Pegembangan Game dengan Menggunakan Teknologi Voice Recognition Berbasis Android

The purpose of this research is to create a new kind of game by using technology that rarely used in current games. It is developed as an entertainment media and also a social media in which the users can play the games together via multiplayer mode. This research uses Scrum development method since it supports small scaled developer and it supports software increment along the development. Using this game application, the users can play and watch interesting animations by controlling it with their voice, listen the character imitating the users' voice, play various mini games both in single player or multiplayer mode via Bluetooth connection. The conclusion is that game application of My Name is Dug use voice recognition and inter-devices connection as its main features. It also has various mini games that support both single player and multiplayer

Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum.

BackgroundA vaccine that interrupts malaria transmission (VIMT) would be a valuable tool for malaria control and elimination. One VIMT approach is to identify sexual erythrocytic and mosquito stage antigens of the malaria parasite that induce immune responses targeted at disrupting parasite development in the mosquito. The standard Plasmodium falciparum membrane-feeding assay (SMFA) is used to assess transmission-blocking activity (TBA) of antibodies against candidate immunogens and of drugs targeting the mosquito stages. To develop its P. falciparum sporozoite (SPZ) products, Sanaria has industrialized the production of P. falciparum-infected Anopheles stephensi mosquitoes, incorporating quantitative analyses of oocyst and P. falciparum SPZ infections as part of the manufacturing process.MethodsThese capabilities were exploited to develop a robust, reliable, consistent SMFA that was used to assess 188 serum samples from animals immunized with the candidate vaccine immunogen, Pfs25, targeting P. falciparum mosquito stages. Seventy-four independent SMFAs were performed. Infection intensity (number of oocysts/mosquito) and infection prevalence (percentage of mosquitoes infected with oocysts) were compared between mosquitoes fed cultured gametocytes plus normal human O(+) serum (negative control), anti-Pfs25 polyclonal antisera (MRA39 or MRA38, at a final dilution in the blood meal of 1:54 as positive control), and test sera from animals immunized with Pfs25 (at a final dilution in the blood meal of 1:9).ResultsSMFA negative controls consistently yielded high infection intensity (mean = 46.1 oocysts/midgut, range of positives 3.7-135.6) and infection prevalence (mean = 94.2%, range 71.4-100.0) and in positive controls, infection intensity was reduced by 81.6% (anti-Pfs25 MRA39) and 97.0% (anti-Pfs25 MRA38), and infection prevalence was reduced by 12.9 and 63.5%, respectively. A range of TBAs was detected among the 188 test samples assayed in duplicate. Consistent administration of infectious gametocytes to mosquitoes within and between assays was achieved, and the TBA of anti-Pfs25 control antibodies was highly reproducible.ConclusionsThese results demonstrate a robust capacity to perform the SMFA in a medium-to-high throughput format, suitable for assessing large numbers of experimental samples of candidate antibodies or drugs

Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population-based sample

© 2017 The Authors Introduction Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal Olmsted County, Minnesota, residents, aged 70 to 89 years with probable RBD. Here, we examine their progression to dementia and other neurodegenerative phenotypes. Methods Fifteen participants with RBD who were diagnosed with either MCI or PD were longitudinally followed, and their subsequent clinical courses were reviewed. Results Over 6.4 ± 2.9 years, six of the 14 participants with MCI developed additional neurodegenerative signs, five of whom had Lewy body disease features. Four of them progressed to dementia at a mean age 84.8 ± 4.9 years, three of whom met the criteria for probable dementia with Lewy bodies. One subject with PD developed MCI, but not dementia. Discussion Our findings from the population-based sample of Olmsted County, Minnesota, residents suggest that a substantial number of RBD patients tend to develop overt synucleinopathy features over time, and RBD patients who develop MCI and subsequent dementia have clinical features most consistent with dementia with Lewy bodies

Pertambahan Bobot Badan Dan Feed Conversion Rate Ayam Broiler Yang Dipelihara Menggunakan Desinfektan Herbal

Senyawa aktif dalam daun babadotan (Ageratum conyzoides) diketahui memiliki aktivitas antibakterial khususnya untuk menghambat perkembangan bakteri patogen. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh penggunaan desinfektan herbal berbahan dasar ekstrak daun babadotan (Ageratium conyzoides) terhadap produktivitas ayam broiler yang diketahui berdasarkan pertambahan bobot badan harian (PBBH) dan FCR (Feed Convertion Rate). Penelitian ini menggunakan desinfektan herbal daun babadotan konsentrasi 1% dan 1,5%, serta desinfektan sintetis komersian 1,5% sebagai pembanding. Hasil penelitian menunjukkan bahwa PBBH ayam broiler yang dipelihara dengan menggunakan desinfektan herbal dan sintetis tidak berbeda (P>0,05). Nilai PBBH desinfektan herbal 1% dan 1,5% adalah 35,11 dan 33,69 g/ekor/hari, sedangkan desinfektan sintetis 32,75 g/ekor/hari. Nilai FCR ayam pada pemeliharaan menggunakan desinfektan herbal juga menunjukkan hasil yang sama (P>0,05) dengan desinfektan sintetis. Nilai FCR desinfektan herbal 1% dan 1,5% adalah 1,6 dan 1,67. Sedangkan FCR desinfektan sintetis sebesar 1,63. Berdasarkan data tersebut disimpulkan bahwa desinfektan herbal ekstrak daun babadotan dapat digunakan sebagai alternatif dalam kegiatan biosecurity di peternakan ayam broiler

PENGARUH HARGA, PEMASARAN DIGITAL, DAN KUALITAS PELAYANAN TERHADAP PURCHASE INTENTION GALERI UMKM PERUMDA BIDADARI LABUAN BAJO

This study explores the impact of price, digital marketing, and service quality on consumer Purchase Intention at Perumda Bidadari MSME Gallery. The population involved all visitors with a sample of 100 respondents selected through the non-probability sampling method, using accidental sampling. Data collection using questionnaires. This research applies a quantitative approach to evaluate the relationship between variables. The research instrument was tested with validity and reliability. Statistical analysis uses t-test, f-test, normality test, multicollinearity, and linearity test. Data analysis using multiple linear regression. The results showed that service quality has a positive and significant impact on Purchase Intention, while the effect of price and digital marketing strategy is not significant. With an R Square value of 0.814, it shows that about 81.4% of the variation in Purchase Intention can be explained by the combination of price, digital marketing, and service quality factors. Keywords: Price; Digital Marketing; Service Quality; Purchase Intention

Community-Guided Focus Group Analysis to Examine Cancer Disparities

Accountability for Cancer Care through Undoing Racism and Equity (ACCURE) is a systems-change intervention addressing disparities in treatment initiation and completion and outcomes for early stage Black and White breast and lung cancer patients. Using a community-based participatory research approach, ACCURE is guided by a diverse partnership involving academic researchers, a non-profit community-based organization, its affiliated broader-based community coalition, and providers and staff from two cancer centers

How Haptic Size Sensations Improve Distance Perception

Determining distances to objects is one of the most ubiquitous perceptual tasks in everyday life. Nevertheless, it is challenging because the information from a single image confounds object size and distance. Though our brains frequently judge distances accurately, the underlying computations employed by the brain are not well understood. Our work illuminates these computions by formulating a family of probabilistic models that encompass a variety of distinct hypotheses about distance and size perception. We compare these models' predictions to a set of human distance judgments in an interception experiment and use Bayesian analysis tools to quantitatively select the best hypothesis on the basis of its explanatory power and robustness over experimental data. The central question is: whether, and how, human distance perception incorporates size cues to improve accuracy. Our conclusions are: 1) humans incorporate haptic object size sensations for distance perception, 2) the incorporation of haptic sensations is suboptimal given their reliability, 3) humans use environmentally accurate size and distance priors, 4) distance judgments are produced by perceptual “posterior sampling”. In addition, we compared our model's estimated sensory and motor noise parameters with previously reported measurements in the perceptual literature and found good correspondence between them. Taken together, these results represent a major step forward in establishing the computational underpinnings of human distance perception and the role of size information.National Institutes of Health (U.S.) (NIH grant R01EY015261)University of Minnesota (UMN Graduate School Fellowship)National Science Foundation (U.S.) (Graduate Research Fellowship)University of Minnesota (UMN Doctoral Dissertation Fellowship)National Institutes of Health (U.S.) (NIH NRSA grant F32EY019228-02)Ruth L. Kirschstein National Research Service Awar

Spontaneous Reorientation Is Guided by Perceived Surface Distance, Not by Image Matching Or Comparison

Humans and animals recover their sense of position and orientation using properties of the surface layout, but the processes underlying this ability are disputed. Although behavioral and neurophysiological experiments on animals long have suggested that reorientation depends on representations of surface distance, recent experiments on young children join experimental studies and computational models of animal navigation to suggest that reorientation depends either on processing of any continuous perceptual variables or on matching of 2D, depthless images of the landscape. We tested the surface distance hypothesis against these alternatives through studies of children, using environments whose 3D shape and 2D image properties were arranged to enhance or cancel impressions of depth. In the absence of training, children reoriented by subtle differences in perceived surface distance under conditions that challenge current models of 2D-image matching or comparison processes. We provide evidence that children’s spontaneous navigation depends on representations of 3D layout geometry.National Institutes of Health (U.S.) (Grant HD 23103

Plasmacytoid Dendritic Cells Capture and Cross-Present Viral Antigens from Influenza-Virus Exposed Cells

Among the different subsets of dendritic cells (DC), plasmacytoid dendritic cells (PDC) play a unique role in secreting large amounts of type I interferons upon viral stimulation, but their efficiency as antigen-presenting cells has not been completely characterized. We show here, by flow cytometry, with human primary blood PDC and with a PDC cell line, that PDC display poor endocytic capacity for soluble or cellular antigens when compared to monocyte-derived myeloid DC. However, immature PDC efficiently take up cellular material from live influenza-exposed cells, subsequently mature and cross-present viral antigens very efficiently to specific CD8+ T cells. Therefore, during viral infection PDC not only secrete immunomodulatory cytokines, but also recognize infected cells and function as antigen cross-presenting cells to trigger the anti-viral immune response