Pulsed laser deposited KNbO3_3 thin films for applications in high frequency range

Potassium niobate thin films were grown by pulsed laser deposition on various substrates. Influence of deposition conditions on film characteristics was studied. Structural investigation evidenced that single phase polycrystalline randomly oriented films were grown on sintered alumina whereas epitaxial films were grown on (100)SrTiO$_3$ and (100)MgO substrates. The microstructure was highly controlled by the structural characteristics. Interdigited capacitors built from KNbO3 films on two different substrates (alumina and MgO) showed the strong influence of the structural characteristics on the dielectric behavior. The variation of the equivalent capacitance measured on the interdigital capacitor on MgO was 6.4% at 2.5 GHz while it was 1.5% on alumina, in both cases for a moderate applied field of $\sim$15 kV cm$^{-1}$. The results show the potentiality of these ferroelectric materials for use in frequency agile microwave electronics

Design, Analysis and Testing of a Novel Mitral Valve for Transcatheter Implantation

Mitral regurgitation is a common mitral valve dysfunction which may lead to heart failure. Because of the rapid aging of the population, conventional surgical repair and replacement of the pathological valve are often unsuitable for about half of symptomatic patients, who are judged high-risk. Transcatheter valve implantation could represent an effective solution. However, currently available aortic valve devices are inapt for the mitral position. This paper presents the design, development and hydrodynamic assessment of a novel bi-leaflet mitral valve suitable for transcatheter implantation. The device consists of two leaflets and a sealing component made from bovine pericardium, supported by a self-expanding wireframe made from superelastic NiTi alloy. A parametric design procedure based on numerical simulations was implemented to identify design parameters providing acceptable stress levels and maximum coaptation area for the leaflets. The wireframe was designed to host the leaflets and was optimised numerically to minimise the stresses for crimping in an 8 mm sheath for percutaneous delivery. Prototypes were built and their hydrodynamic performances were tested on a cardiac pulse duplicator, in compliance with the ISO5840-3:2013 standard. The numerical results and hydrodynamic tests show the feasibility of the device to be adopted as a transcatheter valve implant for treating mitral regurgitation

Obstructive Sleep Apnea Is Associated with Liver Damage and Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease

We assessed whether obstructive sleep apnea (OSA) and nocturnal hypoxemia are associated with severity of liver fibrosis and carotid atherosclerosis in patients with biopsy-proven NAFLD and low prevalence of morbid obesity. Secondary aim was to explore the association of OSA and hypoxemia with NASH and severity of liver pathological changes

From vision to movement: cortico-cortical connections and combinatorial properties of reaching related neurons in parietal areas V6 and V6A

Exp. Brain Res. Suppl