Probing the strength of the Iberian lithosphere

Como indicador de la resistencia de la litosfera a largo plazo, el espesor elástico efectivo (Te) se puede utilizar para entender la relación entre la reología de la litosfera y la evolución geodinámica de ambientes tectónicos complejos. En este trabajo presentamos, por primera vez, un mapa de alta resolución de la variación espacial de Te en la península ibérica, obtenido a partir del análisis espectral de la coherencia entre la topografía y anomalía de Bouguer, con el objetivo de mejorar nuestro conocimiento de la variación regional en la reología y el comportamiento mecánico a largo plazo de su litosfera. La mayor parte de la región se caracteriza por valores de espesor elástico efectivo bajos (Te < 20 km), destacando un domino de valores de Te moderados y altos en la zona centro y sudoeste peninsular, que se prolonga hacia el norte de África, limitado por fuertes gradientes de Te, especialmente en la zona sur.As a proxy for long-term lithospheric strength, the effective elastic thickness (Te) can be used to understand the relationship between lithospheric rheology and geodynamic evolution of complex tectonic settings. Here we investigate the lithospheric strength of the Iberian Peninsula in order to improve our knowledge of the regional variations of the rheology and long-term mechanical behavior of the lithosphere in the study area. For this we present, for the first time, a high-resolution map of spatial variations of Te in the Iberian Peninsula from the spectral analysis of the Bouguer coherence. We find that this region is characterized by low Te values (Te < 20 km), where the most noticeable feature is a band of moderate to high values over the central and southwestern Iberian Peninsula, which connect southward with the high Te values in the North Africa region.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEMinisterio de Economía y Competitividad (MINECO)pu

CALIFA, the Calar Alto Legacy Integral Field Area survey: IV. Third public data release

This paper describes the third public data release (DR3) of the Calar Alto Legacy Integral Field Area (CALIFA) survey. Science-grade quality data for 667 galaxies are made public, including the 200 galaxies of the second public data release (DR2). Data were obtained with the integral-field spectrograph PMAS/PPak mounted on the 3.5 m telescope at the Calar Alto Observatory. Three different spectral setups are available: i) a low-resolution V500 setup covering the wavelength range 3745-7500 Å (4240-7140 Å unvignetted) with a spectral resolution of 6.0 Å (FWHM) for 646 galaxies, ii) a medium-resolution V1200 setup covering the wavelength range 3650-4840 Å (3650-4620 Å unvignetted) with a spectral resolution of 2.3 Å (FWHM) for 484 galaxies, and iii) the combination of the cubes from both setups (called COMBO) with a spectral resolution of 6.0 Å and a wavelength range between 3700-7500 Å (3700-7140 Å unvignetted) for 446 galaxies. The Main Sample, selected and observed according to the CALIFA survey strategy covers a redshift range between 0.005 and 0.03, spans the color-magnitude diagram and probes a wide range of stellar masses, ionization conditions, and morphological types. The Extension Sample covers several types of galaxies that are rare in the overall galaxy population and are therefore not numerous or absent in the CALIFA Main Sample. All the cubes in the data release were processed using the latest pipeline, which includes improved versions of the calibration frames and an even further improved image reconstruction quality. In total, the third data release contains 1576 datacubes, including ~1.5 million independent spectra. © 2016 ESO.SFS thanks the CONACYT-125180 and DGAPA-IA100815 projects for providing him support in this study. R.G.B., R.G.D., and E.P. are supported by grants AYA2014-57490-P and JA-FQM-2828. SZ is supported by the EU Marie Curie Integration Grant >SteMaGE> No. PCIG12-GA-2012-326466 (Call Identifier: FP7-PEOPLE-2012 CIG). J. F.-B. from grant AYA2013-48226-C3-1-P from the Spanish Ministry of Economy and Competitiveness (MINECO), as well as from the FP7 Marie Curie Actions of the European Commission, via the Initial Training Network DAGAL under REA grant agreement 289313 B.G-L- acknowledges financial support by the Spanish MINECO under grants AYA2013-41656-P and AYA2015-68217-P Support for L.G. is provided by the Ministry of Economy, Development, and Tourism's Millennium Science Initiative through grant IC12009, awarded to The Millennium Institute of Astrophysics, MAS. L.G. also acknowledges support by CONICYT through FONDECYT grant 3140566, and AYA2013-42227-P from the Spanish Ministerio de Ciencia e Innovacion and TIC 114 and PO08-TIC-3531 from Junta de Andalucia. AG acknowledges support from the FP7/2007-2013 under grant agreement no. 267251 (AstroFIt). RAM was funded by the Spanish programme of International Campus of Excellence Moncloa (CEI). JMA acknowledges support from the European Research Council Starting Grant (SEDmorph; P.I. V. Wild). I.M. and A.d.O. acknowledge the support by the projects AYA2010-15196 from the Spanish Ministerio de Ciencia e Innovacion and TIC 114 and PO08-TIC-3531 from Junta de Andalucia. AMI acknowledges support from Agence Nationale de la Recherche through the STILISM project (ANR-12-BS05-0016-02). M.M. acknowledges financial support from AYA2010-21887-004-02 from the Ministerio de Economia y Competitividad. PSB acknowledges support from the Ramon y Cajal program, grant ATA2010-21322-C03-02 from the Spanish Ministry of Economy and Competitiveness (MINECO). C.J.W. acknowledges support through the Marie Curie Career Integration Grant 303912. V.W. acknowledges support from the European Research Council Starting Grant (SEDMorph P.I. V. Wild) and European Career Re-integration Grant (Phiz-Ev P.I. V. Wild). YA acknowledges financial support from the Ramon y Cajal programme (RyC-2011-09461) and project AYA2013-47742-C4-3-P, both managed by the Ministerio de Economia y Competitividad, as well as the >Study of Emission-Line Galaxies with Integral Field Spectroscopy> (SELGIFS) programme, funded by the EU (FP7-PEOPLE-2013-IRSES-612701) within the Marie-Sklodowska-Curie Actions scheme. ROM acknowledges support from CAPES (Brazil) through a PDJ fellowship from project 88881.030413/2013-01, program CSF-PVE.Peer Reviewe

Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer

Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the expression/secretion profile of EN2 in five independent samples cohorts from PCa patients and controls (prostate tissues and/or urine) to determine its utility as a PCa biomarker; and 2) the functional role of EN2 in normal (RWPE1) and tumor (LNCaP/22Rv1/PC3) prostate cells to explore its potential value as therapeutic target. EN2 was overexpressed in our two cohorts of PCa tissues compared to control and in tumor cell lines compared with normal-like prostate cells. This profile was corroborated in silico in three independent data sets [The Cancer Genome Atlas(TCGA)/Memorial Sloan Kettering Cancer Center (MSKCC)/Grasso]. Consistently, urine EN2 levels were elevated and enabled discrimination between PCa and control patients. EN2 treatment increased cell proliferation in LNCaP/22Rv1/PC3 cells, migration in RWPE1/PC3 cells, and PSA secretion in LNCaP cells. These effects were associated, at least in the androgen-sensitive LNCaP cells, with increased AKT and androgen-receptor phosphorylation levels and with modulation of key cancer-associated genes. Consistently, EN2 treatment also regulated androgen-receptor activity (full-length and splicing variants) in androgen-sensitive 22Rv1 cells. Altogether, this study demonstrates the potential utility of EN2 as a non-invasive diagnostic biomarker for PCa and provides novel and valuable information to further investigate its putative utility to develop new therapeutic tools in PCa

Revista de Revistas.

Psiquiatría dinámica en la "década del cerebro". Psychodynamic psychiatry in the "decade of the brain". G.o. Gabbard. Am J Pschiatry. Agosto 1992; 149: 991-998. J. Jáuregui Isasmendi El cambio psíquico: desarrollo en la teoría de las técnicas psicoanalíticas. Psychic change: development in the theory of psychoanalytic techniques. A. Cooper. International Journal of Psychoanalysis. Summer 1992; vol 73, part 2: pp 245-250. J. López Castillo ¿Tiene efecto catártico un intento de suicidio?. An attempted suicide actually have a cathartic effect?. Jo. Bronish. Acta Psychiatr Scand. 1992; 86: 228-232. M. Salvador Robert La exposición prenatal a la gripe no causa esquizofrenia. Prenatal exposure to influenza does not cause schizophrenia. JJ. Crovv, D.J. Oone. British Journal of Psychiatry. 1992; 161: 390-393. Rosa Villanueva Peña Alexitimia en mujeres con anorexia nerviosa. Alexithymia in women with anorexia nervosa. M.P Bourke et al. British Journal of Psychiatry. 1992; 161: 240-243. M. A. Casado Prieto Dinámica de caos en la actividad del sistema nervioso autónomo durante una sesión de psicoterapia. Chaotic dynamics in autonomic nervous system activity of a patient during a psychotherapy session. D.J. Redington, S.P Reidbord. Biol Psychiatry. 1992; 31: 984-992. P. Pérez Sales, T. Ferrer Gila Uso de psicofármacos en el paciente con infección por el virus de la inmunodeficiencia humana. J.L. Ayuso Mateas. Farmacología del S.N.C. Septiembre 1992; vol 6, N.o 3: pp 94-101. I. Morales Tratamiento de mantenimiento de la depresión recurrente orientación actual y futura. Maintenance treatment in recurrent depresion: current and future directions. D.J. Kupfer. British Journal 01 Psychiatry 1992; 161: 309-316. F. Rodríguez y González-Nicolás Comportamientos de riesgo para el VIH/SIDA entre los enfermos mentales crónicos. AIDS/HIV risk behavior among the cronic mentally ill. J.A. Kelly et al. Am J Psychiatry. July 1992; 149: 7. J.J. Marin Lozano Tipos de alcohólicos. 1. Evidencia de una tipología empírica basada en indicadores de vulnerabilidad y severidad. Types of alcoholics. l. Evidence for an empirically derived typology based on indicators of vulnerability and severity. TF Babor, M. Hofmann, FK. Del Broca, V Hesselbrock, R. E. Meyer, Z.S. Dolinsky, B. Rounsaville. Arch Gen Psychiatry. 1992; 49: 599-608. Pérez Jiménez, J.P. ¿Es el momento para una moratoria en la desinstitucionalización?. Is it time for a moratorium on deinstitutionalization?. R. Lamb. Hospital and Community Psychiatry. July 1992; vol 43, n.o 77. v. Aparicio Basauri Prevalencia de trastornos mentales en Subtiava, León, Nicaragua V Penayo, T Caldera, L. Jacobson Bol Of Sanit Panamá 1992; 113 (2). V. Aparicio Basauri ¿Cuánto tiempo debe continuarse un tratamiento de mantenimiento con neurolépticos?. How long should neuroleptic maintenance treatment continue?. W Kissling. Relapse. Issues in the Management of Chronic Psychosis. Vol 2, n.o 3. V. Aparicio Basauri El estado de la cuestión en... Consecuencias en pacientes adultos del abuso sexual en la infancia. A.E. Naf

Usual dietary intake, nutritional adequacy and food sources of calcium, phosphorus, magnesium and vitamin D of spanish children aged one to dagger

Bone problems in the population begin to be establish in childhood. The present study aims to assess the usual calcium, phosphorus, magnesium, and vitamin D intakes, along with the food sources of these nutrients, in Spanish children participating in the EsNuPI (Estudio Nutricional en Población Infantil Española) study. Two 24 h dietary recalls were applied to 1448 children (1 to <10 years) divided into two sub-samples: one reference sample (RS) of the general population [n = 707] and another sample which exclusively included children consuming enriched or fortified milks, here called “adapted milks” (AMS) [n = 741]. Estimation of the usual intake shows that nutrient intake increased with age for all nutrients except vitamin D. Using as reference the Dietary Reference Values from the European Food Safety Authority (EFSA), calcium and magnesium intakes were found to be below the average requirement (AR) and adequate intake (AI), respectively, in a considerable percentage of children. Furthermore, phosphorus exceeded the AI in 100% of individuals and vitamin D was lower than the AI in almost all children studied. The results were very similar when considering only plausible reporters. When analyzing the food sources of the nutrients studied, milk and dairy products contributed the most to calcium, phosphorus, magnesium, and vitamin D. Other sources of calcium were cereals and vegetables; for phosphorus: meat, meat products, and cereals; for magnesium: cereals and fruits; and, for vitamin D: fish and eggs. These results highlight the desirability of improving the intake concerning these nutrients, which are involved in bone and metabolic health in children. The AMS group appeared to contribute better to the adequacy of those nutrients than the RS group, but both still need further improvement. Of special interest are the results of vitamin D intakes, which were significantly higher in the AMS group (although still below the AI), independent of age

Revista de Revistas.

Psiquiatría dinámica en la "década del cerebro". Psychodynamic psychiatry in the "decade of the brain". G.o. Gabbard. Am J Pschiatry. Agosto 1992; 149: 991-998. J. Jáuregui Isasmendi El cambio psíquico: desarrollo en la teoría de las técnicas psicoanalíticas. Psychic change: development in the theory of psychoanalytic techniques. A. Cooper. International Journal of Psychoanalysis. Summer 1992; vol 73, part 2: pp 245-250. J. López Castillo ¿Tiene efecto catártico un intento de suicidio?. An attempted suicide actually have a cathartic effect?. Jo. Bronish. Acta Psychiatr Scand. 1992; 86: 228-232. M. Salvador Robert La exposición prenatal a la gripe no causa esquizofrenia. Prenatal exposure to influenza does not cause schizophrenia. JJ. Crovv, D.J. Oone. British Journal of Psychiatry. 1992; 161: 390-393. Rosa Villanueva Peña Alexitimia en mujeres con anorexia nerviosa. Alexithymia in women with anorexia nervosa. M.P Bourke et al. British Journal of Psychiatry. 1992; 161: 240-243. M. A. Casado Prieto Dinámica de caos en la actividad del sistema nervioso autónomo durante una sesión de psicoterapia. Chaotic dynamics in autonomic nervous system activity of a patient during a psychotherapy session. D.J. Redington, S.P Reidbord. Biol Psychiatry. 1992; 31: 984-992. P. Pérez Sales, T. Ferrer Gila Uso de psicofármacos en el paciente con infección por el virus de la inmunodeficiencia humana. J.L. Ayuso Mateas. Farmacología del S.N.C. Septiembre 1992; vol 6, N.o 3: pp 94-101. I. Morales Tratamiento de mantenimiento de la depresión recurrente orientación actual y futura. Maintenance treatment in recurrent depresion: current and future directions. D.J. Kupfer. British Journal 01 Psychiatry 1992; 161: 309-316. F. Rodríguez y González-Nicolás Comportamientos de riesgo para el VIH/SIDA entre los enfermos mentales crónicos. AIDS/HIV risk behavior among the cronic mentally ill. J.A. Kelly et al. Am J Psychiatry. July 1992; 149: 7. J.J. Marin Lozano Tipos de alcohólicos. 1. Evidencia de una tipología empírica basada en indicadores de vulnerabilidad y severidad. Types of alcoholics. l. Evidence for an empirically derived typology based on indicators of vulnerability and severity. TF Babor, M. Hofmann, FK. Del Broca, V Hesselbrock, R. E. Meyer, Z.S. Dolinsky, B. Rounsaville. Arch Gen Psychiatry. 1992; 49: 599-608. Pérez Jiménez, J.P. ¿Es el momento para una moratoria en la desinstitucionalización?. Is it time for a moratorium on deinstitutionalization?. R. Lamb. Hospital and Community Psychiatry. July 1992; vol 43, n.o 77. v. Aparicio Basauri Prevalencia de trastornos mentales en Subtiava, León, Nicaragua V Penayo, T Caldera, L. Jacobson Bol Of Sanit Panamá 1992; 113 (2). V. Aparicio Basauri ¿Cuánto tiempo debe continuarse un tratamiento de mantenimiento con neurolépticos?. How long should neuroleptic maintenance treatment continue?. W Kissling. Relapse. Issues in the Management of Chronic Psychosis. Vol 2, n.o 3. V. Aparicio Basauri El estado de la cuestión en... Consecuencias en pacientes adultos del abuso sexual en la infancia. A.E. Naf

NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial

Simple Summary Multiple Myeloma (MM) is considered an incurable chronic disease, which prognosis depends on the presence of different genomic alterations. To accomplish a complete molecular diagnosis in a single essay, we have designed and validated a capture-based NGS approach to reliably identify pathogenic mutations (SNVs and indels), genomic alterations (CNVs and chromosomic translocations), and IGH rearrangements. We have observed a good correlation of the results obtained using our capture panel with data obtained by both FISH and WES techniques. In this study, the molecular classification performed using our approach was significantly associated with the stratification and outcome of MM patients. Additionally, this panel has been proven to detect specific IGH rearrangements that could be used as biomarkers in patient follow-ups through minimal residual disease (MRD) assays. In conclusion, we think that MM patients could benefit from the use of this capture-based NGS approach with a more accurate, single-essay molecular diagnosis. Next-generation sequencing (NGS) has greatly improved our ability to detect the genomic aberrations occurring in multiple myeloma (MM); however, its transfer to routine clinical labs and its validation in clinical trials remains to be established. We designed a capture-based NGS targeted panel to identify, in a single assay, known genetic alterations for the prognostic stratification of MM. The NGS panel was designed for the simultaneous study of single nucleotide and copy number variations, insertions and deletions, chromosomal translocations and V(D)J rearrangements. The panel was validated using a cohort of 149 MM patients enrolled in the GEM2012MENOS65 clinical trial. The results showed great global accuracy, with positive and negative predictive values close to 90% when compared with available data from fluorescence in situ hybridization and whole-exome sequencing. While the treatments used in the clinical trial showed high efficacy, patients defined as high-risk by the panel had shorter progression-free survival (p = 0.0015). As expected, the mutational status of TP53 was significant in predicting patient outcomes (p = 0.021). The NGS panel also efficiently detected clonal IGH rearrangements in 81% of patients. In conclusion, molecular karyotyping using a targeted NGS panel can identify relevant prognostic chromosomal abnormalities and translocations for the clinical management of MM patients

The dependence of oxygen and nitrogen abundances on stellar mass from the CALIFA survey

Context. The study of the integrated properties of star-forming galaxies is central to understand their formation and evolution. Some of these properties are extensive and therefore their analysis require totally covering and spatially resolved observations. Among these properties, metallicity can be defined in spiral discs by means of integral field spectroscopy (IFS) of individual H ii regions. The simultaneous analysis of the abundances of primary elements, as oxygen, and secondary, as nitrogen, also provides clues about the star formation history and the processes that shape the build-up of spiral discs. Aims. Our main aim is to analyse simultaneously O/H and N/O abundance ratios in H ii regions in different radial positions of the discs in a large sample of spiral galaxies to obtain the slopes and the characteristic abundance ratios that can be related to their integrated properties. Methods. We analysed the optical spectra of individual selected H ii regions extracted from a sample of 350 spiral galaxies of the CALIFA survey. We calculated total O/H abundances and, for the first time, N/O ratios using the semi-empirical routine Hii-Chi-mistry, which, according to Pérez-Montero (2014, MNRAS, 441, 2663), is consistent with the direct method and reduces the uncertainty in the O/H derivation using [N ii] lines owing to the dispersion in the O/H-N/O relation. Then we performed linear fittings to the abundances as a function of the de-projected galactocentric distances. Results. The analysis of the radial distribution both for O/H and N/O in the non-interacting galaxies reveals that both average slopes are negative, but a non-negligible fraction of objects have a flat or even a positive gradient (at least 10% for O/H and 4% for N/O). The slopes normalised to the effective radius appear to have a slight dependence on the total stellar mass and the morphological type, as late low-mass objects tend to have flatter slopes. No clear relation is found, however, to explain the presence of inverted gradients in this sample, and there is no dependence between the average slopes and the presence of a bar. The relation between the resulting O/H and N/O linear fittings at the effective radius is much tighter (correlation coefficient ρ = 0.80) than between O/H and N/O slopes (ρ = 0.39) or for O/H and N/O in the individual H ii regions (ρ = 0.37). These O/H and N/O values at the effective radius also correlate very tightly (less than 0.03 dex of dispersion) with total luminosity and stellar mass. The relation with other integrated properties, such as star formation rate, colour, or morphology, can be understood only in light of the found relation with mass.E.P.M., J.M.V., C.K., S.P., and J.I.P. acknowledge support from the Spanish MICINN through grants AYA2010-21887-C04-01 and AYA2013-47742-C4-1-P and the Junta de Andalucia for grant EXC/2011 FQM-7058. R.G.B., R.G.D., and E.P. acknowledge support from grants AYA2014-57490-P and JA-FQM-2828. Support for L.G. is provided by the Ministry of Economy, Development, and Tourism's Millennium Science Initiative through grant IC120009, awarded to The Millennium Institute of Astrophysics, MAS. L.G. acknowledges support by CONICYT through FONDECYT grant 3140566Peer Reviewe

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

ESRETNET Study Group, The ERDC Study Group, The Associated Clinical Study Group.Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006)