81 research outputs found
Maximum approximate entropy and r threshold: A new approach for regularity changes detection
Approximate entropy (ApEn) has been widely used as an estimator of regularity
in many scientific fields. It has proved to be a useful tool because of its
ability to distinguish different system's dynamics when there is only available
short-length noisy data. Incorrect parameter selection (embedding dimension
, threshold and data length ) and the presence of noise in the signal
can undermine the ApEn discrimination capacity. In this work we show that
() can also be used as a feature to
discern between dynamics. Moreover, the combined use of and
allows a better discrimination capacity to be accomplished, even in
the presence of noise. We conducted our studies using real physiological time
series and simulated signals corresponding to both low- and high-dimensional
systems. When is incapable of discerning between different
dynamics because of the noise presence, our results suggest that
provides additional information that can be useful for classification purposes.
Based on cross-validation tests, we conclude that, for short length noisy
signals, the joint use of and can significantly decrease
the misclassification rate of a linear classifier in comparison with their
isolated use
Classification of atrial electrograms in atrial fibrillation using Information Theory-based measures
International audienc
Separation between coherent and turbulent fluctuations. What can we learn from the Empirical Mode Decomposition?
The performances of a new data processing technique, namely the Empirical
Mode Decomposition, are evaluated on a fully developed turbulent velocity
signal perturbed by a numerical forcing which mimics a long-period flapping.
First, we introduce a "resemblance" criterion to discriminate between the
polluted and the unpolluted modes extracted from the perturbed velocity signal
by means of the Empirical Mode Decomposition algorithm. A rejection procedure,
playing, somehow, the role of a high-pass filter, is then designed in order to
infer the original velocity signal from the perturbed one. The quality of this
recovering procedure is extensively evaluated in the case of a "mono-component"
perturbation (sine wave) by varying both the amplitude and the frequency of the
perturbation. An excellent agreement between the recovered and the reference
velocity signals is found, even though some discrepancies are observed when the
perturbation frequency overlaps the frequency range corresponding to the
energy-containing eddies as emphasized by both the energy spectrum and the
structure functions. Finally, our recovering procedure is successfully
performed on a time-dependent perturbation (linear chirp) covering a broad
range of frequencies.Comment: 23 pages, 13 figures, submitted to Experiments in Fluid
Procesamiento, análisis y modelado de señales biomédicas: un enfoque integrador
Este proyecto se centra en el estudio, desarrollo y aplicación de técnicas de procesamiento, modelado y análisis de señales que permitan abordar los casos de señales biomédicas. Abordaremos métodos adaptativos de análisis de señales, principalmente la descomposición empírica en modos y sus variantes. Se avanzará en el desarrollo de modelos de las señales relacionadas con el aparato fonador. Se continuará el estudio de modelos en espacio de estados que permiten extraer información sobre el estado instantáneo del tracto vocal y de la fuente glótica. Se estudiará la factibilidad de extraer nuevos parámetros acústicos de utilidad clínica. Investigaremos técnicas y herramientas provenientes de la teoría de la información estudiando medidas basadas en la integral de correlación asistida por ruido y la integral de correlación U, propuestas por nuestro grupo, para la estimación de los invariantes dimensión, entropía y ruido, en sistemas simulados y reales de variadas dimensiones. Finalmente, se continuará con la formación de recursos humanos, a través de la realización de becas postdoctorales y doctorales CONICET, y el fortalecimiento de un grupo de investigación en el área de las TICs en el procesamiento de señales biomédicas, en el contexto del Instituto de Bioinformática y Bioingeniería en vías de creación.
ARK/CAICYT: http://id.caicyt.gov.ar/ark:/s22504559/rd18ww2h
Detection, Properties, and Frequency of Local Calcium Release from the Sarcoplasmic Reticulum in Teleost Cardiomyocytes
Calcium release from the sarcoplasmic reticulum (SR) plays a central role in the regulation of cardiac contraction and rhythm in mammals and humans but its role is controversial in teleosts. Since the zebrafish is an emerging model for studies of cardiovascular function and regeneration we here sought to determine if basic features of SR calcium release are phylogenetically conserved. Confocal calcium imaging was used to detect spontaneous calcium release (calcium sparks and waves) from the SR. Calcium sparks were detected in 16 of 38 trout atrial myocytes and 6 of 15 ventricular cells. The spark amplitude was 1.45±0.03 times the baseline fluorescence and the time to half maximal decay of sparks was 27±3 ms. Spark frequency was 0.88 sparks µm−1 min−1 while calcium waves were 8.5 times less frequent. Inhibition of SR calcium uptake reduced the calcium transient (F/F0) from 1.77±0.17 to 1.12±0.18 (p = 0.002) and abolished calcium sparks and waves. Moreover, elevation of extracellular calcium from 2 to 10 mM promoted early and delayed afterdepolarizations (from 0.6±0.3 min−1 to 8.1±2.0 min−1, p = 0.001), demonstrating the ability of SR calcium release to induce afterdepolarizations in the trout heart. Calcium sparks of similar width and duration were also observed in zebrafish ventricular myocytes. In conclusion, this is the first study to consistently report calcium sparks in teleosts and demonstrate that the basic features of calcium release through the ryanodine receptor are conserved, suggesting that teleost cardiac myocytes is a relevant model to study the functional impact of abnormal SR function
Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart
Heart failure (HF) is characterized by molecular and cellular defects which jointly contribute to decreased cardiac pump function. During the development of the initial cardiac damage which leads to HF, adaptive responses activate physiological countermeasures to overcome depressed cardiac function and to maintain blood supply to vital organs in demand of nutrients. However, during the chronic course of most HF syndromes, these compensatory mechanisms are sustained beyond months and contribute to progressive maladaptive remodeling of the heart which is associated with a worse outcome. Of pathophysiological significance are mechanisms which directly control cardiac contractile function including ion- and receptor-mediated intracellular signaling pathways. Importantly, signaling cascades of stress adaptation such as intracellular calcium (Ca2+) and 3′-5′-cyclic adenosine monophosphate (cAMP) become dysregulated in HF directly contributing to adverse cardiac remodeling and depression of systolic and diastolic function. Here, we provide an update about Ca2+ and cAMP dependent signaling changes in HF, how these changes affect cardiac function, and novel therapeutic strategies which directly address the signaling defects
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