: 94 AVR and 289 CABG. The CpGs from three independent blood-derived biological clocks were selected to design a new blood- and the first cardiac-specific clocks. Specifically, 31 CpGs from six age-related genes, ELOVL2, EDARADD, ITGA2B, ASPA, PDE4C, and FHL2, were used to construct the tissue-tailored clocks. The best-fitting variables were combined to define new cardiac- and blood-tailored clocks validated through neural network analysis and elastic regression. In addition, telomere length (TL) was measured by qPCR. These new methods revealed a similarity between chronological and biological age in the blood and heart; the average TL was significantly higher in the heart than in the blood. In addition, the cardiac clock discriminated well between AVR and CABG and was sensitive to cardiovascular risk factors such as obesity and smoking. Moreover, the cardiac-specific clock identified an AVR patient's subgroup whose accelerated bioage correlated with the altered ventricular parameters, including left ventricular diastolic and systolic volume.
CONCLUSION
This study reports on applying a method to evaluate the cardiac biological age revealing epigenetic features that separate subgroups of AVR and CABG
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