189 research outputs found
Determinants of an elevated pulmonary arterial pressure in patients with pulmonary arterial hypertension
Given the difficulty of diagnosing early-stage pulmonary arterial hypertension (PAH) due to the lack of signs and symptoms, and the risk of an open lung biopsy, the precise pathological features of presymptomatic stage lung tissue remain unknown. It has been suggested that the maximum elevation of the mean pulmonary arterial pressure (Ppa) is achieved during the early symptomatic stage, indicating that the elevation of the mean Ppa is primarily driven by the pulmonary vascular tone and/or some degree of pulmonary vascular remodeling completed during this stage. Recently, the examination of a rat model of severe PAH suggested that the severe PAH may be primarily determined by the presence of intimal lesions and/or the vascular tone in the early stage. Human data seem to indicate that intimal lesions are essential for the severely increased pulmonary arterial blood pressure in the late stage of the disease. However, many questions remain. For instance, how does the pulmonary hemodynamics change during the course of the disease, and what drives the development of severe PAH? Although it is generally acknowledged that both pulmonary vascular remodeling and the vascular tone are important determinants of an elevated pulmonary arterial pressure, which is the root cause of the time-dependent progression of the disease? Here we review the recent histopathological concepts of PAH with respect to the progression of the lung vascular disease
Solar Wind and its Evolution
By using our previous results of magnetohydrodynamical simulations for the
solar wind from open flux tubes, I discuss how the solar wind in the past is
different from the current solar wind. The simulations are performed in fixed
one-dimensional super-radially open magnetic flux tubes by inputing various
types of fluctuations from the photosphere, which automatically determines
solar wind properties in a forward manner. The three important parameters which
determine physical properties of the solar wind are surface fluctuation,
magnetic field strengths, and the configuration of magnetic flux tubes.
Adjusting these parameters to the sun at earlier times in a qualitative sense,
I infer that the quasi-steady-state component of the solar wind in the past was
denser and slightly slower if the effect of the magneto-centrifugal force is
not significant. I also discuss effects of magneto-centrifugal force and roles
of coronal mass ejections.Comment: 6 pages, 1 figure, Earth, Planets, & Space in press (based on 5th
Alfven Conference) correction of discussion on a related pape
A Statistical Inference Method for Interpreting the CLASP Observations
On 3rd September 2015, the Chromospheric Lyman-Alpha SpectroPolarimeter
(CLASP) successfully measured the linear polarization produced by scattering
processes in the hydrogen Lyman- line of the solar disk radiation,
revealing conspicuous spatial variations in the and signals. Via
the Hanle effect the line-center and amplitudes encode information
on the magnetic field of the chromosphere-corona transition region (TR), but
they are also sensitive to the three-dimensional structure of this corrugated
interface region. With the help of a simple line formation model, here we
propose a statistical inference method for interpreting the Lyman-
line-center polarization observed by CLASP.Comment: Accepted for publication in The Astrophysical Journa
CLASP Constraints on the Magnetization and Geometrical Complexity of the Chromosphere-Corona Transition Region
The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) is a suborbital
rocket experiment that on 3rd September 2015 measured the linear polarization
produced by scattering processes in the hydrogen Ly- line of the solar
disk radiation, whose line-center photons stem from the chromosphere-corona
transition region (TR). These unprecedented spectropolarimetric observations
revealed an interesting surprise, namely that there is practically no
center-to-limb variation (CLV) in the line-center signals. Using an
analytical model, we first show that the geometrical complexity of the
corrugated surface that delineates the TR has a crucial impact on the CLV of
the and line-center signals. Secondly, we introduce a statistical
description of the solar atmosphere based on a three-dimensional (3D) model
derived from a state-of-the-art radiation magneto-hydrodynamic simulation. Each
realization of the statistical ensemble is a 3D model characterized by a given
degree of magnetization and corrugation of the TR, and for each such
realization we solve the full 3D radiative transfer problem taking into account
the impact of the CLASP instrument degradation on the calculated polarization
signals. Finally, we apply the statistical inference method presented in a
previous paper to show that the TR of the 3D model that produces the best
agreement with the CLASP observations has a relatively weak magnetic field and
a relatively high degree of corrugation. We emphasize that a suitable way to
validate or refute numerical models of the upper solar chromosphere is by
confronting calculations and observations of the scattering polarization in
ultraviolet lines sensitive to the Hanle effect.Comment: Accepted for publication in The Astrophysical Journal Letter
Coronal Temperature Diagnostic Capability of the Hinode/X-Ray Telescope Based on Self-Consistent Calibration
The X-Ray Telescope (XRT) onboard the Hinode satellite is an X-ray imager
that observes the solar corona with unprecedentedly high angular resolution
(consistent with its 1" pixel size). XRT has nine X-ray analysis filters with
different temperature responses. One of the most significant scientific
features of this telescope is its capability of diagnosing coronal temperatures
from less than 1 MK to more than 10 MK, which has never been accomplished
before. To make full use of this capability, accurate calibration of the
coronal temperature response of XRT is indispensable and is presented in this
article. The effect of on-orbit contamination is also taken into account in the
calibration. On the basis of our calibration results, we review the
coronal-temperature-diagnostic capability of XRT
The effect of the regular solution model in the condensation of protoplanetary dust
We utilize a chemical equilibrium code in order to study the condensation
process which occurs in protoplanetary discs during the formation of the first
solids. The model specifically focuses on the thermodynamic behaviour on the
solid species assuming the regular solution model. For each solution, we
establish the relationship between the activity of the species, the composition
and the temperature using experimental data from the literature. We then apply
the Gibbs free energy minimization method and study the resulting condensation
sequence for a range of temperatures and pressures within a protoplanetary
disc. Our results using the regular solution model show that grains condense
over a large temperature range and therefore throughout a large portion of the
disc. In the high temperature region (T > 1400 K) Ca-Al compounds dominate and
the formation of corundum is sensitive to the pressure. The mid-temperature
region is dominated by Fe(s) and silicates such as Mg2SiO4 and MgSiO3 . The
chemistry of forsterite and enstatite are strictly related, and our simulations
show a sequence of forsterite-enstatite-forsterite with decreasing temperature.
In the low temperature regions (T < 600 K) a range of iron compounds and
sulfides form. We also run simulations using the ideal solution model and see
clear differences in the resulting condensation sequences with changing
solution model In particular, we find that the turning point in which
forsterite replaces enstatite in the low temperature region is sensitive to the
solution model. Our results show that the ideal solution model is often a poor
approximation to experimental data at most temperatures important in
protoplanetary discs. We find some important differences in the resulting
condensation sequences when using the regular solution model, and suggest that
this model should provide a more realistic condensation sequence.Comment: MNRAS: Accepted 2011 February 16. Received 2011 February 14; in
original form 2010 July 2
Sounding Rocket Experiment CLASP2: Development of the UV High-Precision Polarization Spectroscopy Device
Sounding Rocket Experiment CLASP2 (Chromospheric LAyer Spectro-Polarimeter-2): Development of the UV (Ultraviolet) High-Precision Polarization Spectroscopy Devic
The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency
<p>Abstract</p> <p>Background</p> <p>Genetic variation may underlie phenotypic variation in chronic obstructive pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD). Genotype specific sub-phenotypes are likely and may underlie the poor replication of previous genetic studies. This study investigated subjects with AATD to determine the relationship between specific phenotypes and <it>TNFα </it>polymorphisms.</p> <p>Methods</p> <p>424 unrelated subjects of the PiZZ genotype were assessed for history of chronic bronchitis, impairment of lung function and radiological presence of emphysema and bronchiectasis. A subset of subjects with 3 years consecutive lung function data was assessed for decline of lung function. Four single nucleotide polymorphisms (SNPs) tagging <it>TNFα </it>were genotyped using TaqMan<sup>® </sup>genotyping technologies and compared between subjects affected by each phenotype and those unaffected. Plasma TNFα levels were measured in all PiZZ subjects.</p> <p>Results</p> <p>All SNPs were in Hardy-Weinberg equilibrium. A significant difference in rs361525 genotype (p = 0.01) and allele (p = 0.01) frequency was seen between subjects with and without chronic bronchitis, independent of the presence of other phenotypes. TNFα plasma level showed no phenotypic or genotypic associations.</p> <p>Conclusion</p> <p>Variation in <it>TNFα </it>is associated with chronic bronchitis in AATD.</p
Signatures of the slow solar wind streams from active regions in the inner corona
Some of local sources of the slow solar wind can be associated with
spectroscopically detected plasma outflows at edges of active regions
accompanied with specific signatures in the inner corona. The EUV telescopes
(e.g. SPIRIT/CORONAS-F, TESIS/CORONAS-Photon and SWAP/PROBA2) sometimes
observed extended ray-like structures seen at the limb above active regions in
1MK iron emission lines and described as "coronal rays". To verify the
relationship between coronal rays and plasma outflows, we analyze an isolated
active region (AR) adjacent to small coronal hole (CH) observed by different
EUV instruments in the end of July - beginning of August 2009. On August 1 EIS
revealed in the AR two compact outflows with the Doppler velocities V =10-30
km/s accompanied with fan loops diverging from their regions. At the limb the
ARCH interface region produced coronal rays observed by EUVI/STEREO-A on July
31 as well as by TESIS on August 7. The rays were co-aligned with open magnetic
field lines expanded to the streamer stalks. Using the DEM analysis, it was
found that the fan loops diverged from the outflow regions had the dominant
temperature of ~1 MK, which is similar to that of the outgoing plasma streams.
Parameters of the solar wind measured by STEREO-B, ACE, WIND, STEREO-A were
conformed with identification of the ARCH as a source region at the
Wang-Sheeley-Arge map of derived coronal holes for CR 2086. The results of the
study support the suggestion that coronal rays can represent signatures of
outflows from ARs propagating in the inner corona along open field lines into
the heliosphere.Comment: Accepted for publication in Solar Physics; 31 Pages; 13 Figure
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