612 research outputs found
Examples of q-regularization
An Introduction to Hopf algebras as a tool for the regularization of relavent
quantities in quantum field theory is given. We deform algebraic spaces by
introducing q as a regulator of a non-commutative and non-cocommutative Hopf
algebra. Relevant quantities are finite provided q\neq 1 and diverge in the
limit q\rightarrow 1. We discuss q-regularization on different q-deformed
spaces for \lambda\phi^4 theory as example to illustrate the idea.Comment: 17 pages, LaTex, to be published in IJTP 1995.1
Measurement of Aerosols at the Pierre Auger Observatory
The air fluorescence detectors (FDs) of the Pierre Auger Observatory are
vital for the determination of the air shower energy scale. To compensate for
variations in atmospheric conditions that affect the energy measurement, the
Observatory operates an array of monitoring instruments to record hourly
atmospheric conditions across the detector site, an area exceeding 3,000 square
km. This paper presents results from four instruments used to characterize the
aerosol component of the atmosphere: the Central Laser Facility (CLF), which
provides the FDs with calibrated laser shots; the scanning backscatter lidars,
which operate at three FD sites; the Aerosol Phase Function monitors (APFs),
which measure the aerosol scattering cross section at two FD locations; and the
Horizontal Attenuation Monitor (HAM), which measures the wavelength dependence
of aerosol attenuation.Comment: Contribution to the 30th International Cosmic Ray Conference, Merida
Mexico, July 2007; 4 pages, 4 figure
Access to Preprimary Education and Progression in Primary School: Evidence from Rural Guatemala
Health Outcome Predictive Evaluation for COVID 19 international registry (HOPE COVID-19), rationale and design
The disease produced by the new coronavirus known as SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), named COVID-19 (Coronavirus Disease-2019) has recently been classified as a pandemic by the World Health Organization (WHO). However, scarce clinical data is available and generally limited to the Chinese population due to the first cases were identified in Wuhan (Hubei, China).This article describes the rationale and design of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) registry (ClinicalTrials.gov Identifier: NCT04334291). With an ambispective cohort design, eligible patients are those discharged, deceased or alive, from any hospital center with a confirmed diagnosis or a COVID-19 high suspicion. With a current recruitment of more than 7000 cases, in 46 hospitals in 8 countries, since it is not possible to estimate the sample size based on literature reports, the investigators will try to get the maximum numbers of patients possible. The study primary objective is all cause mortality and aims to characterize the clinical profile of patients infected in order to develop a prognostic clinical score allowing, rapid logistic decision making. As secondary objectives, the analysis of other clinical events, the risk-adjusted influence of treatments and previous comorbidities of patients infected with the disease will be performed.The results of HOPE COVID-19 will contribute to a better understanding of this condition. We aim to describe the management of this condition as well as the outcomes in relation to the therapy chosen, in order to gain insight into improving patient care in the coming months. Clinical Trial registration: ClinicalTrials.gov. Unique identifier: NCT04334291
Validation of Calprotectin As a Novel Biomarker For The Diagnosis of Pleural Effusion: a Multicentre Trial
Discriminating between malignant pleural effusion (MPE) and benign pleural effusion (BPE) remains difficult. Thus, novel and efficient biomarkers are required for the diagnosis of pleural effusion (PE). The aim of this study was to validate calprotectin as a diagnostic biomarker of PE in clinical settings. A total of 425 patients were recruited, and the pleural fluid samples collected had BPE in 223 cases (53.7%) or MPE in 137 patients (33%). The samples were all analysed following the same previously validated clinical laboratory protocols and methodology. Calprotectin levels ranged from 772.48 to 3,163.8 ng/mL (median: 1,939 ng/mL) in MPE, and 3,216-24,000 ng/mL in BPE (median: 9,209 ng/mL; p < 0.01), with an area under the curve of 0.848 [95% CI: 0.810-0.886]. For a cut-off value of </= 6,233.2 ng/mL, we found 96% sensitivity and 60% specificity, with a negative and positive predictive value, and negative and positive likelihood ratios of 96%, 57%, 0.06, and 2.4, respectively. Multivariate analysis showed that low calprotectin levels was a better discriminator of PE than any other variable [OR 28.76 (p < 0.0001)]. Our results confirm that calprotectin is a new and useful diagnostic biomarker in patients with PE of uncertain aetiology which has potential applications in clinical practice because it may be a good complement to cytological methods
Biogeographical origin and timing of the founder ichthyosis TGM1 c.1187G > A mutation in an isolated Ecuadorian population
An unusually high frequency of the lamellar ichthyosis TGM1 mutation, c.1187G > A, has been observed in the Ecuadorian province of Manabi. Recently, the same mutation has been detected in a Galician patient (Northwest of Spain). By analyzing patterns of genetic variation around this mutation in Ecuadorian patients and population matched controls, we were able to estimate the age of c.1187G > A and the time to their most recent common ancestor (TMRCA) of c.1187G > A Ecuadorian carriers. While the estimated mutation age is 41 generations ago (~1,025 years ago [ya]), the TMRCA of Ecuadorian c.1187G > A carrier haplotypes dates to just 17 generations (~425 ya). Probabilistic-based inferences of local ancestry allowed us to infer a most likely European origin of a few (16% to 30%) Ecuadorian haplotypes carrying this mutation. In addition, inferences on demographic historical changes based on c.1187G > A Ecuadorian carrier haplotypes estimated an exponential population growth starting ~20 generations, compatible with a recent founder effect occurring in Manabi. Two main hypotheses can be considered for the origin of c.1187G > A: (i) the mutation could have arisen in Spain >1,000 ya (being Galicia the possible homeland) and then carried to Ecuador by Spaniards in colonial times ~400 ya, and (ii) two independent mutational events originated this mutation in Ecuador and Galicia. The geographic and cultural characteristics of Manabi could have favored a founder effect that explains the high prevalence of TGM1 c.1187G > A in this region
Exploring pre-main sequence variables of ONC: The new variables
Since 2004, we have been engaged in a long-term observing program to monitor
young stellar objects in the Orion Nebula Cluster. We have collected about two
thousands frames in V, R, and I broad-band filters on more than two hundred
nights distributed over five consecutive observing seasons. The high-quality
and time-extended photometric data give us an opportunity to address various
phenomena associated with young stars. The prime motivations of this project
are i) to explore various manifestations of stellar magnetic activity in very
young low-mass stars; ii) to search for new pre-main sequence eclipsing
binaries; and iii) to look for any EXor and FUor like transient activities
associated with YSOs. Since this is the first paper on this program, we give a
detailed description of the science drivers, the observation and the data
reduction strategies as well. In addition to these, we also present a large
number of new periodic variables detected from our first five years of
time-series photometric data. Our study reveals that about 72% of CTTS in our
FoV are periodic, whereas, the percentage of periodic WTTS is just 32%. This
indicates that inhomogeneities patterns on the surface of CTTS of the ONC stars
are much more stable than on WTTS. From our multi-year monitoring campaign we
found that the photometric surveys based on single-season are incapable of
identifying all periodic variables. And any study on evolution of angular
momentum based on single-season surveys must be carried out with caution.Comment: Accepted for publication by MNRAS, 26 pages, 17 figures, 6 table
Effect of the Monocyte Chemoattractant Protein-1/CC Chemokine Receptor 2 System on Nephrin Expression in Streptozotocin-Treated Mice and Human Cultured Podocytes
OBJECTIVE-Monocyte chemoattractant protein-1 (MCP-1), a chemokine binding to the CC chemokine receptor 2 (CCR2) and promoting monocyte infiltration, has been implicated in the pathogenesis of diabetic nephropathy. To assess the potential relevance of the MCP-1/CCR2 system in the pathogenesis of diabetic proteinuria, we studied in vitro if MCP-1 binding to the CCR2 receptor modulates nephrin expression in cultured podocytes. Moreover, we investigated in vivo if glomerular CCR2 expression is altered in kidney biopsies from patients with diabetic nephropathy and whether lack of MCP-1 affects proteinuria and expression of nephrin in experimental diabetes.
RESEARCH DESIGN AND METHODS-Expression of nephrin was assessed in human podocytes exposed to rh-MCP-1 by immunofluorescence and real-time PCR. Glomerular CCR2 expression was studied in 10 kidney sections from patients with overt nephropathy and eight control subjects by immunohistochemistry. Both wild-type and MCP-1 knockout mice were made diabetic with streptozotocin. Ten weeks after the onset of diabetes, albuminuria and expression of nephrin, synaptopodin, and zonula occludens-1 were examined by immunofluorescence and immunoblotting.
RESULTS-In human podocytes, MCP-1 binding to the CCR2 receptor induced a significant reduction in nephrin both mRNA and protein expression via a Rho-dependent mechanism. The MCP-1 receptor, CCR2, was overexpressed in the glomerular podocytes of patients with overt nephropathy. In experimental diabetes, MCP-1 was overexpressed within the glomeruli and the absence of MCP-1 reduced both albuminuria and downregulation of nephrin and synaptopodin.
CONCLUSIONS-These findings suggest that the MCP-1/CCR2 system may be relevant in the pathogenesis of proteinuria in diabetes
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